David A. Fruman

2.7k citations

13 papers · 2.2k indexed · 1 hit paper · h-index 13

Molecular Biology top 5%
Immunology top 5%
Cell Biology top 5%
Oncology top 10%
Genetics top 5%

Co-authors: Lewis C. Cantley Rachel Meyers Owen N. Witte Anne B. Satterthwaite Lucia E. Rameh Christopher L. Carpenter Amber C. Donahue Roderick T. Bronson
Topics: T-cell and B-cell Immunology (4 papers)PI3K/AKT/mTOR signaling in cancer (3 papers)Protein Kinase Regulation and GTPase Signaling (3 papers)
Cited by: Immunology Cell Biology Genetics
Journals: Cell Proceedings of the National Academy of Sciences Journal of Biological Chemistry
Partner nations: United States Switzerland Japan

In The Last Decade

David A. Fruman

13 papers receiving 2.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

PHOSPHOINOSITIDE KINASES

1998 1.2k citations David A. Fruman, Rachel Meyers et al. Annual Review of Biochemistry profile →

Peers

Countries citing papers authored by David A. Fruman

Since Specialization

Citations

This map shows the geographic impact of David A. Fruman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David A. Fruman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David A. Fruman more than expected).

Fields of papers citing papers by David A. Fruman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David A. Fruman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David A. Fruman. The network helps show where David A. Fruman may publish in the future.

Co-authorship network of co-authors of David A. Fruman

This figure shows the co-authorship network connecting the top 25 collaborators of David A. Fruman. A scholar is included among the top collaborators of David A. Fruman based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David A. Fruman. David A. Fruman is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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13 of 13 papers shown

#	Work	Indexed citations
1	Organ‐specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene‐targeting of the PI3K regulatory isoforms p85α, p55α, and p50α 2009 ·Developmental Dynamics ·(unknown),(unknown),(unknown),Maria Mancini,Tatiana V. Petrova,Lucy Liaw,Igor Prudovsky,Philip E. Thorpe,Naoyuki Miura,Lewis C. Cantley,Kari Alitalo,David A. Fruman,Calvin Vary	48
2	Distinct signaling mechanisms activate the target of rapamycin in response to different B‐cell stimuli 2007 ·European Journal of Immunology ·Amber C. Donahue,David A. Fruman	62
3	Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase 2006 ·Proceedings of the National Academy of Sciences ·Jean Oak,Jonathan A. Deane,Michael G. Kharas,Ji Luo,Thomas E. Lane,Lewis C. Cantley,David A. Fruman	54
4	T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling 2006 ·Blood ·Jonathan A. Deane,Michael G. Kharas,Jean Oak,(unknown),Ji Luo,Travis I. Moore,Hong Ji,Christian Rommel,Lewis C. Cantley,Thomas E. Lane,David A. Fruman	50
5	Altered Signaling and Cell Cycle Regulation in Embryonal Stem Cells with a Disruption of the Gene for Phosphoinositide 3-Kinase Regulatory Subunit p85α 2003 ·Journal of Biological Chemistry ·(unknown),K Trümper,Heidi Trusheim,Kohjiro Ueki,C. Ronald Kahn,Lewis C. Cantley,David A. Fruman,Dieter Hörsch	34
6	Phosphatidylinositol 3-Kinase Confers Resistance to Encephalomyocarditis and Herpes Simplex Virus-Induced Cell Death Through the Activation of Distinct Downstream Effectors 2001 ·The Journal of Immunology ·(unknown),(unknown),Oleg V. Kurnasov,Anna Usacheva,Brian A. Hemmings,Lewis C. Cantley,David A. Fruman,Lynda A. Morrison,R. Mark L. Buller,Oscar R. Colamonici	23
7	Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α 2000 ·Nature Genetics ·David A. Fruman,(unknown),Daniel A. Pollard,Claudine M. Yballe,Derek P. Brazil,Roderick T. Bronson,(unknown),Lewis C. Cantley	240
8	Xid-like Phenotypes 2000 ·Immunity ·David A. Fruman,Anne B. Satterthwaite,Owen N. Witte	166
9	Impaired Kit- but Not FcεRI-initiated Mast Cell Activation in the Absence of Phosphoinositide 3-Kinase p85α Gene Products 2000 ·Journal of Biological Chemistry ·Jennifer M. Lu-Kuo,David A. Fruman,(unknown),Lewis C. Cantley,Howard R. Katz	71
10	A Peptide Library Approach Identifies a Specific Inhibitor for the ZAP-70 Protein Tyrosine Kinase 2000 ·Molecular Cell ·Kiyotaka Nishikawa,Sansana Sawasdikosol,David A. Fruman,Jack H. Lai,Zhou Songyang,Steven J. Burakoff,Michael B. Yaffe,Lewis C. Cantley	28
11	Phosphoinositide Binding Domains 1999 ·Cell ·David A. Fruman,Lucia E. Rameh,Lewis C. Cantley	106
12	PHOSPHOINOSITIDE KINASESbreakdown → 1998 ·Annual Review of Biochemistry ·David A. Fruman,Rachel Meyers,Lewis C. Cantley	1199
13	Structural Organization and Alternative Splicing of the Murine Phosphoinositide 3-Kinase p85α Gene 1996 ·Genomics ·David A. Fruman,Lewis C. Cantley,Christopher L. Carpenter	101

About David A. Fruman

David A. Fruman is a scholar working on Immunology, Genetics and Oncology, having authored 13 papers that have together received 2.2k indexed citations. Recurring topics across this work include T-cell and B-cell Immunology (4 papers), PI3K/AKT/mTOR signaling in cancer (3 papers) and Protein Kinase Regulation and GTPase Signaling (3 papers). The work is most often cited by research in Immunology (540 citations), Cell Biology (409 citations) and Genetics (263 citations). David A. Fruman has collaborated with scholars based in United States, Switzerland and Japan. Frequent co-authors include Lewis C. Cantley, Rachel Meyers, Owen N. Witte, Anne B. Satterthwaite, Lucia E. Rameh, Christopher L. Carpenter, Amber C. Donahue, Roderick T. Bronson, Derek P. Brazil and Claudine M. Yballe. Their work appears in journals such as Cell, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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