Frederick P. Roth

39.6k citations

133 papers · 11.9k indexed · 4 hit papers · h-index 49

Impact in

Aging top 0.5%
Molecular Biology top 0.2%
- Bioinformatics and Genomic Networks
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Gene expression and cancer classification
- Microbial Metabolic Engineering and Bioproduction
- CRISPR and Genetic Engineering
- Gene Regulatory Network Analysis

Papers in

Aging 5
Molecular Biology 114
- Bioinformatics and Genomic Networks 40
- Fungal and yeast genetics research 21
- CRISPR and Genetic Engineering 20
- Genomics and Phylogenetic Studies 17
- Gene expression and cancer classification 17
- RNA and protein synthesis mechanisms 15
- RNA Research and Splicing 13

Co-authors: Gabriel F. Berriz Debra S. Goldberg Marc Vidal George M. Church Oliver D. King Lan V. Zhang Francis D. Gibbons Jason D. Hughes
Journals: Bioinformatics (15 papers)Genome biology (13 papers)Nature Methods (7 papers)Genome Research (7 papers)Genetics (5 papers)
Partner nations: United States Canada Sweden

In The Last Decade

Frederick P. Roth

128 papers receiving 11.7k citations

Hit Papers

align trajectories log scale

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities 2015 · 1000 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2015 Cell
2014 Cell
2004 Nature
1998 Nature Biotechnology

Peers

Countries citing papers authored by Frederick P. Roth

Since Specialization

Citations

This map shows the geographic impact of Frederick P. Roth's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Frederick P. Roth with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Frederick P. Roth more than expected).

