Hal A. Lewis

2.8k citations

31 papers · 2.4k · h-index 20

Impact in

Pulmonary and Respiratory Medicine top 5%
- Cystic Fibrosis Research Advances
Biological Psychiatry top 10%

Papers in

Physiology 6
- Alzheimer's disease research and treatments 6
Infectious Diseases 5
- HIV/AIDS drug development and treatment 5

Co-authors: Stephen Kevin Burley (4 shared papers)Robert B. Darnell (3 shared papers)Kirk B. Jensen (2 shared papers)Hua Chen (2 shared papers)Kiran Musunuru (2 shared papers)J.M. Sauder (3 shared papers)Xun Zhao (3 shared papers)John Francis Hunt (3 shared papers)
Journals: Journal of Medicinal Chemistry (7 papers)Proceedings of the National Academy of Sciences (4 papers)Bioorganic & Medicinal Chemistry Letters (3 papers)Journal of Biological Chemistry (2 papers)ACS Medicinal Chemistry Letters (2 papers)
Partner nations: United States India Australia

In The Last Decade

Hal A. Lewis

31 papers receiving 2.3k citations

Peers

Countries citing papers authored by Hal A. Lewis

Since Specialization

Citations

This map shows the geographic impact of Hal A. Lewis's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hal A. Lewis with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hal A. Lewis more than expected).

Fields of papers citing papers by Hal A. Lewis

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hal A. Lewis. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hal A. Lewis. The network helps show where Hal A. Lewis may publish in the future.

