Standout Papers

Stress-Dependent Regulation of FOXO Transcription Factors by the... 1994 2026 2004 2015 2.7k
  1. Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase (2004)
    Anne Brunet, Lora B. Sweeney et al. Science
  2. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation (2010)
    Matthew D. Hirschey, Tadahiro Shimazu et al. Nature
  3. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy (2008)
    In Hye Lee, Liu Cao et al. Proceedings of the National Academy of Sciences
  4. An early haematopoietic defect in mice lacking the transcription factor GATA-2 (1994)
    Fong‐Ying Tsai, Gordon Keller et al. Nature
  5. SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation (2008)
    Gad Asher, David Gatfield et al. Cell
  6. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α (2007)
    Zachary Gerhart‐Hines, Joseph T. Rodgers et al. The EMBO Journal
  7. Plasma cell differentiation requires the transcription factor XBP-1 (2001)
    Andreas Reimold, Neal N. Iwakoshi et al. Nature
  8. Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation (2007)
    David B. Lombard, Frederick W. Alt et al. Molecular and Cellular Biology
  9. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. (1996)
    Merja Lakso, José G. Pichel et al. Proceedings of the National Academy of Sciences
  10. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice (2003)
    Hwei-Ling Cheng, Raúl Mostoslavsky et al. Proceedings of the National Academy of Sciences
  11. SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells (2006)
    Marcia C. Haigis, Raúl Mostoslavsky et al. Cell
  12. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment (1995)
    Dennis M. Willerford, Jianzhu Chen et al. Immunity
  13. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation (1995)
    T Blunt, Guillermo E. Taccioli et al. Cell
  14. DNA Repair, Genome Stability, and Aging (2005)
    David B. Lombard, Katrin F. Chua et al. Cell
  15. The Mechanism and Regulation of Chromosomal V(D)J Recombination (2002)
    Craig H. Bassing, Wojciech Swat et al. Cell
  16. SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging (2008)
    Philipp Oberdoerffer, Shaday Michán et al. Cell
  17. Ordered rearrangement of immunoglobulin heavy chain variable region segments. (1984)
    Frederick W. Alt, George D. Yancopoulos et al. The EMBO Journal
  18. Transcription-targeted DNA deamination by the AID antibody diversification enzyme (2003)
    Jayanta Chaudhuri, Ming Tian et al. Nature
  19. Transposition and amplification of oncogene-related sequences in human neuroblastomas (1983)
    Nancy E. Kohl, Naotoshi Kanda et al. Cell
  20. The T Cell Leukemia Oncoprotein SCL/tal-1 Is Essential for Development of All Hematopoietic Lineages (1996)
    Catherine Porcher, Wojciech Swat et al. Cell
  21. Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination (1994)
    Guillermo E. Taccioli, Tanya Gottlieb et al. Science
  22. Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines (1984)
    George D. Yancopoulos, Stephen Desiderio et al. Nature
  23. The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo (1996)
    Qing Wang, Terryl Stacy et al. Cell
  24. Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α (1999)
    Roberta Buono, Scott B. Snapper et al. Science
  25. Development of the Primary Antibody Repertoire (1987)
    Frederick W. Alt, T. Keith Blackwell et al. Science
  26. Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases (2014)
    Richard L. Frock, Jiazhi Hu et al. Nature Biotechnology
  27. SIRT1 controls endothelial angiogenic functions during vascular growth (2007)
    Michael Potente, Danila Baldessari et al. Genes & Development
  28. Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3′ ends (1980)
    Frederick W. Alt Cell
  29. Differential expression of myc family genes during murine development (1986)
    Kathryn A. Zimmerman, George D. Yancopoulos et al. Nature
  30. Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies (2022)
    Barton F. Haynes, Kevin Wiehe et al. Nature reviews. Immunology

Immediate Impact

45 by Nobel laureates 82 from Science/Nature 145 standout
Sub-graph 1 of 18

Citing Papers

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
2016 StandoutNature
In vivo genome editing using Staphylococcus aureus Cas9
2015 StandoutNature

Works of Frederick W. Alt being referenced

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
2014 Standout

Author Peers

Author Last Decade Papers Cites
Frederick W. Alt 26758 41129 12296 482 72.9k
George D. Yancopoulos 15739 54500 14103 425 101.4k
Ettore Appella 17042 33099 17694 549 54.1k
Roderick T. Bronson 11362 45554 22954 543 76.8k
Ronald A. DePinho 9669 55409 22760 416 84.9k
Tak W. Mak 33684 49026 22375 703 94.7k
Paul Tempst 8945 61550 8205 320 79.9k
Manuel Serrano 5648 30375 12523 268 50.9k
Kun‐Liang Guan 7248 57090 9818 418 87.4k
Pier Paolo Pandolfi 10452 61139 12933 449 79.2k
Stanley J. Korsmeyer 15078 59060 15203 230 83.2k

All Works

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