Dirk Leysen

825 citations

27 papers · 647 indexed · h-index 13

Impact in

Ophthalmology top 5%
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
Pharmacology top 10%
- Pharmacogenetics and Drug Metabolism

Papers in ⓘ

Molecular Biology 13
- Receptor Mechanisms and Signaling 3
- Steroid Chemistry and Biochemistry 3
Organic Chemistry 7
- Synthesis and Biological Evaluation 3
- Coordination Chemistry and Organometallics 3

Co-authors: Karolien Castermans (6 shared papers)Olivier Defert (5 shared papers)C.L.E. Broekkamp (1 shared paper)B.W.M.M. Peeters (1 shared paper)R. M. Pinder (1 shared paper)Ingeborg Stalmans (4 shared papers)Sandro Boland (4 shared papers)Arnaud Bourin (4 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (3 papers)Journal of Medicinal Chemistry (3 papers)Steroids (2 papers)Investigative Ophthalmology & Visual Science (2 papers)Journal of Pharmacy and Pharmacology (1 paper)
Partner nations: Belgium Netherlands Austria

In The Last Decade

Dirk Leysen

24 papers receiving 612 citations

Peers

Countries citing papers authored by Dirk Leysen

Since Specialization

Citations

This map shows the geographic impact of Dirk Leysen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Dirk Leysen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Dirk Leysen more than expected).

Fields of papers citing papers by Dirk Leysen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Dirk Leysen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Dirk Leysen. The network helps show where Dirk Leysen may publish in the future.

