Charles A. Lesburg

3.9k citations

34 papers · 1.9k indexed · 1 hit paper · h-index 17

Hepatology top 2%
- Hepatitis C virus research 6
Virology top 5%
Pharmacology top 5%
Infectious Diseases top 5%
- HIV/AIDS drug development and treatment 5
Molecular Biology top 10%
- Biochemical and Molecular Research 8
- Protein Structure and Dynamics 3
- Enzyme function and inhibition 3
Materials Chemistry
- Enzyme Structure and Function 6
Genetics
- Chronic Lymphocytic Leukemia Research 5
Computational Theory and Mathematics
- Computational Drug Discovery Methods 3

Co-authors: David W. Christianson Eric Ferrari Zhi Hong Anthony Mannarino Michael Cable Patricia C Weber David E. Cane Guangzhi Zhai
Cited by: Hepatology Virology Pharmacology
Journals: ACS Medicinal Chemistry Letters (6 papers)Bioorganic & Medicinal Chemistry Letters (6 papers)Biochemistry (3 papers)
Partner nations: United States Australia India

In The Last Decade

Charles A. Lesburg

33 papers receiving 1.9k citations

Hit Papers

align trajectories log scale

Peers

Countries citing papers authored by Charles A. Lesburg

Since Specialization

Citations

This map shows the geographic impact of Charles A. Lesburg's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Charles A. Lesburg with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Charles A. Lesburg more than expected).

