David E. Nichols

3.2k total citations · 1 hit paper
50 papers, 2.5k citations indexed

About

David E. Nichols is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Organic Chemistry. According to data from OpenAlex, David E. Nichols has authored 50 papers receiving a total of 2.5k indexed citations (citations by other indexed papers that have themselves been cited), including 40 papers in Molecular Biology, 30 papers in Cellular and Molecular Neuroscience and 9 papers in Organic Chemistry. Recurrent topics in David E. Nichols's work include Receptor Mechanisms and Signaling (33 papers), Neurotransmitter Receptor Influence on Behavior (25 papers) and Neuroscience and Neuropharmacology Research (11 papers). David E. Nichols is often cited by papers focused on Receptor Mechanisms and Signaling (33 papers), Neurotransmitter Receptor Influence on Behavior (25 papers) and Neuroscience and Neuropharmacology Research (11 papers). David E. Nichols collaborates with scholars based in United States, Italy and China. David E. Nichols's co-authors include Richard B. Mailman, Val J. Watts, Bryan L. Roth, Jonathan D. Urban, Harel Weinstein, Jonathan A. Javitch, Patrick M. Sexton, Keith J. Miller, Arthur Christopoulos and Brian K. Kobilka and has published in prestigious journals such as Journal of Biological Chemistry, Nature Communications and Brain Research.

In The Last Decade

David E. Nichols

48 papers receiving 2.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

2006 883 citations Jonathan D. Urban, William P. Clarke et al. Journal of Pharmacology and Experimental Therapeutics profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
David E. Nichols United States	20	1.7k	1.6k	341	294	157	50	2.5k
Milt Teitler United States	32	1.6k 1.0×	1.6k 1.0×	550 1.6×	398 1.4×	251 1.6×	73	2.8k
Katharine Herrick‐Davis United States	28	1.4k 0.9×	1.7k 1.0×	208 0.6×	159 0.5×	140 0.9×	49	2.4k
Ian T. Forbes United Kingdom	26	1.3k 0.8×	1.3k 0.8×	663 1.9×	98 0.3×	195 1.2×	59	2.6k
Stephen M. Husbands United Kingdom	33	2.5k 1.5×	2.7k 1.7×	419 1.2×	75 0.3×	296 1.9×	157	4.0k
Raymond G. Booth United States	23	784 0.5×	810 0.5×	211 0.6×	159 0.5×	102 0.6×	70	1.4k
Steven M. Bromidge United Kingdom	20	1.5k 0.9×	1.2k 0.7×	516 1.5×	99 0.3×	274 1.7×	41	2.3k
Douglas J. Sheffler United States	28	1.6k 1.0×	2.3k 1.4×	286 0.8×	105 0.4×	311 2.0×	63	3.6k
Ethan S. Burstein United States	32	1.3k 0.8×	1.9k 1.2×	135 0.4×	68 0.2×	258 1.6×	91	3.1k
Enza Lacivita Italy	33	1.3k 0.8×	1.6k 1.0×	401 1.2×	78 0.3×	230 1.5×	116	2.8k
Barbara Costa Italy	31	565 0.3×	1.2k 0.8×	586 1.7×	148 0.5×	100 0.6×	111	2.7k

Countries citing papers authored by David E. Nichols

Since Specialization

Citations

This map shows the geographic impact of David E. Nichols's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David E. Nichols with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David E. Nichols more than expected).

Fields of papers citing papers by David E. Nichols

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David E. Nichols. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David E. Nichols. The network helps show where David E. Nichols may publish in the future.

Co-authorship network of co-authors of David E. Nichols

This figure shows the co-authorship network connecting the top 25 collaborators of David E. Nichols. A scholar is included among the top collaborators of David E. Nichols based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David E. Nichols. David E. Nichols is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Cummins, Benjamin, et al.. (2025). 5-HT2A receptors: Pharmacology and functional selectivity. Pharmacological Reviews. 77(4). 100059–100059. 2 indexed citations

Nguyen, Anh Minh, et al.. (2025). Characterization of Gαs and Gαolf activation by catechol and non-catechol dopamine D1 receptor agonists. iScience. 28(5). 112345–112345. 1 indexed citations

McCorvy, John D., et al.. (2012). Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D3 receptor-selective full agonist ligand. Bioorganic & Medicinal Chemistry. 20(21). 6366–6374. 7 indexed citations

McCorvy, John D., et al.. (2011). Assessment of dopamine D1 receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393. Bioorganic & Medicinal Chemistry. 19(18). 5420–5431. 7 indexed citations

Nichols, David E., et al.. (2010). Structural Analysis of the Extracellular Entrance to the Serotonin Transporter Permeation Pathway. Journal of Biological Chemistry. 285(20). 15369–15379. 10 indexed citations

Chemel, Benjamin R., et al.. (2010). Facile synthesis of octahydrobenzo[h]isoquinolines: Novel and highly potent D1 dopamine agonists. Bioorganic & Medicinal Chemistry. 18(18). 6763–6770. 8 indexed citations

Walline, Crystal C., David E. Nichols, F. Ivy Carroll, & Eric L. Barker. (2008). Comparative Molecular Field Analysis Using Selectivity Fields Reveals Residues in the Third Transmembrane Helix of the Serotonin Transporter Associated with Substrate and Antagonist Recognition. Journal of Pharmacology and Experimental Therapeutics. 325(3). 791–800. 19 indexed citations

Rodríguez, Gustavo, et al.. (2008). Helix XI contributes to the entrance of the serotonin transporter permeation pathway. Protein Science. 17(10). 1761–1770. 3 indexed citations

Urban, Jonathan D., William P. Clarke, Mark von Zastrow, et al.. (2006). Functional Selectivity and Classical Concepts of Quantitative Pharmacology. Journal of Pharmacology and Experimental Therapeutics. 320(1). 1–13. 883 indexed citations breakdown →

10.

Chemel, Benjamin R., Bryan L. Roth, Blaine N. Armbruster, Val J. Watts, & David E. Nichols. (2006). WAY-100635 is a potent dopamine D4 receptor agonist. Psychopharmacology. 188(2). 244–251. 128 indexed citations

11.

Ryman-Rasmussen, Jessica P., David E. Nichols, & Richard B. Mailman. (2005). Differential Activation of Adenylate Cyclase and Receptor Internalization by Novel Dopamine D1 Receptor Agonists. Molecular Pharmacology. 68(4). 1039–1048. 55 indexed citations

12.

Rodríguez, Gustavo, David L. Roman, Kate White, David E. Nichols, & E L Barker. (2003). Distinct Recognition of Substrates by the Human and Drosophila Serotonin Transporters. Journal of Pharmacology and Experimental Therapeutics. 306(1). 338–346. 17 indexed citations

13.

Kurrasch‐Orbaugh, Deborah, Val J. Watts, Eric L. Barker, & David E. Nichols. (2003). Serotonin 5-Hydroxytryptamine2A Receptor-Coupled Phospholipase C and Phospholipase A2 Signaling Pathways Have Different Receptor Reserves. Journal of Pharmacology and Experimental Therapeutics. 304(1). 229–237. 130 indexed citations

14.

Mottola, David, Jason D. Kilts, Mechelle M. Lewis, et al.. (2002). Functional Selectivity of Dopamine Receptor Agonists. I. Selective Activation of Postsynaptic Dopamine D2 Receptors Linked to Adenylate Cyclase. Journal of Pharmacology and Experimental Therapeutics. 301(3). 1166–1178. 96 indexed citations

15.

Ma, Wenwen, et al.. (1998). Molecular modeling study of tubulosine and other related ipecac alkaloids. Journal of Computer-Aided Molecular Design. 12(5). 411–418. 10 indexed citations

16.

Nichols, David E., et al.. (1997). Locomotor inhibition, yawning and vacuous chewing induced by a novel dopamine D2 post-synaptic receptor agonist. European Journal of Pharmacology. 323(1). 27–36. 18 indexed citations

17.

Cozzi, Nicholas V. & David E. Nichols. (1996). 5-HT2A receptor antagonists inhibit potassium-stimulated γ-aminobutyric acid release in rat frontal cortex. European Journal of Pharmacology. 309(1). 25–31. 35 indexed citations

18.

Lovenberg, Timothy W., David E. Nichols, Eric J. Nestler, Robert H. Roth, & Richard B. Mailman. (1991). Guanine nucleotide binding proteins and the regulation of cyclic AMP synthesis in NS20Y neuroblastoma cells: role of D1 dopamine and muscarinic receptors. Brain Research. 556(1). 101–107. 7 indexed citations

19.

Lovenberg, Timothy W., Robert H. Roth, David E. Nichols, & Richard B. Mailman. (1991). D₁ Dopamine Receptors of NS20Y Neuroblastoma Cells Are Functionally Similar to Rat Striatal D₁ Receptors. Journal of Neurochemistry. 57(5). 1563–1569. 14 indexed citations

20.

Brewster, William K., David E. Nichols, Robert M. Riggs, et al.. (1990). Trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist. Journal of Medicinal Chemistry. 33(6). 1756–1764. 143 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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