Hamilton O. Smith

90.2k citations

125 papers · 20.5k indexed · 13 hit papers · h-index 54

Impact in

Molecular Biology top 0.1%
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- Microbial Metabolic Engineering and Bioproduction
- Genomics and Phylogenetic Studies
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
Genetics top 0.1%
- Bacterial Genetics and Biotechnology

Papers in

Microbiology 12
- Microbial infections and disease research 10
Molecular Biology 105
- RNA and protein synthesis mechanisms 53
- DNA and Nucleic Acid Chemistry 23
- Genomics and Phylogenetic Studies 15
- Advanced biosensing and bioanalysis techniques 10

Co-authors: J. Craig Venter Clyde A. Hutchison Daniel G. Gibson Lei Young Ray-Yuan Chuang Max L. Birnstiel Daniel Nathans Thomas J. Kelly
Journals: Proceedings of the National Academy of Sciences (13 papers)Journal of Bacteriology (13 papers)Science (10 papers)Journal of Biological Chemistry (9 papers)Journal of Molecular Biology (8 papers)
Partner nations: United States Switzerland United Kingdom

In The Last Decade

Hamilton O. Smith

125 papers receiving 19.3k citations

Hit Papers

13 papers align trajectories log scale

The Sequence of the Human Genome 2015 · 536 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2015 Clinical Chemistry
2009 Nature Methods
2008 Science
2006 Proceedings of the National Academy of Sciences
1999 Science
1978 Cell
1977 Nucleic Acids Research
1976 Nucleic Acids Research
1975 Annual Review of Biochemistry
1973 Journal of Molecular Biology
1970 Journal of Molecular Biology
1970 Journal of Molecular Biology
1967 Virology

Peers

Countries citing papers authored by Hamilton O. Smith

Since Specialization

Citations

This map shows the geographic impact of Hamilton O. Smith's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hamilton O. Smith with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hamilton O. Smith more than expected).

