T. Jake Liang

20.7k citations

195 papers · 13.2k indexed · 2 hit papers · h-index 68

Impact in

Hepatology top 0.02%
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease and Transplantation
Epidemiology top 0.05%
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment

Papers in

Hepatology 155
- Hepatitis C virus research 146
- Hepatitis Viruses Studies and Epidemiology 11
Epidemiology 138
- Hepatitis B Virus Studies 126
- Liver Disease Diagnosis and Treatment 69

Co-authors: Jay H. Hoofnagle Barbara Rehermann Rohit Loomba Marc G. Ghany Theo Heller Jack R. Wands Edward Doo Leonard B. Seeff
Journals: Gastroenterology (25 papers)Journal of Virology (22 papers)Hepatology (15 papers)Alimentary Pharmacology & Therapeutics (10 papers)Journal of Clinical Investigation (8 papers)
Partner nations: United States Japan United Kingdom

In The Last Decade

T. Jake Liang

190 papers receiving 12.9k citations

Hit Papers

align trajectories log scale

Hepatitis B Reactivation Associated With Immune Suppressive and Biological Modifier Therapies: Current Concepts, Management Strategies, and Future Directions 2017 · 416 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2017 Gastroenterology
2000 Annals of Internal Medicine

Peers

Countries citing papers authored by T. Jake Liang

Since Specialization

Citations

This map shows the geographic impact of T. Jake Liang's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by T. Jake Liang with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites T. Jake Liang more than expected).

Fields of papers citing papers by T. Jake Liang

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by T. Jake Liang. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by T. Jake Liang. The network helps show where T. Jake Liang may publish in the future.

Co-authors

The 25 scholars most cited alongside T. Jake Liang, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with T. Jake Liang Line = papers co-authored together T. Jake Liang links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Macrocyclic dihydropyridine analogs as pan-BET BD2-preferred inhibitors European Journal of Medicinal Chemistry ·Jiewei Jiang, T. Jake Liang, Jonathan Solberg, A. Chan, Prakriti Kalra, Rui Shi, William C. K. Pomerantz, Jon E. Hawkinson, E. Schönbrunn, Gunda I. Georg	2025	0
2	Targets of protective immunity and opportunities in hepatitis C virus vaccine development Nature reviews. Immunology ·Seung Bum Park, Paul Zimmer-Harwood, T. Jake Liang	2025	1
3	Hepatitis B virus genotypes A1 and A2 have distinct replication phenotypes due to polymorphisms in the HBx gene PLoS Pathogens ·Min Zhang, Karim Mouzannar, Zhensheng Zhang, Yuji Teraoka, Jason Piotrowski, Yuji Ishida, Chise Tateno-Mukaidani, Takeshi Saito, Hiromi Abe‐Chayama, Kazuaki Chayama, T. Jake Liang	2025	1
4	Recent Advances in Enhancing Functionalization of Atomically Precise Copper Hydride Clusters Aggregate ·Miao‐Miao Zhang, T. Jake Liang, Chong Zhang, Huanhuan Zhang, Yufan Li, Yuanyuan Li, Shuang‐Quan Zang	2025	0
5	The Post-Transcriptional Regulatory Element of Hepatitis B Virus: From Discovery to Therapy Viruses ·Karim Mouzannar, A. Schauer, T. Jake Liang	2024	1
6	Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model Clinical Infectious Diseases ·T. Jake Liang, John Law, Thomas Pietschmann, Stuart C. Ray, Jens Bukh, Rowena A. Bull, Raymond T. Chung, D. Lorne Tyrrell, Michael Houghton, Charles M. Rice	2023	4
7	Hepatitis Delta Virus–Host Protein Interactions: From Entry to Egress Viruses ·Susannah Stephenson-Tsoris, T. Jake Liang	2023	6
8	SARS-CoV-2 omicron variants harbor spike protein mutations responsible for their attenuated fusogenic phenotype Communications Biology ·Seung Bum Park, Mohsin Khan, Sai Chaitanya Chiliveri, Xin Hu, Parker Irvin, Madeleine Leek, Ailis Grieshaber, Zongyi Hu, Eun Sun Jang, Ad Bax, T. Jake Liang	2023	19
9	HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice Hepatology ·Takuro Uchida, Michio Imamura, C. Nelson Hayes, Yosuke Suehiro, Yuji Teraoka, Kazuki Ohya, Hiroshi Aikata, Hiromi Abe‐Chayama, Yuji Ishida, Chise Tateno, Yuichi Hara, Keisuke Hino, Toru Okamoto, Yoshiharu Matsuura, Hideki Aizaki, Kenjiro Wake, Michinori Kohara, T. Jake Liang, Shiro Oka, Kazuaki Chayama	2023	7
10	Targeting the Fusion Process of SARS-CoV-2 Infection by Small Molecule Inhibitors mBio ·Seung Bum Park, Parker Irvin, Zongyi Hu, Mohsin Khan, Xin Hu, Qiru Zeng, Catherine Chen, Miao Xu, Madeleine Leek, Ruochen Zang, James Brett Case, Wei Zheng, Siyuan Ding, T. Jake Liang	2022	10
11	Genetically edited hepatic cells expressing the NTCP-S267F variant are resistant to hepatitis B virus infection Molecular Therapy — Methods & Clinical Development ·Takuro Uchida, Seung Bum Park, Tadashi Inuzuka, Min Zhang, Joselyn Natasha Allen, Kazuaki Chayama, T. Jake Liang	2021	10
12	Infection courses, virological features and IFN-α responses of HBV genotypes in cell culture and animal models Journal of Hepatology ·Min Zhang, Zhensheng Zhang, Michio Imamura, Mitsutaka Osawa, Yuji Teraoka, Jason Piotrowski, Yuji Ishida, Vitina Sozzi, Peter Revill, Takeshi Saito, Kazuaki Chayama, T. Jake Liang	2021	23
13	Modeling PNPLA3‐Associated NAFLD Using Human‐Induced Pluripotent Stem Cells Hepatology ·Samantha Grace Tilson, Carola Maria Morell, An‐Sofie Lenaerts, Seung Bum Park, Zongyi Hu, Benjamin Jenkins, Albert Koulman, T. Jake Liang, Ludovic Vallier	2021	43
14	Metabolic Profiling Reveals Aggravated Non-Alcoholic Steatohepatitis in High-Fat High-Cholesterol Diet-Fed Apolipoprotein E-Deficient Mice Lacking Ron Receptor Signaling Metabolites ·Joselyn Natasha Allen, Adwitia Dey, Jingwei Cai, Jingtao Zhang, Yuan Tian, Mary J. Kennett, Yanling Ma, T. Jake Liang, Andrew D. Patterson, Pamela Hankey‐Giblin	2020	5
15	A randomized, proof-of-concept clinical trial on repurposing chlorcyclizine for the treatment of chronic hepatitis C Antiviral Research ·Christopher Koh, Preeti Dubey, Ma Ai Thanda Han, Peter J. Walter, H. Martin Garraffo, Pallavi Surana, Noel Southall, N. Borochov, Susan L. Uprichard, Scott J. Cotler, Ohad Etzion, Theo Heller, Harel Dahari, T. Jake Liang	2019	7
16	Hepatitis C Virus Infection Induces Hepatic Expression of NF-κB-Inducing Kinase and Lipogenesis by Downregulating miR-122 mBio ·B. Lowey, Laura Hertz, Stephan Chiu, Kristin Valdez, Qisheng Li, T. Jake Liang	2019	13
17	MicroRNA-135a Modulates Hepatitis C Virus Genome Replication through Downregulation of Host Antiviral Factors Virologica Sinica ·Catherine Sodroski, B. Lowey, Laura Hertz, T. Jake Liang, Qisheng Li	2018	22
18	Hepatitis C virus depends on E-cadherin as an entry factor and regulates its expression in epithelial-to-mesenchymal transition Proceedings of the National Academy of Sciences ·Qisheng Li, Catherine Sodroski, B. Lowey, Cameron J. Schweitzer, Helen Cha, Fang Zhang, T. Jake Liang	2016	51
19	Long-term therapy of chronic delta hepatitis with peginterferon alfa Alimentary Pharmacology & Therapeutics ·Theo Heller, Yaron Rotman, Christopher Koh, Shauna Clark, Vanessa Haynes–Williams, Richard Chang, Robert P. McBurney, Peter Schmid, J. Albrecht, David E. Kleiner, Marc G. Ghany, T. Jake Liang, Jay H. Hoofnagle	2014	81
20	Hepatitis B virus precore mutation and fulminant hepatitis in the United States. A polymerase chain reaction-based assay for the detection of specific mutation. Journal of Clinical Investigation ·T. Jake Liang, Kiyoshi Hasegawa, Santiago J. Muñoz, Craig N. Shapiro, Boris Yoffe, Brian J. McMahon, Chao Feng, Bei Hu, M J Alter, Jules L. Dienstag	1994	71

About T. Jake Liang

T. Jake Liang is a scholar working on Hepatology, Epidemiology, Virology, Infectious Diseases and Rheumatology, having authored 195 papers that have together received 13.2k indexed citations. Recurring topics across this work include Hepatitis C virus research (146 papers), Hepatitis B Virus Studies (126 papers), Liver Disease Diagnosis and Treatment (69 papers), Monoclonal and Polyclonal Antibodies Research (19 papers), Systemic Lupus Erythematosus Research (14 papers), HIV Research and Treatment (13 papers), Hepatitis Viruses Studies and Epidemiology (11 papers) and HIV/AIDS drug development and treatment (10 papers). The work is most often cited by research in Hepatology (8.9k citations), Epidemiology (9.1k citations), Virology (623 citations), Infectious Diseases (1.6k citations) and Immunology (1.7k citations). T. Jake Liang has collaborated with scholars based in United States, Japan and United Kingdom. Frequent co-authors include Jay H. Hoofnagle, Barbara Rehermann, Rohit Loomba, Marc G. Ghany, Theo Heller, Jack R. Wands, Edward Doo, Leonard B. Seeff, Zongyi Hu and Kiyoshi Hasegawa. Their work appears in journals such as Gastroenterology, Journal of Virology, Hepatology, Alimentary Pharmacology & Therapeutics and Journal of Clinical Investigation.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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