Standout Papers

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce... 1986 2026 1999 2012 1.8k
  1. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin (1986)
    Toshio Hirano, Kiyoshi Yasukawa et al. Nature
  2. The biology of interleukin-6 (1989)
    Tadamitsu Kishimoto Blood
  3. Impaired immune and acute-phase responses in interleukin-6-deficient mice (1994)
    Manfred Köpf, Heinz Baumann et al. Nature
  4. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas (1988)
    Michio Kawano, Toshio Hirano et al. Nature
  5. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice (1998)
    Qing Ma, Dan Jones et al. Proceedings of the National Academy of Sciences
  6. The biology of interleukin-6 (1989)
    Tadamitsu Kishimoto Blood
  7. IL‐6: Regulator of Treg/Th17 balance (2010)
    Akihiro Kimura, Tadamitsu Kishimoto European Journal of Immunology
  8. gp130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES (1997)
    Tetsuya Taga, Tadamitsu Kishimoto Annual Review of Immunology
  9. Molecular cloning and expression of an IL-6 signal transducer, gp130 (1990)
    Masahiko Hibi, Masaaki Murakami et al. Cell
  10. Structure and function of a new STAT-induced STAT inhibitor (1997)
    Tetsuji Naka, Masashi Narazaki et al. Nature
  11. Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF) (1990)
    Shizuo Akira, Toshio Hirano et al. The FASEB Journal
  12. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality (1997)
    Kiyoshi Takeda, Wei Shi et al. Proceedings of the National Academy of Sciences
  13. Interleukin-6 family of cytokines and gp130 (1995)
    Tadamitsu Kishimoto, Shizuo Akira et al. Blood
  14. Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor (1988)
    Katsuhiko Yamasaki, Tetsuya Taga et al. Science
  15. The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation (1994)
    Tsutomu Kawabe, Tetsuji Naka et al. Immunity
  16. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway (1994)
    Shizuo Akira, Yukihiro Nishio et al. Cell
  17. INTERLEUKIN-6: From Basic Science to Medicine—40 Years in Immunology (2004)
    Tadamitsu Kishimoto Annual Review of Immunology
  18. Interleukin-6 and Its Receptor: A Paradigm for Cytokines (1992)
    Tadamitsu Kishimoto, Shizuo Akira et al. Science
  19. Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130 (1994)
    Claudia Lütticken, Ursula Maria Wegenka et al. Science
  20. Molecular cloning and structure of a pre-B-cell growth-stimulating factor. (1994)
    Takashi Nagasawa, Hitoshi Kikutani et al. Proceedings of the National Academy of Sciences
  21. Excessive production of interleukin 6/B cell stimulatory factor‐2 in rheumatoid arthritis (1988)
    Toshio Hirano, Tadashi Matsuda et al. European Journal of Immunology
  22. The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. (1988)
    Atsushi Muraguchi, T Hirano et al. The Journal of Experimental Medicine
  23. IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase (1993)
    Masaaki Murakami, Masahiko Hibi et al. Science
  24. Treatment of rheumatoid arthritis with humanized anti–interleukin‐6 receptor antibody: A multicenter, double‐blind, placebo‐controlled trial (2004)
    Norihiro Nishimoto, Kazuyuki Yoshizaki et al. Arthritis & Rheumatism
  25. CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130 (1992)
    Nancy Y. Ip, Steven H. Nye et al. Cell
  26. Double‐blind randomized controlled clinical trial of the interleukin‐6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate (2006)
    Ravinder N. Maini, Peter C. Taylor et al. Arthritis & Rheumatism
  27. TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling (2004)
    Christoph Becker, Massimo Claudio Fantini et al. Immunity
  28. Targeting Interleukin-6 Signaling in Clinic (2019)
    Sujin Kang, Toshio Tanaka et al. Immunity
  29. Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab (2007)
    Naoki Nishimoto, Jun Hashi­moto et al. Annals of the Rheumatic Diseases
  30. Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial (2008)
    Shumpei Yokota, Tomoyuki Imagawa et al. The Lancet
  31. LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor (1993)
    Samuel Davis, Thomas H. Aldrich et al. Science
  32. Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism (2010)
    Nam‐Trung Nguyen, Akihiro Kimura et al. Proceedings of the National Academy of Sciences
  33. SOCS-1 Participates in Negative Regulation of LPS Responses (2002)
    Reiko Nakagawa, Tetsuji Naka et al. Immunity
  34. Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. (1993)
    Takeshi Nakajima, Shigemi Kinoshita et al. Proceedings of the National Academy of Sciences
  35. Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice (1998)
    Kiyoshi Takeda, Tsuneyasu Kaisho et al. The Journal of Immunology
  36. Immunotherapeutic Implications of Il-6 Blockade for Cytokine Storm (2016)
    Toshio Tanaka, Masashi Narazaki et al. Immunotherapy
  37. Interleukin 6: from bench to bedside (2006)
    Norihiro Nishimoto, Tadamitsu Kishimoto Nature Clinical Practice Rheumatology
  38. B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes. (1988)
    Martin Lotz, Frank R. Jirik et al. The Journal of Experimental Medicine
  39. Translating IL-6 biology into effective treatments (2020)
    Ernest Choy, Fabrizio De Benedetti et al. Nature Reviews Rheumatology
  40. Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms (2021)
    Sujin Kang, Tadamitsu Kishimoto Experimental & Molecular Medicine

Immediate Impact

17 by Nobel laureates 60 from Science/Nature 125 standout
Sub-graph 1 of 17

Citing Papers

Astrocyte scar formation aids central nervous system axon regeneration
2016 StandoutNature
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
3 intermediate papers

Works of Tadamitsu Kishimoto being referenced

Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice
1998 Standout
Impaired immune and acute-phase responses in interleukin-6-deficient mice
1994 StandoutNatureNobel
and 2 more

Author Peers

Author Last Decade Papers Cites
Tadamitsu Kishimoto 33603 25455 21971 633 76.3k
Charles A. Dinarello 46442 11690 36261 864 106.0k
Tak W. Mak 33684 22375 49026 703 94.7k
Hideo Yagita∥ 43090 21401 18011 909 66.3k
Vijay K. Kuchroo 58286 20240 12985 424 77.7k
Dan R. Littman 55424 13627 30144 343 96.9k
Nico van Rooijen 37722 9854 21141 836 79.3k
Toshio Suda 11801 16318 31977 723 57.6k
Georg Schett 17536 8377 21051 1.1k 57.5k
Marc Feldmann 23651 7826 11157 554 52.9k
Robert D. Schreiber 47711 33142 20381 378 78.3k

All Works

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