John M. Chirgwin

34.4k total citations · 5 hit papers
122 papers, 31.4k citations indexed

About

John M. Chirgwin is a scholar working on Molecular Biology, Oncology and Surgery. According to data from OpenAlex, John M. Chirgwin has authored 122 papers receiving a total of 31.4k indexed citations (citations by other indexed papers that have themselves been cited), including 72 papers in Molecular Biology, 46 papers in Oncology and 28 papers in Surgery. Recurrent topics in John M. Chirgwin's work include Bone health and treatments (37 papers), Pancreatic function and diabetes (25 papers) and Bone Metabolism and Diseases (17 papers). John M. Chirgwin is often cited by papers focused on Bone health and treatments (37 papers), Pancreatic function and diabetes (25 papers) and Bone Metabolism and Diseases (17 papers). John M. Chirgwin collaborates with scholars based in United States, United Kingdom and France. John M. Chirgwin's co-authors include William J. Rutter, Alan Przybyla, Raymond J. MacDonald, Theresa A. Guise, Howard M. Goodman, Raymond Pictet, Stuart Kornfeld, Juan Juan Yin, Pierrick G.J. Fournier and Edmund Tischer and has published in prestigious journals such as Science, New England Journal of Medicine and Cell.

In The Last Decade

John M. Chirgwin

119 papers receiving 30.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 21.3k citations John M. Chirgwin et al. profile →
Rat Insulin Genes: Construction of Plasmids Containing the Coding Sequences

1977 1.1k citations John M. Chirgwin et al. profile →
TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

1999 766 citations Juan Juan Yin, Katri S. Selander et al. Journal of Clinical Investigation profile →
Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A.

1987 596 citations John M. Chirgwin et al. profile →
[20] Isolation of RNA using guanidinium salts

1987 574 citations John M. Chirgwin et al. profile →

Peers

Countries citing papers authored by John M. Chirgwin

Since Specialization

Citations

This map shows the geographic impact of John M. Chirgwin's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John M. Chirgwin with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John M. Chirgwin more than expected).

Fields of papers citing papers by John M. Chirgwin

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John M. Chirgwin. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John M. Chirgwin. The network helps show where John M. Chirgwin may publish in the future.

