John Newcomb

2.4k citations

25 papers · 1.2k indexed · h-index 15

Impact in

Immunology top 5%
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immune Response and Inflammation
Radiology, Nuclear Medicine and Imaging top 10%
- Monoclonal and Polyclonal Antibodies Research

Papers in ⓘ

Molecular Biology 15
- Glycosylation and Glycoproteins Research 5
- Protein Kinase Regulation and GTPase Signaling 5
Immunology 11
- Toxin Mechanisms and Immunotoxins 5
- Immunotherapy and Immune Responses 4
- T-cell and B-cell Immunology 3

Co-authors: Peter Cresswell (4 shared papers)Janice M. Riberdy (1 shared paper)Peter Cresswell (1 shared paper)Xiaotian Zhu (2 shared papers)Huilin Zhao (1 shared paper)Kurt Morgenstern (1 shared paper)David R. Stover (1 shared paper)Paul Rose (1 shared paper)
Journals: Bioorganic & Medicinal Chemistry Letters (4 papers)The Journal of Immunology (3 papers)Cellular Immunology (2 papers)Journal of Medical Microbiology (2 papers)The Journal of Experimental Medicine (2 papers)
Partner nations: United States Netherlands Taiwan

In The Last Decade

John Newcomb

25 papers receiving 1.1k citations

Peers

Countries citing papers authored by John Newcomb

Since Specialization

Citations

This map shows the geographic impact of John Newcomb's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John Newcomb with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John Newcomb more than expected).

Fields of papers citing papers by John Newcomb

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John Newcomb. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John Newcomb. The network helps show where John Newcomb may publish in the future.

