Caroline A. Jefferies

7.0k citations

76 papers · 5.1k indexed · 1 hit paper · h-index 36

Impact in

Immunology top 0.5%
- Immune Response and Inflammation
- interferon and immune responses
- Immune Cell Function and Interaction
- Immune cells in cancer
Cancer Research top 2%
- NF-κB Signaling Pathways

Papers in

Immunology 55
- Immune Response and Inflammation 26
- interferon and immune responses 25
- Immune Cell Function and Interaction 18
- T-cell and B-cell Immunology 9
Rheumatology 20
- Systemic Lupus Erythematosus Research 17

Co-authors: Luke O'neill Joan Ní Gabhann Katherine A. Fitzgerald Rowan Higgs Aisling Dunne Sally‐Ann Cryan Ciara Kelly Sarah Doyle
Journals: Frontiers in Immunology (6 papers)Journal of Biological Chemistry (6 papers)The Journal of Immunology (5 papers)PLoS ONE (5 papers)Scientific Reports (3 papers)
Partner nations: Ireland United States United Kingdom

In The Last Decade

Caroline A. Jefferies

74 papers receiving 5.0k citations

Hit Papers

align trajectories log scale

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction 2001 · 1.0k citations

Peers

Countries citing papers authored by Caroline A. Jefferies

Since Specialization

Citations

This map shows the geographic impact of Caroline A. Jefferies's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Caroline A. Jefferies with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Caroline A. Jefferies more than expected).

Fields of papers citing papers by Caroline A. Jefferies

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Caroline A. Jefferies. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Caroline A. Jefferies. The network helps show where Caroline A. Jefferies may publish in the future.