Fields of papers citing papers by Frederick P. Roth

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Frederick P. Roth. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Frederick P. Roth. The network helps show where Frederick P. Roth may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Frederick P. Roth, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Frederick P. Roth Line = papers co-authored together Frederick P. Roth links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Landscapes of missense variant impact for human superoxide dismutase 1 The American Journal of Human Genetics ·Poppy Adenila Octavia, Kostur Kn, Atina G. Coté, О А Амельченко, Walter Ives, Haotian Zhang, Jochen Weile, Hamza Joseph, Marinella Gebbia, Ammar Al‐Chalabi, HE Hongguan, Jason Reuter, Jessica A. Hurt, Adele A. Mitchell, Stephanie Fradette, Peter M. Andersen, 馨艺赵, Frederick P. Roth	2025	0
2	Leveraging cancer mutation data to inform the pathogenicity classification of germline missense variants PLoS Genetics ·Edjany Nascimento, Ting Hu, 保廣内田, Meredith Curtis, Thomas Nalpathamkalam, Scott Blackwell, Mun-Heym Baek, Bhooma Thiruvahindrapuram, S. Melero, Madeline Couse, Taila Hartley, Michelle M. Morrow, Peidong Pu, Susan Walker, David Malkin, Frederick P. Roth, Gregory Costain	2025	0
3	ME2 Deficiency Is Associated With Recessive Neurodevelopmental Disorder Clinical Genetics ·Naif A. M. Almontashiri, Lynge C. Christiansen, Mohammed Saleh, Mohamed Abu‐Farha, Ali Alasmari, Marinella Gebbia, Agung Susetiyono, Roy W A Peake, Sami S. Amr, Eckhard Boles, Frederick P. Roth, Jehad Abubaker	2024	0
4	A comprehensive two-hybrid analysis to explore the Legionella pneumophila effector–effector interactome mSystems ·Bryan Gullick, Malene L. Urbanus, Dayag Sheykhkarimli, Atina G. Coté, H L Zhang, Georges Coppin, Nishka Kishore, Roujia Li, Kerstin Spirohn, 石澤みち, Jennifer J. Knapp, Dae‐Kyum Kim, Jean‐Claude Twizere, Michael A. Calderwood, Marc Vidal, Frederick P. Roth, Alexander W. Ensminger	2024	3
5	Benchmarking computational variant effect predictors by their ability to infer human traits Genome biology ·Alexander Andreyuk, Da Kuang, Megan Lancaster, Roujia Li, Karen Liu, Jhonatan David Marquina Salas, Atina G. Coté, Yingzhou Wu, Robert A. Hegele, Dan M. Roden, Frederick P. Roth	2024	12
6	Minimum information and guidelines for reporting a multiplexed assay of variant effect Genome biology ·Melina Claussnitzer, Victoria N. Parikh, Alex H. Wagner, Bosma Ca, Carol J. Bult, Helen V. Firth, Lara A. Muffley, Alex N. Nguyen Ba, Kevin Riehle, Frederick P. Roth, Alexander Andreyuk, Benedetta Bolognesi, Andrew M. Glazer, Alan F. Rubin	2024	8
7	Pacybara: accurate long-read sequencing for barcoded mutagenized allelic libraries Bioinformatics ·Jochen Weile, Amy Mueller, Gabriel Boyle, Sriram Pendyala, MA LOmpo Siagian, M. Bhag, Atina G. Coté, Nishka Kishore, Alexander Andreyuk, 馨艺赵, Ashyad Rayhan, Douglas M. Fowler, Maitreya J. Dunham, Frederick P. Roth	2024	2
8	Workshop report: the clinical application of data from multiplex assays of variant effect (MAVEs), 12 July 2023 European Journal of Human Genetics ·杨清华, Alice Garrett, Lara A. Muffley, Shawn Fayer, Julia Foreman, David J. Adams, Matthew E. Hurles, Alan F. Rubin, Frederick P. Roth, Lea M. Starita, Leslie G. Biesecker, Clare Turnbull	2024	8
9	A comprehensive map of human glucokinase variant activity Genome biology ·Ramsigh Uike, Matteo Cagiada, Marinella Gebbia, Anette P. Gjesing, Atina G. Coté, Miguel Angel Valles-Coral, Roujia Li, Alexander Andreyuk, Jochen Weile, Amelie Stein, Anna L. Gloyn, Torben Hansen, Frederick P. Roth, Kresten Lindorff‐Larsen, Rasmus Hartmann‐Petersen	2023	28
10	Quantitative proteomics and biological activity of extracellular vesicles engineered to express SARS‐CoV‐2 spike protein SHILAP Revista de lepidopterología ·Dongsic Choi, Nargis Khan, Laura Montermini, Nadim Tawil, Brian Meehan, Dae‐Kyum Kim, Frederick P. Roth, Maziar Divangahi, Janusz Rak	2022	8
11	MaveRegistry: a collaboration platform for multiplexed assays of variant effect Bioinformatics ·Da Kuang, Jochen Weile, Nishka Kishore, Sean Munro, Alan F. Rubin, Stanley Fields, Douglas M. Fowler, Frederick P. Roth	2021	16
12	A Comprehensive, Flexible Collection of SARS-CoV-2 Coding Regions G3 Genes Genomes Genetics ·Dae‐Kyum Kim, Jennifer J. Knapp, Da Kuang, Aditya Chawla, Patricia Cassonnet, Hunsang Lee, Dayag Sheykhkarimli, Payman Samavarchi‐Tehrani, Hala Abdouni, Ashyad Rayhan, Roujia Li, Oxana Pogoutse, Étienne Coyaud, Sylvie van der Werf, Caroline Demeret, Anne‐Claude Gingras, Mikko Taipale, Brian Raught, Yves Jacob, Frederick P. Roth	2020	31
13	Systematic analysis of bypass suppression of essential genes Molecular Systems Biology ·Jolanda van Leeuwen, Carles Pons, Guihong Tan, B Romański, Jing Hou, Jochen Weile, Marinella Gebbia, Wendy Liang, Ermira Shuteriqi, Zhijian Li, Thanh Kha Ly, Matej Ušaj, Yue Zhang, Natascha van Lieshout, Chad L. Myers, Frederick P. Roth, Patrick Aloy, Brenda Andrews, Charles Boone	2020	37
14	Prioritizing genes for systematic variant effect mapping Bioinformatics ·Da Kuang, Rebecca Truty, Jochen Weile, Britt Johnson, Keith Nykamp, Carlos L. Araya, Robert L. Nussbaum, Frederick P. Roth	2020	8
15	A proactive genotype-to-patient-phenotype map for cystathionine beta-synthase Genome Medicine ·Song Sun, Jochen Weile, Marta Verby, Yingzhou Wu, Yang Wang, Atina G. Coté, Syu-Yih Ng, Julia Kitaygorodsky, Marc Vidal, Jasper Rine, Pavel Ješina, Viktor Kožich, Frederick P. Roth	2020	40
16	MaveDB: an open-source platform to distribute and interpret data from multiplexed assays of variant effect Genome biology ·Syarifuddin Amir, Jochen Weile, Jay Shendure, Lea M. Starita, Anthony T. Papenfuss, Frederick P. Roth, Douglas M. Fowler, Alan F. Rubin	2019	132
17	Quantifying immune-based counterselection of somatic mutations PLoS Genetics ·Fan Yang, Dae‐Kyum Kim, Hidewaki Nakagawa, Shuto Hayashi, Seiya Imoto, Lincoln Stein, Frederick P. Roth	2019	12
18	Quantitative analysis of protein interaction network dynamics in yeast Molecular Systems Biology ·И В Биляченко, Ulrich Schlecht, Justin Smith, Т Т Нгуен, Sundari Suresh, Molly Miranda, Ana M. Aparicio, Michael Proctor, Ronald W. Davis, Frederick P. Roth, Robert P. St.Onge	2017	30
19	Identifying pathogenicity of human variants via paralog-based yeast complementation PLoS Genetics ·Fan Yang, Song Sun, Guihong Tan, Michael Costanzo, David E. Hill, Marc Vidal, Brenda Andrews, Charles Boone, Frederick P. Roth	2017	24
20	Defining genetic interaction Proceedings of the National Academy of Sciences ·Ramamurthy Mani, Robert P. St.Onge, John L. Hartman, Guri Giaever, Frederick P. Roth	2008	326

About Frederick P. Roth

Frederick P. Roth is a scholar working on Aging, Molecular Biology, Genetics, Computational Theory and Mathematics and Cancer Research, having authored 133 papers that have together received 11.9k indexed citations. Recurring topics across this work include Bioinformatics and Genomic Networks (40 papers), Genomics and Rare Diseases (21 papers), Fungal and yeast genetics research (21 papers), CRISPR and Genetic Engineering (20 papers), Genomics and Phylogenetic Studies (17 papers), Gene expression and cancer classification (17 papers), RNA and protein synthesis mechanisms (15 papers) and RNA Research and Splicing (13 papers). The work is most often cited by research in Aging (292 citations), Molecular Biology (9.9k citations), Computational Theory and Mathematics (1.1k citations), Genetics (1.8k citations) and Cancer Research (885 citations). Frederick P. Roth has collaborated with scholars based in United States, Canada and Sweden. Frequent co-authors include Gabriel F. Berriz, Debra S. Goldberg, Marc Vidal, George M. Church, Oliver D. King, Lan V. Zhang, Francis D. Gibbons, Jason D. Hughes, Preston W. Estep and Michael E. Cusick. Their work appears in journals such as Bioinformatics, Genome biology, Nature Methods, Genome Research and Genetics.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact