Hiroshi Handa

26.0k total citations · 6 hit papers
407 papers, 20.0k citations indexed

About

Hiroshi Handa is a scholar working on Molecular Biology, Genetics and Immunology. According to data from OpenAlex, Hiroshi Handa has authored 407 papers receiving a total of 20.0k indexed citations (citations by other indexed papers that have themselves been cited), including 249 papers in Molecular Biology, 79 papers in Genetics and 45 papers in Immunology. Recurrent topics in Hiroshi Handa's work include RNA Research and Splicing (50 papers), Virus-based gene therapy research (45 papers) and Genomics and Chromatin Dynamics (37 papers). Hiroshi Handa is often cited by papers focused on RNA Research and Splicing (50 papers), Virus-based gene therapy research (45 papers) and Genomics and Chromatin Dynamics (37 papers). Hiroshi Handa collaborates with scholars based in Japan, United States and Nepal. Hiroshi Handa's co-authors include Yuki Yamaguchi, Takumi Ito, Tadashi Wada, Hideki Ando, Yasuaki Kabe, Takuro Wada, Toshihiko Ogura, Yoshimasa Imamura, Hajime Watanabe and Takayuki Suzuki and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Hiroshi Handa

401 papers receiving 19.5k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Identification of a Primary Target of Thalidomide Teratogenicity

2010 1.5k citations Takumi Ito, Hideki Ando et al. Science profile →
NELF, a Multisubunit Complex Containing RD, Cooperates with DSIF to Repress RNA Polymerase II Elongation

1999 651 citations Yuki Yamaguchi, Tadashi Wada et al. profile →
Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

2012 606 citations Takumi Ito, Anita K. Gandhi et al. profile →
DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs

1998 603 citations Yuki Yamaguchi, Takeshi Imai et al. Genes & Development profile →
Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate T cells by inducing degradation of T cell repressors I karos and A iolos via modulation of the E 3 ubiquitin ligase complex CRL 4 ^CRBN

2013 457 citations Anita K. Gandhi, Jian Kang et al. British Journal of Haematology profile →
Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs

2014 371 citations Takumi Ito, Hideki Ando et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Hiroshi Handa Japan	70	14.3k	2.7k	2.6k	2.1k	2.0k	407	20.0k
Robert M. Stroud United States	74	11.7k 0.8×	1.6k 0.6×	1.5k 0.6×	1.2k 0.5×	2.2k 1.1×	296	17.8k
Osamu Ohara Japan	67	7.6k 0.5×	1.9k 0.7×	1.7k 0.7×	1.3k 0.6×	5.0k 2.5×	422	15.7k
Jan J. Enghild Denmark	66	8.4k 0.6×	2.3k 0.9×	1.4k 0.6×	2.0k 0.9×	1.7k 0.8×	358	19.8k
Robert Liddington United States	66	9.4k 0.7×	1.3k 0.5×	2.1k 0.8×	1.6k 0.8×	2.8k 1.4×	145	18.1k
Thomas Walz United States	87	17.5k 1.2×	2.2k 0.8×	1.7k 0.7×	1.0k 0.5×	3.5k 1.8×	271	28.0k
Barbara B. Knowles United States	64	11.6k 0.8×	2.1k 0.8×	3.3k 1.3×	573 0.3×	3.4k 1.7×	218	18.1k
Reuben Lotan United States	76	14.9k 1.0×	3.7k 1.4×	3.3k 1.3×	523 0.2×	4.3k 2.2×	324	21.3k
Hendrik G. Stunnenberg Netherlands	82	15.7k 1.1×	1.8k 0.7×	3.5k 1.3×	675 0.3×	6.5k 3.2×	239	24.9k
Benedikt M. Kessler United Kingdom	82	15.6k 1.1×	3.7k 1.4×	2.2k 0.9×	683 0.3×	3.3k 1.6×	416	24.2k
David W. Speicher United States	72	12.6k 0.9×	2.3k 0.8×	1.2k 0.5×	619 0.3×	2.0k 1.0×	278	19.3k

Countries citing papers authored by Hiroshi Handa

Since Specialization

Citations

This map shows the geographic impact of Hiroshi Handa's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hiroshi Handa with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hiroshi Handa more than expected).

Fields of papers citing papers by Hiroshi Handa

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hiroshi Handa. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hiroshi Handa. The network helps show where Hiroshi Handa may publish in the future.