Co-authors

The 25 scholars most cited alongside Dirk Leysen, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Dirk Leysen Line = papers co-authored together Dirk Leysen links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 27 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Treatment of Intestinal Fibrosis in Experimental Inflammatory Bowel Disease by the Pleiotropic Actions of a Local Rho Kinase Inhibitor Gastroenterology ·Tom Holvoet, Sarah Devriese, Karolien Castermans, Sandro Boland, Dirk Leysen, Yves‐Paul Vandewynckel, Lindsey Devisscher, Lien Van den Bossche, Sophie Van Welden, Mélissa Dullaers, Roosmarijn E. Vandenbroucke, Riet De Rycke, Karel Geboes, Arnaud Bourin, Olivier Defert, Pieter Hindryckx, Martine De Vos, Debby Laukens	2017	110
2	AMA0076, a Novel, Locally Acting Rho Kinase Inhibitor, Potently Lowers Intraocular Pressure in New Zealand White Rabbits with Minimal Hyperemia Investigative Ophthalmology & Visual Science ·Sarah Van de Velde, Tine Van Bergen, Davine Sijnave, Karolien Hollanders, Karolien Castermans, Olivier Defert, Dirk Leysen, Evelien Vandewalle, Lieve Moons, Ingeborg Stalmans	2014	76
3	Prospects for Improved Antidepressants Journal of Medicinal Chemistry ·C.L.E. Broekkamp, Dirk Leysen, B.W.M.M. Peeters, R. M. Pinder	1995	75
4	Construction of 3D models of the CYP11B family as a tool to predict ligand binding characteristics Journal of Computer-Aided Molecular Design ·Luc Roumen, Marijn P. A. Sanders, K. Pieterse, P.A.J. Hilbers, Ralf Plate, Erica M.G. Custers, Marcel de Gooyer, Jos F.M. Smits, Ilona P. E. Beugels, Judith M. A. Emmen, H. C. J. OTTENHEIJM, Dirk Leysen, J. J. Rob Hermans	2007	47
5	Tibolone is not converted by human aromatase to 7α-methyl-17α-ethynylestradiol (7α-MEE): Steroids ·Marcel E. de Gooyer, Hendrika M. Oppers-Tiemissen, Dirk Leysen, H.A.M. Verheul, Helenius J. Kloosterboer	2003	47
6	The Effect of AMA0428, a Novel and Potent ROCK Inhibitor, in a Model of Neovascular Age-Related Macular Degeneration Investigative Ophthalmology & Visual Science ·Karen Hollanders, Tine Van Bergen, Nadège Kindt, Karolien Castermans, Dirk Leysen, Evelien Vandewalle, Lieve Moons, Ingeborg Stalmans	2015	43
7	A Comparison of the Physicochemical and Biological Properties of Mirtazapine and Mianserin Journal of Pharmacy and Pharmacology ·J. Kelder, Carel W. Funke, Thus de Boer, L. P. C. Delbressine, Dirk Leysen, Victor J. Nickolson	1997	43
8	Design, Synthesis, and Biological Evaluation of Novel, Highly Active Soft ROCK Inhibitors Journal of Medicinal Chemistry ·Sandro Boland, Arnaud Bourin, Jo Alen, Jacques Geraets, Pieter Schroeders, Karolien Castermans, Nele Kindt, Nicki Boumans, Laura Panitti, Silke Fransen, Jessica Vanormelingen, Jean Marie Stassen, Dirk Leysen, Olivier Defert	2015	43
9	Synthesis, Biological Evaluation, and Molecular Modeling of 1-Benzyl-1H-imidazoles as Selective Inhibitors of Aldosterone Synthase (CYP11B2) Journal of Medicinal Chemistry ·Luc Roumen, Joris W. Peeters, Judith M. A. Emmen, Ilona P. E. Beugels, Erica M.G. Custers, Marcel de Gooyer, Ralf Plate, K. Pieterse, P.A.J. Hilbers, Jos F.M. Smits, Jef A. J. M. Vekemans, Dirk Leysen, H. C. J. OTTENHEIJM, Henk M. Janssen, J. J. Rob Hermans	2010	34
10	Novel Roflumilast analogs as soft PDE4 inhibitors Bioorganic & Medicinal Chemistry Letters ·Sandro Boland, Jo Alen, Arnaud Bourin, Karolien Castermans, Nicki Boumans, Laura Panitti, Jessica Vanormelingen, Dirk Leysen, Olivier Defert	2014	30
11	3-[2-(Aminomethyl)-5-[(pyridin-4-yl)carbamoyl]phenyl] benzoates as soft ROCK inhibitors Bioorganic & Medicinal Chemistry Letters ·Sandro Boland, Olivier Defert, Jo Alen, Arnaud Bourin, Karolien Castermans, Nele Kindt, Nicki Boumans, Laura Panitti, Sarah Van de Velde, Ingeborg Stalmans, Dirk Leysen	2013	26
12	Synthesis and preliminary in vivo evaluation of 4‐[¹⁸F]fluoro‐N‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)piperazin‐1‐yl]ethyl}benzamide, a potential PET radioligand for the 5‐HT_1A receptor Journal of Labelled Compounds and Radiopharmaceuticals ·M. Vandecapelle, F. Dumont, Filip De Vos, Koen Strijckmans, Dirk Leysen, Kurt Audenaert, R. A. Dierckx, Guido Slegers	2004	17
13	(Q) SAR study on the metabolic stability of steroidal androgens Journal of Molecular Graphics and Modelling ·Roberta Bursi, Marcel E. de Gooyer, A.J. Grootenhuis, Peter L Jacobs, Jaap van der Louw, Dirk Leysen	2001	12
14	In vivo evaluation of 4-[123I]iodo-N-{2-[4-(6-trifluoromethyl-2-pyridinyl)-1-piperazinyl]ethyl}benzamide, a potential SPECT radioligand for the 5-HT1A receptor Nuclear Medicine and Biology ·M. Vandecapelle, Filip De Vos, H. Vermeirsch, G. De Ley, Kurt Audenaert, Dirk Leysen, R. A. Dierckx, Guido Slegers	2001	10
15	Structure and Serotonin 5-HT_2C Receptor Activity of ortho- and meta-Substituted Phenylpiperazines Acta Crystallographica Section B Structural Science ·Marcel L. Verdonk, J.W. Voogd, J. A. Kanters, J. Kroon, R.Den Besten, Л. Брандсма, Dirk Leysen, J. Kelder	1997	7
16	Structure–activity relationship study of human liver microsomes-catalyzed hydrolysis rate of ester prodrugs of MENT by comparative molecular field analysis (CoMFA) Steroids ·Roberta Bursi, A.J. Grootenhuis, Jaap van der Louw, Jos Verhagen, Marcel de Gooyer, Peter W. Jacobs, Dirk Leysen	2003	5
17	Synthesis and preliminary in vivo evaluation of 4‐[¹²³I]iodo‐N‐{2‐[4‐(6‐trifluoromethyl‐2‐pyridinyl)‐1‐piperazinyl]ethyl}benzamide, a potential SPECT radioligand for the 5‐HT_1A receptor Journal of Labelled Compounds and Radiopharmaceuticals ·M. Vandecapelle, Filip De Vos, F. Dumont, Kurt Audenaert, Dirk Leysen, R. A. Dierckx, Guido Slegers	2001	5
18	Predicting Residual Adsorbable Organic Halides Concentrations in Industrial Wastewater Using Typical Wastewater Parameters Water ·Hannah Milh, Kwinten Van Eyck, Bert Bastiaens, Steven De Laet, Dirk Leysen, Deirdre Cabooter, Raf Dewil	2020	5
19	Application of a ligand‐based theoretical approach to derive conversion paths and ligand conformations in CYP11B2‐mediated aldosterone formation Journal of Computational Chemistry ·Luc Roumen, Bram van Hoof, K. Pieterse, P.A.J. Hilbers, Erica M.G. Custers, Ralf Plate, Marcel de Gooyer, Ilona P. E. Beugels, Judith M. A. Emmen, Dirk Leysen, Jos F.M. Smits, H. C. J. OTTENHEIJM, J. J. Rob Hermans	2011	2
20	Novel stereoselective calcium channel ligands of the diphenylalkylamine-type Bioorganic & Medicinal Chemistry Letters ·Ming‐Qiang Zhang, Patrizia Caldirola, Dirk Leysen, H. Timmerman	1992	2

About Dirk Leysen

Dirk Leysen is a scholar working on Molecular Biology, Organic Chemistry, Endocrinology, Diabetes and Metabolism, Pharmacology and Ophthalmology, having authored 27 papers that have together received 647 indexed citations. Recurring topics across this work include Glaucoma and retinal disorders (4 papers), Pharmacogenetics and Drug Metabolism (4 papers), Synthesis and Biological Evaluation (3 papers), Hormonal and reproductive studies (3 papers), Hormonal Regulation and Hypertension (3 papers), Receptor Mechanisms and Signaling (3 papers), Steroid Chemistry and Biochemistry (3 papers) and Coordination Chemistry and Organometallics (3 papers). The work is most often cited by research in Ophthalmology (105 citations), Pharmacology (60 citations), Endocrinology, Diabetes and Metabolism (103 citations), Pharmaceutical Science (32 citations) and Genetics (110 citations). Dirk Leysen has collaborated with scholars based in Belgium, Netherlands and Austria. Frequent co-authors include Karolien Castermans, Olivier Defert, C.L.E. Broekkamp, B.W.M.M. Peeters, R. M. Pinder, Ingeborg Stalmans, Sandro Boland, Arnaud Bourin, Evelien Vandewalle and Tine Van Bergen. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, Steroids, Investigative Ophthalmology & Visual Science and Journal of Pharmacy and Pharmacology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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