Grant A. Challen

7.7k total citations · 3 hit papers
76 papers, 5.1k citations indexed

About

Grant A. Challen is a scholar working on Hematology, Molecular Biology and Genetics. According to data from OpenAlex, Grant A. Challen has authored 76 papers receiving a total of 5.1k indexed citations (citations by other indexed papers that have themselves been cited), including 56 papers in Hematology, 43 papers in Molecular Biology and 20 papers in Genetics. Recurrent topics in Grant A. Challen's work include Acute Myeloid Leukemia Research (43 papers), Epigenetics and DNA Methylation (26 papers) and Hematopoietic Stem Cell Transplantation (21 papers). Grant A. Challen is often cited by papers focused on Acute Myeloid Leukemia Research (43 papers), Epigenetics and DNA Methylation (26 papers) and Hematopoietic Stem Cell Transplantation (21 papers). Grant A. Challen collaborates with scholars based in United States, Australia and Canada. Grant A. Challen's co-authors include Margaret A. Goodell, Melissa H. Little, Nathan C. Boles, Andrew L. Young, Todd E. Druley, Brenda M. Birmann, Stuart M. Chambers, Mira Jeong, Hamza Celik and Min Luo and has published in prestigious journals such as Journal of Biological Chemistry, Nature Communications and Nature Genetics.

In The Last Decade

Grant A. Challen

72 papers receiving 5.0k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Dnmt3a is essential for hematopoietic stem cell differentiation

2011 791 citations Grant A. Challen, Margaret A. Goodell et al. profile →
Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

2016 456 citations Andrew L. Young, Grant A. Challen et al. profile →
Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling

2021 211 citations Katie A. Matatall, Grant A. Challen et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Grant A. Challen United States	31	2.8k	2.4k	1.2k	1.1k	712	76	5.1k
Louise E. Purton Australia	31	2.2k 0.8×	1.7k 0.7×	1.0k 0.9×	624 0.6×	550 0.8×	85	4.0k
Marieke von Lindern Netherlands	43	3.9k 1.4×	1.4k 0.6×	618 0.5×	884 0.8×	699 1.0×	134	5.7k
Motomi Osato Singapore	35	2.8k 1.0×	1.6k 0.6×	1.1k 0.9×	453 0.4×	582 0.8×	120	4.5k
Hideo Ema Japan	34	2.5k 0.9×	3.2k 1.3×	2.1k 1.8×	1.2k 1.1×	358 0.5×	78	5.8k
Olga I. Gan Canada	22	2.0k 0.7×	1.6k 0.7×	1.1k 1.0×	745 0.7×	523 0.7×	51	4.1k
Feng‐Chun Yang United States	39	2.8k 1.0×	1.2k 0.5×	1.1k 0.9×	764 0.7×	560 0.8×	131	5.6k
Yohei Morita Japan	32	2.2k 0.8×	1.9k 0.8×	1.4k 1.2×	632 0.6×	389 0.5×	57	4.4k
Alexander Medvinsky United Kingdom	34	3.7k 1.3×	1.9k 0.8×	1.8k 1.6×	582 0.5×	440 0.6×	66	6.6k
Françoise Pflumio France	37	2.1k 0.7×	1.6k 0.7×	1.4k 1.2×	692 0.6×	365 0.5×	97	4.4k
M Valtieri Italy	39	3.6k 1.3×	1.9k 0.8×	1.2k 1.0×	1.2k 1.1×	1.2k 1.6×	86	6.0k

Countries citing papers authored by Grant A. Challen

Since Specialization

Citations

This map shows the geographic impact of Grant A. Challen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Grant A. Challen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Grant A. Challen more than expected).

Fields of papers citing papers by Grant A. Challen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Grant A. Challen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Grant A. Challen. The network helps show where Grant A. Challen may publish in the future.