Fields of papers citing papers by Hamilton O. Smith

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hamilton O. Smith. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hamilton O. Smith. The network helps show where Hamilton O. Smith may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Hamilton O. Smith, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Hamilton O. Smith Line = papers co-authored together Hamilton O. Smith links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Fundamental behaviors emerge from simulations of a living minimal cell Cell ·Zane R. Thornburg, Ferenc Bánáti, Mathieu Billod, Ligue nationale contre l’obésité, Tyler M. Earnest, Marcelo C. R. Melo, 乙彦加賀, James Sáenz, 吕明超, Kim S. Wise, Clyde A. Hutchison, Hamilton O. Smith, John I. Glass, Zaida Luthey‐Schulten	2022	85
2	Essential metabolism for a minimal cell eLife ·Marian Breuer, Tyler M. Earnest, Chuck Merryman, Kim S. Wise, Lijie Sun, Muhammad Fachril Haris, Clyde A. Hutchison, Hamilton O. Smith, John D. Lapek, David J. Gonzalez, Valérie de Crécy‐Lagard, Amina Yasmin, Andrew D. Hanson, Aidil Syukri, John I. Glass, Zaida Luthey‐Schulten	2019	104
3	Kinetic Modeling of the Genetic Information Processes in a Minimal Cell Frontiers in Molecular Biosciences ·Zane R. Thornburg, Marcelo C. R. Melo, Ferenc Bánáti, Mathieu Billod, 民子安冨, Marian Breuer, Hamilton O. Smith, Clyde A. Hutchison, John I. Glass, Zaida Luthey‐Schulten	2019	15
4	Where Next for Microbiome Research? PLoS Biology ·Matthew K. Waldor, Gene W. Tyson, Elhanan Borenstein, Howard Ochman, Andrew H. Moeller, B. Brett Finlay, Heidi H. Kong, Jeffrey I. Gordon, William Nelson, Karim Dabbagh, Hamilton O. Smith	2015	119
5	A broad survey reveals substitution tolerance of residues ligating FeS clusters in [NiFe] hydrogenase BMC Biochemistry ·Isaac T. Yonemoto, B Brejwo, Hamilton O. Smith, Philip D. Weyman	2014	9
6	Transferring whole genomes from bacteria to yeast spheroplasts using entire bacterial cells to reduce DNA shearing Nature Protocols ·Bogumil J. Karas, Jelena Jablanovic, Edward B. Irvine, Lijie Sun, Li Ma, Philip D. Weyman, Daniel G. Gibson, John I. Glass, J. Craig Venter, Clyde A. Hutchison, Hamilton O. Smith, Yo Suzuki	2014	34
7	Assembly of eukaryotic algal chromosomes in yeast Journal of Biological Engineering ·Bogumil J. Karas, Bhuvan Molparia, Jelena Jablanovic, 真伊藤, Herman Krauch, Christopher L. Dupont, Christian Tagwerker, Isaac T. Yonemoto, Vladimir N. Noskov, Ray-Yuan Chuang, Andrew E. Allen, John I. Glass, Clyde A. Hutchison, Hamilton O. Smith, J. Craig Venter, Philip D. Weyman	2013	54
8	Sequence analysis of a complete 1.66 Mb Prochlorococcus marinus MED4 genome cloned in yeast Nucleic Acids Research ·Christian Tagwerker, Christopher L. Dupont, Bogumil J. Karas, Li Ma, Ray-Yuan Chuang, Gwynedd A. Benders, 将之宗兼, Mark Novotny, Michael Montague, Pratap Venepally, Daniel Brami, Ariel Schwartz, Cynthia Andrews‐Pfannkoch, Daniel G. Gibson, John I. Glass, Hamilton O. Smith, J. Craig Venter, Clyde A. Hutchison	2012	41
9	Heterologous Expression of Alteromonas macleodii and Thiocapsa roseopersicina [NiFe] Hydrogenases in Synechococcus elongatus PLoS ONE ·Philip D. Weyman, Walter A. Vargas, JooYunSun, Jianping Yu, Pin‐Ching Maness, Hamilton O. Smith, Sara Luay Thanoon	2011	33
10	Cloning whole bacterial genomes in yeast Nucleic Acids Research ·Gwynedd A. Benders, Vladimir N. Noskov, SeongHee Ho, Carole Lartigue, Daniel G. Gibson, Nacyra Assad-Garcia, Ray-Yuan Chuang, Abderraouf Guediri, Hafidhotul Amaliyah, Mikkel A. Algire, Quang N. Phan, Nina Alperovich, Sanjay Vashee, Chuck Merryman, J. Craig Venter, Hamilton O. Smith, John I. Glass, Clyde A. Hutchison	2010	105
11	Single-step linker-based combinatorial assembly of promoter and gene cassettes for pathway engineering Biotechnology Letters ·将之宗兼, Hamilton O. Smith	2010	35
12	Creating Bacterial Strains from Genomes That Have Been Cloned and Engineered in Yeast Science ·Carole Lartigue, Sanjay Vashee, Mikkel A. Algire, Ray-Yuan Chuang, Gwynedd A. Benders, Li Ma, Vladimir N. Noskov, SeongHee Ho, Daniel G. Gibson, Nacyra Assad-Garcia, Nina Alperovich, David W. Thomas, Chuck Merryman, Lady Ynes, Hamilton O. Smith, J. Craig Venter, John I. Glass	2009	208
13	Complete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genome Science ·Daniel G. Gibson, Gwynedd A. Benders, Cynthia Andrews‐Pfannkoch, SeongHee Ho, Holly Baden-Tillson, Jayshree Zaveri, Timothy B. Stockwell, Gaku FUJITA, David W. Thomas, Mikkel A. Algire, Chuck Merryman, Lei Young, Vladimir N. Noskov, John I. Glass, J. Craig Venter, Clyde A. Hutchison, Hamilton O. Smith Hit paper breakdown →	2008	840
14	Genome Transplantation in Bacteria: Changing One Species to Another Science ·Carole Lartigue, John I. Glass, Nina Alperovich, Rembert Pieper, Prashanth P. Parmar, Lady Ynes, Hamilton O. Smith, J. Craig Venter	2007	288
15	Cell-free cloning using φ29 DNA polymerase Proceedings of the National Academy of Sciences ·Clyde A. Hutchison, Hamilton O. Smith, Cynthia Pfannkoch, J. Craig Venter	2005	146
16	Generating a synthetic genome by whole genome assembly: φX174 bacteriophage from synthetic oligonucleotides Proceedings of the National Academy of Sciences ·Hamilton O. Smith, Clyde A. Hutchison, Cynthia Pfannkoch, J. Craig Venter	2003	409
17	The Malaria Genome Sequencing Project Protist ·Malcolm J. Gardner, Hervé Tettelin, Daniel J. Carucci, Leda M. Cummings, Mark D. Adams, Hamilton O. Smith, J. Craig Venter, Stephen L. Hoffman	1998	5
18	Construction of an efficient overproducer clone of HinfI restriction endonuclease using the polymerase chain reaction Gene ·S. Deb, Hamilton O. Smith, 治郎早矢止	1990	24
19	The Molecular biology of plant development Hamilton O. Smith, Donald Grierson	1982	29
20	[46] Recovery of DNA from gels Methods in enzymology on CD-ROM/Methods in enzymology ·Hamilton O. Smith	1980	272

About Hamilton O. Smith

Hamilton O. Smith is a scholar working on Microbiology, Molecular Biology, Genetics, Ecology and Renewable Energy, Sustainability and the Environment, having authored 125 papers that have together received 20.5k indexed citations. Recurring topics across this work include RNA and protein synthesis mechanisms (53 papers), Bacterial Genetics and Biotechnology (37 papers), Bacteriophages and microbial interactions (31 papers), DNA and Nucleic Acid Chemistry (23 papers), Genomics and Phylogenetic Studies (15 papers), Microbial infections and disease research (10 papers), Advanced biosensing and bioanalysis techniques (10 papers) and Metalloenzymes and iron-sulfur proteins (10 papers). The work is most often cited by research in Molecular Biology (16.2k citations), Genetics (5.7k citations), Microbiology (1.1k citations), Ecology (4.0k citations) and Aging (245 citations). Hamilton O. Smith has collaborated with scholars based in United States, Switzerland and United Kingdom. Frequent co-authors include J. Craig Venter, Clyde A. Hutchison, Daniel G. Gibson, Lei Young, Ray-Yuan Chuang, Max L. Birnstiel, Daniel Nathans, Thomas J. Kelly, Myron Levine and John I. Glass. Their work appears in journals such as Proceedings of the National Academy of Sciences, Journal of Bacteriology, Science, Journal of Biological Chemistry and Journal of Molecular Biology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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