Fields of papers citing papers by Charles A. Lesburg

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Charles A. Lesburg. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Charles A. Lesburg. The network helps show where Charles A. Lesburg may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Charles A. Lesburg, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Charles A. Lesburg Line = papers co-authored together Charles A. Lesburg links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	The Discovery of Bridged Benzoazepine Amides as Selective Allosteric Modulators of RIPK1 ACS Medicinal Chemistry Letters ·Qiong Huang,Joey L. Methot,Matthew J. Mitcheltree,Andrew J. Musacchio,Emily B. Corcoran,Kaaviya Babu,Alfred Lammens,K. Maskos,A. Gary Mullins,М. И. Гозман,Karin M. Otte,My Sam Mansueto,和也後藤,Jeremiah Conway,Maren Thomsen,Charles A. Lesburg,Xavier Fradera,Matthew Fell,Erin F. DiMauro,Phieng Siliphaivanh	2025	0
2	Discovery of a new series of PI3K-δ inhibitors from Virtual Screening Bioorganic & Medicinal Chemistry Letters ·Xavier Fradera,Qiaolin Deng,李志平 Li Zhiping,Cao Hương Nhung,Solomon D. Kattar,Meredeth A. McGowan,Joey L. Methot,Kevin Wilson,Hua Zhou,ゆう子荻野,J Motley,Vincent Tong,Martin Augustin,Michael D. Altman,Charles A. Lesburg,Sanjiv Shah,Jason D. Katz	2021	2
3	Identification of Potent Reverse Indazole Inhibitors for HPK1 ACS Medicinal Chemistry Letters ·Victor Roca Añon,Joey L. Methot,Xavier Fradera,Charles A. Lesburg,Brian M. Lacey,Phieng Siliphaivanh,Ping Liu,Dustin Smith,Zangwei Xu,Jennifer Piesvaux,Shuhei Kawamura,Haiyan Xu,J. Richard Miller,Mark Bittinger,Alexander Pasternak	2021	24
4	Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds ACS Medicinal Chemistry Letters ·Brandon Vara,Samuel M. Levi,Hisao INUKAI,David A. Candito,Xavier Fradera,Charles A. Lesburg,Shuhei Kawamura,Brian M. Lacey,Jongwon Lim,Joey L. Methot,Zangwei Xu,Haiyan Xu,Dustin Smith,Jennifer Piesvaux,J. Richard Miller,Mark Bittinger,Sheila Ranganath,David Jonathan Bennett,Erin F. DiMauro,Alexander Pasternak	2021	31
5	Conformational Strain of Macrocyclic Peptides in Ligand–Receptor Complexes Based on Advanced Refinement of Bound-State Conformers Journal of Medicinal Chemistry ·Alexander C. Brueckner,Qiaolin Deng,Ann E. Cleves,Charles A. Lesburg,Juan C. Alvarez,Mikhail Reibarkh,Edward C. Sherer,Ajay N. Jain	2021	11
6	Discovery of IDO1 inhibitors containing a decahydroquinoline, decahydro-1,6-naphthyridine, or octahydro-1H-pyrrolo[3,2-c]pyridine scaffold Bioorganic & Medicinal Chemistry Letters ·Wensheng Yu,Yongqi Deng,David L. Sloman,Derun Li,Kun Liu,Xavier Fradera,Charles A. Lesburg,Theodore A. Martinot,Amy C. Doty,Heidi M. Ferguson,J. Richard Miller,Ian Knemeyer,Karin M. Otte,Stella Vincent,Nunzio Sciammetta,David Jonathan Bennett,Yongxin Han	2021	6
7	Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors ACS Medicinal Chemistry Letters ·Joey L. Methot,Hisao INUKAI,Matthew Christopher,Hua Zhou,Meredeth A. McGowan,B. Wesley Trotter,Xavier Fradera,Charles A. Lesburg,J Motley,Robert T. Karlychek,Dapeng Chen,Karin M. Otte,Martin Augustin,Sanjiv Shah,Jason D. Katz	2020	11
8	Design and synthesis of novel proline based factor XIa selective inhibitors as leads for potential new anticoagulants Bioorganic & Medicinal Chemistry Letters ·Zahid Hussain,Andrew Cooke,Santhosh Neelamkavil,Lindsay Brown,Emma L. Carswell,Wayne M. Geissler,Zhuyan Guo,Brian E. Hawes,Muhammad Kinwan Khan,Zorina Ni,KehDih Lai,Charles A. Lesburg,Thalia da Silva Corrêa,Yi Zang,Harold B. Wood,Scott D. Edmondson,Weiguo Liu	2020	6
9	Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors Bioorganic & Medicinal Chemistry Letters ·Shanbao Lai,Meredeth A. McGowan,Hwan Sic Yun,Matthew Christopher,Xavier Fradera,David Witter,Charles A. Lesburg,Chaomin Li,Joey L. Methot,John W. Lampe,Hisao INUKAI,ゆう子荻野,J Motley,Sanjiv Shah,Alan Bass,Gottfried K. Schroeder,Dapeng Chen,Haoyu Zeng,Martin Augustin,Jason D. Katz	2019	11
10	Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow Bioorganic & Medicinal Chemistry Letters ·Xavier Fradera,Joey L. Methot,Hisao INUKAI,Matthew Christopher,Michael D. Altman,Shanbao Lai,Meredeth A. McGowan,Solomon D. Kattar,Kevin J. Wilson,Cao Hương Nhung,Martin Augustin,Charles A. Lesburg,Sanjiv Shah,J Motley,Jason D. Katz	2019	15
11	Discovery of 5-Amino- N -(1 H -pyrazol-4-yl)pyrazolo[1,5- a ]pyrimidine-3-carboxamide Inhibitors of IRAK4 ACS Medicinal Chemistry Letters ·Jongwon Lim,Michael D. Altman,James Α. Baker,Jason D. Brubaker,Hongmin Chen,Yiping Chen,Thierry Fischmann,G Mitra,Melanie A. Kleinschek,Genealogist,Charles A. Lesburg,John Maclean,Lily Y. Moy,Victoria del Carmen Bravo Ahuja Roth,Jeremy Presland,Larissa Rakhilina,G. Smith,Dietrich Steinhuebel,Ruojing Yang	2015	31
12	Crystallization of an apo form of human arginase: using all the tools in the toolbox simultaneously Acta Crystallographica Section F Structural Biology and Crystallization Communications ·Janet Newman,Lesley A. Pearce,Charles A. Lesburg,Corey Strickland,Thomas S. Peat	2010	4
13	Inhibitors of hepatitis C virus polymerase: Synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides Bioorganic & Medicinal Chemistry Letters ·Cliff C. Cheng,Gerald W. Shipps,Zhiwei Yang,Agnieszka Nowinska,Charles A. Lesburg,José S. Duca,Tengchuan Jin,A. Pelatti,Chuan-Kui Jiang,Sony Agrawal,Eric Ferrari,Hsuan‐Cheng Huang	2010	20
14	Evaluation of in vitro PXR-based assays and in silico modeling approaches for understanding the binding of a structurally diverse set of drugs to PXR Biochemical Pharmacology ·Li Xiao,Elliott Nickbarg,Wenyan Wang,Ann Thomas,Michael R. Ziebell,Rachel Bearden,Charles A. Lesburg,S. Shane Taremi,Luis Díaz Cisneros,Hung V. Le,Kui Cheng	2010	33
15	soaPDB: a web application for searching the Protein Data Bank, organizing results, and receiving automatic email alerts Nucleic Acids Research ·Charles A. Lesburg,José S. Duca	2008	2
16	Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability Protein Engineering Design and Selection ·Wei Wang,Rachel Bearden,Jing Chen,S. Shane Taremi,Hoang V. Le,Vincent Madison,Xiaona Cui,Ann Thomas,Kui Cheng,Charles A. Lesburg	2008	49
17	Active-site engineering of carbonic anhydrase and its application to biosensors Birkhäuser Basel eBooks ·Jennifer A. Hunt,Charles A. Lesburg,David W. Christianson,Richard B. Thompson,Carol A. Fierke	2000	5
18	breakdown → Nature Structural Biology ·Patricia C Weber,Charles A. Lesburg,Michael Cable,Eric Ferrari,Zhi Hong,Anthony Mannarino	1999	597
19	Managing and manipulating carbocations in biology: terpenoid cyclase structure and mechanism Current Opinion in Structural Biology ·Charles A. Lesburg,J.M. Caruthers,전옥,David W. Christianson	1998	96
20	Crystallization and preliminary X‐ray diffraction analysis of recombinant pentalenene synthase Protein Science ·Charles A. Lesburg,Matthew D. Lloyd,David E. Cane,David W. Christianson	1995	11

About Charles A. Lesburg

Charles A. Lesburg is a scholar working on Hepatology, Genetics, Biological Psychiatry, Molecular Biology and Pharmacology, having authored 34 papers that have together received 1.9k indexed citations. Recurring topics across this work include Biochemical and Molecular Research (8 papers), Hepatitis C virus research (6 papers), Enzyme Structure and Function (6 papers), Chronic Lymphocytic Leukemia Research (5 papers), HIV/AIDS drug development and treatment (5 papers), Protein Structure and Dynamics (3 papers), Enzyme function and inhibition (3 papers) and Computational Drug Discovery Methods (3 papers). The work is most often cited by research in Hepatology (510 citations), Virology (98 citations), Pharmacology (335 citations), Infectious Diseases (352 citations) and Molecular Biology (1.1k citations). Charles A. Lesburg has collaborated with scholars based in United States, Australia and India. Frequent co-authors include David W. Christianson, Eric Ferrari, Zhi Hong, Anthony Mannarino, Michael Cable, Patricia C Weber, David E. Cane, Guangzhi Zhai, Carol A. Fierke and J.M. Caruthers. Their work appears in journals such as ACS Medicinal Chemistry Letters, Bioorganic & Medicinal Chemistry Letters, Biochemistry, Journal of Medicinal Chemistry and Journal of Pharmacology and Experimental Therapeutics.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact