Christopher Tsu

2.3k citations

34 papers · 1.8k indexed · h-index 26

Impact in

Hematology top 5%
- Multiple Myeloma Research and Treatments
Oncology top 5%
- Peptidase Inhibition and Analysis

Papers in ⓘ

Aging 2
Cancer Research 11
- Protease and Inhibitor Mechanisms 10

Co-authors: Lawrence R. Dick (16 shared papers)Charles S. Craik (5 shared papers)John J. Perona (5 shared papers)Olke C. Uhlenbeck (2 shared papers)Paul Hales (8 shared papers)Robert J. Fletterick (3 shared papers)Frank J. Bruzzese (8 shared papers)Paul Fleming (7 shared papers)
Journals: Journal of Biological Chemistry (6 papers)Biochemistry (6 papers)Journal of the American Chemical Society (2 papers)Bioorganic & Medicinal Chemistry Letters (2 papers)Journal of Molecular Biology (2 papers)
Partner nations: United States Germany Japan

In The Last Decade

Christopher Tsu

34 papers receiving 1.8k citations

Peers

Countries citing papers authored by Christopher Tsu

Since Specialization

Citations

This map shows the geographic impact of Christopher Tsu's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christopher Tsu with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christopher Tsu more than expected).

Fields of papers citing papers by Christopher Tsu

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christopher Tsu. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christopher Tsu. The network helps show where Christopher Tsu may publish in the future.

