Standout Papers

Targeting the Raf-MEK-ERK mitogen-activated protein kinase ca... 1997 2026 2006 2016 2.2k
  1. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer (2007)
    Patrick J. Roberts, Channing J. Der Oncogene
  2. Drugging the undruggable RAS: Mission Possible? (2014)
    Adrienne D. Cox, Stephen W. Fesik et al. Nature Reviews Drug Discovery
  3. GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors (2005)
    Kent L. Rossman, Channing J. Der et al. Nature Reviews Molecular Cell Biology
  4. Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts (1997)
    Kaikobad Irani, Yong Xia et al. Science
  5. The Ras superfamily at a glance (2005)
    Krister Wennerberg, Kent L. Rossman et al. Journal of Cell Science
  6. Increasing complexity of Ras signaling (1998)
    Sharon L. Campbell, Roya Khosravi‐Far et al. Oncogene
  7. p21ras is modified by a farnesyl isoprenoid. (1989)
    Patrick J. Casey, Patricia A. Solski et al. Proceedings of the National Academy of Sciences
  8. Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K (1997)
    John Westwick, Ian P. Whitehead et al. Nature
  9. Understanding Ras: ‘it ain’t over ’til it’s over’ (2000)
    Kevin Pruitt, Aidan J. McFall et al. Trends in Cell Biology
  10. RAS isoforms and mutations in cancer at a glance (2016)
    G. Aaron Hobbs, Channing J. Der et al. Journal of Cell Science
  11. Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? (2010)
    Dominico Vigil, Jacqueline Cherfils et al. Nature reviews. Cancer
  12. Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. (1982)
    Channing J. Der, Theodore G. Krontiris et al. Proceedings of the National Academy of Sciences
  13. Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation (1995)
    Roya Khosravi‐Far, Patricia A. Solski et al. Molecular and Cellular Biology
  14. KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer (2017)
    Andrew M. Waters, Channing J. Der Cold Spring Harbor Perspectives in Medicine
  15. BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein (1993)
    Ann Marie Pendergast, Lawrence A. Quilliam et al. Cell
  16. Ras history (2010)
    Adrienne D. Cox, Channing J. Der Small GTPases
  17. KRAS: feeding pancreatic cancer proliferation (2014)
    Kirsten L. Bryant, Joseph D. Mancias et al. Trends in Biochemical Sciences

Immediate Impact

33 by Nobel laureates 158 from Science/Nature 154 standout
Sub-graph 1 of 13

Citing Papers

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Comprehensive genomic characterization of head and neck squamous cell carcinomas
2015 StandoutNature
10 intermediate papers

Works of Channing J. Der being referenced

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
2010 Standout
Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras
1997 Science
and 24 more

Author Peers

Author Last Decade Papers Cites
Channing J. Der 35801 12591 10541 403 47.7k
Julian Downward 29860 11325 5875 289 41.2k
Frank McCormick 42325 14260 9298 376 56.7k
Meenhard Herlyn 26134 16922 6633 539 42.2k
Walter Birchmeier 30481 8343 6442 240 41.9k
Joan S. Brugge 25405 10106 9464 258 41.4k
Mariano Barbacid 30539 14700 6107 262 51.4k
Johannes L. Bos 25358 11047 4812 244 39.3k
Richard G. Pestell 32954 15007 8201 459 49.3k
Dario R. Alessi 50134 7625 10045 308 64.7k
Lena Claesson‐Welsh 22006 6841 4782 253 31.8k

All Works

Loading papers...

Rankless by CCL
2026