Gary L. Grunewald

2.4k citations

119 papers · 2.0k indexed · h-index 24

Organic Chemistry top 2%
- Chemical synthesis and alkaloids 12
- Carbohydrate Chemistry and Synthesis 11
- Synthesis and Biological Evaluation 7
Pharmaceutical Science top 2%
Cancer Research top 5%
- Synthesis and Biological Activity 56
Physical and Theoretical Chemistry top 5%
Biochemistry top 5%
- Traditional and Medicinal Uses of Annonaceae 11
Molecular Biology
- Chemical Synthesis and Analysis 37
Pharmacology
- Berberine and alkaloids research 18
Spectroscopy
- Analytical Chemistry and Chromatography 10

Co-authors: Kevin R. Criscione Howard E. Zimmerman Vilas H. Dahanukar Michael J. McLeish Daniel J. Sall Jennifer L. Martin Ronald T. Borchardt Gunda I. Georg
Cited by: Organic Chemistry Pharmaceutical Science Cancer Research
Journals: Journal of the American Chemical Society (6 papers)Biochemistry (1 paper)Analytical Biochemistry (1 paper)
Partner nations: United States Australia New Zealand

In The Last Decade

Gary L. Grunewald

117 papers receiving 1.9k citations

Peers

Countries citing papers authored by Gary L. Grunewald

Since Specialization

Citations

This map shows the geographic impact of Gary L. Grunewald's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Gary L. Grunewald with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Gary L. Grunewald more than expected).