Co-authorship network of co-authors of Grant A. Challen

This figure shows the co-authorship network connecting the top 25 collaborators of Grant A. Challen. A scholar is included among the top collaborators of Grant A. Challen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Grant A. Challen. Grant A. Challen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Kong, Tim, Angelo B. A. Laranjeira, Christopher T. Letson, et al.. (2024). RSK1 dependency in FLT3-ITD acute myeloid leukemia. Blood Cancer Journal. 14(1). 207–207. 2 indexed citations

Young, Andrew L., et al.. (2024). Spatial Mapping of Hematopoietic Clones in Human Bone Marrow. Blood Cancer Discovery. 5(3). 153–163. 1 indexed citations

Young, Andrew L., et al.. (2023). Droplet Digital PCR for Oncogenic KMT2A Fusion Detection. Journal of Molecular Diagnostics. 25(12). 898–906. 2 indexed citations

Toma, Monika M., Margaret Nieborowska-Skorska, Marie‐Christine Caron, et al.. (2023). Inactivation of DNA Polymerase Theta (PolΘ) Is Synthetic Lethal in DNMT3A Mutated Myeloid Malignancies - Potential Clinical Applications. Blood. 142(Supplement 1). 580–580. 1 indexed citations

Eudy, Elizabeth, Matthew A. Loberg, Kira Young, et al.. (2022). Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness versus Lineage Output in Dnmt3a -Mutant Clonal Hematopoiesis. Cancer Discovery. 12(12). 2763–2773. 50 indexed citations

Zhang, Christine, Elizabeth L. Ostrander, Cates Mallaney, et al.. (2022). Txnip Enhances Fitness of Dnmt3a -Mutant Hematopoietic Stem Cells via p21. Blood Cancer Discovery. 3(3). 220–239. 13 indexed citations

Kong, Tim, Angelo B. A. Laranjeira, Daniel A.C. Fisher, et al.. (2022). DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression. Nature Cancer. 4(1). 108–127. 25 indexed citations

Young, Andrew L., Kristine M. Erlandson, Katherine Tassiopoulos, et al.. (2022). Effect of Clonal Hematopoiesis on Cardiovascular Disease in People Living with HIV. Experimental Hematology. 114. 18–21. 10 indexed citations

Cheng, Xiaogang, Ancy Joseph, Alice Chen-Liaw, et al.. (2021). Epigenomic regulation of human T-cell leukemia virus by chromatin-insulator CTCF. PLoS Pathogens. 17(5). e1009577–e1009577. 12 indexed citations

10.

Challen, Grant A., Eric M. Pietras, Nina Cabezas‐Wallscheid, & Robert Signer. (2021). Simplified murine multipotent progenitor isolation scheme: Establishing a consensus approach for multipotent progenitor identification. Experimental Hematology. 104. 55–63. 46 indexed citations

11.

Li, Qiong, Yali Chen, Daoxiang Zhang, et al.. (2019). IRAK4 mediates colitis-induced tumorigenesis and chemoresistance in colorectal cancer. JCI Insight. 4(19). 31 indexed citations

12.

Xu, Yali, Joseph P. Milazzo, Tim D.D. Somerville, et al.. (2018). A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia. Cancer Cell. 33(1). 13–28.e8. 57 indexed citations

13.

Celik, Hamza, Ashley C. Kramer, Elizabeth L. Ostrander, et al.. (2018). JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells. Cancer Cell. 34(5). 741–756.e8. 39 indexed citations

14.

McDonald, James I., Hamza Celik, Ashley C. Kramer, et al.. (2016). Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation. Biology Open. 5(6). 866–874. 208 indexed citations

15.

Luís, Tiago C., Cédric S. Tremblay, Markus G. Manz, et al.. (2016). Inflammatory signals in HSPC development and homeostasis: Too much of a good thing?. Experimental Hematology. 44(10). 908–912. 10 indexed citations

16.

Challen, Grant A., et al.. (2016). DNMT3A regulates T-cell development and suppresses T-all transformation. Experimental Hematology. 44(9). S41–S41. 2 indexed citations

17.

Matatall, Katie A., et al.. (2014). Type II interferon promotes differentiation of myeloid-biased hematopoietic stem cells. Experimental Hematology. 42(8). S14–S14. 39 indexed citations

18.

Mallaney, Cates, et al.. (2013). Clonal-level responses of functionally distinct hematopoietic stem cells to trophic factors. Experimental Hematology. 42(4). 317–327.e2. 4 indexed citations

19.

Liao, Jiehong, et al.. (2011). Investigating the role of hematopoietic stem and progenitor cells in regulating the osteogenic differentiation of mesenchymal stem cells in vitro. Journal of Orthopaedic Research®. 29(10). 1544–1553. 25 indexed citations

20.

Challen, Grant A., et al.. (2008). Mouse hematopoietic stem cell identification and analysis. Cytometry Part A. 75A(1). 14–24. 259 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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