Co-authors

The 25 scholars most cited alongside Hal A. Lewis, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Hal A. Lewis Line = papers co-authored together Hal A. Lewis links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 31 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Structure of nucleotide‐binding domain 1 of the cystic fibrosis transmembrane conductance regulator The EMBO Journal ·Hal A. Lewis, Sean G. Buchanan, Stephen Kevin Burley, Kris Conners, M. Dickey, Michael R. Dorwart, Richard T. Fowler, Xia Gao	2003	347
2	Sequence-Specific RNA Binding by a Nova KH Domain Cell ·Hal A. Lewis, Kirk B. Jensen, Carme Edo, Hua Chen, Robert B. Darnell, Stephen Kevin Burley +1 other	2000	279
3	Impact of the ΔF508 Mutation in First Nucleotide-binding Domain of Human Cystic Fibrosis Transmembrane Conductance Regulator on Domain Folding and Structure Journal of Biological Chemistry ·Hal A. Lewis, Xun Zhao, Chi Chiu Wang, J.M. Sauder, Isabelle Anne Rooney, Brian W. Noland, Don D. Lorimer, Margaret C. Kearins	2004	234
4	Structural analysis of a set of proteins resulting from a bacterial genomics project Proteins Structure Function and Bioinformatics ·John Badger, J.M. Sauder, Jason M. Adams, Stephen Antonysamy, K.T. Bain, M.G. Bergseid, Sean G. Buchanan, Michelle D. Buchanan	2005	213
5	Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form Proceedings of the National Academy of Sciences ·Micah T. Nelp, Patrick A. Kates, John T. Hunt, John A. Newitt, Aaron Balog, Derrick Maley, Xiao Bing Zhu, Lynn M. Abell	2018	175
6	The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain Proceedings of the National Academy of Sciences ·Kirk B. Jensen, Kiran Musunuru, Hal A. Lewis, Stephen Kevin Burley, Robert B. Darnell	2000	129
7	Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers Proceedings of the National Academy of Sciences ·Samuel W. Gerritz, Christopher Cianci, Sean Kim, Bradley C. Pearce, Carol A. Deminie, Linda F. Discotto, Brian V. McAuliffe, Beatrice Minassian	2011	114
8	Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core Bioorganic & Medicinal Chemistry Letters ·Prasanna Sivaprakasam, Xiaojun Han, Rita L. Civiello, Swanee Jacutin-Porte, Kevin Kish, Matt E. Pokross, Hal A. Lewis, Nazia Ahmed	2015	109
9	Structure and Dynamics of NBD1 from CFTR Characterized Using Crystallography and Hydrogen/Deuterium Exchange Mass Spectrometry Journal of Molecular Biology ·Hal A. Lewis, Xun Zhao, Yoshitomo Hamuro, Kris Conners, Margaret C. Kearins, Frances Lu, J.M. Sauder, Kathleen S. Molnar	2009	108
10	Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains Structure ·Hal A. Lewis, Hua Chen, Carme Edo, Ronald J. Buckanovich, Yolanda Y. L. Yang, Kiran Musunuru, Zhong Ru, Robert B. Darnell	1999	99
11	Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant Protein Engineering Design and Selection ·S. Atwell, Christie G. Brouillette, Kris Conners, Spencer Emtage, T. Gheyi, William B. Guggino, Jörg Hendle, John Francis Hunt	2010	85
12	A Structural Genomics Approach to the Study of Quorum Sensing Structure ·Hal A. Lewis, Eva Bric-Furlong, B. Laubert, Galina A. Eroshkina, Yelena Batiyenko, Jason M. Adams, M.G. Bergseid, Curtis D. Marsh	2001	83
13	SGX393 inhibits the CML mutant Bcr-Abl T315I and preempts in vitro resistance when combined with nilotinib or dasatinib Proceedings of the National Academy of Sciences ·Thomas O’Hare, Christopher A. Eide, Jeffrey W Tyner, Amie S. Corbin, Matthew J. Wong, Sean G. Buchanan, Kevin R. Holme, Katayoun Alavi Jessen	2008	68
14	Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors Journal of Medicinal Chemistry ·Guanglin Luo, Ling Chen, Catherine R. Burton, Prasanna Sivaprakasam, Carol Krause, Yang Cao, Nengyin Liu, Jonathan Lippy	2016	66
15	Synthesis and NMR of RNA with Selective isotopic enrichment in the bases Nucleic Acids Research ·John SantaLucia, Ling X. Shen, Zhuoping Cai, Hal A. Lewis, Ignacio Tinoco	1995	38
16	5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors Journal of Medicinal Chemistry ·Kevin M. Peese, Christopher W. Allard, Timothy P. Connolly, Chen Li, Margaret E. Sorensen, Michael Andrew Walker, Nicholas A. Meanwell, Brian V. McAuliffe	2019	31
17	Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents ACS Medicinal Chemistry Letters ·Yong‐Jin Wu, Jason M. Guernon, Fukang Yang, Lawrence B. Snyder, Jianliang Shi, Andrea C. McClure, Ramkumar Rajamani, Hyunsoo Park	2016	29
18	Design, Structure–Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-b]pyridazines as Glycogen Synthase Kinase-3β (GSK-3β) Inhibitors Journal of Medicinal Chemistry ·Richard A. Hartz, Vijay T. Ahuja, Prasanna Sivaprakasam, Carol Krause, Wendy Clarke, Kevin Kish, Hal A. Lewis, Nicolas Szapiel	2023	25
19	Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors Journal of Medicinal Chemistry ·Li Guo, Nicholas A. Meanwell, Mark Krystal, David R. Langley, B. Narasimhulu Naidu, Prasanna Sivaprakasam, Hal A. Lewis, Kevin Kish	2020	24
20	Synthesis of thymine and alpha-putrescinylthymine in bacteriophage phi W-14-infected Pseudomonas acidovorans Journal of Virology ·K L Maltman, Jan Neuhard, Hal A. Lewis, R. A. J. Warren	1980	22

About Hal A. Lewis

Hal A. Lewis is a scholar working on Physiology, Infectious Diseases, Pulmonary and Respiratory Medicine, Hematology and Molecular Biology, having authored 31 papers that have together received 2.4k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (6 papers), HIV/AIDS drug development and treatment (5 papers), Cystic Fibrosis Research Advances (5 papers), Chronic Myeloid Leukemia Treatments (2 papers), RNA Research and Splicing (2 papers), Synthesis and biological activity (1 paper), Bacteriophages and microbial interactions (1 paper) and Bacterial biofilms and quorum sensing (1 paper). The work is most often cited by research in Pulmonary and Respiratory Medicine (561 citations), Biological Psychiatry (16 citations), Molecular Biology (586 citations), Oncology (94 citations) and Physiology (108 citations). Hal A. Lewis has collaborated with scholars based in United States, India and Australia. Frequent co-authors include Stephen Kevin Burley, Robert B. Darnell, Kirk B. Jensen, Hua Chen, Kiran Musunuru, J.M. Sauder, Xun Zhao, John Francis Hunt, Kris Conners and William B. Guggino. Their work appears in journals such as Journal of Medicinal Chemistry, Proceedings of the National Academy of Sciences, Bioorganic & Medicinal Chemistry Letters, Journal of Biological Chemistry and ACS Medicinal Chemistry Letters.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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