Fields of papers citing papers by Gary L. Grunewald

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Gary L. Grunewald. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Gary L. Grunewald. The network helps show where Gary L. Grunewald may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Gary L. Grunewald, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Gary L. Grunewald Line = papers co-authored together Gary L. Grunewald links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline Bioorganic & Medicinal Chemistry Letters ·Qian Wu,Joanne M. Caine,Stuart Thomson,Meri Slavica,Gary L. Grunewald,Michael J. McLeish	2009	2
2	Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitors Bioorganic & Medicinal Chemistry ·Gary L. Grunewald,Mitchell R. Seim,R.C. Regier,Kevin R. Criscione	2006	9
3	Disulfide-linked dimers of human adrenaline synthesizing enzyme PNMT are catalytically active Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics ·Christine L. Gee,Amanda Nourse,A-Yen Hsin,Qian Wu,Joel D. A. Tyndall,Gary L. Grunewald,Michael J. McLeish,Jennifer L. Martin	2005	4
4	Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines Bioorganic & Medicinal Chemistry Letters ·Gary L. Grunewald,F. Anthony Romero,Mitchell R. Seim,Kevin R. Criscione,Jean D. Deupree,Christy C. Spackman,David B. Bylund	2004	5
5	Phenylethanolamine N-methyltransferase inhibition: re-evaluation of kinetic data Bioorganic & Medicinal Chemistry Letters ·Qian Wu,Kevin R. Criscione,Gary L. Grunewald,Michael J. McLeish	2004	11
6	Effects of a 3-Alkyl-, 4-Hydroxy- and/or 8-Aromatic-substituent on the Phenylethanolamine N-Methyltransferase Inhibitor Potency and α2-Adrenoceptor Affinity of 2,3,4,5-Tetrahydro-1H-2-benzazepines Bioorganic & Medicinal Chemistry ·Gary L. Grunewald,Vilas H. Dahanukar,Kevin R. Criscione	2001	18
7	Getting the Adrenaline Going Structure ·Jennifer L. Martin,Jakob Begun,Michael J. McLeish,Joanne M. Caine,Gary L. Grunewald	2001	53
8	Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the α2-adrenoceptor: The development of new, highly selective inhibitors of PNMT Bioorganic & Medicinal Chemistry Letters ·Gary L. Grunewald,Timothy M. Caldwell,Vilas H. Dahanukar,Ravi Jalluri,Kevin R. Criscione	1999	14
9	1,3-Dimethyl-7-substituted-1,2,3,4-tetrahydroisoquinolines as probes for the binding orientation of tetrahydroisoquinoline at the active site of phenylethanolamine N-methyltransferase[1] Bioorganic & Medicinal Chemistry ·Gary L. Grunewald,Timothy M. Caldwell,Qifang Li,Kevin R. Criscione	1999	10
10	The oxetane conformational lock of paclitaxel: Structural analysis of D-secopaclitaxel Bioorganic & Medicinal Chemistry Letters ·Thomas C. Boge,Michael Hepperle,David G. Vander Velde,Christopher W. Gunn,Gary L. Grunewald,Gunda I. Georg	1999	18
11	Recombinant Human PhenylethanolamineN-Methyltransferase: Overproduction inEscherichia coli,Purification, and Characterization Protein Expression and Purification ·Joanne M. Caine,Ian Macreadie,Gary L. Grunewald,Michael J. McLeish	1996	21
12	Influence of stereochemical factors on the partition-coefficient of diastereoisomers in a biphasic octan-1-Ol water-system Archive ouverte UNIGE (University of Geneva) ·Ruey‐Shiuan Tsai,Pierre‐Alain Carrupt,Bernard Testa,Nabil El Tayar,Gary L. Grunewald,A. F. Casy	1993	3
13	Homoallylic amines related to zimeldine. Comparative study on neuronal serotonin and norepinephrine reuptake based on conformational analysis Journal of Medicinal Chemistry ·Thomas Högberg,Svante B. Ross,Patrik Ström,Gary L. Grunewald,M W Creese,Jeffrey D. Bunce	1988	13
14	Conformational preference for the binding of biaryl substrates and inhibitors to the active site of phenylethanolamine N-methyltransferase (PNMT) Journal of Medicinal Chemistry ·Gary L. Grunewald,Anne E. Carter,Daniel J. Sall,James A. Monn	1988	7
15	Conformationally defined adrenergic agents. 13. Conformational and steric aspects of the inhibition of phenylethanolamine N-methyltransferase by benzylamines Journal of Medicinal Chemistry ·Gary L. Grunewald,Daniel J. Sall,James A. Monn	1988	23
16	Anticonvulsant activities of phenyl-substituted bicyclic 2,4-oxazolidinediones and monocyclic models. Comparison with binding to the neuronal voltage-dependent sodium channel Journal of Medicinal Chemistry ·Wayne J. Brouillette,George Bosworth Brown,Timothy M. DeLorey,Shyam Shirali,Gary L. Grunewald	1988	16
17	Conformationally defined adrenergic agents. 10. Binding orientation of amphetamine and norfenfluramine analogs in the benzonorbornene and benzobicyclo[3.2.1]octane ring systems at the active site of phenylethanolamine N-methyltransferase (PNMT) Journal of Medicinal Chemistry ·Gary L. Grunewald,Kimberly M. Markovich,Daniel J. Sall	1987	12
18	Inhibition of phenylethanolamine N-methyltransferase (PNMT) by aromatic hydroxy-substituted 1,2,3,4-tetrahydroisoquinolines. Further studies on the hydrophilic pocket of the aromatic ring binding region of the active site Journal of Medicinal Chemistry ·Daniel J. Sall,Gary L. Grunewald	1987	26
19	Conformationally defined adrenergic agents. III. The importance of compartmentation in the release of norepinephrine from rat atria by endo- and exo-2-methylaminobenzobicyclo-[2.2.2]octene, conformationally defined analogs of methamphetamine. Journal of Pharmacology and Experimental Therapeutics ·James A. Ruth,Gary L. Grunewald,Charles O. Rutledge	1978	9
20	2,3-ジクロロ-5,6-ジシアノベンゾキノン(DDQ)の相当するヒドロキノン(DDHQ)からの再生のための速く,簡便で,高収率な方法 Kim K H,Gary L. Grunewald	1976	2

About Gary L. Grunewald

Gary L. Grunewald is a scholar working on Cancer Research, Organic Chemistry and Biochemistry, having authored 119 papers that have together received 2.0k indexed citations. Recurring topics across this work include Synthesis and Biological Activity (56 papers), Chemical Synthesis and Analysis (37 papers), Berberine and alkaloids research (18 papers), Chemical synthesis and alkaloids (12 papers), Carbohydrate Chemistry and Synthesis (11 papers), Traditional and Medicinal Uses of Annonaceae (11 papers), Analytical Chemistry and Chromatography (10 papers) and Synthesis and Biological Evaluation (7 papers). The work is most often cited by research in Organic Chemistry (1.1k citations), Pharmaceutical Science (212 citations) and Cancer Research (394 citations). Gary L. Grunewald has collaborated with scholars based in United States, Australia and New Zealand. Frequent co-authors include Kevin R. Criscione, Howard E. Zimmerman, Vilas H. Dahanukar, Michael J. McLeish, Daniel J. Sall, Jennifer L. Martin, Ronald T. Borchardt, Gunda I. Georg, Timothy M. Caldwell and David G. Vander Velde. Their work appears in journals such as Journal of the American Chemical Society, Biochemistry and Analytical Biochemistry.

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