Darell D. Bigner

150.0k citations

623 papers · 48.1k indexed · 12 hit papers · h-index 103

Impact in

Genetics top 0.01%
- Glioma Diagnosis and Treatment
Cancer Research top 0.02%
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation

Papers in

Genetics 201
- Glioma Diagnosis and Treatment 200
- Virus-based gene therapy research 53
Radiology, Nuclear Medicine and Imaging 160
- Monoclonal and Polyclonal Antibodies Research 96
- Radiopharmaceutical Chemistry and Applications 76

Co-authors: Roger E. McLendon Henry S. Friedman Jeremy N. Rich Allan H. Friedman Carol J. Wikstrand John H. Sampson James E. Herndon David A. Reardon
Journals: Journal of Clinical Oncology (39 papers)Journal of Neuropathology & Experimental Neurology (37 papers)Neuro-Oncology (34 papers)Cancer Chemotherapy and Pharmacology (23 papers)Cancer Research (20 papers)
Partner nations: United States Sweden Canada

In The Last Decade

Darell D. Bigner

606 papers receiving 46.9k citations

Hit Papers

12 papers align trajectories log scale

Recurrent Glioblastoma Treated with Recombinant Poliovirus 2018 · 582 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2018 New England Journal of Medicine
2015 Nature
2012 Nature Medicine
2010 Journal of Clinical Oncology
2009 New England Journal of Medicine
2007 Journal of Clinical Oncology
2007 Clinical Cancer Research
2006 Cancer Research
2006 Nature
2003 Journal of Clinical Oncology
1987 Science
1987 Proceedings of the National Academy of Sciences

Peers

Countries citing papers authored by Darell D. Bigner

Since Specialization

Citations

This map shows the geographic impact of Darell D. Bigner's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Darell D. Bigner with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Darell D. Bigner more than expected).

Fields of papers citing papers by Darell D. Bigner

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Darell D. Bigner. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Darell D. Bigner. The network helps show where Darell D. Bigner may publish in the future.

Co-authors

The 25 scholars most cited alongside Darell D. Bigner, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Darell D. Bigner Line = papers co-authored together Darell D. Bigner links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities Cancer Research ·Matthew S. Waitkus, Christopher J. Pirozzi, Casey J. Moure, Bill H. Diplas, Landon J. Hansen, Austin B. Carpenter, Rui Yang, Zhaohui Wang, Brian O. Ingram, Edward D. Karoly, Robert P. Mohney, Ivan Spasojević, Roger E. McLendon, Henry S. Friedman, Yiping He, Darell D. Bigner, Hai Yan	2017	33
2	Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination Clinical Cancer Research ·Kristen A. Batich, Elizabeth A. Reap, Gary E. Archer, Luis Sánchez-Pérez, Smita K. Nair, Robert J. Schmittling, Pam Norberg, Weihua Xie, James E. Herndon, Patrick Healy, Roger E. McLendon, Allan H. Friedman, Henry S. Friedman, Darell D. Bigner, Gordana Vlahovic, Duane A. Mitchell, John H. Sampson	2017	242
3	Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation Cancer Research ·Rui Yang, Lee H. Chen, Landon J. Hansen, Austin B. Carpenter, Casey J. Moure, Heng Liu, Christopher J. Pirozzi, Bill H. Diplas, Matthew S. Waitkus, Paula K. Greer, Huishan Zhu, Roger E. McLendon, Darell D. Bigner, Yiping He, Hai Yan	2017	33
4	CAR T Cells Targeting Podoplanin Reduce Orthotopic Glioblastomas in Mouse Brains Cancer Immunology Research ·Satoshi Shiina, Masasuke Ohno, Fumiharu Ohka, Shunichiro Kuramitsu, Akane Yamamichi, Akira Kato, Kazuya Motomura, Kuniaki Tanahashi, Takashi Yamamoto, Reiko Watanabe, Ichiro Ito, Takeshi Senga, Michinari Hamaguchi, Toshihiko Wakabayashi, Mika K. Kaneko, Yukinari Kato, Vidyalakshmi Chandramohan, Darell D. Bigner, Atsushi Natsume	2016	80
5	Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy Clinical Cancer Research ·Vidyalakshmi Chandramohan, Xuhui Bao, Stephen T. Keir, Charles N. Pegram, Scott E. Szafranski, Hailan Piao, Carol J. Wikstrand, Roger E. McLendon, Chien‐Tsun Kuan, Ira Pastan, Darell D. Bigner	2013	58
6	Deletion or Epigenetic Silencing of AJAP1 on 1p36 in Glioblastoma Molecular Cancer Research ·Ningjing Lin, Chunhui Di, Kathy Bortoff, Jinrong Fu, Peter Truszkowski, Patrick Killela, Christopher G. Duncan, Roger E. McLendon, Darell D. Bigner, Simon G. Gregory, David Cory Adamson	2012	33
7	The Addition of Bevacizumab to Standard Radiation Therapy and Temozolomide Followed by Bevacizumab, Temozolomide, and Irinotecan for Newly Diagnosed Glioblastoma Clinical Cancer Research ·James J. Vredenburgh, Annick Desjardins, David A. Reardon, Katherine B. Peters, James E. Herndon, Jennifer Marcello, John P. Kirkpatrick, John H. Sampson, Leighann Bailey, Stevie Threatt, Allan H. Friedman, Darell D. Bigner, Henry S. Friedman	2011	112
8	Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma Science ·Chetan Bettegowda, Nishant Agrawal, Yuchen Jiao, Mark Sausen, Laura D. Wood, Ralph H. Hruban, Fausto J. Rodríguez, Daniel P. Cahill, Roger E. McLendon, Gregory J. Riggins, Victor E. Velculescu, Sueli Mieko Oba‐Shinjo, Suely Kazue Nagahashi Marie, Bert Vogelstein, Darell D. Bigner, Hai Yan, Nickolas Papadopoulos, Kenneth W. Kinzler	2011	370
9	Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma Journal of Clinical Oncology ·John H. Sampson, Amy B. Heimberger, Gary E. Archer, Kenneth Aldape, Allan H. Friedman, Henry S. Friedman, Mark R. Gilbert, James E. Herndon, Roger E. McLendon, Duane A. Mitchell, David A. Reardon, Raymond Sawaya, Robert J. Schmittling, Weiming Shi, James J. Vredenburgh, Darell D. Bigner Hit paper breakdown →	2010	613
10	Sample Type Bias in the Analysis of Cancer Genomes Cancer Research ·David A. Solomon, Jung-Sik Kim, Habtom W. Ressom, Zita A. Sibenaller, Timothy C. Ryken, Walter C. Jean, Darell D. Bigner, Hai Yan, Todd Waldman	2009	26
11	Glioblastoma Proto-oncogene SEC61γ Is Required for Tumor Cell Survival and Response to Endoplasmic Reticulum Stress Cancer Research ·Zheming Lu, Lei Zhou, Patrick Killela, Ahmed B. Rasheed, Chunhui Di, William E. Poe, Roger E. McLendon, Darell D. Bigner, Christopher V. Nicchitta, Hai Yan	2009	53
12	OTX2 Is Critical for the Maintenance and Progression of Shh-Independent Medulloblastomas Cancer Research ·David Cory Adamson, Qun Shi, Matthew Wortham, Paul A. Northcott, Chunhui Di, Christopher G. Duncan, Jianjun Li, Roger E. McLendon, Darell D. Bigner, Michael D. Taylor, Hai Yan	2009	80
13	Development of a Real-time RT-PCR Assay for Detecting EGFRvIII in Glioblastoma Samples Clinical Cancer Research ·Koji Yoshimoto, Julie Dang, Shaojun Zhu, David A. Nathanson, Tiffany Huang, Rebecca A. Dumont, David B. Seligson, William H. Yong, Zhenggang Xiong, Nagesh Rao, Henrik Winther, Arnab Chakravarti, Darell D. Bigner, Ingo K. Mellinghoff, Steve Horvath, Webster K. Cavenee, Timothy F. Cloughesy, Paul S. Mischel	2008	81
14	Bevacizumab Plus Irinotecan in Recurrent WHO Grade 3 Malignant Gliomas Clinical Cancer Research ·Annick Desjardins, David A. Reardon, James E. Herndon, Jennifer Marcello, Jennifer A. Quinn, Jeremy N. Rich, Sith Sathornsumetee, Sridharan Gururangan, John H. Sampson, Leighann Bailey, Darell D. Bigner, Allan H. Friedman, Henry S. Friedman, James J. Vredenburgh	2008	130
15	Identification of p18INK4c as a Tumor Suppressor Gene in Glioblastoma Multiforme Cancer Research ·David A. Solomon, Jung-Sik Kim, Sultan Jenkins, Habtom W. Ressom, Michael C. Huang, Nicholas D. Coppa, Lauren Mabanta, Darell D. Bigner, Hai Yan, Walter C. Jean, Todd Waldman	2008	38
16	Mutational Inactivation of PTPRD in Glioblastoma Multiforme and Malignant Melanoma Cancer Research ·David A. Solomon, Jung-Sik Kim, Julia C. Cronin, Zita A. Sibenaller, Timothy C. Ryken, Steven A. Rosenberg, Habtom W. Ressom, Walter C. Jean, Darell D. Bigner, Hai Yan, Yardena Samuels, Todd Waldman	2008	102
17	Systemic CTLA-4 Blockade Ameliorates Glioma-Induced Changes to the CD4+ T Cell Compartment without Affecting Regulatory T-Cell Function Clinical Cancer Research ·Peter E. Fecci, Hidenobu Ochiai, Duane A. Mitchell, Peter M. Grossi, Alison E. Sweeney, Gary E. Archer, Thomas J. Cummings, James P. Allison, Darell D. Bigner, John H. Sampson	2007	265
18	Stem Cell–like Glioma Cells Promote Tumor Angiogenesis through Vascular Endothelial Growth Factor Cancer Research ·Shideng Bao, Qiulian Wu, Sith Sathornsumetee, Yueling Hao, Zhizhong Li, Anita B. Hjelmeland, Qing Shi, Roger E. McLendon, Darell D. Bigner, Jeremy N. Rich Hit paper breakdown →	2006	1022
19	Loss of Phosphatase and Tensin Homologue Increases Transforming Growth Factor β–Mediated Invasion with Enhanced SMAD3 Transcriptional Activity Cancer Research ·Anita B. Hjelmeland, Mark D. Hjelmeland, Qing Shi, Janet L. Hart, Darell D. Bigner, Xiao-Fan Wang, Christopher D. Kontos, Jeremy N. Rich	2005	33
20	Gene Expression Profiling and Genetic Markers in Glioblastoma Survival Cancer Research ·Jeremy N. Rich, Christopher Hans, Beatrix Jones, Edwin S. Iversen, Roger E. McLendon, Binish Rasheed, Adrian Dobra, Holly K. Dressman, Darell D. Bigner, Joseph R. Nevins, Mike West	2005	257

