K. Dane Wittrup

23.0k total citations · 7 hit papers
235 papers, 16.8k citations indexed

About

K. Dane Wittrup is a scholar working on Molecular Biology, Radiology, Nuclear Medicine and Imaging and Immunology. According to data from OpenAlex, K. Dane Wittrup has authored 235 papers receiving a total of 16.8k indexed citations (citations by other indexed papers that have themselves been cited), including 134 papers in Molecular Biology, 123 papers in Radiology, Nuclear Medicine and Imaging and 86 papers in Immunology. Recurrent topics in K. Dane Wittrup's work include Monoclonal and Polyclonal Antibodies Research (122 papers), Immunotherapy and Immune Responses (49 papers) and Glycosylation and Glycoproteins Research (39 papers). K. Dane Wittrup is often cited by papers focused on Monoclonal and Polyclonal Antibodies Research (122 papers), Immunotherapy and Immune Responses (49 papers) and Glycosylation and Glycoproteins Research (39 papers). K. Dane Wittrup collaborates with scholars based in United States, Switzerland and United Kingdom. K. Dane Wittrup's co-authors include Eric T. Boder, Michael M. Schmidt, Greg M. Thurber, Benjamin J. Hackel, Shaun M. Lippow, Eric V. Shusta, S. Annie Gai, Katarina S. Midelfort, Ginger Chao and David M. Kranz and has published in prestigious journals such as Science, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

K. Dane Wittrup

233 papers receiving 16.3k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Yeast surface display for screening combinatorial polypeptide libraries

1997 1.3k citations Eric T. Boder, K. Dane Wittrup profile →
Isolating and engineering human antibodies using yeast surface display

2006 687 citations K. Dane Wittrup et al. profile →
Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity

2000 529 citations Eric T. Boder, K. Dane Wittrup et al. Proceedings of the National Academy of Sciences profile →
Biophysical properties of the clinical-stage antibody landscape

2017 412 citations Tushar Jain, Tingwan Sun et al. Proceedings of the National Academy of Sciences profile →
Monovalent, reduced-size quantum dots for imaging receptors on living cells

2008 335 citations Michael M. Schmidt, K. Dane Wittrup et al. profile →
Enhanced CAR–T cell activity against solid tumors by vaccine boosting through the chimeric receptor

2019 319 citations Leyuan Ma, Tanmay Dichwalkar et al. Science profile →
Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity

2021 233 citations Emi A. Lutz, K. Dane Wittrup et al. profile →

Peers

Countries citing papers authored by K. Dane Wittrup

Since Specialization

Citations

This map shows the geographic impact of K. Dane Wittrup's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by K. Dane Wittrup with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites K. Dane Wittrup more than expected).

Fields of papers citing papers by K. Dane Wittrup

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by K. Dane Wittrup. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by K. Dane Wittrup. The network helps show where K. Dane Wittrup may publish in the future.

Co-authorship network of co-authors of K. Dane Wittrup

This figure shows the co-authorship network connecting the top 25 collaborators of K. Dane Wittrup. A scholar is included among the top collaborators of K. Dane Wittrup based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with K. Dane Wittrup. K. Dane Wittrup is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	CLN-617 Retains IL2 and IL12 in Injected Tumors to Drive Robust and Systemic Immune-Mediated Antitumor Activity 2024 ·Cancer Immunology Research ·Naveen K. Mehta, Kavya Rakhra, Kristan Meetze, (unknown), Noor Momin, Jason Y.H. Chang, K. Dane Wittrup, Patrick A. Baeuerle, Jennifer S. Michaelson	6
2	Tumor-Localized Interleukin-2 and Interleukin-12 Combine with Radiation Therapy to Safely Potentiate Regression of Advanced Malignant Melanoma in Pet Dogs 2024 ·Clinical Cancer Research ·Jordan A. Stinson, (unknown), (unknown), Noor Momin, (unknown), (unknown), Kim A. Selting, (unknown), Keith Bailey, K. Dane Wittrup, Timothy M. Fan	3
3	Tumor Integrin-Targeted Glucose Oxidase Enzyme Promotes ROS-Mediated Cell Death that Combines with Interferon Alpha Therapy for Tumor Control 2024 ·Molecular Cancer Therapeutics ·Jordan A. Stinson, (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), Joseph R. Palmeri, K. Dane Wittrup	2
4	Targeting of the CD161 inhibitory receptor enhances T-cell–mediated immunity against hematological malignancies 2023 ·Blood ·Francesca Alvarez‐Calderon, Byong H. Kang, Oleksandr Kyrysyuk, Shiwei Zheng, Hao Wang, Nathan D. Mathewson, Adrienne Luoma, Xiaohan Ning, Jason W. Pyrdol, Xuan Cao, Mario L. Suvà, Guo‐Cheng Yuan, K. Dane Wittrup, Kai W. Wucherpfennig	12
5	Therapy of Myeloid Leukemia using Novel Bispecific Fusion Proteins Targeting CD45 and 90Y-DOTA 2020 ·Molecular Cancer Therapeutics ·Johnnie J. Orozco, Aimee L. Kenoyer, Yukang Lin, Shyril O’Steen, (unknown), (unknown), (unknown), Mark D. Hylarides, Darrell R. Fisher, (unknown), Donald K. Hamlin, D. Scott Wilbur, Kelly Davis Orcutt, K. Dane Wittrup, Damian J. Green, Ajay K. Gopal, Brian G. Till, Brenda M. Sandmaier, Oliver W. Press, John M. Pagel	8
6	Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy 2019 ·Science Translational Medicine ·Noor Momin, Naveen K. Mehta, Nitasha R. Bennett, Leyuan Ma, Joseph R. Palmeri, (unknown), Emi A. Lutz, Byong H. Kang, Darrell J. Irvine, Stefani Spranger, K. Dane Wittrup	158
7	Enhanced CAR–T cell activity against solid tumors by vaccine boosting through the chimeric receptor breakdown → 2019 ·Science ·Leyuan Ma, Tanmay Dichwalkar, Jason Y.H. Chang, Benjamin Cossette, Daniel Garafola, Angela Q. Zhang, Michael Fichter, Chensu Wang, Simon Liang, Murillo Silva, Sudha Kumari, Naveen K. Mehta, Wuhbet Abraham, Nikki Thai, Na Li, K. Dane Wittrup, Darrell J. Irvine	319
8	A Raf-Competitive K-Ras Binder Can Fail to Functionally Antagonize Signaling 2018 ·Molecular Cancer Therapeutics ·Monique J. Kauke, (unknown), Ryan L. Kelly, Christian Braun, Michael T. Hemann, K. Dane Wittrup	7
9	Biophysical properties of the clinical-stage antibody landscape breakdown → 2017 ·Proceedings of the National Academy of Sciences ·Tushar Jain, Tingwan Sun, Stéphanie Durand, Amy Hall, (unknown), Juergen H. Nett, Beth Sharkey, (unknown), Isabelle Caffry, Yao Yu, Yuan Cao, Heather Lynaugh, Michael E. Brown, Hemanta Baruah, Laura Gray, Eric Krauland, Yingda Xu, Maximiliano Vásquez, K. Dane Wittrup	412
10	An engineered protein antagonist of K-Ras/B-Raf interaction 2017 ·Scientific Reports ·Monique J. Kauke, Michael W. Traxlmayr, Jillian A. Parker, (unknown), (unknown), (unknown), (unknown), Carla Mattos, K. Dane Wittrup	52
11	Comparative Analysis of Bispecific Antibody and Streptavidin-Targeted Radioimmunotherapy for B-cell Cancers 2016 ·Cancer Research ·Damian J. Green, Shani L. Frayo, Yukang Lin, Donald K. Hamlin, Darrell R. Fisher, Sofia H.L. Frost, Aimee L. Kenoyer, Mark D. Hylarides, Ajay K. Gopal, Theodore A. Gooley, Johnnie J. Orozco, Brian G. Till, Shyril O’Steen, Kelly Davis Orcutt, D. Scott Wilbur, K. Dane Wittrup, Oliver W. Press	22
12	Targeted Cytolysins Synergistically Potentiate Cytoplasmic Delivery of Gelonin Immunotoxin 2013 ·Molecular Cancer Therapeutics ·(unknown), (unknown), K. Dane Wittrup	26
13	Localized Immunotherapy via Liposome-Anchored Anti-CD137 + IL-2 Prevents Lethal Toxicity and Elicits Local and Systemic Antitumor Immunity 2013 ·Cancer Research ·Brandon Kwong, S. Annie Gai, Jamal Elkhader, K. Dane Wittrup, Darrell J. Irvine	168
14	Localized Immunotherapy via Liposome-Anchored Anti-CD137 + IL-2 Prevents Lethal Toxicity and Elicits Local and Systemic Antitumor Immunity 2013 ·DSpace@MIT (Massachusetts Institute of Technology) ·Brandon Kwong, S. Annie Gai, Jamal Elkhader, K. Dane Wittrup, Darrell J. Irvine	52
15	Effect of Small-Molecule–Binding Affinity on Tumor Uptake In Vivo : A Systematic Study Using a Pretargeted Bispecific Antibody 2012 ·Molecular Cancer Therapeutics ·Kelly Davis Orcutt, John J. Rhoden, (unknown), John V. Frangioni, K. Dane Wittrup	37
16	A series of anti-CEA/anti-DOTA bispecific antibody formats evaluated for pre-targeting: comparison of tumor uptake and blood clearance 2012 ·Protein Engineering Design and Selection ·Paul J. Yazaki, (unknown), Divya Channappa, Chi Wai Cheung, Desiree Crow, Junie Chea, Erasmus Poku, (unknown), Jan Terje Andersen, Inger Sandlie, Kelly Davis Orcutt, K. Dane Wittrup, John E. Shively, Andrew Raubitschek, David Colcher	29
17	A modeling analysis of the effects of molecular size and binding affinity on tumor targeting 2009 ·Molecular Cancer Therapeutics ·Michael M. Schmidt, K. Dane Wittrup	454
18	Quantitative Spatiotemporal Analysis of Antibody Fragment Diffusion and Endocytic Consumption in Tumor Spheroids 2008 ·Cancer Research ·Greg M. Thurber, K. Dane Wittrup	83
19	Rapid tolerization of virus-activated tumor-specific CD8 ⁺ T cells in prostate tumors of TRAMP mice 2008 ·Proceedings of the National Academy of Sciences ·Ailin Bai, (unknown), Herman N. Eisen, K. Dane Wittrup, Jianzhu Chen	56
20	A yeast surface display system for the discovery of ligands that trigger cell activation 1998 ·Journal of Immunological Methods ·Bryan K. Cho, Michele C. Kieke, Eric T. Boder, K. Dane Wittrup, David M. Kranz	22

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact