Standout Papers

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular ... 1994 2026 2004 2015 5.0k
  1. Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins (1994)
    James Darnell, George R. Stark et al. Science
  2. STATs and Gene Regulation (1997)
    James Darnell Science
  3. STATs: transcriptional control and biological impact (2002)
    David T. Levy, James Darnell Nature Reviews Molecular Cell Biology
  4. Stat3 as an Oncogene (1999)
    Jacqueline Bromberg, Geeta Devgan et al. Cell
  5. Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6 (1994)
    Zhong Zhong, Zilong Wen et al. Science
  6. Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation (1995)
    Zilong Wen, Zhong Zhong et al. Cell
  7. TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway (1995)
    Christian Schindler, James Darnell Annual Review of Biochemistry
  8. The JAK-STAT Pathway at Twenty (2012)
    George R. Stark, James Darnell Immunity
  9. The role of STATs in transcriptional control and their impact on cellular function (2000)
    Jacqueline Bromberg, James Darnell Oncogene
  10. Transcription factors as targets for cancer therapy (2002)
    James Darnell Nature reviews. Cancer
  11. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. (1990)
    Frances M. Sladek, Weimin Zhong et al. Genes & Development
  12. Sedimentation characteristics of rapidly labelled RNA from HeLa cells (1962)
    Klaus Scherrer, James Darnell Biochemical and Biophysical Research Communications
  13. Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice (1996)
    Christian Vaisse, Jeffrey L. Halaas et al. Nature Genetics
  14. Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors (1995)
    Neil Stahl, Thomas J. Farruggella et al. Science
  15. Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor (1992)
    Chris Schindler, Ke Shuai et al. Science
  16. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions (1994)
    Ke Shuai, Curt M. Horvath et al. Cell
  17. A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ (1993)
    Ke Shuai, George R. Stark et al. Science
  18. Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein (1992)
    Ke Shuai, Chris Schindler et al. Science
  19. The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo (1994)
    Daniel C. Weinstein, Ariel Ruiz i Altaba et al. Cell
  20. A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation (2015)
    Shengdong Ke, Endalkachew A. Alemu et al. Genes & Development
  21. Variety in the level of gene control in eukaryotic cells (1982)
    James Darnell Nature
  22. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. (1995)
    Susanne J. Szabo, R Weber-Nordt et al. The Journal of Experimental Medicine
  23. Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA (1998)
    Xiaohong Chen, Uwe Vinkemeier et al. Cell
  24. Stat3 Activation Is Required for Cellular Transformation by v-src (1998)
    Jacqueline Bromberg, Curt M. Horvath et al. Molecular and Cellular Biology
  25. Transcriptional control in the production of liver-specific mRNAs (1981)
    Eva Derman, Kenneth Krauter et al. Cell
  26. Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control. (1988)
    David T. Levy, Daniel S. Kessler et al. Genes & Development
  27. Polyadenylic Acid Sequences: Role in Conversion of Nuclear RNA into Messenger RNA (1971)
    James Darnell, Lennart Philipson et al. Science
  28. m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover (2017)
    Shengdong Ke, Amy Pandya‐Jones et al. Genes & Development
  29. Rapidly labeled HeLa cell nuclear RNA (1966)
    Jonathan R. Warner, Ruy Soeiro et al. Journal of Molecular Biology
  30. POLYRIBOSOMES IN NORMAL AND POLIOVIRUS-INFECTED HELA CELLS AND THEIR RELATIONSHIP TO MESSENGER-RNA (1963)
    Sheldon Penman, Klaus Scherrer et al. Proceedings of the National Academy of Sciences
  31. The JAK-STAT pathway at 30: Much learned, much more to do (2022)
    Rachael L. Philips, Yuxin Wang et al. Cell

Immediate Impact

40 by Nobel laureates 61 from Science/Nature 127 standout
Sub-graph 1 of 19

Citing Papers

Modular regulatory principles of large non-coding RNAs
2012 StandoutNature
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
5 intermediate papers

Works of James Darnell being referenced

Transcriptional induction by interferon. New protein(s) determine the extent and length of the induction.
1986
Transcriptional induction of two genes in human cells by beta interferon.
1984
and 12 more

Author Peers

Author Last Decade Papers Cites
James Darnell 40025 30620 22541 356 72.5k
George R. Stark 27625 20780 19709 349 54.4k
Ira Pastan 45198 29761 20106 1.2k 89.2k
Robert D. Schreiber 20381 33142 47711 378 78.3k
Tak W. Mak 49026 22375 33684 703 94.7k
John C. Reed 72596 21174 20246 788 106.2k
Shigekazu Nagata 41993 10748 32653 608 75.6k
Tadatsugu Taniguchi 22536 18660 34406 284 57.9k
Vishva M. Dixit 61633 12826 32645 312 86.9k
Tony Hunter 77156 23136 11765 502 103.0k
Stanley J. Korsmeyer 59060 15203 15078 230 83.2k

All Works

Loading papers...

Rankless by CCL
2026