Co-authorship network of co-authors of John M. Chirgwin

This figure shows the co-authorship network connecting the top 25 collaborators of John M. Chirgwin. A scholar is included among the top collaborators of John M. Chirgwin based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John M. Chirgwin. John M. Chirgwin is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Osteoclast-derived IGF1 induces RANKL production in osteocytes and contributes to pagetic lesion formation 2023 ·JCI Insight ·Kazuaki Miyagawa, (unknown), Patrick L. Mulcrone, Jesús Delgado‐Calle, Mark A. Subler, Jolene J. Windle, John M. Chirgwin, G. David Roodman, Noriyoshi Kurihara	6
2	Pharmacologic targeting of the p62 ZZ domain enhances both anti-tumor and bone-anabolic effects of bortezomib in multiple myeloma 2023 ·Haematologica ·Silvia Marino, Daniela N. Petrusca, Ryan T. Bishop, Judith L. Anderson, (unknown), Cody Ashby, (unknown), (unknown), Utpal P. Davé, Fabiana Perna, Jesús Delgado‐Calle, John M. Chirgwin, G. David Roodman	2
3	The Role of Semaphorin 4D in Bone Remodeling and Cancer Metastasis 2018 ·PMC ·Konstantinos Lontos, Juraj Adamik, Anastasia Tsagianni, Deborah L. Galson, John M. Chirgwin, Attaya Suvannasankha	1
4	Small molecules inhibit ex vivo tumor growth in bone 2018 ·Bioorganic & Medicinal Chemistry ·Donghui Zhou, Khuchtumur Bum‐Erdene, David Xu, Degang Liu, (unknown), Rania S. Sulaiman, Timothy W. Corson, John M. Chirgwin, Samy O. Meroueh	3
5	Cell Adhesion Molecule CD166 Drives Malignant Progression and Osteolytic Disease in Multiple Myeloma 2016 ·Cancer Research ·Linlin Xu, Khalid S. Mohammad, Hao Wu, Colin Crean, Bradley Poteat, Ying‐Hua Cheng, Angelo A. Cardoso, (unknown), Helmut Hanenberg, Rafat Abonour, Melissa A. Kacena, John M. Chirgwin, Attaya Suvannasankha, Edward F. Srour	22
6	Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma 2016 ·Cancer Research ·Jesús Delgado‐Calle, Judith Anderson, Meloney Cregor, Masahiro Hiasa, John M. Chirgwin, Nadia Carlesso, Toshiyuki Yoneda, Khalid S. Mohammad, Lilian I. Plotkin, G. David Roodman, Teresita Bellido	158
7	Role Of CD166 In Multiple Myeloma Cell Homing To The Bone Marrow Microenvironment and Disease Progression 2013 ·Blood ·Linlin Xu, (unknown), Hao Wu, Bradley Poteat, Colin Crean, Angelo A. Cardoso, John M. Chirgwin, Helmut Hanenberg, Khalid S. Mohammad, (unknown), Edward F. Srour	0
8	Regulation of postnatal trabecular bone formation by the osteoblast endothelin A receptor 2011 ·Journal of Bone and Mineral Research ·Gregory A. Clines, Khalid S. Mohammad, Jessica M. Grunda, Katrina L. Clines, Maria Niewolna, Christopher R. McKenna, (unknown), Masashi Yanagisawa, Larry J. Suva, John M. Chirgwin, Theresa A. Guise	26
9	New insights into the role of T cells in the vicious cycle of bone metastases 2006 ·Current Opinion in Rheumatology ·Pierrick G.J. Fournier, John M. Chirgwin, Theresa A. Guise	44
10	Molecular Mechanisms of Breast Cancer Metastases to Bone 2005 ·Clinical Breast Cancer ·Theresa A. Guise, Wende Kozlow, (unknown), Susan S. Padalecki, Juan Juan Yin, John M. Chirgwin	134
11	The structure of human phosphoglucose isomerase complexed with a transition-state analogue 2003 ·Acta Crystallographica Section D Biological Crystallography ·Christopher J. Davies, Hilary Muirhead, John M. Chirgwin	27
12	TGF β signaling in osteolytic cancer cell lines: Stimulation of IL-6, IL-11, PTHrP, and VEGF through MAP kinase pathways 2001 ·Breast Cancer Research and Treatment ·Sanna-Maria Käkönen, Katri S. Selander, (unknown), Yuqi Cui, Molly E. Heft Neal, John M. Chirgwin, Barry G. Grubbs, Theresa A. Guise	2
13	The crystal structure of human phosphoglucose isomerase at 1.6 Å resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia 2001 ·Journal of Molecular Biology ·Jon Read, Jake T. M. Pearce, Xiaochun Li, Hilary Muirhead, John M. Chirgwin, Christopher Davies	89
14	Rabbit phosphoglucose isomerase/neuroleukin/autocrine motility factor: cloning via interspecies identity 2000 ·Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology ·Xiaochun Li, John M. Chirgwin	7
15	TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development breakdown → 1999 ·Journal of Clinical Investigation ·Juan Juan Yin, Katri S. Selander, John M. Chirgwin, Mark Dallas, Barry G. Grubbs, Rotraud Wieser, Joan Massagué, G R Mundy, Theresa Guise	766
16	Order of Fusions between Bacterial and Mammalian Proteins Can Determine Solubility inEscherichia coli 1998 ·Biochemical and Biophysical Research Communications ·Deepali Sachdev, John M. Chirgwin	59
17	Immunological evidence for a conformational difference between recombinant bovine rhodanese and rhodanese purified from bovine liver 1992 ·Journal of Protein Chemistry ·Gerald A. Merrill, David M. Miller, John M. Chirgwin, (unknown)	6
18	Mapping of Lysosomal Targeting Determinants of Cathepsin D 1991 ·Advances in experimental medicine and biology ·Jeff Schorey, John M. Chirgwin	3
19	Efficient Mutagenesis, Expression and Purification of Procathepsin D 1991 ·Advances in experimental medicine and biology ·Deepali Sachdev, Jeff Schorey, John M. Chirgwin	6
20	Cathepsin D and Prognosis in Breast Cancer 1990 ·New England Journal of Medicine ·Atul K. Tandon, Gary M. Clark, Gary C. Chamness, John M. Chirgwin, William McGuire	385

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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