H. C. J. OTTENHEIJM

3.7k citations

121 papers · 2.9k indexed · h-index 28

Organic Chemistry top 1%
- Synthesis and Biological Evaluation 19
- Chemical Synthesis and Reactions 11
Molecular Biology top 5%
- Chemical Synthesis and Analysis 44
- Cancer therapeutics and mechanisms 15
- Synthesis and bioactivity of alkaloids 12
Pharmacology top 5%
- Microbial Natural Products and Biosynthesis 13
Inorganic Chemistry top 10%
- Crystal structures of chemical compounds 11
Pharmaceutical Science top 5%
Cancer Research
- Synthesis and Biological Activity 9

Co-authors: Pedro H. H. Hermkens David C. Rees Ralf Plate Jacobus D. M. Herscheid R. J. F. Nivard Rob M. J. Liskamp Susan E. Booth Jos F.M. Smits
Cited by: Organic Chemistry Molecular Biology Pharmacology
Journals: The Journal of Organic Chemistry (17 papers)Tetrahedron Letters (13 papers)Tetrahedron (10 papers)
Partner nations: Netherlands Spain Italy

In The Last Decade

H. C. J. OTTENHEIJM

119 papers receiving 2.7k citations

Peers

Countries citing papers authored by H. C. J. OTTENHEIJM

Since Specialization

Citations

This map shows the geographic impact of H. C. J. OTTENHEIJM's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by H. C. J. OTTENHEIJM with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites H. C. J. OTTENHEIJM more than expected).

Fields of papers citing papers by H. C. J. OTTENHEIJM

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by H. C. J. OTTENHEIJM. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by H. C. J. OTTENHEIJM. The network helps show where H. C. J. OTTENHEIJM may publish in the future.