Co-authorship network of co-authors of Hiroshi Handa

This figure shows the co-authorship network connecting the top 25 collaborators of Hiroshi Handa. A scholar is included among the top collaborators of Hiroshi Handa based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hiroshi Handa. Hiroshi Handa is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Kikushige, Yoshikane, Shunsuke Yamamoto, Toshihiro Miyamoto, et al.. (2024). Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug–induced thromboembolism. Blood Advances. 8(3). 785–796. 2 indexed citations

Ishibashi, Mariko, Junichi Yamamoto, Takumi Ito, et al.. (2021). Durvalumab Combined with Immunomodulatory Drugs (IMiD) Overcomes Suppression of Antitumor Responses due to IMiD-induced PD-L1 Upregulation on Myeloma Cells. Molecular Cancer Therapeutics. 20(7). 1283–1294. 1 indexed citations

Kabe, Yasuaki, Tatsuya Yamamoto, Miwa Hirai, et al.. (2021). Glycyrrhizin Derivatives Suppress Cancer Chemoresistance by Inhibiting Progesterone Receptor Membrane Component 1. Cancers. 13(13). 3265–3265. 25 indexed citations

Kabe, Yasuaki, Daisuke Takemoto, Miwa Hirai, et al.. (2020). Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites. npj Science of Food. 4(1). 4–4. 9 indexed citations

Hirose, Yuki, Manabu Abe, Kenji Sakimura, et al.. (2020). Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway. Proceedings of the National Academy of Sciences. 117(37). 23106–23112. 12 indexed citations

Tsugawa, Hitoshi, Yasuaki Kabe, Yuki Sugiura, et al.. (2020). Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection. PLoS Biology. 18(9). e3000813–e3000813. 38 indexed citations

Natori, Michiya, et al.. (2019). Estradiol accelerates liver regeneration through estrogen receptor α. SHILAP Revista de lepidopterología. 1 indexed citations

Gandhi, Anita K., Jian Kang, Courtney G. Havens, et al.. (2013). Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate T cells by inducing degradation of T cell repressors I karos and A iolos via modulation of the E 3 ubiquitin ligase complex CRL 4 ^CRBN . British Journal of Haematology. 164(6). 811–821. 457 indexed citations breakdown →

Ito, Takumi, Hideki Ando, Takayuki Suzuki, et al.. (2010). Identification of a Primary Target of Thalidomide Teratogenicity. Science. 327(5971). 1345–1350. 1512 indexed citations breakdown →

10.

Nagasaki, Shuji, Takashi Suzuki, Yasuhiro Miki, et al.. (2009). 17β-Hydroxysteroid Dehydrogenase Type 12 in Human Breast Carcinoma: A Prognostic Factor via Potential Regulation of Fatty Acid Synthesis. Cancer Research. 69(4). 1392–1399. 37 indexed citations

11.

Abe, Masanori, Kosuke Nishio, Mamoru Hatakeyama, et al.. (2009). Development of High Throughput Automated Bioscreening System Using Magnetic Beads and Elucidation of Molecular Mechanisms of Anticancer Drugs. Journal of the Magnetics Society of Japan. 33(2). 154–158. 1 indexed citations

12.

Nakanishi, Akira, Benoît Chapellier, Naoya Maekawa, et al.. (2008). SV40 vectors carrying minimal sequence of viral origin with exchangeable capsids. Virology. 379(1). 110–117. 17 indexed citations

13.

Miyagawa, Shinichi, Atsuko Suzuki, Yoshinao Katsu, et al.. (2004). Persistent gene expression in mouse vagina exposed neonatally to diethylstilbestrol. Journal of Molecular Endocrinology. 32(3). 663–677. 27 indexed citations

14.

Watanabe, Hajime, Atsushi Suzuki, M. Goto, et al.. (2004). Comparative uterine gene expression analysis after dioxin and estradiol administration. Journal of Molecular Endocrinology. 33(3). 763–771. 17 indexed citations

15.

Aiyar, Sarah E., Christopher A. Moskaluk, Yunzhe Lu, et al.. (2004). Attenuation of estrogen receptor α-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. Genes & Development. 18(17). 2134–2146. 98 indexed citations

16.

Oda, Taiko, Atsuhisa Ueda, Noriaki Shimizu, Hiroshi Handa, & Tadashi Kasahara. (2002). Suppression of Monocyte Chemoattractant Protein 1, But Not IL-8, by Alprazolam: Effect of Alprazolam on c-Rel/p65 and c-Rel/p50 Binding to the Monocyte Chemoattractant Protein 1 Promoter Region. The Journal of Immunology. 169(6). 3329–3335. 14 indexed citations

17.

Yamaguchi, Yuki, Jun‐ichi Sawada, Masao Yamada, Hiroshi Handa, & Noriyuki Azuma. (1997). Autoregulation of Pax6 transcriptional activation by two distinct DNA‐binding subdomains of the paired domain. Genes to Cells. 2(4). 255–261. 39 indexed citations

18.

Murakami, Masao, Motoyasu Ui, Yukihito Kabuyama, et al.. (1997). Phosphorylation and high level expression of Fra-2 in v-src transformed cells: a pathway of activation of endogenous AP-1. Oncogene. 14(20). 2435–2444. 53 indexed citations

19.

Kawaguchi, Haruma, et al.. (1991). Improvement of DNA Immobilized Latex for the Purification of Transcription Factors.. KOBUNSHI RONBUNSHU. 48(5). 335–340.

20.

Handa, Hiroshi, et al.. (1982). Treatment of malignant glioma with mumps virus. 10(2). 143–147. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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