Derek LeRoith

24.3k total citations · 5 hit papers
281 papers, 18.9k citations indexed

About

Derek LeRoith is a scholar working on Molecular Biology, Endocrinology, Diabetes and Metabolism and Surgery. According to data from OpenAlex, Derek LeRoith has authored 281 papers receiving a total of 18.9k indexed citations (citations by other indexed papers that have themselves been cited), including 165 papers in Molecular Biology, 161 papers in Endocrinology, Diabetes and Metabolism and 50 papers in Surgery. Recurrent topics in Derek LeRoith's work include Growth Hormone and Insulin-like Growth Factors (129 papers), Metabolism, Diabetes, and Cancer (115 papers) and Pancreatic function and diabetes (38 papers). Derek LeRoith is often cited by papers focused on Growth Hormone and Insulin-like Growth Factors (129 papers), Metabolism, Diabetes, and Cancer (115 papers) and Pancreatic function and diabetes (38 papers). Derek LeRoith collaborates with scholars based in United States, Israel and Italy. Derek LeRoith's co-authors include Emily J. Gallagher, Charles T. Roberts, Shoshana Yakar, Martin L. Adamo, Ignacio Torres‐Alemán, Haim Werner, Jun‐Li Liu, Mohan K. Raizada, William L. Lowe and Teresa Gómez‐Isla and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Journal of Clinical Investigation.

In The Last Decade

Derek LeRoith

281 papers receiving 18.5k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice

1999 769 citations Derek LeRoith et al. profile →
Circulating levels of IGF-1 directly regulate bone growth and density

2002 703 citations Shoshana Yakar, Derek LeRoith et al. Journal of Clinical Investigation profile →
Circulating levels of IGF-1 directly regulate bone growth and density

2002 604 citations Shoshana Yakar, Derek LeRoith et al. Journal of Clinical Investigation profile →
Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality

2015 566 citations Emily J. Gallagher, Derek LeRoith profile →
Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent

2023 153 citations Syed Faizan Mehdi, Kevin J. Tracey et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Derek LeRoith United States	73	9.3k	8.4k	3.0k	2.8k	2.5k	281	18.9k
Derek LeRoith United States	64	8.0k 0.9×	9.3k 1.1×	1.7k 0.6×	2.4k 0.9×	2.0k 0.8×	181	16.1k
Charles T. Roberts United States	67	8.4k 0.9×	8.4k 1.0×	1.8k 0.6×	2.3k 0.8×	1.4k 0.5×	264	16.9k
Pinchas Cohen United States	79	10.1k 1.1×	8.6k 1.0×	5.8k 1.9×	3.6k 1.3×	1.9k 0.7×	318	22.5k
Paul A. Kelly France	81	7.8k 0.8×	10.2k 1.2×	2.0k 0.7×	1.7k 0.6×	3.8k 1.5×	404	23.2k
John J. Kopchick United States	70	6.3k 0.7×	9.3k 1.1×	5.7k 1.9×	1.9k 0.7×	1.3k 0.5×	458	18.6k
Robert C. Baxter Australia	78	10.4k 1.1×	16.0k 1.9×	2.3k 0.8×	4.4k 1.6×	2.0k 0.8×	397	22.9k
John S. Parks United States	68	6.8k 0.7×	5.8k 0.7×	1.6k 0.5×	2.2k 0.8×	2.2k 0.9×	330	17.9k
Philip W. Shaul United States	69	5.4k 0.6×	4.1k 0.5×	4.1k 1.3×	1.9k 0.7×	1.2k 0.5×	211	18.7k
Evan R. Simpson United States	84	7.7k 0.8×	6.7k 0.8×	1.8k 0.6×	1.9k 0.7×	3.1k 1.2×	332	23.9k
Fred C.G.J. Sweep Netherlands	73	6.6k 0.7×	3.4k 0.4×	926 0.3×	3.6k 1.3×	2.9k 1.2×	491	18.5k

Countries citing papers authored by Derek LeRoith

Since Specialization

Citations

This map shows the geographic impact of Derek LeRoith's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Derek LeRoith with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Derek LeRoith more than expected).

Fields of papers citing papers by Derek LeRoith

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Derek LeRoith. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Derek LeRoith. The network helps show where Derek LeRoith may publish in the future.

Co-authorship network of co-authors of Derek LeRoith

This figure shows the co-authorship network connecting the top 25 collaborators of Derek LeRoith. A scholar is included among the top collaborators of Derek LeRoith based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Derek LeRoith. Derek LeRoith is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Mehdi, Syed Faizan, Miti Shah, Christine N. Metz, et al.. (2025). Endocrine and metabolic alterations in response to systemic inflammation and sepsis: a review article. Molecular Medicine. 31(1). 16–16. 11 indexed citations

Arcidiacono, Diletta, Arben Dedja, Cinzia Giacometti, et al.. (2018). Hyperinsulinemia Promotes Esophageal Cancer Development in a Surgically-Induced Duodeno-Esophageal Reflux Murine Model. International Journal of Molecular Sciences. 19(4). 1198–1198. 17 indexed citations

Obr, Alison E., Sushil Kumar, Yun‐Juan Chang, et al.. (2018). Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment. Breast Cancer Research. 20(1). 138–138. 34 indexed citations

Gallagher, Emily J., Zara Zelenko, Brian A. Neel, et al.. (2017). Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia. Oncogene. 36(46). 6462–6471. 162 indexed citations

Lin, Jenny J., Emily J. Gallagher, Keith Sigel, et al.. (2014). Survival of Patients with Stage IV Lung Cancer with Diabetes Treated with Metformin. American Journal of Respiratory and Critical Care Medicine. 191(4). 448–454. 113 indexed citations

Novosyadlyy, Ruslan, Archana Vijayakumar, Anne Rowzee, et al.. (2010). Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes. Cancer Research. 70(2). 741–751. 219 indexed citations

Brown, Marie T. & Derek LeRoith. (2010). Overcoming challenges in Type 2 diabetes management to improve patient outcomes. Expert Review of Endocrinology & Metabolism. 5(5). 741–751. 4 indexed citations

LeRoith, Derek & Aaron I. Vinik. (2008). Controversies in treating diabetes : clinical and research aspects. Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)). 2 indexed citations

Gallagher, Emily J., Derek LeRoith, & Eddy Karnieli. (2008). The Metabolic Syndrome—from Insulin Resistance to Obesity and Diabetes. Endocrinology and Metabolism Clinics of North America. 37(3). 559–579. 78 indexed citations

10.

Shukla, Vivek, Xavier Coumoul, Liu Cao, et al.. (2006). Absence of the Full-Length Breast Cancer–Associated Gene-1 Leads to Increased Expression of Insulin-Like Growth Factor Signaling Axis Members. Cancer Research. 66(14). 7151–7157. 36 indexed citations

11.

Yakar, Shoshana, P. Pennisi, Hong Zhao, Yang Zhang, & Derek LeRoith. (2004). Circulating IGF‐1 and Its Role in Cancer: Lessons from the IGF‐1 Gene Deletion (LID) Mouse. Novartis Foundation symposium. 262. 3–18. 19 indexed citations

12.

Blakesley, Vicky A., Thea Kalebic, Lee J. Helman, et al.. (1996). Tumorigenic and mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor (IGF)-I receptors. The role of tyrosine residues 1250, 1251, and 1316 in the carboxy-terminus of the IGF-I receptor.. Endocrinology. 137(2). 410–417. 55 indexed citations

13.

Neuenschwander, Stefan, A M Schwartz, Teresa L. Wood, et al.. (1996). Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.. Journal of Clinical Investigation. 97(10). 2225–2232. 171 indexed citations

14.

LeRoith, Derek & Carolyn A. Bondy. (1996). Growth factors and cytokines in health and disease : a multi-volume treatise. JAI Press eBooks. 1 indexed citations

15.

Werner, Haim, Zila Shen‐Orr, Frank J. Rauscher, et al.. (1995). Inhibition of Cellular Proliferation by the Wilms’ Tumor Suppressor WT1 Is Associated with Suppression of Insulin-Like Growth Factor I Receptor Gene Expression. Molecular and Cellular Biology. 15(7). 3516–3522. 92 indexed citations

16.

Draznin, Boris & Derek LeRoith. (1994). Molecular Biology of Diabetes. Humana Press eBooks. 59 indexed citations

17.

Hadari, Yaron R., Benjamin Geiger, Orna Nadiv, et al.. (1993). Hepatic tyrosine-phosphorylated proteins identified and localized following in vivo inhibition of protein tyrosine phosphatases: effects of H2O2 and vanadate administration into rat livers. Molecular and Cellular Endocrinology. 97(1-2). 9–17. 37 indexed citations

18.

Draznin, Boris, David K. Lewis, Nancy Sherman, et al.. (1989). Mechanism of Insulin Resistance Induced by Sustained Levels of Cytosolic Free Calcium in Rat Adipocytes*. Endocrinology. 125(5). 2341–2349. 101 indexed citations

19.

Raizada, Mohan K., et al.. (1988). Insulin receptors in the brain: Structural and physiological characterization. Neurochemical Research. 13(4). 297–303. 56 indexed citations

20.

Spitz, Irving M., Derek LeRoith, Edit Zylber-Haran, et al.. (1980). Exaggerated Prolactin Response to Thyrotropin-Releasing Hormone and Metoclopramide in Primary Testicular Failure. Fertility and Sterility. 34(6). 573–580. 13 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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