Peter D. J. Grootenhuis

7.7k citations

109 papers · 5.0k indexed · 2 hit papers · h-index 32

Molecular Biology top 5%
Organic Chemistry top 2%
Pulmonary and Respiratory Medicine top 2%
Spectroscopy top 1%
Computational Theory and Mathematics top 0.5%

Co-authors: Peter A. Kollman J. Kelder L. P. C. Delbressine David N. Reinhoudt Fredrick Van Goor Paul A. Negulescu Sabine Hadidaꝉ Eric R. Olson
Topics: Computational Drug Discovery Methods (15 papers)Chemical Synthesis and Analysis (13 papers)Molecular Sensors and Ion Detection (12 papers)
Cited by: Spectroscopy Computational Theory and Mathematics Organic Chemistry
Journals: Proceedings of the National Academy of Sciences Journal of the American Chemical Society Journal of Biological Chemistry
Partner nations: Netherlands United States United Kingdom

In The Last Decade

Peter D. J. Grootenhuis

107 papers receiving 4.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

2011 831 citations Fredrick Van Goor, Sabine Hadidaꝉ et al. Proceedings of the National Academy of Sciences profile →
Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs

1999 643 citations J. Kelder, Peter D. J. Grootenhuis et al. Pharmaceutical Research profile →

Peers

Countries citing papers authored by Peter D. J. Grootenhuis

Since Specialization

Citations

This map shows the geographic impact of Peter D. J. Grootenhuis's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Peter D. J. Grootenhuis with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Peter D. J. Grootenhuis more than expected).

Fields of papers citing papers by Peter D. J. Grootenhuis

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Peter D. J. Grootenhuis. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Peter D. J. Grootenhuis. The network helps show where Peter D. J. Grootenhuis may publish in the future.

Co-authorship network of co-authors of Peter D. J. Grootenhuis

This figure shows the co-authorship network connecting the top 25 collaborators of Peter D. J. Grootenhuis. A scholar is included among the top collaborators of Peter D. J. Grootenhuis based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Peter D. J. Grootenhuis. Peter D. J. Grootenhuis is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809breakdown → 2011 ·Proceedings of the National Academy of Sciences ·Fredrick Van Goor,Sabine Hadidaꝉ,Peter D. J. Grootenhuis,Bill Burton,Jeffrey H. Stack,Kimberly Straley,Caroline J. Decker,Mark A. Miller,(unknown),Eric R. Olson,Jeffrey J. Wine,(unknown),Melissa A. Ashlock,Paul A. Negulescu	831
2	Efficient Screening of Cytochrome P450 BM3 Mutants for Their Metabolic Activity and Diversity toward a Wide Set of Drug-Like Molecules in Chemical Space 2011 ·Drug Metabolism and Disposition ·(unknown),Jolanda van Leeuwen,Yongmin Li,(unknown),Peter D. J. Grootenhuis,Caroline J. Decker,John Saunders,Nico Vermeulen,Jan N. M. Commandeur	40
3	In silico prediction of drug safety: despite progress there is abundant room for improvement 2004 ·Drug Discovery Today Technologies ·William J. Egan,Gregor Zlokarnik,Peter D. J. Grootenhuis	36
4	Design of a gene family screening library targeting G-protein coupled receptors 2004 ·Journal of Molecular Graphics and Modelling ·Michelle L. Lamb,Erin K. Bradley,Graham Beaton,Steven Bondy,Angelo J. Castellino,(unknown),Mark J. Suto,Peter D. J. Grootenhuis	5
5	Predicting Passive Transport In Silico - History, Hype, Hope 2003 ·Current Topics in Medicinal Chemistry ·David D. Clark,Peter D. J. Grootenhuis	19
6	A Method To Identify and Screen Libraries of Guests That Complex to a Synthetic Host 2002 ·Angewandte Chemie International Edition ·Menno R. de Jong,Ronald M. A. Knegtel,Peter D. J. Grootenhuis,Jurriaan Huskens,David N. Reinhoudt	30
7	Random mutagenesis and screening of complex glycoproteins: expression of human gonadotropins in Dictyostelium discoideum 1999 ·FEBS Journal ·Maarten H.K. Linskens,Peter D. J. Grootenhuis,Mieke Blaauw,(unknown),(unknown),Peter J.M. Van Haastert,(unknown)	2
8	Towards minimized gonadotropins with full bioactivity 1999 ·European Journal of Biochemistry ·(unknown),(unknown),Peter D. J. Grootenhuis	6
9	Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugsbreakdown → 1999 ·Pharmaceutical Research ·J. Kelder,Peter D. J. Grootenhuis,(unknown),L. P. C. Delbressine,(unknown)	643
10	Comparative molecular field analysis and energy interaction studies of thrombin-inhibitor complexes 1999 ·Journal of Computer-Aided Molecular Design ·Roberta Bursi,Peter D. J. Grootenhuis	19
11	Comparison of two implementations of the incremental construction algorithm in flexible docking of thrombin inhibitors 1999 ·Journal of Computer-Aided Molecular Design ·Ronald M. A. Knegtel,(unknown),Richard A. Engh,Wolfgang von der Saal,V. J. van Geerestein,Peter D. J. Grootenhuis	23
12	Novel acylguanidine containing thrombin inhibitors with reduced basicity at the P1 moiety 1998 ·Bioorganic & Medicinal Chemistry Letters ·Anton E.P. Adang,Hans Lucas,(unknown),Richard A. Engh,Peter D. J. Grootenhuis	26
13	Evaluation of Subunit Truncation and the Nature of the Spacer for Single Chain Human Gonadotropins 1997 ·European Journal of Biochemistry ·(unknown),(unknown),Paul van den Boogaart,Peter D. J. Grootenhuis	24
14	Functionality map analysis of the active site cleft of human thrombin 1996 ·Journal of Computer-Aided Molecular Design ·Peter D. J. Grootenhuis,Martin Karplus	21
15	Peptide-derived transition state analogue inhibitors of thrombin; Synthesis, activity and selectivity 1995 ·Bioorganic & Medicinal Chemistry ·(unknown),(unknown),Arie Visser,Peter D. J. Grootenhuis,J. W. VAN NISPEN,H. C. J. OTTENHEIJM	10
16	The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactions 1994 ·Nature Structural & Molecular Biology ·Herman Schreuder,(unknown),R. Dijkema,John W. M. Mulders,Henri Theunissen,Peter D. J. Grootenhuis,Wim G. J. Hol	238
17	Carbohydrates and drug discovery — the role of computer simulation 1994 ·Trends in biotechnology ·Peter D. J. Grootenhuis,C. A. A. VAN BOECKEL,C. A. G. Haasnoot	6
18	Crown ether-neutral molecule interactions studied by molecular mechanics, normal mode analysis, and free energy perturbation calculations. Near quantitative agreement between theory and experimental binding free energies 1989 ·Journal of the American Chemical Society ·Peter D. J. Grootenhuis,Peter A. Kollman	54
19	A discussion on the origin and treatment of noise in industrial environments - Sandwich damping treatment applied to concrete structures 1968 ·Philosophical Transactions of the Royal Society of London Series A Mathematical and Physical Sciences ·Peter D. J. Grootenhuis	3
20	Vibration of rigid bodies on semi-infinite elastic media 1965 ·Proceedings of the Royal Society of London A Mathematical and Physical Sciences ·(unknown),Peter D. J. Grootenhuis	70

About Peter D. J. Grootenhuis

Peter D. J. Grootenhuis is a scholar working on Spectroscopy, Computational Theory and Mathematics and Organic Chemistry, having authored 109 papers that have together received 5.0k indexed citations. Recurring topics across this work include Computational Drug Discovery Methods (15 papers), Chemical Synthesis and Analysis (13 papers) and Molecular Sensors and Ion Detection (12 papers). The work is most often cited by research in Spectroscopy (795 citations), Computational Theory and Mathematics (696 citations) and Organic Chemistry (1.2k citations). Peter D. J. Grootenhuis has collaborated with scholars based in Netherlands, United States and United Kingdom. Frequent co-authors include Peter A. Kollman, J. Kelder, L. P. C. Delbressine, David N. Reinhoudt, Fredrick Van Goor, Paul A. Negulescu, Sabine Hadidaꝉ, Eric R. Olson, Jeffrey H. Stack and Kimberly Straley. Their work appears in journals such as Proceedings of the National Academy of Sciences, Journal of the American Chemical Society and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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