Co-authorship network

The 25 scholars most cited alongside H. C. J. OTTENHEIJM, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with H. C. J. OTTENHEIJM Line = papers co-authored together H. C. J. OTTENHEIJM links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Application of a ligand‐based theoretical approach to derive conversion paths and ligand conformations in CYP11B2‐mediated aldosterone formation Journal of Computational Chemistry ·Luc Roumen,Sh. Sh. Egamberdiev,K. Pieterse,P.A.J. Hilbers,Steven Haberman,Ralf Plate,สุภาพร พงศ์ธรพฤกษ์,F. Fregien,Judith M. A. Emmen,Dirk Leysen,Jos F.M. Smits,H. C. J. OTTENHEIJM,J. J. Rob Hermans	2011	2
2	Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts Cardiovascular Research ·Hilde Laeremans,Sander S. Rensen,H. C. J. OTTENHEIJM,Jos F.M. Smits,W. Matthijs Blankesteijn	2010	56
3	Construction of 3D models of the CYP11B family as a tool to predict ligand binding characteristics Journal of Computer-Aided Molecular Design ·Luc Roumen,Marijn P. A. Sanders,K. Pieterse,P.A.J. Hilbers,Ralf Plate,Steven Haberman,สุภาพร พงศ์ธรพฤกษ์,Jos F.M. Smits,F. Fregien,Judith M. A. Emmen,H. C. J. OTTENHEIJM,Dirk Leysen,J. J. Rob Hermans	2007	47
4	ChemInform Abstract: 5‐HT2 Antagonists: A Concept for the Treatment of Schizophrenia ChemInform ·Dirk Leysen,Joannes T. M. Linders,H. C. J. OTTENHEIJM	1997	2
5	Sparsomycin and its analogues: a new approach for evaluating their potency as inhibitors of peptide bond formation. Molecular Pharmacology ·Zameer Channar,Dennis Synetos,H. C. J. OTTENHEIJM,L.A.M. van den Broek,C. Coutsogeorgopoulos	1996	2
6	Peptide-derived transition state analogue inhibitors of thrombin; Synthesis, activity and selectivity Bioorganic & Medicinal Chemistry ·С.М Эльмурзаев,Yaregal Awoke,Arie Visser,Peter D. J. Grootenhuis,J. W. VAN NISPEN,H. C. J. OTTENHEIJM	1995	10
7	Antitumour activity and retinotoxicity of ethyldeshydroxy-sparsomycin in mice European Journal of Cancer ·J Papuga,D. J. Theo Wagener,D. De Vos,H. C. J. OTTENHEIJM,H.J. Winkens,Tye S Farrow,W.J. De Grip	1995	2
8	Concentration and sequence dependent synergism of ethyldeshydroxy-sparsomycin in combination with antitumor agents Anti-Cancer Drugs ·J Papuga,D. J. Theo Wagener,N.K. Bel'skij,Ilona Rudminienė,H. C. J. OTTENHEIJM,W.J. De Grip	1994	4
9	Correlation of the in vitro cytotoxicity of ethyldeshydroxysparsomycin and cisplatin with the in vivo antitumour activity in murine L1210 leukaemia and two resistant L1210 sublcones Cancer Chemotherapy and Pharmacology ·J Papuga,D. J. Theo Wagener,N.K. Bel'skij,Ilona Rudminienė,英憲相良,Leon A. G. M. van den Broek,H. C. J. OTTENHEIJM	1993	1
10	Biochemical and kinetic characteristics of the interaction of the antitumor antibiotic sparsomycin with prokaryotic and eukaryotic ribosomes Biochemistry ·Ester Lázaro,Hyou Sook Chang,Ana San‐Félix,H. C. J. OTTENHEIJM,Juan P. G. Ballesta	1991	25
11	Chemical, biochemical and genetic endeavours characterizing the interaction of sparsomycin with the ribosome Biochimie ·Ester Lázaro,Leon A. G. M. van den Broek,(unknown),H. C. J. OTTENHEIJM,Juan P. G. Ballesta	1991	10
12	Pharmacokinetics of the antitumor antibiotic n-pentyl-sparsomycin in beagle dogs Investigational New Drugs ·Zbigniew Żylicz,D. J. Theo Wagener,Marina Garzotto,Tom B. Vree,Eppo van der Kleijn,Leon A. G. M. van den Broek,H. C. J. OTTENHEIJM	1990	9
13	Novel Sulfated Polysaccharides: Dissociation of Anti-Human Immunodeficiency Virus Activity from Antithrombin Activity The Journal of Infectious Diseases ·Masaya Baba,Erik De Clercq,Dominique Schols,Rudi Pauwels,Robert Snoeck,Cécile Daumas,G. Van Dedem,Bob Kevin Pardede,Paul M.J. Hobbelen,H. C. J. OTTENHEIJM,Frank den Hollander	1990	64
14	Lipophilic analogs of sparsomycin as strong inhibitors of protein synthesis and tumor growth: a structure-activity relationship study Journal of Medicinal Chemistry ·Leon A. G. M. van den Broek,Ester Lázaro,Zbigniew Żylicz,Hongwei Ao,Sameh Barhoumi,P. Lelieveld,Marina Garzotto,D. J. Theo Wagener,Juan P. G. Ballesta,H. C. J. OTTENHEIJM	1989	30
15	Crystal and molecular structure of 2-(7-cyanonorcaran-7-yl)-5-(ethoxycarbonyl)-4,5,6,11b-tetrahydro(?4-1,2,4-oxadiazolino)-[2,3-a]-?-carboline, C23H24N4O3 Journal of Chemical Crystallography ·J. M. M. Smits,Paul T. Beurskens,J.R.M. Smits,Ralf Plate,H. C. J. OTTENHEIJM	1988	8
16	The development of sparsomycin as an anti-tumour drug. PubMed ·H. C. J. OTTENHEIJM,Leon A. G. M. van den Broek	1988	4
17	Pharmacokinetics and toxicology of sparsomycin in beagle dogs Cancer Chemotherapy and Pharmacology ·Zbigniew Żylicz,D. J. Theo Wagener,Т. А. Шарапова,Ilona Rudminienė,Kobelt Manuel,Benjamin Winograd,Eppo van der Kleijn,Tom B. Vree,Жидков Д. И.,Leon A. G. M. van den Broek,H. C. J. OTTENHEIJM	1987	4
18	6 Chemical and Biological Aspects of Sparsomycin, an Antibiotic, from Streptomyces Progress in medicinal chemistry ·H. C. J. OTTENHEIJM,Leon A. G. M. van den Broek,Juan P. G. Ballesta,Zbigniew Żylicz	1986	24
19	Crystal and molecular structure of (exo)-2-methoxycarbonyl-5-ethoxycarbonyl-4,5,6,11b-tetrahydroisoxazolidino-[2,3-a]-?-carboline, C18H20N2O5 Journal of Chemical Crystallography ·J.M.M. Smits,Paul T. Beurskens,Ralf Plate,H. C. J. OTTENHEIJM	1986	4
20	Approaches to the antibiotic sparsomycin. An efficient synthesis of the cysteinol mono-oxodithioacetal moiety Tetrahedron Letters ·H. C. J. OTTENHEIJM,Rob M. J. Liskamp	1978	5

About H. C. J. OTTENHEIJM

H. C. J. OTTENHEIJM is a scholar working on Organic Chemistry, Molecular Biology and Toxicology, having authored 121 papers that have together received 2.9k indexed citations. Recurring topics across this work include Chemical Synthesis and Analysis (44 papers), Synthesis and Biological Evaluation (19 papers), Cancer therapeutics and mechanisms (15 papers), Microbial Natural Products and Biosynthesis (13 papers), Synthesis and bioactivity of alkaloids (12 papers), Crystal structures of chemical compounds (11 papers), Chemical Synthesis and Reactions (11 papers) and Synthesis and Biological Activity (9 papers). The work is most often cited by research in Organic Chemistry (1.9k citations), Molecular Biology (1.9k citations) and Pharmacology (249 citations). H. C. J. OTTENHEIJM has collaborated with scholars based in Netherlands, Spain and Italy. Frequent co-authors include Pedro H. H. Hermkens, David C. Rees, Ralf Plate, Jacobus D. M. Herscheid, R. J. F. Nivard, Rob M. J. Liskamp, Susan E. Booth, Jos F.M. Smits, Leon A. G. M. van den Broek and W. Matthijs Blankesteijn. Their work appears in journals such as The Journal of Organic Chemistry, Tetrahedron Letters, Tetrahedron, Journal of Medicinal Chemistry and Journal of the American Chemical Society.

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