Standout Papers

Alzheimer's disease 1998 2026 2007 2016 2.3k
  1. Alzheimer's disease (2016)
    Philip Scheltens, Kaj Blennow et al. The Lancet
  2. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain (1999)
    Bart De Strooper, Wim Annaert et al. Nature
  3. The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics (2011)
    Eric Karran, Marc Mercken et al. Nature Reviews Drug Discovery
  4. The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes (2012)
    Iryna Benilova, Eric Karran et al. Nature Neuroscience
  5. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein (1998)
    Bart De Strooper, Paul Säftig et al. Nature
  6. OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion (2006)
    Christian Frezza, Sara Cipolat et al. Cell
  7. The Cellular Phase of Alzheimer’s Disease (2016)
    Bart De Strooper, Eric Karran Cell
  8. Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons (1998)
    Mikael Simons, Patrick Keller et al. Proceedings of the National Academy of Sciences
  9. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression (2008)
    Sébastien S. Hébert, Katrien Horré et al. Proceedings of the National Academy of Sciences
  10. Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex (2003)
    Bart De Strooper Neuron
  11. The secretases: enzymes with therapeutic potential in Alzheimer disease (2010)
    Bart De Strooper, Robert Vassar et al. Nature Reviews Neurology
  12. Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling (2006)
    Sara Cipolat, Dieter Hartmann et al. Cell
  13. Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations (2006)
    Huiping Tu, Omar L. Nelson et al. Cell
  14. ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and β-catenin translocation (2005)
    Thorsten Maretzky, Karina Reiß et al. Proceedings of the National Academy of Sciences
  15. Control of Peripheral Nerve Myelination by the ß-Secretase BACE1 (2006)
    Michael Willem, Alistair N. Garratt et al. Science
  16. The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques (2019)
    Carlo Sala Frigerio, Leen Wolfs et al. Cell Reports
  17. APP mouse models for Alzheimer's disease preclinical studies (2017)
    Hiroki Sasaguri, Per Nilsson et al. The EMBO Journal
  18. The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics (2022)
    Eric Karran, Bart De Strooper Nature Reviews Drug Discovery
  19. Pyroptosis in Alzheimer’s disease: cell type-specific activation in microglia, astrocytes and neurons (2022)
    Marta J. Koper, Evelien Van Schoor et al. Acta Neuropathologica
  20. MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease (2023)
    Sriram Balusu, Katrien Horré et al. Science
  21. Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology (2024)
    Renzo Mancuso, Nicola Fattorelli et al. Nature Neuroscience

Immediate Impact

11 by Nobel laureates 94 from Science/Nature 263 standout
Sub-graph 1 of 15

Citing Papers

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2024 StandoutNature
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81 intermediate papers

Works of Bart De Strooper being referenced

OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
2006 Standout
Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling
2006 Standout
and 78 more

Author Peers

Author Last Decade Papers Cites
Bart De Strooper 27579 26248 9032 382 50.4k
Rudolph E. Tanzi 31996 22518 8915 474 56.2k
Christian Haass 29329 23797 9602 383 49.1k
Takaomi C. Saido 19264 16107 8067 498 35.4k
Konrad Beyreuther 26704 20903 6464 436 40.5k
Todd E. Golde 18492 14019 5617 312 31.5k
Sangram S. Sisodia 20551 15619 8318 236 33.0k
William R. Markesbery 21881 16818 5689 402 49.0k
Takeshi Iwatsubo 22599 14628 10187 454 40.6k
Guojun Bu 14461 11785 4546 334 29.9k
Frank M. LaFerla 22863 12862 9987 247 36.0k

All Works

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