Standout Papers

Toll-like receptor signalling 2000 2026 2008 2017 6.6k
  1. Toll-like receptor signalling (2004)
    Shizuo Akira, Kiyoshi Takeda Nature reviews. Immunology
  2. A Toll-like receptor recognizes bacterial DNA (2000)
    Hiroaki Hemmi, Osamu Takeuchi et al. Nature
  3. Toll-Like Receptors (2003)
    Kiyoshi Takeda, Tsuneyasu Kaisho et al. Annual Review of Immunology
  4. Toll-like receptors: critical proteins linking innate and acquired immunity (2001)
    Shizuo Akira, Kiyoshi Takeda et al. Nature Immunology
  5. Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria (2009)
    Ivaylo I. Ivanov, Koji Atarashi et al. Cell
  6. Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product (1999)
    Katsuaki Hoshino, Osamu Takeuchi et al. The Journal of Immunology
  7. Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species (2010)
    Koji Atarashi, Takeshi Tanoue et al. Science
  8. Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components (1999)
    Osamu Takeuchi, Katsuaki Hoshino et al. Immunity
  9. Toll-like receptors in innate immunity (2004)
    Kiyoshi Takeda International Immunology
  10. Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway (2003)
    Masahiro Yamamoto, Shintaro Sato et al. Science
  11. Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway (2002)
    Hiroaki Hemmi, Tsuneyasu Kaisho et al. Nature Immunology
  12. TLR signaling pathways (2004)
    Kiyoshi Takeda, Shizuo Akira Seminars in Immunology
  13. Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function (1998)
    Osamu Adachi, Taro Kawai et al. Immunity
  14. Unresponsiveness of MyD88-Deficient Mice to Endotoxin (1999)
    Taro Kawai, Osamu Adachi et al. Immunity
  15. Toll-like receptors control activation of adaptive immune responses (2001)
    Markus Schnare, Gregory M. Barton et al. Nature Immunology
  16. Cell Type-Specific Involvement of RIG-I in Antiviral Response (2005)
    Hiroki Kato, Shintaro Sato et al. Immunity
  17. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality (1997)
    Kiyoshi Takeda, Wei Shi et al. Proceedings of the National Academy of Sciences
  18. Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins (2002)
    Osamu Takeuchi, Shintaro Sato et al. The Journal of Immunology
  19. Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils (1999)
    Kiyoshi Takeda, Björn E. Clausen et al. Immunity
  20. Discrimination of bacterial lipoproteins by Toll-like receptor 6 (2001)
    Osamu Takeuchi, Taro Kawai et al. International Immunology
  21. Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling (2002)
    Masahiro Yamamoto, Shintaro Sato et al. The Journal of Immunology
  22. ATP drives lamina propria TH17 cell differentiation (2008)
    Koji Atarashi, Junichi Nishimura et al. Nature
  23. TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway (2003)
    Masahiro Yamamoto, Shintaro Sato et al. Nature Immunology
  24. Essential function for the kinase TAK1 in innate and adaptive immune responses (2005)
    Shintaro Sato, Hideki Sanjo et al. Nature Immunology
  25. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 (2002)
    Masahiro Yamamoto, Shintaro Sato et al. Nature
  26. STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury (2008)
    Julia Herrmann, Tetsuya Imura et al. Journal of Neuroscience
  27. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. (1998)
    Tomohiro Yoshimoto, Kiyoshi Takeda et al. PubMed
  28. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis (2004)
    Daniel Rachmilewitz, Kyoko Katakura et al. Gastroenterology
  29. Cutting Edge: Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression (2000)
    Fumiko Nomura, Sachiko Akashi et al. The Journal of Immunology
  30. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages (2003)
    Hideo Yasukawa, Masanobu Ohishi et al. Nature Immunology
  31. IL-12 Up-Regulates IL-18 Receptor Expression on T Cells, Th1 Cells, and B Cells: Synergism with IL-18 for IFN-γ Production (1998)
    Tomohiro Yoshimoto, Kiyoshi Takeda et al. The Journal of Immunology
  32. Toll/IL-1 Receptor Domain-Containing Adaptor Inducing IFN-β (TRIF) Associates with TNF Receptor-Associated Factor 6 and TANK-Binding Kinase 1, and Activates Two Distinct Transcription Factors, NF-κB and IFN-Regulatory Factor-3, in the Toll-Like Receptor Signaling (2003)
    Shintaro Sato, Masanaka Sugiyama et al. The Journal of Immunology
  33. SOCS-1 Participates in Negative Regulation of LPS Responses (2002)
    Reiko Nakagawa, Tetsuji Naka et al. Immunity
  34. Limb and Skin Abnormalities in Mice Lacking IKKα (1999)
    Kiyoshi Takeda, Osamu Takeuchi et al. Science
  35. Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice (1998)
    Kiyoshi Takeda, Tsuneyasu Kaisho et al. The Journal of Immunology
  36. Roles of intestinal epithelial cells in the maintenance of gut homeostasis (2017)
    Ryu Okumura, Kiyoshi Takeda Experimental & Molecular Medicine
  37. Interaction Between the Microbiota, Epithelia, and Immune Cells in the Intestine (2020)
    Hisako Kayama, Ryu Okumura et al. Annual Review of Immunology
  38. Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine (2016)
    Yuichi Maeda, Takashi Kurakawa et al. Arthritis & Rheumatology
  39. Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation (2014)
    Masanori Matsumoto, Akemi Baba et al. Immunity

Immediate Impact

74 by Nobel laureates 155 from Science/Nature 408 standout
Sub-graph 1 of 15

Citing Papers

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2021 Standout
The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients
2018 StandoutScience
1 intermediate paper

Works of Kiyoshi Takeda being referenced

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
2010 StandoutScience
Toll-like receptor signalling
2004 Standout

Author Peers

Author Last Decade Papers Cites
Kiyoshi Takeda 56555 27378 14493 454 91.3k
Ruslan Medzhitov 60569 27356 13228 221 95.1k
Osamu Takeuchi 55315 23714 15082 349 80.2k
Gabriel Núñez 33855 47173 10577 407 83.1k
Bruce Beutler 37780 17041 10744 401 63.8k
Charles A. Dinarello 46442 36261 15647 864 106.0k
Taro Kawai 46136 19829 12341 175 65.8k
Siamon Gordon 40753 21755 10477 453 76.9k
Katherine A. Fitzgerald 39041 37056 12136 331 67.9k
Jürg Tschopp 42911 51322 11729 282 86.1k
Luke O'neill 31895 23194 8150 380 59.7k

All Works

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