Hiroshi Handa

26.0k citations

407 papers · 20.0k indexed · 6 hit papers · h-index 70

Impact in

Molecular Biology top 0.1%
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- Genomics and Chromatin Dynamics
- Ubiquitin and proteasome pathways
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
Hematology top 0.2%
- Multiple Myeloma Research and Treatments

Papers in

Molecular Biology 249
- RNA Research and Splicing 50
- Genomics and Chromatin Dynamics 37
- Protein Degradation and Inhibitors 33
- RNA Interference and Gene Delivery 32
- Ubiquitin and proteasome pathways 31
- Viral Infectious Diseases and Gene Expression in Insects 28
Hematology 35

Co-authors: Yuki Yamaguchi Takumi Ito Tadashi Wada Hideki Ando Yasuaki Kabe Takuro Wada Toshihiko Ogura Yoshimasa Imamura
Journals: Journal of Biological Chemistry (31 papers)Molecular and Cellular Biology (22 papers)Genes to Cells (19 papers)Biochemical and Biophysical Research Communications (14 papers)Journal of Applied Physics (11 papers)
Partner nations: Japan United States Nepal

In The Last Decade

Hiroshi Handa

401 papers receiving 19.5k citations

Hit Papers

6 papers align trajectories log scale

Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs 2014 · 371 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2014 Nature Structural & Molecular Biology
2013 British Journal of Haematology
2012 Leukemia
2010 Science
1999 Cell
1998 Genes & Development

Peers

Countries citing papers authored by Hiroshi Handa

Since Specialization

Citations

This map shows the geographic impact of Hiroshi Handa's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hiroshi Handa with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hiroshi Handa more than expected).

