Tip W. Loo

10.0k total citations · 1 hit paper
131 papers, 8.7k citations indexed

About

Tip W. Loo is a scholar working on Oncology, Molecular Biology and Infectious Diseases. According to data from OpenAlex, Tip W. Loo has authored 131 papers receiving a total of 8.7k indexed citations (citations by other indexed papers that have themselves been cited), including 88 papers in Oncology, 51 papers in Molecular Biology and 46 papers in Infectious Diseases. Recurrent topics in Tip W. Loo's work include Drug Transport and Resistance Mechanisms (88 papers), HIV/AIDS drug development and treatment (46 papers) and Pharmacological Effects and Toxicity Studies (34 papers). Tip W. Loo is often cited by papers focused on Drug Transport and Resistance Mechanisms (88 papers), HIV/AIDS drug development and treatment (46 papers) and Pharmacological Effects and Toxicity Studies (34 papers). Tip W. Loo collaborates with scholars based in Canada, United States and Hungary. Tip W. Loo's co-authors include David M. Clarke, M. Claire Bartlett, David H. MacLennan, Giuseppe Inesi, Ying Wang, Shirley Gillam, John R. Riordan, Fabian S. Seibert, Philip D. Bragg and Kei Maruyama and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and Nucleic Acids Research.

In The Last Decade

Tip W. Loo

131 papers receiving 8.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Location of high affinity Ca2 +-binding sites within the predicted transmembrahe domain of the sarco-plasmic reticulum Ca2+-ATPase

1989 496 citations David M. Clarke, Tip W. Loo et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Tip W. Loo Canada	59	4.9k	4.3k	1.8k	1.6k	1.3k	131	8.7k
I Pastan United States	29	8.4k 1.7×	4.7k 1.1×	1.5k 0.8×	2.6k 1.6×	359 0.3×	48	10.8k
Frances J. Sharom Canada	50	5.2k 1.1×	4.5k 1.0×	1.1k 0.6×	1.5k 0.9×	197 0.1×	140	8.7k
Norbert Kartner Canada	33	3.2k 0.7×	4.0k 0.9×	482 0.3×	574 0.3×	2.9k 2.2×	49	7.7k
Ina L. Urbatsch United States	34	4.1k 0.8×	2.8k 0.7×	1.3k 0.7×	994 0.6×	299 0.2×	84	6.1k
Ahmad R. Safa United States	43	3.8k 0.8×	3.8k 0.9×	577 0.3×	720 0.4×	244 0.2×	130	6.1k
Christine A. Hrycyna United States	37	3.7k 0.8×	3.4k 0.8×	1.0k 0.6×	1.3k 0.8×	113 0.1×	82	6.5k
Ursula A. Germann United States	31	2.9k 0.6×	2.4k 0.5×	791 0.4×	935 0.6×	132 0.1×	49	4.8k
Hermann Lage Germany	45	3.1k 0.6×	4.2k 1.0×	341 0.2×	372 0.2×	346 0.3×	173	6.7k
William T. Beck United States	50	4.2k 0.9×	5.3k 1.2×	542 0.3×	605 0.4×	193 0.1×	131	7.4k
Mikihiko Naito Japan	54	3.5k 0.7×	6.6k 1.5×	241 0.1×	660 0.4×	256 0.2×	224	9.7k

Countries citing papers authored by Tip W. Loo

Since Specialization

Citations

This map shows the geographic impact of Tip W. Loo's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tip W. Loo with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tip W. Loo more than expected).

Fields of papers citing papers by Tip W. Loo

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tip W. Loo. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tip W. Loo. The network helps show where Tip W. Loo may publish in the future.

Co-authorship network of co-authors of Tip W. Loo

This figure shows the co-authorship network connecting the top 25 collaborators of Tip W. Loo. A scholar is included among the top collaborators of Tip W. Loo based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Tip W. Loo. Tip W. Loo is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Loo, Tip W. & David M. Clarke. (2014). Cysteines Introduced into Extracellular Loops 1 and 4 of Human P-Glycoprotein That Are Close Only in the Open Conformation Spontaneously Form a Disulfide Bond That Inhibits Drug Efflux and ATPase Activity. Journal of Biological Chemistry. 289(36). 24749–24758. 13 indexed citations

Loo, Tip W. & David M. Clarke. (2014). The cystic fibrosis V232D mutation inhibits CFTR maturation by disrupting a hydrophobic pocket rather than formation of aberrant interhelical hydrogen bonds. Biochemical Pharmacology. 88(1). 46–57. 9 indexed citations

Loo, Tip W., M. Claire Bartlett, & David M. Clarke. (2008). Arginines in the First Transmembrane Segment Promote Maturation of a P-glycoprotein Processing Mutant by Hydrogen Bond Interactions with Tyrosines in Transmembrane Segment 11. Journal of Biological Chemistry. 283(36). 24860–24870. 26 indexed citations