About Darell D. Bigner

Darell D. Bigner is a scholar working on Genetics, Radiology, Nuclear Medicine and Imaging, Immunology, Oncology and Cancer Research, having authored 623 papers that have together received 48.1k indexed citations. Recurring topics across this work include Glioma Diagnosis and Treatment (200 papers), Monoclonal and Polyclonal Antibodies Research (96 papers), Radiopharmaceutical Chemistry and Applications (76 papers), Immunotherapy and Immune Responses (72 papers), Neuroblastoma Research and Treatments (66 papers), Virus-based gene therapy research (53 papers), CAR-T cell therapy research (46 papers) and Cancer Research and Treatments (38 papers). The work is most often cited by research in Genetics (18.5k citations), Cancer Research (10.4k citations), Oncology (15.6k citations), Immunology (8.3k citations) and Molecular Biology (22.1k citations). Darell D. Bigner has collaborated with scholars based in United States, Sweden and Canada. Frequent co-authors include Roger E. McLendon, Henry S. Friedman, Jeremy N. Rich, Allan H. Friedman, Carol J. Wikstrand, John H. Sampson, James E. Herndon, David A. Reardon, Sandra H. Bigner and Anita B. Hjelmeland. Their work appears in journals such as Journal of Clinical Oncology, Journal of Neuropathology & Experimental Neurology, Neuro-Oncology, Cancer Chemotherapy and Pharmacology and Cancer Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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