Standout Papers

Cerebral organoids model human brain develo... 1998 2026 2007 2016 3.5k
  1. Cerebral organoids model human brain development and microcephaly (2013)
    Madeline A. Lancaster, Magdalena Renner et al. Nature
  2. Molecular characterization of mitochondrial apoptosis-inducing factor (1999)
    Santos A. Susín, Hans Kristian Lorenzo et al. Nature
  3. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis (1999)
    Young‐Yun Kong, Hiroki Yoshida et al. Nature
  4. Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN (1998)
    Vuk Stambolic, Akira Suzuki et al. Cell
  5. Angiotensin-converting enzyme 2 protects from severe acute lung failure (2005)
    Yumiko Imai, Keiji Kuba et al. Nature
  6. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target (2020)
    Haibo Zhang, Josef Penninger et al. Intensive Care Medicine
  7. Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2 (2020)
    Vanessa Monteil, Hyesoo Kwon et al. Cell
  8. Angiotensin-converting enzyme 2 is an essential regulator of heart function (2002)
    Michael A. Crackower, Renu Sarao et al. Nature
  9. Evidence for osteocyte regulation of bone homeostasis through RANKL expression (2011)
    Tomoki Nakashima, Mikihito Hayashi et al. Nature Medicine
  10. Mitogen-activated protein kinases in apoptosis regulation (2004)
    Teiji Wada, Josef Penninger Oncogene
  11. Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo (1998)
    Razqallah Hakem, Anne Hakem et al. Cell
  12. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death (2001)
    Nicholas Joza, Santos A. Susín et al. Nature
  13. Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development (1998)
    Hiroki Yoshida, Young‐Yun Kong et al. Cell
  14. RANKL–RANK signaling in osteoclastogenesis and bone disease (2005)
    Teiji Wada, Tomoki Nakashima et al. Trends in Molecular Medicine
  15. Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration (2000)
    Takehiko Sasaki, Junko Irie-Sasaki et al. Science
  16. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN (2006)
    Min Zhao, Bing Song et al. Nature
  17. Heat-shock protein 70 antagonizes apoptosis-inducing factor (2001)
    L Ravagnan, Sandeep Gurbuxani et al. Nature Cell Biology
  18. Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis (2000)
    Éric Daugas, Santos A. Susín et al. The FASEB Journal
  19. RANK-L and RANK: T Cells, Bone Loss, and Mammalian Evolution (2002)
    Lars E. Theill, William J. Boyle et al. Annual Review of Immunology
  20. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4 (2002)
    Nobutaka Suzuki, Shinobu Suzuki et al. Nature
  21. SARS‐coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS (2009)
    Gavin Y. Oudit, Zamaneh Kassiri et al. European Journal of Clinical Investigation
  22. Two Distinct Pathways Leading to Nuclear Apoptosis (2000)
    Santos A. Susín, Éric Daugas et al. The Journal of Experimental Medicine
  23. Regulation of cancer cell migration and bone metastasis by RANKL (2006)
    Tomoki Nakashima, Otto Sánchez et al. Nature
  24. The Osteoclast Differentiation Factor Osteoprotegerin-Ligand Is Essential for Mammary Gland Development (2000)
    Jimmie E. Fata, Young‐Yun Kong et al. Cell
  25. ICOS is essential for effective T-helper-cell responses (2001)
    Agostino Tafuri, Arda Shahinian et al. Nature
  26. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b (2000)
    Kurt Bachmaier, Connie M. Krawczyk et al. Nature
  27. Human blood vessel organoids as a model of diabetic vasculopathy (2019)
    Reiner Wimmer, Alexandra Leopoldi et al. Nature
  28. Temporally Regulated and Tissue-Specific Gene Manipulations in the Adult and Embryonic Heart Using a Tamoxifen-Inducible Cre Protein (2001)
    Mai P. Nghiem, Michael A. Crackower et al. Circulation Research
  29. T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance (2001)
    Akira Suzuki, Toshiaki Ohteki et al. Immunity
  30. Coupling of bone resorption and formation by RANKL reverse signalling (2018)
    Yuki Ikebuchi, Shigeki Aoki et al. Nature
  31. Ferritinophagy and ferroptosis in the management of metabolic diseases (2021)
    Amir Ajoolabady, Peter Libby et al. Trends in Endocrinology and Metabolism
  32. Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics (2021)
    Amir Ajoolabady, Shuyi Wang et al. Pharmacology & Therapeutics
  33. Angiotensin-converting enzyme 2—at the heart of the COVID-19 pandemic (2023)
    Gavin Y. Oudit, Kaiming Wang et al. Cell

Immediate Impact

8 by Nobel laureates 55 from Science/Nature 111 standout
Sub-graph 1 of 21

Citing Papers

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
2020 StandoutScience
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
2020 Standout
13 intermediate papers

Works of Josef Penninger being referenced

Angiotensin-converting enzyme 2 protects from severe acute lung failure
2005 StandoutNature
Angiotensin-converting enzyme 2 is an essential regulator of heart function
2002 StandoutNature
and 12 more

Author Peers

Author Last Decade Papers Cites
Josef Penninger 40322 17755 7859 14525 578 76.7k
Charles A. Dinarello 36261 46442 5141 11690 864 106.0k
Nahum Sonenberg 75137 8932 9874 6966 664 94.7k
Carl Nathan 23625 21985 3038 4977 316 72.0k
Tadamitsu Kishimoto 21971 33603 2628 25455 633 76.3k
Simon C. Watkins 27957 12746 3855 5655 779 58.2k
George D. Yancopoulos 54500 15739 6777 14103 425 101.4k
Ira Pastan 45198 20106 1242 29761 1.2k 89.2k
Nico van Rooijen 21141 37722 2223 9854 836 79.3k
Anthony Cerami 18668 20595 3634 6477 513 75.8k
Christian Weber 22208 22205 7817 8770 1.1k 67.8k

All Works

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2026