Irene Tom

3.5k total citations · 2 hit papers
20 papers, 2.4k citations indexed

About

Irene Tom is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Oncology. According to data from OpenAlex, Irene Tom has authored 20 papers receiving a total of 2.4k indexed citations (citations by other indexed papers that have themselves been cited), including 14 papers in Molecular Biology, 6 papers in Cellular and Molecular Neuroscience and 4 papers in Oncology. Recurrent topics in Irene Tom's work include Advanced Biosensing Techniques and Applications (3 papers), Neuropeptides and Animal Physiology (3 papers) and T-cell and B-cell Immunology (3 papers). Irene Tom is often cited by papers focused on Advanced Biosensing Techniques and Applications (3 papers), Neuropeptides and Animal Physiology (3 papers) and T-cell and B-cell Immunology (3 papers). Irene Tom collaborates with scholars based in United States, France and India. Irene Tom's co-authors include Lino C. Gonzalez, Morgan Sheng, Yuanyuan Wang, Felix L. Yeh, Dan Eaton, Hilary Clark, Michelle Francesco, Eugene Y. Chiang, Canio J. Refino and Jane L. Grogan and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Irene Tom

20 papers receiving 2.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

2008 1.1k citations Xin Yu, Lino C. Gonzalez et al. Nature Immunology profile →
TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

2016 650 citations Felix L. Yeh, Yuanyuan Wang et al. Neuron profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Irene Tom United States	13	1.3k	766	520	492	321	20	2.4k
David O. Willenborg Australia	32	1.9k 1.4×	597 0.8×	668 1.3×	656 1.3×	323 1.0×	77	3.2k
Sigrid R. Ruuls Netherlands	20	1.3k 1.0×	361 0.5×	489 0.9×	852 1.7×	244 0.8×	25	2.5k
Erik Wallström Sweden	27	1.3k 1.0×	551 0.7×	747 1.4×	531 1.1×	126 0.4×	57	2.9k
Anthony Slavin United States	28	1.9k 1.4×	617 0.8×	986 1.9×	395 0.8×	142 0.4×	53	3.6k
Katsuichi Miyamoto Japan	24	1.2k 0.9×	275 0.4×	443 0.9×	295 0.6×	237 0.7×	78	2.5k
Alan M. Fong United States	22	1.2k 0.9×	1.1k 1.5×	834 1.6×	129 0.3×	202 0.6×	31	2.5k
Hiromitsu Kimura Japan	18	1.2k 0.9×	234 0.3×	594 1.1×	847 1.7×	268 0.8×	52	2.4k
Douglas A. Carlow Canada	22	1.1k 0.8×	395 0.5×	547 1.1×	213 0.4×	268 0.8×	36	1.9k
Barry J. Dussault United States	10	798 0.6×	601 0.8×	514 1.0×	143 0.3×	353 1.1×	11	2.2k
Yoko Hamazaki Japan	25	861 0.7×	290 0.4×	752 1.4×	334 0.7×	244 0.8×	49	2.2k

Countries citing papers authored by Irene Tom

Since Specialization

Citations

This map shows the geographic impact of Irene Tom's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Irene Tom with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Irene Tom more than expected).

Fields of papers citing papers by Irene Tom

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Irene Tom. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Irene Tom. The network helps show where Irene Tom may publish in the future.

Co-authorship network of co-authors of Irene Tom

This figure shows the co-authorship network connecting the top 25 collaborators of Irene Tom. A scholar is included among the top collaborators of Irene Tom based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Irene Tom. Irene Tom is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Gerhardy, Stefan, Mark Ultsch, Jeffrey K. Holden, et al.. (2022). Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration. Nature Communications. 13(1). 5222–5222. 11 indexed citations

Khanani, Arshad M., Vrinda Hershberger, Dante J. Pieramici, et al.. (2021). Phase 1 Study of the Anti-HtrA1 Antibody-binding Fragment FHTR2163 in Geographic Atrophy Secondary to Age-related Macular Degeneration. American Journal of Ophthalmology. 232. 49–57. 24 indexed citations

Tom, Irene, Victoria C. Pham, Kenneth J. Katschke, et al.. (2020). Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy. Proceedings of the National Academy of Sciences. 117(18). 9952–9963. 40 indexed citations

Pieramici, Dante J., Arshad M. Khanani, Flávia Brunstein, et al.. (2020). Phase 1 safety study of intravitreal (ITV) Anti-High Temperature Requirement A1 (aHtrA1), a novel serine protease inhibitor, in patients with Geographic Atrophy (GA). Investigative Ophthalmology & Visual Science. 61(7). 1942–1942. 1 indexed citations

Wang, Yuanyuan, et al.. (2020). PCDH7 interacts with GluN1 and regulates dendritic spine morphology and synaptic function. Scientific Reports. 10(1). 10951–10951. 17 indexed citations

Ramani, Sree R., Jason A. Hackney, Irene Tom, et al.. (2016). The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation. Nature Communications. 7(1). 11473–11473. 37 indexed citations

Yeh, Felix L., Yuanyuan Wang, Irene Tom, Lino C. Gonzalez, & Morgan Sheng. (2016). TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron. 91(2). 328–340. 650 indexed citations breakdown →

Tom, Irene, Alberto Estevez, Krista K. Bowman, & Lino C. Gonzalez. (2015). Baculovirus display for discovery of low-affinity extracellular receptor–ligand interactions using protein microarrays. Analytical Biochemistry. 479. 1–5. 2 indexed citations

Jaworski, A., Irene Tom, Raymond K. Tong, et al.. (2015). Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2. Science. 350(6263). 961–965. 81 indexed citations

10.

Haddick, Patrick C. G., Irene Tom, Elizabeth Luis, et al.. (2014). Defining the Ligand Specificity of the Deleted in Colorectal Cancer (DCC) Receptor. PLoS ONE. 9(1). e84823–e84823. 40 indexed citations

11.

Tom, Irene, Nicholas Lewin‐Koh, Sree R. Ramani, & Lino C. Gonzalez. (2013). Protein Microarrays for Identification of Novel Extracellular Protein‐Protein Interactions. Current Protocols in Protein Science. 72(1). Unit 27.3–Unit 27.3. 10 indexed citations

12.

Lobito, Adrian A., Sree R. Ramani, Irene Tom, et al.. (2011). Murine Insulin Growth Factor-like (IGFL) and Human IGFL1 Proteins Are Induced in Inflammatory Skin Conditions and Bind to a Novel Tumor Necrosis Factor Receptor Family Member, IGFLR1. Journal of Biological Chemistry. 286(21). 18969–18981. 35 indexed citations

13.

Ramani, Sree R., Irene Tom, Nicholas Lewin‐Koh, et al.. (2011). A secreted protein microarray platform for extracellular protein interaction discovery. Analytical Biochemistry. 420(2). 127–138. 45 indexed citations

14.

Yu, Xin, Lino C. Gonzalez, Michelle Francesco, et al.. (2008). The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nature Immunology. 10(1). 48–57. 1118 indexed citations breakdown →

15.

Pan, Clark Q., et al.. (2007). Generation of PEGylated VPAC1-selective antagonists that inhibit proliferation of a lung cancer cell line. Peptides. 29(3). 479–486. 4 indexed citations

16.

Tom, Irene, Jun Ouyang, Joanne C. Severs, et al.. (2007). Reproductible production of a PEGylated dual-acting peptide for diabetes. The AAPS Journal. 9(2). E227–E234. 12 indexed citations

17.

Pan, Clark Q., Fugang Li, Irene Tom, et al.. (2006). Engineering Novel VPAC2-Selective Agonists with Improved Stability and Glucose-Lowering Activity in Vivo. Journal of Pharmacology and Experimental Therapeutics. 320(2). 900–906. 22 indexed citations

18.

Pan, Clark Q., Joanne Buxton, Stephanie Yung, et al.. (2006). Design of a Long Acting Peptide Functioning as Both a Glucagon-like Peptide-1 Receptor Agonist and a Glucagon Receptor Antagonist. Journal of Biological Chemistry. 281(18). 12506–12515. 64 indexed citations

19.

Compaan, Deanne M., Lino C. Gonzalez, Irene Tom, et al.. (2005). Attenuating Lymphocyte Activity. Journal of Biological Chemistry. 280(47). 39553–39561. 138 indexed citations

20.

Shetterly, Susan, Irene Tom, Rohit Joshi, et al.. (2001). 1,3 galactosyltransferase: new sequences and characterization of conserved cysteine residues. Glycobiology. 11(8). 645–653. 8 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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