Co-authors

The 25 scholars most cited alongside John Newcomb, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John Newcomb Line = papers co-authored together John Newcomb links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 25 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides Nature ·Janice M. Riberdy, John Newcomb, Michael J. Surman, James A. Barbosat, Peter Cresswell	1992	318
2	Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors Structure ·Xiaotian Zhu, Joseph L. Kim, John Newcomb, Paul Rose, David R. Stover, Leticia M. Toledo, Huilin Zhao, Kurt Morgenstern	1999	205
3	Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles. The Journal of Experimental Medicine ·Sebastián Amigorena, Paul Webster, James R. Drake, John Newcomb, Peter Cresswell, Ira Mellman	1995	129
4	Characterization of endogenous peptides bound to purified HLA-DR molecules and their absence from invariant chain-associated alpha beta dimers The Journal of Immunology ·John Newcomb, Peter Cresswell	1993	122
5	Structural analysis of proteolytic products of MHC class II-invariant chain complexes generated in vivo. The Journal of Immunology ·John Newcomb, Peter Cresswell	1993	54
6	Characterization of the Loss of SUMO Pathway Function on Cancer Cells and Tumor Proliferation PLoS ONE ·Xingyue He, Jessica Riceberg, Sai Murali Krishna Pulukuri, Steve Grossman, Vaishali Shinde, Pooja Shah, James E. Brownell, Lawrence R. Dick, John Newcomb, Neil Bence	2015	49
7	Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: Development of an expedient and divergent synthetic route and preliminary SAR Bioorganic & Medicinal Chemistry Letters ·Erin F. DiMauro, John Newcomb, Joseph J. Nunes, Jean E. Bemis, Christina Boucher, John L. Buchanan, William H. Buckner, Alan C. Cheng, Theodore Faust, Faye Hsieh, Xin Huang, Josie H. Lee, Teresa L. Marshall, Matthew W. Martin, David C. McGowan, Stephen E. Schneider, Susan M. Turci, Ryan D. White, Xiaotian Zhu	2007	37
8	Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties Bioorganic & Medicinal Chemistry Letters ·Matthew W. Martin, John Newcomb, Joseph J. Nunes, Jean E. Bemis, David C. McGowan, Ryan D. White, John L. Buchanan, Erin F. DiMauro, Christina Boucher, Theodore Faust, Faye Hsieh, Xin Huang, Josie H. Lee, Stephen E. Schneider, Susan M. Turci, Xiaotian Zhu	2007	28
9	Mutations in Chlamydomonas reinhardtii Conferring Resistance to the Herbicide Sulfometuron Methyl PLANT PHYSIOLOGY ·M. Elizabeth Hartnett, John Newcomb, Robert C. Hodson	1987	27
10	Affinity and kinetics of the interactions between an αβ T-cell receptor and its superantigen and class II-MHC/peptide ligands Molecular Immunology ·Sanjay S. Khandekar, Pamela P. Brauer, Jerome W. Naylor, Hsiu‐Ching Chang, Petra Kern, John Newcomb, Kenneth LeClair, Holly S. Stump, Brian M. Bettencourt, Ernest S. Kawasaki, Julian Banerji, Albert T. Profy, Barry Jones	1997	20
11	Trimeric Interactions of the Invariant Chain and Its Association with Major Histocompatibility Complex Class II αβ Dimers Journal of Biological Chemistry ·John Newcomb, Cerinda Carboy-Newcomb, Peter Cresswell	1996	20
12	Effect of isotypic and allotypic variations of MHC class II molecules on staphylococcal enterotoxin presentation to murine T cells Cellular Immunology ·Dennis D. Taub, John Newcomb, Thomas J. Rogers	1992	20
13	2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors Bioorganic & Medicinal Chemistry Letters ·Zihao Hua, Xin Huang, Howard Bregman, Nagasree Chakka, Erin F. DiMauro, Elizabeth M. Doherty, Jonathan T. Goldstein, Hakan Günaydin, Hongbing Huang, Stephanie Mercede, John Newcomb, Vinod F. Patel, Susan M. Turci, Jie Yan, Cindy Wilson, Matthew W. Martin	2012	20
14	Production and characterisation of monoclonal antibodies specific for staphylococcal enterotoxin B Journal of Medical Microbiology ·Y.-S. Lin, Michael Largen, John Newcomb, Thomas J. Rogers	1988	18
15	Localisation of the mitogenic epitope of staphylococcal enterotoxin B Journal of Medical Microbiology ·М. Бiнек, John Newcomb, Christina M. Rogers, Thomas J. Rogers	1992	14
16	Abstract 2384: TAK-169, an exceptionally potent CD38 targeted engineered toxin body, as a novel direct cell kill approach for the treatment of multiple myeloma Cancer Research ·Erin K. Willert, Garrett L. Robinson, Jack P. Higgins, Jensing Liu, Janice Lee, Sakeena Syed, Yuhong Zhang, Dan Tavares, Anya Lublinsky, Nibedita Chattopadhyay, Haiqing Wang, Laura E. Packer, Pujiang Shi, Carole E. Harbison, Sanjay Patel, John Newcomb	2019	14
17	In vitro immunomodulatory activity of ruthenium complexes Inflammation Research ·John Newcomb, Benjamin Rivnay, Cecilia M. Bastos, Timothy D. Ocain, Kristin A. Gordon, Philip D. Gregory, Susan M. Turci, K. A. Sterne, Michael I. Jesson, Jeffrey Krieger, James C. Jenson, Barry Jones	2003	13
18	TAK-169, a Novel Recombinant Immunotoxin Specific for CD38, Induces Powerful Preclinical Activity Against Patient-Derived Multiple Myeloma Cells Blood ·Wassilis S.C. Bruins, Wenrou Zheng, Jack P. Higgins, Erin K. Willert, John Newcomb, Ajeeta B. Dash, Niels W.C.J. van de Donk, Sonja Zweegman, Tuna Mutis	2020	12
19	N-(3-(Phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: Structure, synthesis and SAR Bioorganic & Medicinal Chemistry Letters ·Holly L. Deak, John Newcomb, Joseph J. Nunes, Christina Boucher, Alan C. Cheng, Erin F. DiMauro, Linda F. Epstein, Paul Gallant, Brian L. Hodous, Xin Huang, Josie H. Lee, Vinod F. Patel, Stephen E. Schneider, Susan M. Turci, Xiaotian Zhu	2007	9
20	Immunization with soluble BDC 2.5 T cell receptor-immunoglobulin chimeric protein:antibody specificity and protection of nonobese diabetic mice against adoptive transfer of diabetes by maternal immunization. The Journal of Experimental Medicine ·Una McKeever, Sanjay Khandekar, John Newcomb, Jerome W. Naylor, Paula E. Gregory, Pamela P. Brauer, Michael I. Jesson, Brian M. Bettencourt, Elizabeth Burke, Amanda Alderson, Julian Banerji, Kathryn Haskins, Barry Jones	1996	8

About John Newcomb

John Newcomb is a scholar working on Molecular Biology, Immunology, Radiology, Nuclear Medicine and Imaging, Organic Chemistry and Oncology, having authored 25 papers that have together received 1.2k indexed citations. Recurring topics across this work include Monoclonal and Polyclonal Antibodies Research (8 papers), Toxin Mechanisms and Immunotoxins (5 papers), Glycosylation and Glycoproteins Research (5 papers), Protein Kinase Regulation and GTPase Signaling (5 papers), Synthesis and Biological Evaluation (4 papers), Immunotherapy and Immune Responses (4 papers), T-cell and B-cell Immunology (3 papers) and Cytokine Signaling Pathways and Interactions (2 papers). The work is most often cited by research in Immunology (671 citations), Radiology, Nuclear Medicine and Imaging (193 citations), Molecular Biology (481 citations), Oncology (173 citations) and Immunology and Allergy (31 citations). John Newcomb has collaborated with scholars based in United States, Netherlands and Taiwan. Frequent co-authors include Peter Cresswell, Janice M. Riberdy, Peter Cresswell, Xiaotian Zhu, Huilin Zhao, Kurt Morgenstern, David R. Stover, Paul Rose, Joseph L. Kim and Leticia M. Toledo. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, The Journal of Immunology, Cellular Immunology, Journal of Medical Microbiology and The Journal of Experimental Medicine.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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