Co-authors

The 25 scholars most cited alongside Christopher Tsu, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Christopher Tsu Line = papers co-authored together Christopher Tsu links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 34 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Evaluation of the Proteasome Inhibitor MLN9708 in Preclinical Models of Human Cancer Cancer Research ·Erik Kupperman, Edmund C. Lee, Yueying Cao, Bret Bannerman, Michael Fitzgerald, Allison Berger, Jie Yu, Yang Yu, Paul Hales, Frank J. Bruzzese, Jane Liu, Jonathan L. Blank, Khristofer Garcia, Christopher Tsu, Lawrence R. Dick, Paul Fleming, Li Yu, Mark Manfredi, Mark Rolfe, Joe Bolen	2010	409
2	Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit Biochemical Journal ·Christopher Blackburn, Kenneth M. Gigstad, Paul Hales, Khristofer Garcia, Matthew D. Jones, Frank J. Bruzzese, Cynthia Barrett, Jane X. Liu, Teresa A. Soucy, Darshan S. Sappal, Nancy J. Bump, Edward J. Olhava, Paul Fleming, Lawrence R. Dick, Christopher Tsu, Michael D. Sintchak, Jonathan L. Blank	2010	129
3	Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity Molecular Microbiology ·Gang Lin, Guiqing Hu, Christopher Tsu, Yune Z. Kunes, Huilin Li, Lawrence R. Dick, Thomas F. Parsons, Ping Li, Zhiqiang Chen, Peter Zwickl, Nadine Weich, Carl Nathan	2006	92
4	The Escherichia coli DEAD protein DbpA recognizes a small RNA hairpin in 23S rRNA RNA ·Christopher Tsu, Karl Kossen, Olke C. Uhlenbeck	2001	80
5	Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues Journal of Biological Chemistry ·Jesse J. Chen, Christopher Tsu, James M. Gavin, Michael A. Milhollen, Frank J. Bruzzese, William D. Mallender, Michael D. Sintchak, Nancy J. Bump, Xiaofeng Yang, Jingya Ma, Huay-Keng Loke, Qing Xu, Ping Li, Neil Bence, James E. Brownell, Lawrence R. Dick	2011	66
6	Kinetic Analysis of the RNA-Dependent Adenosinetriphosphatase Activity of DbpA, an Escherichia coli DEAD Protein Specific for 23S Ribosomal RNA Biochemistry ·Christopher Tsu, Olke C. Uhlenbeck	1998	66
7	Crystal Structure of an Ecotin−Collagenase Complex Suggests a Model for Recognition and Cleavage of the Collagen Triple Helix Biochemistry ·John J. Perona, Christopher Tsu, Charles S. Craik, Robert J. Fletterick	1997	64
8	Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells International Journal of Cancer ·Yoshiki Uemura, Stephen C. Pak, Cliff J. Luke, Sule Ccedil ataltepe, Christopher Tsu, Charles Schick, Yoshiro Kamachi, Scott L. Pomeroy, David H. Perlmutter, Gary A. Silverman	2000	63
9	Co‐inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity EMBO Reports ·Michael Basler, Michelle Lindström, Jacob LaStant, J. Michael Bradshaw, Timothy D. Owens, Christian Schmidt, Elmer Maurits, Christopher Tsu, Herman S. Overkleeft, Christopher J. Kirk, Claire L. Langrish, Marcus Groettrup	2018	62
10	Crystal Structure of Rat Anionic Trypsin Complexed with the Protein Inhibitors APPI and BPTI Journal of Molecular Biology ·John J. Perona, Christopher Tsu, Charles S. Craik, Robert J. Fletterick	1993	61
11	Relocating a Negative Charge in the Binding Pocket of Trypsin Journal of Molecular Biology ·John J. Perona, Christopher Tsu, Mary E. McGrath, Charles S. Craik, Robert J. Fletterick	1993	60
12	Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib Molecular Cancer Therapeutics ·Mark J. Williamson, Jonathan L. Blank, Frank J. Bruzzese, Yueying Cao, J. Scott Daniels, Lawrence R. Dick, Jason Labutti, Anne Marie Mazzola, Ashok D. Patil, Corinne Reimer, Marjorie S. Solomon, Matthew Stirling, Yuan Tian, Christopher Tsu, Gabriel S. Weatherhead, Julie X. Zhang, Mark Rolfe	2006	57
13	Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity Journal of Biological Chemistry ·Tatos Akopian, Olga Kandror, Christopher Tsu, Jack H. Lai, Wengen Wu, Yuxin Liu, Peng Zhao, Annie Park, Lisa Wolf, Lawrence R. Dick, Eric J. Rubin, William W. Bachovchin, Alfred L. Goldberg	2015	48
14	N,C-Capped Dipeptides with Selectivity for Mycobacterial Proteasome over Human Proteasomes: Role of S3 and S1 Binding Pockets Journal of the American Chemical Society ·Gang Lin, Tamutenda Chidawanyika, Christopher Tsu, Thulasi Warrier, Julien Vaubourgeix, Christopher Blackburn, Kenneth M. Gigstad, Michael D. Sintchak, Lawrence R. Dick, Carl Nathan	2013	48
15	The Serpin SQN-5 Is a Dual Mechanistic-Class Inhibitor of Serine and Cysteine Proteinases Biochemistry ·May Al-Khunaizi, Cliff J. Luke, Yuko S. Askew, Stephen C. Pak, David J. Askew, Sule Çataltepe, David M. Miller, David Mills, Christopher Tsu, Dieter Brömme, James A. Irving, James C. Whisstock, Gary A. Silverman	2002	47
16	Identification of Potent and Selective Non-covalent Inhibitors of the Plasmodium falciparum Proteasome Journal of the American Chemical Society ·Hao Li, Christopher Tsu, Christopher Blackburn, Gang Li, Paul Hales, Lawrence R. Dick, Matthew Bogyo	2014	46
17	Distinct Specificities of Mycobacterium tuberculosis and Mammalian Proteasomes for N-Acetyl Tripeptide Substrates Journal of Biological Chemistry ·Gang Lin, Christopher Tsu, Lawrence R. Dick, Xi Kathy Zhou, Carl Nathan	2008	45
18	Simple Modifications of the Serpin Reactive Site Loop Convert SCCA2 into a Cysteine Proteinase Inhibitor: A Critical Role for the P3‘ Proline in Facilitating RSL Cleavage Biochemistry ·Cliff J. Luke, Charles Schick, Christopher Tsu, James C. Whisstock, James A. Irving, Dieter Brömme, Luiz Juliano, Guo‐Ping Shi, Harold A. Chapman, Gary A. Silverman	2000	41
19	Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome Bioorganic & Medicinal Chemistry Letters ·Christopher Blackburn, Cynthia Barrett, Jonathan L. Blank, Frank J. Bruzzese, Nancy J. Bump, Lawrence R. Dick, Paul Fleming, Khristofer Garcia, Paul Hales, Zhigen Hu, Matthew D. Jones, Jane X. Liu, Darshan S. Sappal, Michael D. Sintchak, Christopher Tsu, Kenneth M. Gigstad	2010	39
20	Structural Basis for the Broad Substrate Specificity of Fiddler Crab Collagenolytic Serine Protease 1 Biochemistry ·Christopher Tsu, John J. Perona, Robert J. Fletterick, Charles S. Craik	1997	38

About Christopher Tsu

Christopher Tsu is a scholar working on Aging, Cancer Research, Biotechnology, Oncology and Hematology, having authored 34 papers that have together received 1.8k indexed citations. Recurring topics across this work include Ubiquitin and proteasome pathways (16 papers), Peptidase Inhibition and Analysis (13 papers), Protease and Inhibitor Mechanisms (10 papers), Enzyme Production and Characterization (5 papers), Glycosylation and Glycoproteins Research (4 papers), Biochemical and Molecular Research (3 papers), RNA and protein synthesis mechanisms (3 papers) and Blood Coagulation and Thrombosis Mechanisms (3 papers). The work is most often cited by research in Hematology (284 citations), Oncology (584 citations), Molecular Biology (1.4k citations), Cancer Research (211 citations) and Biotechnology (112 citations). Christopher Tsu has collaborated with scholars based in United States, Germany and Japan. Frequent co-authors include Lawrence R. Dick, Charles S. Craik, John J. Perona, Olke C. Uhlenbeck, Paul Hales, Robert J. Fletterick, Frank J. Bruzzese, Paul Fleming, Jonathan L. Blank and Khristofer Garcia. Their work appears in journals such as Journal of Biological Chemistry, Biochemistry, Journal of the American Chemical Society, Bioorganic & Medicinal Chemistry Letters and Journal of Molecular Biology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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