Standout Papers

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal n... 2007 2026 2013 2019 5.0k
  1. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche (2009)
    Toshiro Sato, Robert G.J. Vries et al. Nature
  2. Identification of stem cells in small intestine and colon by marker gene Lgr5 (2007)
    Nick Barker, Johan H. van Es et al. Nature
  3. Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium (2011)
    Toshiro Sato, Daniel E. Stange et al. Gastroenterology
  4. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts (2010)
    Toshiro Sato, Johan H. van Es et al. Nature
  5. Crypt stem cells as the cells-of-origin of intestinal cancer (2008)
    Nick Barker, Rachel A. Ridgway et al. Nature
  6. Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells (2010)
    Hugo J.G. Snippert, Laurens G. van der Flier et al. Cell
  7. Caught up in a Wnt storm: Wnt signaling in cancer (2003)
    Rachel H. Giles, Johan H. van Es et al. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  8. Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells (2005)
    Johan H. van Es, Mariëlle van Gijn et al. Nature
  9. Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro (2010)
    Nick Barker, Meritxell Huch et al. Cell stem cell
  10. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration (2013)
    Meritxell Huch, Craig Dorrell et al. Nature
  11. Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF (1997)
    Marc van de Wetering, Rossana Cavallo et al. Cell
  12. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling (2011)
    Wim de Lau, Nick Barker et al. Nature
  13. Lineage Tracing Reveals Lgr5 + Stem Cell Activity in Mouse Intestinal Adenomas (2012)
    Arnout Schepers, Hugo J.G. Snippert et al. Science
  14. Lgr5 marks cycling, yet long-lived, hair follicle stem cells (2008)
    Viljar Jaks, Nick Barker et al. Nature Genetics
  15. Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors (2012)
    Bon‐Kyoung Koo, Maureen Spit et al. Nature
  16. De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse Intestine (2004)
    Anna-Pavlina G. Haramis, Harry Begthel et al. Science
  17. Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin (2010)
    Hugo J.G. Snippert, Andrea Haegebarth et al. Science
  18. Dll1+ secretory progenitor cells revert to stem cells upon crypt damage (2012)
    Johan H. van Es, Toshiro Sato et al. Nature Cell Biology
  19. Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids (2018)
    Huili Hu, Helmuth Gehart et al. Cell
  20. The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers (2012)
    Javier Muñoz, Daniel E. Stange et al. The EMBO Journal
  21. Mutations in the APC tumour suppressor gene cause chromosomal instability (2001)
    Riccardo Fodde, Jeroen Kuipers et al. Nature Cell Biology
  22. Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate (2009)
    Laurens G. van der Flier, Mariëlle van Gijn et al. Cell
  23. Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis (2013)
    Meritxell Huch, Paola Bonfanti et al. The EMBO Journal
  24. Wnt signalling induces maturation of Paneth cells in intestinal crypts (2005)
    Johan H. van Es, Philippe Jay et al. Nature Cell Biology
  25. Redundant Sources of Wnt Regulate Intestinal Stem Cells and Promote Formation of Paneth Cells (2012)
    Henner F. Farin, Johan H. van Es et al. Gastroenterology
  26. Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny (2013)
    Xiaolei Yin, Henner F. Farin et al. Nature Methods
  27. Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters (2016)
    Paul W. Tetteh, Onur Başak et al. Cell stem cell
  28. Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer (2015)
    Lukas E. Dow, Kevin P. O’Rourke et al. Cell
  29. Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium (2013)
    Daniel E. Stange, Bon‐Kyoung Koo et al. Cell
  30. De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data (2016)
    Dominic Grün, Mauro J. Muraro et al. Cell stem cell
  31. Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27 Kip1 and p57 Kip2 (2008)
    Orbicia Riccio, Mariëlle van Gijn et al. EMBO Reports

Immediate Impact

10 by Nobel laureates 89 from Science/Nature 167 standout
Sub-graph 1 of 14

Citing Papers

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 Standout
A human liver cell atlas reveals heterogeneity and epithelial progenitors
2019 StandoutNature
6 intermediate papers

Works of Johan H. van Es being referenced

De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data
2016 Standout
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
2013 StandoutNature
and 9 more

Author Peers

Author Last Decade Papers Cites
Johan H. van Es 22781 17434 7848 127 40.6k
Nick Barker 23635 14949 6728 117 38.1k
Marc van de Wetering 20452 12738 6079 83 32.3k
Toshiro Sato 11879 12091 5420 234 27.5k
Anita B. Roberts 31347 10283 5685 286 52.9k
Rik Derynck 38504 17119 5122 209 56.2k
Sean J. Morrison 31942 21386 3302 181 61.2k
Peter ten Dijke 40183 12336 4473 483 56.5k
Harold L. Moses 24171 14456 3544 311 40.1k
Christer Betsholtz 28465 7736 3327 321 51.5k
Roel Nusse 43096 7708 7953 206 54.4k

All Works

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2026