Clifford C. Shone

5.6k citations

88 papers · 4.2k indexed · h-index 38

Neurology top 0.2%
- Botulinum Toxin and Related Neurological Disorders 57
- Neurological disorders and treatments 33
Cellular and Molecular Neuroscience top 1%
- Hereditary Neurological Disorders 6
Cell Biology top 1%
- Cellular transport and secretion 15
Endocrinology top 5%
Infectious Diseases top 5%
- Clostridium difficile and Clostridium perfringens research 20
- Antimicrobial Resistance in Staphylococcus 11
Molecular Biology
- Biochemical and Structural Characterization 21
Immunology
- Toxin Mechanisms and Immunotoxins 16

Co-authors: Cesare Montecucco J. Melling Ornella Rossetto Peter Hambleton Giampietro Schiavo K. Ravi Acharya April K. Roberts J. Oliver Dolly
Cited by: Neurology Cellular and Molecular Neuroscience Cell Biology
Journals: Proceedings of the National Academy of Sciences (1 paper)Journal of Biological Chemistry (11 papers)Applied and Environmental Microbiology (2 papers)
Partner nations: United Kingdom Italy United States

In The Last Decade

Clifford C. Shone

85 papers receiving 4.0k citations

Peers

Countries citing papers authored by Clifford C. Shone

Since Specialization

Citations

This map shows the geographic impact of Clifford C. Shone's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Clifford C. Shone with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Clifford C. Shone more than expected).

Fields of papers citing papers by Clifford C. Shone

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Clifford C. Shone. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Clifford C. Shone. The network helps show where Clifford C. Shone may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Clifford C. Shone, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Clifford C. Shone Line = papers co-authored together Clifford C. Shone links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	The structure of the S-layer of Clostridium difficile Journal of Cell Communication and Signaling ·W.J. Bradshaw,April K. Roberts,Clifford C. Shone,K. Ravi Acharya	2017	37
2	High prevalence of subclass-specific binding and neutralizing antibodies against <em>Clostridium difficile</em> toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic <em>C. difficile</em> infection Clinical and Experimental Gastroenterology ·Tanya Monaghan,Ola H. Negm,Brendon MacKenzie,Mohamed R. Hamed,Clifford C. Shone,David P. Humphreys,K. Ravi Acharya,Mark H. Wilcox	2017	10
3	Functional significance of active site residues in the enzymatic component of the Clostridium difficile binary toxin Biochemistry and Biophysics Reports ·Abigail H. Davies,Joanna McGlashan,Mareike G. Posner,April K. Roberts,Clifford C. Shone,K. Ravi Acharya	2016	5
4	Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism Biochemical Pharmacology ·Giulia Zanetti,Domenico Azarnia Tehran,Marco Pirazzini,Thomas Binz,Clifford C. Shone,Silvia Fillo,Florigio Lista,Ornella Rossetto,Cesare Montecucco	2015	28
5	A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins Scientific Reports ·Domenico Azarnia Tehran,Giulia Zanetti,Oneda Leka,Florigio Lista,Silvia Fillo,Thomas Binz,Clifford C. Shone,Ornella Rossetto,Cesare Montecucco,Cristina Paradisi,Andrea Mattarei,Marco Pirazzini	2015	26
6	Cwp84, aClostridium difficilecysteine protease, exhibits conformational flexibility in the absence of its propeptide Acta Crystallographica Section F Structural Biology Communications ·W.J. Bradshaw,April K. Roberts,Clifford C. Shone,K. Ravi Acharya	2015	5
7	Double anchorage to the membrane and intact inter-chain disulfide bond are required for the low pH induced entry of tetanus and botulinum neurotoxins into neurons Cellular Microbiology ·Marco Pirazzini,Ornella Rossetto,Paolo Bolognese,Clifford C. Shone,Cesare Montecucco	2011	54
8	Expression, purification and cell cytotoxicity of actin-modifying binary toxin from Clostridium difficile Protein Expression and Purification ·Amit Sundriyal,April K. Roberts,Roger Ling,Joanna McGlashan,Clifford C. Shone,K. Ravi Acharya	2010	31
9	Structural Basis for Substrate Recognition in the Enzymatic Component of ADP-ribosyltransferase Toxin CDTa from Clostridium difficile Journal of Biological Chemistry ·Amit Sundriyal,April K. Roberts,Clifford C. Shone,K. Ravi Acharya	2009	40
10	The 5th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Neurotoxins. Workshop Review: Assays and Detection Neurotoxicity Research ·Clifford C. Shone,Joseph Ferreira,Anne E. Boyer,Nick M. Cirino,Christina Egan,Elizabeth Evans,John J. Kools,Shashi Sharma	2006	15
11	Analysis of the substrate recognition domain determinants of Botulinum Type B toxin using Phage Display Toxicon ·Elizabeth Evans,J. Mark Sutton,A. Gravett,Clifford C. Shone	2005	10
12	Retargeted clostridial endopeptidases: Inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain Movement Disorders ·John A. Chaddock,John R. Purkiss,Frances C.G. Alexander,Sarah Doward,Sarah J. Fooks,Lorna M. Friis,Yper Hall,Elizabeth R. Kirby,Nicola Leeds,H. Moulsdale,Anthony H. Dickenson,G. Mark Green,Wahida Rahman,Rie Suzuki,Michael Duggan,Conrad P. Quinn,Clifford C. Shone,Keith Foster	2004	50
13	Isolation of the gene and large-scale expression and purification of recombinant Erythrina cristagalli lectin Protein Expression and Purification ·Patrick Stancombe,Frances C.G. Alexander,Roger Ling,Mary A Matheson,Clifford C. Shone,John A. Chaddock	2003	13
14	Development of in vitro assays for the detection of botulinum toxins in foods FEMS Immunology & Medical Microbiology ·Matthew Wictome,Kirsti A. Newton,Karen Jameson,Paul Dunnigan,Sally Clarke,J.E. Gaze,A. Tauk,Keith Foster,Clifford C. Shone	1999	38
15	Botulinum Neurotoxin Type C Cleaves a Single Lys-Ala Bond within the Carboxyl-terminal Region of Syntaxins Journal of Biological Chemistry ·Giampietro Schiavo,Clifford C. Shone,Mark K. Bennett,Richard H. Scheller,Cesare Montecucco	1995	223
16	Peptide Substrate Specificity and Properties of the zinc‐endopeptidase Activity of Botulinum Type B Neurotoxin European Journal of Biochemistry ·Clifford C. Shone,April K. Roberts	1994	86
17	Proteolytic cleavage of synthetic fragments of vesicle‐associated membrane protein, isoform‐2 by botulinum type B neurotoxin European Journal of Biochemistry ·Clifford C. Shone,Conrad P. Quinn,Robin Wait,Bassam Hallis,Sarah G. FOOKS,Peter Hambleton	1993	98
18	Inhibition of transmitter release by botulinum neurotoxin A European Journal of Biochemistry ·Bernard Poulain,Jonathan D. F. Wadsworth,E. Anne MAISEY,Clifford C. Shone,J. Melling,L Tauc,J. Oliver Dolly	1989	22
19	Clostridium botulinum toxins: nature and preparation for clinical use Eye ·J. Melling,Peter Hambleton,Clifford C. Shone	1988	71
20	Evaluation of a monoclonal antibody‐based immunoassay for detecting type A Clostridium botulinum toxin produced in pure culture and an inoculated model cured meat system Journal of Applied Bacteriology ·Angela M. Gibson,N Modi,T.A. Roberts,Clifford C. Shone,Peter Hambleton,J. Melling	1987	39

About Clifford C. Shone

Clifford C. Shone is a scholar working on Neurology, Infectious Diseases and Cell Biology, having authored 88 papers that have together received 4.2k indexed citations. Recurring topics across this work include Botulinum Toxin and Related Neurological Disorders (57 papers), Neurological disorders and treatments (33 papers), Biochemical and Structural Characterization (21 papers), Clostridium difficile and Clostridium perfringens research (20 papers), Toxin Mechanisms and Immunotoxins (16 papers), Cellular transport and secretion (15 papers), Antimicrobial Resistance in Staphylococcus (11 papers) and Hereditary Neurological Disorders (6 papers). The work is most often cited by research in Neurology (2.9k citations), Cellular and Molecular Neuroscience (1.3k citations) and Cell Biology (803 citations). Clifford C. Shone has collaborated with scholars based in United Kingdom, Italy and United States. Frequent co-authors include Cesare Montecucco, J. Melling, Ornella Rossetto, Peter Hambleton, Giampietro Schiavo, K. Ravi Acharya, April K. Roberts, J. Oliver Dolly, Keith Foster and Patrick Foran. Their work appears in journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Applied and Environmental Microbiology.

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