Standout Papers

Pathogen Recognition and Innate Immunity 1999 2026 2008 2017 9.1k
  1. Pathogen Recognition and Innate Immunity (2006)
    Shizuo Akira, Satoshi Uematsu et al. Cell
  2. Pattern Recognition Receptors and Inflammation (2010)
    Osamu Takeuchi, Shizuo Akira Cell
  3. A Toll-like receptor recognizes bacterial DNA (2000)
    Hiroaki Hemmi, Osamu Takeuchi et al. Nature
  4. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses (2006)
    Hiroki Kato, Osamu Takeuchi et al. Nature
  5. Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product (1999)
    Katsuaki Hoshino, Osamu Takeuchi et al. The Journal of Immunology
  6. Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components (1999)
    Osamu Takeuchi, Katsuaki Hoshino et al. Immunity
  7. Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway (2003)
    Masahiro Yamamoto, Shintaro Sato et al. Science
  8. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction (2005)
    Taro Kawai, Ken Takahashi et al. Nature Immunology
  9. Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway (2002)
    Hiroaki Hemmi, Tsuneyasu Kaisho et al. Nature Immunology
  10. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production (2008)
    Tatsuya Saitoh, Naonobu Fujita et al. Nature
  11. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5 (2008)
    Hiroki Kato, Osamu Takeuchi et al. The Journal of Experimental Medicine
  12. Cell Type-Specific Involvement of RIG-I in Antiviral Response (2005)
    Hiroki Kato, Shintaro Sato et al. Immunity
  13. Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins (2002)
    Osamu Takeuchi, Shintaro Sato et al. The Journal of Immunology
  14. Discrimination of bacterial lipoproteins by Toll-like receptor 6 (2001)
    Osamu Takeuchi, Taro Kawai et al. International Immunology
  15. Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling (2002)
    Masahiro Yamamoto, Shintaro Sato et al. The Journal of Immunology
  16. Innate immunity to virus infection (2008)
    Osamu Takeuchi, Shizuo Akira Immunological Reviews
  17. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection (2010)
    Takashi Satoh, Osamu Takeuchi et al. Nature Immunology
  18. Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes (2001)
    Taro Kawai, Osamu Takeuchi et al. The Journal of Immunology
  19. Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible to Staphylococcus aureus Infection (2000)
    Osamu Takeuchi, Katsuaki Hoshino et al. The Journal of Immunology
  20. Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 (2004)
    Taro Kawai, Shintaro Sato et al. Nature Immunology
  21. TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway (2003)
    Masahiro Yamamoto, Shintaro Sato et al. Nature Immunology
  22. Essential function for the kinase TAK1 in innate and adaptive immune responses (2005)
    Shintaro Sato, Hideki Sanjo et al. Nature Immunology
  23. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 (2002)
    Masahiro Yamamoto, Shintaro Sato et al. Nature
  24. Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia (2005)
    Anna C. Schinzel, Osamu Takeuchi et al. Proceedings of the National Academy of Sciences
  25. Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response (2009)
    Tatsuya Saitoh, Naonobu Fujita et al. Proceedings of the National Academy of Sciences
  26. A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA (2005)
    Ken J. Ishii, Cevayir Coban et al. Nature Immunology
  27. Induction of Direct Antimicrobial Activity Through Mammalian Toll-Like Receptors (2001)
    Sybille Thoma-Uszynski, Steffen Stenger et al. Science
  28. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle (2009)
    Eri Ishikawa, Yasu S. Morita et al. The Journal of Experimental Medicine
  29. SOCS-1 Participates in Negative Regulation of LPS Responses (2002)
    Reiko Nakagawa, Tetsuji Naka et al. Immunity
  30. Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay (2009)
    Kazufumi Matsushita, Osamu Takeuchi et al. Nature
  31. Limb and Skin Abnormalities in Mice Lacking IKKα (1999)
    Kiyoshi Takeda, Osamu Takeuchi et al. Science
  32. LGP2 is a positive regulator of RIG-I– and MDA5-mediated antiviral responses (2010)
    Takashi Satoh, Hiroki Kato et al. Proceedings of the National Academy of Sciences
  33. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines (2008)
    Ken J. Ishii, Tatsukata Kawagoe et al. Nature

Immediate Impact

50 by Nobel laureates 88 from Science/Nature 242 standout
Sub-graph 1 of 12

Citing Papers

Necroptosis and its role in inflammation
2015 StandoutNature
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
2015 StandoutNature
33 intermediate papers

Works of Osamu Takeuchi being referenced

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
2008 StandoutNature
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells
2006
and 16 more

Author Peers

Author Last Decade Papers Cites
Osamu Takeuchi 55315 23714 844 15082 349 80.2k
Kiyoshi Takeda 56555 27378 89 14493 454 91.3k
Ruslan Medzhitov 60569 27356 20 13228 221 95.1k
Taro Kawai 46136 19829 29 12341 175 65.8k
Bruce Beutler 37780 17041 11 10744 401 63.8k
Katherine A. Fitzgerald 39041 37056 12 12136 331 67.9k
Siamon Gordon 40753 21755 34 10477 453 76.9k
Gabriel Núñez 33855 47173 4 10577 407 83.1k
Douglas T. Golenbock 30420 14972 12 10569 287 50.3k
Charles A. Dinarello 46442 36261 10 15647 864 106.0k
Carl Nathan 21985 23625 57 10484 316 72.0k

All Works

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2026