Loo, Tip W., M. Claire Bartlett, & David M. Clarke. (2008). Processing Mutations Disrupt Interactions between the Nucleotide Binding and Transmembrane Domains of P-glycoprotein and the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). Journal of Biological Chemistry. 283(42). 28190–28197. 67 indexed citations

Wang, Ying, Tip W. Loo, M. Claire Bartlett, & David M. Clarke. (2007). Correctors Promote Maturation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-processing Mutants by Binding to the Protein. Journal of Biological Chemistry. 282(46). 33247–33251. 117 indexed citations

Wang, Ying, M. Claire Bartlett, Tip W. Loo, & David M. Clarke. (2006). Specific Rescue of Cystic Fibrosis Transmembrane Conductance Regulator Processing Mutants Using Pharmacological Chaperones. Molecular Pharmacology. 70(1). 297–302. 82 indexed citations

Loo, Tip W. & David M. Clarke. (2005). Recent Progress in Understanding the Mechanism of P-Glycoprotein-mediated Drug Efflux. The Journal of Membrane Biology. 206(3). 173–185. 167 indexed citations

Loo, Tip W., M. Claire Bartlett, & David M. Clarke. (2004). Thapsigargin or curcumin does not promote maturation of processing mutants of the ABC transporters, CFTR, and P-glycoprotein. Biochemical and Biophysical Research Communications. 325(2). 580–585. 49 indexed citations

Loo, Tip W., M. Claire Bartlett, & David M. Clarke. (2002). Introduction of the Most Common Cystic Fibrosis Mutation (ΔF508) into Human P-glycoprotein Disrupts Packing of the Transmembrane Segments. Journal of Biological Chemistry. 277(31). 27585–27588. 34 indexed citations

10.

Loo, Tip W. & David M. Clarke. (2000). Drug-stimulated ATPase Activity of Human P-glycoprotein Is Blocked by Disulfide Cross-linking between the Nucleotide-binding Sites. Journal of Biological Chemistry. 275(26). 19435–19438. 48 indexed citations

11.

Loo, Tip W. & David M. Clarke. (1999). Identification of Residues in the Drug-binding Domain of Human P-glycoprotein. Journal of Biological Chemistry. 274(50). 35388–35392. 98 indexed citations

12.

Loo, Tip W. & David M. Clarke. (1998). [35] Mutational analysis of human P-glycoprotein. Methods in enzymology on CD-ROM/Methods in enzymology. 292. 480–492. 17 indexed citations

13.

Loo, Tip W. & David M. Clarke. (1998). Superfolding of the Partially Unfolded Core-glycosylated Intermediate of Human P-glycoprotein into the Mature Enzyme Is Promoted by Substrate-induced Transmembrane Domain Interactions. Journal of Biological Chemistry. 273(24). 14671–14674. 82 indexed citations

14.

Loo, Tip W. & David M. Clarke. (1997). Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators. Journal of Biological Chemistry. 272(2). 709–712. 202 indexed citations

15.

Loo, Tip W. & David M. Clarke. (1997). Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12. Journal of Biological Chemistry. 272(34). 20986–20989. 96 indexed citations

16.

Seibert, Fabian S., Paul Linsdell, Tip W. Loo, et al.. (1996). Disease-associated Mutations in the Fourth Cytoplasmic Loop of Cystic Fibrosis Transmembrane Conductance Regulator Compromise Biosynthetic Processing and Chloride Channel Activity. Journal of Biological Chemistry. 271(25). 15139–15145. 105 indexed citations

17.

Loo, Tip W. & David M. Clarke. (1996). The Minimum Functional Unit of Human P-glycoprotein Appears to be a Monomer. Journal of Biological Chemistry. 271(44). 27488–27492. 52 indexed citations

18.

Loo, Tip W. & David M. Clarke. (1995). P-glycoprotein. Journal of Biological Chemistry. 270(37). 21839–21844. 113 indexed citations

19.

Loo, Tip W. & David M. Clarke. (1994). Mutations to Amino Acids Located in Predicted Transmembrane Segment 6 (TM6) Modulate the Activity and Substrate Specificity of Human P-glycoprotein. Biochemistry. 33(47). 14049–14057. 111 indexed citations

20.

Skerjanc, Ilona S., David M. Clarke, Tip W. Loo, & David H. MacLennan. (1993). Deletion of NH₂⁻ and COOH‐terminal sequences destroys function of the Ca²⁺ ATPase of rabbit fast‐twitch skeletal muscle sarcoplasmic reticulum. FEBS Letters. 336(1). 168–170. 15 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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