Hisao Hirota

4.3k total citations · 1 hit paper
38 papers, 3.6k citations indexed

About

Hisao Hirota is a scholar working on Molecular Biology, Cardiology and Cardiovascular Medicine and Oncology. According to data from OpenAlex, Hisao Hirota has authored 38 papers receiving a total of 3.6k indexed citations (citations by other indexed papers that have themselves been cited), including 20 papers in Molecular Biology, 15 papers in Cardiology and Cardiovascular Medicine and 14 papers in Oncology. Recurrent topics in Hisao Hirota's work include Cytokine Signaling Pathways and Interactions (14 papers), Cardiac Fibrosis and Remodeling (9 papers) and Signaling Pathways in Disease (6 papers). Hisao Hirota is often cited by papers focused on Cytokine Signaling Pathways and Interactions (14 papers), Cardiac Fibrosis and Remodeling (9 papers) and Signaling Pathways in Disease (6 papers). Hisao Hirota collaborates with scholars based in Japan, United States and Belgium. Hisao Hirota's co-authors include Tetsuya Taga, Tadamitsu Kishimoto, Keiko Yamauchi‐Takihara, Yasushi Fujio, T. Kishimoto, Kiyoshi Yoshida, Keita Kunisada, Shoko Sugiyama, Werner Müller and John Ross and has published in prestigious journals such as Cell, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Hisao Hirota

38 papers receiving 3.5k citations

Hit Papers

Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a... 1999 2026 2008 2017 1999 100 200 300 400 500
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress
    1999 548 citations Hisao Hirota et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Hisao Hirota Japan 22 1.9k 1.2k 1.2k 576 329 38 3.6k
Kazuhito Ichikawa Japan 27 1.7k 0.9× 568 0.5× 643 0.5× 347 0.6× 447 1.4× 96 3.2k
Wei Zheng China 33 1.8k 0.9× 455 0.4× 1.1k 0.9× 539 0.9× 526 1.6× 88 3.6k
Chung‐Hyun Cho South Korea 32 1.8k 0.9× 509 0.4× 586 0.5× 478 0.8× 375 1.1× 87 3.5k
John J. Lepore United States 38 2.4k 1.3× 1.3k 1.0× 481 0.4× 333 0.6× 841 2.6× 61 4.7k
W. Matthijs Blankesteijn Netherlands 32 2.2k 1.2× 1.6k 1.3× 487 0.4× 285 0.5× 815 2.5× 80 4.0k
Oleg Tarnavski United States 14 2.3k 1.2× 1.7k 1.4× 413 0.4× 253 0.4× 715 2.2× 14 4.1k
Valerie P. Sah United States 14 2.9k 1.5× 1.3k 1.0× 693 0.6× 171 0.3× 183 0.6× 16 3.6k
Mikiyoshi Saito Japan 13 1.2k 0.6× 489 0.4× 990 0.8× 736 1.3× 168 0.5× 19 2.5k
Lin Zuo China 19 1.4k 0.7× 398 0.3× 656 0.6× 586 1.0× 266 0.8× 42 3.0k
Burns C. Blaxall United States 43 3.6k 1.9× 3.2k 2.6× 616 0.5× 419 0.7× 879 2.7× 88 6.3k

Countries citing papers authored by Hisao Hirota

Since Specialization
Citations

This map shows the geographic impact of Hisao Hirota's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hisao Hirota with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hisao Hirota more than expected).

Fields of papers citing papers by Hisao Hirota

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hisao Hirota. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hisao Hirota. The network helps show where Hisao Hirota may publish in the future.

Co-authorship network of co-authors of Hisao Hirota

This figure shows the co-authorship network connecting the top 25 collaborators of Hisao Hirota. A scholar is included among the top collaborators of Hisao Hirota based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hisao Hirota. Hisao Hirota is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Nakaoka, Yoshikazu, Yasushi Fujio, Hisao Hirota, et al.. (2008). Interaction of Scaffolding Adaptor Protein Gab1 with Tyrosine Phosphatase SHP2 Negatively Regulates IGF-I-dependent Myogenic Differentiation via the ERK1/2 Signaling Pathway. Journal of Biological Chemistry. 283(35). 24234–24244. 21 indexed citations
2.
Nakaoka, Yoshikazu, Keigo Nishida, Masahiro Narimatsu, et al.. (2007). Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling. Journal of Clinical Investigation. 117(7). 1771–1781. 55 indexed citations
3.
Kuroda, Tadashi, Hisao Hirota, Yasushi Fujio, et al.. (2007). Carbacyclin induces carnitine palmitoyltransferase-1 in cardiomyocytes via peroxisome proliferator-activated receptor (PPAR) δ independent of the IP receptor signaling pathway. Journal of Molecular and Cellular Cardiology. 43(1). 54–62. 4 indexed citations
4.
Izumi, Masahiro, Mitsuru Masaki, Yoshimune Hiramoto, et al.. (2006). Cross-talk between bone morphogenetic protein 2 and leukemia inhibitory factor through ERK 1/2 and Smad1 in protection against doxorubicin-induced injury of cardiomyocytes. Journal of Molecular and Cellular Cardiology. 40(2). 224–233. 21 indexed citations
5.
Sugiyama, Shoko, Hisao Hirota, Rina Kimura, et al.. (2006). Haplotype of thrombomodulin gene associated with plasma thrombomodulin level and deep vein thrombosis in the Japanese population. Thrombosis Research. 119(1). 35–43. 30 indexed citations
6.
Kuroda, Tadashi, Hisao Hirota, Mitsuru Masaki, et al.. (2005). Sildenafil as Adjunct Therapy to High-Dose Epoprostenol in a Patient with Pulmonary Veno-Occlusive Disease. Heart Lung and Circulation. 15(2). 139–142. 22 indexed citations
7.
Hirota, Hisao, Masahiro Izumi, Shoko Sugiyama, et al.. (2004). Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure. Heart and Vessels. 19(5). 237–41. 74 indexed citations
8.
Masaki, Mitsuru, Tadashi Kuroda, Naoki Hosen, et al.. (2004). Solitary right ventricle metastasis by renal cell carcinoma. Journal of the American Society of Echocardiography. 17(4). 397–398. 14 indexed citations
9.
Osugi, Tomoaki, Yuichi Oshima, Yasushi Fujio, et al.. (2002). Cardiac-specific Activation of Signal Transducer and Activator of Transcription 3 Promotes Vascular Formation in the Heart. Journal of Biological Chemistry. 277(8). 6676–6681. 133 indexed citations
10.
Oshima, Yuichi, Yasushi Fujio, Masanobu Funamoto, et al.. (2002). Aldosterone augments endothelin‐1‐induced cardiac myocyte hypertrophy with the reinforcement of the JNK pathway. FEBS Letters. 524(1-3). 123–126. 16 indexed citations
11.
Izumi, Masahiro, Yasushi Fujio, Keita Kunisada, et al.. (2001). Bone Morphogenetic Protein-2 Inhibits Serum Deprivation-induced Apoptosis of Neonatal Cardiac Myocytes through Activation of the Smad1 Pathway. Journal of Biological Chemistry. 276(33). 31133–31141. 79 indexed citations
12.
Funamoto, Masanobu, Yasushi Fujio, Keita Kunisada, et al.. (2000). Signal Transducer and Activator of Transcription 3 Is Required for Glycoprotein 130-mediated Induction of Vascular Endothelial Growth Factor in Cardiac Myocytes. Journal of Biological Chemistry. 275(14). 10561–10566. 139 indexed citations
13.
Oh, Hidemasa, Yasushi Fujio, Keita Kunisada, et al.. (1998). Activation of Phosphatidylinositol 3-Kinase through Glycoprotein 130 Induces Protein Kinase B and p70 S6 Kinase Phosphorylation in Cardiac Myocytes. Journal of Biological Chemistry. 273(16). 9703–9710. 182 indexed citations
14.
Fujio, Yasushi, et al.. (1997). Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes.. Journal of Clinical Investigation. 99(12). 2898–2905. 171 indexed citations
15.
Hirota, Hisao, Hiroshi Kiyama, Tadamitsu Kishimoto, & Tetsuya Taga. (1996). Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma.. The Journal of Experimental Medicine. 183(6). 2627–2634. 269 indexed citations
16.
Hirota, Hisao, Kanji Yoshida, Tetsuya Taga, & Tadamitsu Kishimoto. (1996). gp130 signaling pathways: Recent advances and implications for cardiovascular disease. Trends in Cardiovascular Medicine. 6(4). 109–115. 13 indexed citations
17.
Yamauchi‐Takihara, Keiko, Hisao Hirota, Keita Kunisada, et al.. (1996). Roles of gp130 signaling pathways in cardiac myocytes: Recent advances and implications for cardiovascular disease. Journal of Cardiac Failure. 2(4 Suppl). S63–S67. 3 indexed citations
18.
Udagawa, Nobuyuki, N. Takahashi, Takashi Katagiri, et al.. (1995). Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors.. The Journal of Experimental Medicine. 182(5). 1461–1468. 334 indexed citations
19.
Murohashi, I, Kazuo Endoh, Mei Feng, et al.. (1995). Roles of Stem Cell Factor in the In Vitro Growth of Blast Clonogenic Cells from Patients with Acute Myeloblastic Leukemia. Journal of Interferon & Cytokine Research. 15(10). 829–835. 6 indexed citations
20.
Otsuji, Satoru, et al.. (1993). Highly purified eicosapentaenoic acid attenuates tissue damage in experimental myocardial infarction.. Japanese Circulation Journal. 57(4). 335–343. 19 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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