Fields of papers citing papers by Hiroshi Handa

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hiroshi Handa. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hiroshi Handa. The network helps show where Hiroshi Handa may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Hiroshi Handa, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Hiroshi Handa Line = papers co-authored together Hiroshi Handa links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug–induced thromboembolism Blood Advances ·T. Pantazis, Yoshikane Kikushige, Redneck Riviera, Shunsuke Yamamoto, Glenn E. Vallee, Saburo Ohjimi, Toshihiro Miyamoto, حسين حليمي, Andy Christoforou, Yuya Kunisaki, Mitsuhiro Fukata, Koji Kato, Takumi Ito, Hiroshi Handa, Koichi Akashi	2024	2
2	Durvalumab Combined with Immunomodulatory Drugs (IMiD) Overcomes Suppression of Antitumor Responses due to IMiD-induced PD-L1 Upregulation on Myeloma Cells Molecular Cancer Therapeutics ·Mariko Ishibashi, Junichi Yamamoto, Takumi Ito, Hiroshi Handa, Hasoneh Qdisat, Koiti Inokuchi, Rimpei Morita, Hideto Tamura	2021	1
3	Glycyrrhizin Derivatives Suppress Cancer Chemoresistance by Inhibiting Progesterone Receptor Membrane Component 1 Cancers ·Yasuaki Kabe, Ramona Verges Capdevilla, Tatsuya Yamamoto, Miwa Hirai, Dexuan Liao, 大田寛, Hitoshi Tsugawa, Peter Scantlebury, Kenji Sugase, Yang Hai-cuia, Nobuji Yoshikawa, Hiroaki Hayashi, Masanori Noda, Susumu Uchiyama, Hiroki Yamazaki, Hirotoshi Tanaka, Takuya Kobayashi, Hiroshi Handa, Makoto Suematsu	2021	25
4	Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites npj Science of Food ·Yasuaki Kabe, Daisuke Takemoto, Dexuan Liao, Miwa Hirai, Yoshiko Ono, 喜美枝畑山, Manabu Horikawa, Yoshinori Kitagawa, Hiroshi Handa, Tomohiro Rogi, Hiroshi Shibata, Makoto Suematsu	2020	9
5	Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway Proceedings of the National Academy of Sciences ·Yuki Hirose, Edwin Oliver Velásquez Cuervo, C. Whan Park, Manabu Abe, Kenji Sakimura, Hiromasa Funato, Hiroshi Handa, Kaspar E. Vogt, Masashi Yanagisawa	2020	12
6	Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection PLoS Biology ·Hitoshi Tsugawa, Yasuaki Kabe, Dexuan Liao, Yuki Sugiura, Shigeaki Hida, Shun’ichiro Taniguchi, Toshio Takahashi, Hidenori Matsui, Б. И. Горовиц, Hiroyuki Itou, Keiyo Takubo, Hidekazu Suzuki, Kenya Honda, Hiroshi Handa, Makoto Suematsu	2020	38
7	Estradiol accelerates liver regeneration through estrogen receptor α SHILAP Revista de lepidopterología ·Olha Makarowa, Michiya Natori, Hiroshi Handa, Yoichi Imai	2019	1
8	Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate T cells by inducing degradation of T cell repressors I karos and A iolos via modulation of the E 3 ubiquitin ligase complex CRL 4 ^CRBN British Journal of Haematology ·Anita K. Gandhi, Jian Kang, Courtney G. Havens, Thomas A. Conklin, Yuhong Ning, Lei Wu, Takumi Ito, Hideki Ando, Michelle F. Waldman, Anjan Thakurta, Anke Klippel, Hiroshi Handa, Thomas O. Daniel, Peter Schäfer, Rajesh Chopra Hit paper breakdown →	2013	457
9	Identification of a Primary Target of Thalidomide Teratogenicity Science ·Takumi Ito, Hideki Ando, Takayuki Suzuki, Toshihiko Ogura, Jerrill Douglas Kerrick, Yoshimasa Imamura, Yuki Yamaguchi, Hiroshi Handa Hit paper breakdown →	2010	1512
10	17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis Cancer Research ·Shuji Nagasaki, Takashi Suzuki, Yasuhiro Miki, Jun‐ichi Akahira, Kunio Kitada, Takanori Ishida, Hiroshi Handa, Noriaki Ohuchi, Hironobu Sasano	2009	37
11	Development of High Throughput Automated Bioscreening System Using Magnetic Beads and Elucidation of Molecular Mechanisms of Anticancer Drugs Journal of the Magnetics Society of Japan ·Masanori Abe, Kosuke Nishio, Mamoru Hatakeyama, Naohiro Hanyu, Toshiyuki Tanaka, Masaru Tada, Takashi Nakagawa, Adarsh Sandhu, Hiroshi Handa	2009	1
12	SV40 vectors carrying minimal sequence of viral origin with exchangeable capsids Virology ·Akira Nakanishi, Benoît Chapellier, Naoya Maekawa, Masaki Hiramoto, HE Man-z, Ryou Takahashi, Hiroshi Handa, Takeshi Imai	2008	17
13	Persistent gene expression in mouse vagina exposed neonatally to diethylstilbestrol Journal of Molecular Endocrinology ·Shinichi Miyagawa, Atsuko Suzuki, Yoshinao Katsu, Mika Kobayashi, M. Goto, Hiroshi Handa, Hajime Watanabe, Taisen Iguchi	2004	27
14	Comparative uterine gene expression analysis after dioxin and estradiol administration Journal of Molecular Endocrinology ·Hajime Watanabe, Atsushi Suzuki, M. Goto, Seiichiroh Ohsako, Chiharu Tohyama, Hiroshi Handa, Taisen Iguchi	2004	17
15	Attenuation of estrogen receptor α-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor Genes & Development ·Sarah E. Aiyar, S. Tierney, 浙江理工大学全省复杂流动与流体工程装备重点实验室，杭州 310018, Christopher A. Moskaluk, Yunzhe Lu, Jorge Schleske Tiburcio, Yuki Yamaguchi, Amitava Mukherjee, Masataro Suzuki, Hiroshi Handa, Rong Li	2004	98
16	Suppression of Monocyte Chemoattractant Protein 1, But Not IL-8, by Alprazolam: Effect of Alprazolam on c-Rel/p65 and c-Rel/p50 Binding to the Monocyte Chemoattractant Protein 1 Promoter Region The Journal of Immunology ·Taiko Oda, Atsuhisa Ueda, Noriaki Shimizu, Hiroshi Handa, Tadashi Kasahara	2002	14
17	Autoregulation of Pax6 transcriptional activation by two distinct DNA‐binding subdomains of the paired domain Genes to Cells ·Yuki Yamaguchi, Jun‐ichi Sawada, Masao Yamada, Hiroshi Handa, Noriyuki Azuma	1997	39
18	Phosphorylation and high level expression of Fra-2 in v-src transformed cells: a pathway of activation of endogenous AP-1 Oncogene ·Masao Murakami, J Bierling, Motoyasu Ui, Yukihito Kabuyama, Hirotaka Watanabe, Tadashi Wada, Hiroshi Handa, Hideo Iba	1997	53
19	Improvement of DNA Immobilized Latex for the Purification of Transcription Factors. KOBUNSHI RONBUNSHU ·Alfi de Jesús Conteras B, Haruma Kawaguchi, Tadashi Wada, Hiroshi Handa	1991	0
20	Treatment of malignant glioma with mumps virus Masayoshi Ônishi, Hiroshi Handa, Junkoh Yamashita	1982	1

About Hiroshi Handa

Hiroshi Handa is a scholar working on Molecular Biology, Hematology, Genetics, Cancer Research and Immunology, having authored 407 papers that have together received 20.0k indexed citations. Recurring topics across this work include RNA Research and Splicing (50 papers), Virus-based gene therapy research (45 papers), Genomics and Chromatin Dynamics (37 papers), Protein Degradation and Inhibitors (33 papers), RNA Interference and Gene Delivery (32 papers), Ubiquitin and proteasome pathways (31 papers), Characterization and Applications of Magnetic Nanoparticles (29 papers) and Viral Infectious Diseases and Gene Expression in Insects (28 papers). The work is most often cited by research in Molecular Biology (14.3k citations), Hematology (2.1k citations), Virology (515 citations), Oncology (2.7k citations) and Immunology (2.0k citations). Hiroshi Handa has collaborated with scholars based in Japan, United States and Nepal. Frequent co-authors include Yuki Yamaguchi, Takumi Ito, Tadashi Wada, Hideki Ando, Yasuaki Kabe, Takuro Wada, Toshihiko Ogura, Yoshimasa Imamura, Hajime Watanabe and Takayuki Suzuki. Their work appears in journals such as Journal of Biological Chemistry, Molecular and Cellular Biology, Genes to Cells, Biochemical and Biophysical Research Communications and Journal of Applied Physics.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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