Co-authors

The 25 scholars most cited alongside Caroline A. Jefferies, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Caroline A. Jefferies Line = papers co-authored together Caroline A. Jefferies links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Loss of Tripartite Motif–Containing Protein 21 and UVB ‐Induced Systemic Inflammation by Regulating DNA ‐Sensing Pathways Arthritis & Rheumatology ·Gantsetseg Tumurkhuu, Sarah Anne, Richard E. Moore, Lihong Huo, Л. А. Лесина, Richard I. Ainsworth, Д.Д. Каюмов, Hata Yuzuru, David R. Gibb, Jessica Carrière, Jeong Min Yu, Rachel Abuav, Lindsy Forbess, Daniel J. Wallace, Mariko Ishimori, Wonwoo Shon, Christian Stehlik, Caroline A. Jefferies	2025	2
2	High-throughput mRNA sequencing of human placenta shows sex differences across gestation Placenta ·Elnaz Kalemati, Tania L Gonzalez, Yizhou Wang, Chintda Santiskulvong, 肖笛, Tada-aki HAGIUDA, Caroline A. Jefferies, Kate Lawrenson, Jessica L. Chan, Т.Г. Левченко, Yazhen Zhu, Hsian‐Rong Tseng, Erica T. Wang, Mariko Ishimori, S. Ananth Karumanchi, John W Williams, Margareta D. Pisarska	2024	1
3	High-throughput mRNA-seq atlas of human placenta shows vast transcriptome remodeling from first to third trimester Biology of Reproduction ·Tania L Gonzalez, AM de Sousa, Elnaz Kalemati, Yizhou Wang, Chintda Santiskulvong, 肖笛, Caroline A. Jefferies, Kate Lawrenson, Jessica L. Chan, Т.Г. Левченко, Yazhen Zhu, Hsian‐Rong Tseng, S. Ananth Karumanchi, John G Williams, Margareta D. Pisarska	2024	5
4	Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta Biology of Sex Differences ·Tania L Gonzalez, G. Umadevi, Erica T. Wang, Kent D. Taylor, Tada-aki HAGIUDA, Eduardo Marino García Palacios, Duan Xiaoping, Jacky Bolding, Caroline A. Jefferies, Kate Lawrenson, Jerome I. Rotter, Yii‐Der Ida Chen, John Williams, Jinrui Cui, Mark O. Goodarzi, Margareta D. Pisarska	2024	1
5	Interaction effects of significant risk factors on low bone mineral density in ankylosing spondylitis PeerJ ·Ana María Lomas Esteban, Debasmita Kar, Caroline A. Jefferies, Thomas J. Learch, Mariko Ishimori, Juan Wu, 李慎谦, Nan Zhang, Qingwen Tao, A. H. Arkle, Xiaoping Yan, Michael H. Weisman	2023	0
6	Herpes simplex virus 1 targets IRF7 via ICP0 to limit type I IFN induction Scientific Reports ·Hangtian Li, S Wittaya-areekul, Claire Wynne, Caroline A. Jefferies, Joan Ní Gabhann, Conor C. Murphy	2020	19
7	Regulating IRFs in IFN Driven Disease Frontiers in Immunology ·Caroline A. Jefferies	2019	272
8	Role of DNA/RNA sensors and contribution to autoimmunity Cytokine & Growth Factor Reviews ·Siobhán Smith, Caroline A. Jefferies	2014	44
9	Btk Regulates Macrophage Polarization in Response to Lipopolysaccharide PLoS ONE ·Joan Ní Gabhann, Emily Hams, Siobhán Smith, Claire Wynne, Jennifer C. Byrne, Kiva Brennan, Shaun Spence, Adrien Kissenpfennig, James A. Johnston, Padraic G. Fallon, Caroline A. Jefferies	2014	111
10	Tyrosine Phosphorylation of the E3 Ubiquitin Ligase TRIM21 Positively Regulates Interaction with IRF3 and Hence TRIM21 Activity PLoS ONE ·Kevin Stacey, Eamon P. Breen, Caroline A. Jefferies	2012	33
11	Defects in acute responses to TLR4 in Btk-deficient mice result in impaired dendritic cell-induced IFN-γ production by natural killer cells Clinical Immunology ·Joan Ní Gabhann, Shaun Spence, Claire Wynne, Siobhán Smith, Jennifer C. Byrne, Barbara M. Coffey, Kevin Stacey, Adrien Kissenpfennig, Jim Johnston, Caroline A. Jefferies	2011	27
12	Antiviral TRIMs: friend or foe in autoimmune and autoinflammatory disease? Nature reviews. Immunology ·Caroline A. Jefferies, Claire Wynne, Rowan Higgs	2011	79
13	Evaluation and optimization of IgY Spin Column technology in the depletion of abundant proteins from human serum PROTEOMICS ·Yambay Paucar, Caroline A. Jefferies, Sh. Toshtemirov, Jacqueline S. Daly	2011	5
14	Siglec-E is up-regulated and phosphorylated following lipopolysaccharide stimulation in order to limit TLR-driven cytokine production The Journal of Immunology ·Caroline R. Boyd, Selinda J. Orr, Shaun Spence, James F. Burrows, Joanne Elliott, Helen P. Carroll, Kiva Brennan, Joan Ní Gabhann, Wilson A. Coulter, James A. Johnston, Caroline A. Jefferies	2010	1
15	Absence of SHIP-1 Results in Constitutive Phosphorylation of Tank-Binding Kinase 1 and Enhanced TLR3-Dependent IFN-β Production The Journal of Immunology ·Joan Ní Gabhann, Rowan Higgs, Kiva Brennan, Warren Thomas, Jacqueline E. Damen, Nadia Ben Larbi, Gerald Krystal, Caroline A. Jefferies	2010	72
16	Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway The Journal of Experimental Medicine ·Alexander Espinosa, Valérie Dardalhon, Susanna Brauner, Aurélie Ambrosi, Rowan Higgs, Aderibigbe Ezekiel Adebiyi, Maria Sjöstrand, Maija‐Leena Eloranta, Joan Ní Gabhann, Ola Winqvist, Birgitta Sundelin, Caroline A. Jefferies, Björn Rozell, Vijay K. Kuchroo, Marie Wahren‐Herlenius	2009	232
17	Siglec-E Is Up-Regulated and Phosphorylated Following Lipopolysaccharide Stimulation in Order to Limit TLR-Driven Cytokine Production The Journal of Immunology ·Caroline R. Boyd, Selinda J. Orr, Shaun Spence, James F. Burrows, Joanne Elliott, Helen P. Carroll, Kiva Brennan, Joan Ní Gabhann, Wilson A. Coulter, James A. Johnston, Caroline A. Jefferies	2009	64
18	Bruton’s tyrosine kinase (Btk)—the critical tyrosine kinase in LPS signalling? Immunology Letters ·Caroline A. Jefferies, Luke O'neill	2004	65
19	Interferon Regulatory Factor-3-mediated Activation of the Interferon-sensitive Response Element by Toll-like receptor (TLR) 4 but Not TLR3 Requires the p65 Subunit of NF-κ Journal of Biological Chemistry ·Claudia Wietek, Sinéad M. Miggin, Caroline A. Jefferies, Luke O'neill	2003	99
20	Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction Nature ·Katherine A. Fitzgerald, Eva M. Pålsson‐McDermott, Andrew Bowie, Caroline A. Jefferies, Ashley Mansell, Gareth Brady, Elizabeth Brint, Aisling Dunne, Pearl Gray, Mary T. Harte, Franci Vosloo, Dirk E. Smith, John E. Sims, Timothy A. Bird, Luke O'neill Hit paper breakdown →	2001	1006

About Caroline A. Jefferies

Caroline A. Jefferies is a scholar working on Immunology, Rheumatology, Cancer Research, Oncology and Molecular Biology, having authored 76 papers that have together received 5.1k indexed citations. Recurring topics across this work include Immune Response and Inflammation (26 papers), interferon and immune responses (25 papers), Immune Cell Function and Interaction (18 papers), Systemic Lupus Erythematosus Research (17 papers), NF-κB Signaling Pathways (16 papers), Cytokine Signaling Pathways and Interactions (12 papers), T-cell and B-cell Immunology (9 papers) and Inflammasome and immune disorders (7 papers). The work is most often cited by research in Immunology (3.4k citations), Cancer Research (820 citations), Rheumatology (460 citations), Oncology (705 citations) and Molecular Biology (1.7k citations). Caroline A. Jefferies has collaborated with scholars based in Ireland, United States and United Kingdom. Frequent co-authors include Luke O'neill, Joan Ní Gabhann, Katherine A. Fitzgerald, Rowan Higgs, Aisling Dunne, Sally‐Ann Cryan, Ciara Kelly, Sarah Doyle, Elizabeth Brint and Pearl Gray. Their work appears in journals such as Frontiers in Immunology, Journal of Biological Chemistry, The Journal of Immunology, PLoS ONE and Scientific Reports.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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