Yugesh Kharel

1.5k total citations
36 papers, 1.2k citations indexed

About

Yugesh Kharel is a scholar working on Molecular Biology, Cell Biology and Organic Chemistry. According to data from OpenAlex, Yugesh Kharel has authored 36 papers receiving a total of 1.2k indexed citations (citations by other indexed papers that have themselves been cited), including 36 papers in Molecular Biology, 16 papers in Cell Biology and 6 papers in Organic Chemistry. Recurrent topics in Yugesh Kharel's work include Sphingolipid Metabolism and Signaling (32 papers), Lipid Membrane Structure and Behavior (14 papers) and Cellular transport and secretion (11 papers). Yugesh Kharel is often cited by papers focused on Sphingolipid Metabolism and Signaling (32 papers), Lipid Membrane Structure and Behavior (14 papers) and Cellular transport and secretion (11 papers). Yugesh Kharel collaborates with scholars based in United States and Japan. Yugesh Kharel's co-authors include Kevin R. Lynch, Webster L. Santos, Tanetoshi Koyama, Timothy L. Macdonald, Jose L. Tomsig, Mithun Raje, Thomas P. Mathews, Perry Kennedy, Ashley H. Snyder and Ming Gao and has published in prestigious journals such as Journal of Biological Chemistry, PLoS ONE and Analytical Biochemistry.

In The Last Decade

Yugesh Kharel

35 papers receiving 1.2k citations

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Yugesh Kharel United States 20 1.1k 357 146 116 112 36 1.2k
Marina Y. Pushkareva United States 8 894 0.8× 188 0.5× 46 0.3× 153 1.3× 145 1.3× 10 1.0k
Francisco Iñesta-Vaquera United Kingdom 12 655 0.6× 124 0.3× 66 0.5× 152 1.3× 100 0.9× 19 997
James I. Fells United States 18 717 0.7× 201 0.6× 61 0.4× 81 0.7× 59 0.5× 27 848
Renae K. Barr Australia 11 676 0.6× 136 0.4× 74 0.5× 117 1.0× 94 0.8× 17 971
Sumeer Dhar Sweden 17 450 0.4× 76 0.2× 71 0.5× 96 0.8× 69 0.6× 28 780
Alban Girault France 16 648 0.6× 95 0.3× 55 0.4× 42 0.4× 65 0.6× 28 949
Daniel Stafford United States 8 546 0.5× 257 0.7× 143 1.0× 70 0.6× 40 0.4× 10 764
N Kajikawa Japan 9 610 0.6× 284 0.8× 71 0.5× 96 0.8× 82 0.7× 14 909
Charles A. Berdan United States 11 436 0.4× 144 0.4× 55 0.4× 129 1.1× 36 0.3× 12 742

Countries citing papers authored by Yugesh Kharel

Since Specialization
Citations

This map shows the geographic impact of Yugesh Kharel's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Yugesh Kharel with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Yugesh Kharel more than expected).

Fields of papers citing papers by Yugesh Kharel

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Yugesh Kharel. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Yugesh Kharel. The network helps show where Yugesh Kharel may publish in the future.

Co-authorship network of co-authors of Yugesh Kharel

This figure shows the co-authorship network connecting the top 25 collaborators of Yugesh Kharel. A scholar is included among the top collaborators of Yugesh Kharel based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Yugesh Kharel. Yugesh Kharel is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Kharel, Yugesh, et al.. (2024). Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors. Journal of Medicinal Chemistry. 67(13). 11273–11295. 1 indexed citations
2.
Kharel, Yugesh, et al.. (2023). 2-Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2). Journal of Medicinal Chemistry. 66(8). 5873–5891. 5 indexed citations
3.
Kharel, Yugesh, Tao Huang, Webster L. Santos, & Kevin R. Lynch. (2023). Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors. SLAS DISCOVERY. 28(6). 284–287. 2 indexed citations
4.
Kharel, Yugesh, et al.. (2023). Imidazole-based sphingosine-1-phosphate transporter Spns2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 96. 129516–129516. 1 indexed citations
5.
Tanaka, Shinji, Shuqiu Zheng, Yugesh Kharel, et al.. (2022). Sphingosine 1-phosphate signaling in perivascular cells enhances inflammation and fibrosis in the kidney. Science Translational Medicine. 14(658). eabj2681–eabj2681. 35 indexed citations
6.
Fritzemeier, Russell G., et al.. (2022). Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors. Journal of Medicinal Chemistry. 65(11). 7656–7681. 16 indexed citations
7.
Pashikanti, Srinath, Yugesh Kharel, Anne M. Brown, et al.. (2022). Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues. PubMed. 2(5). 469–489. 5 indexed citations
8.
Fritzemeier, Russell G., Yugesh Kharel, Anne M. Brown, et al.. (2020). Probing the substitution pattern of indole-based scaffold reveals potent and selective sphingosine kinase 2 inhibitors. European Journal of Medicinal Chemistry. 212. 113121–113121. 6 indexed citations
9.
Sibley, Christopher D., Yugesh Kharel, Anne M. Brown, et al.. (2020). Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity. Journal of Medicinal Chemistry. 63(3). 1178–1198. 15 indexed citations
10.
Sibley, Christopher D., Yugesh Kharel, Tao Huang, et al.. (2020). Lipophilic tail modifications of 2-(hydroxymethyl)pyrrolidine scaffold reveal dual sphingosine kinase 1 and 2 inhibitors. Bioorganic & Medicinal Chemistry. 30. 115941–115941. 13 indexed citations
11.
Kharel, Yugesh, Tao Huang, Anita Salamon, et al.. (2020). Mechanism of sphingosine 1-phosphate clearance from blood. Biochemical Journal. 477(5). 925–935. 28 indexed citations
12.
Kharel, Yugesh, Sayeh Agah, Tao Huang, et al.. (2018). Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors. PLoS ONE. 13(4). e0192179–e0192179. 6 indexed citations
13.
Cao, Rui, Jun Li, Yugesh Kharel, et al.. (2018). Photoacoustic microscopy reveals the hemodynamic basis of sphingosine 1-phosphate-induced neuroprotection against ischemic stroke. Theranostics. 8(22). 6111–6120. 33 indexed citations
14.
Childress, Elizabeth S., et al.. (2015). Structure–activity relationship studies of the lipophilic tail region of sphingosine kinase 2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 25(21). 4956–4960. 15 indexed citations
15.
Kharel, Yugesh, et al.. (2015). Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels. Journal of Pharmacology and Experimental Therapeutics. 355(1). 23–31. 58 indexed citations
16.
Mathews, Thomas P., Andrew Kennedy, Yugesh Kharel, et al.. (2010). Discovery, Biological Evaluation, and Structure−Activity Relationship of Amidine Based Sphingosine Kinase Inhibitors. Journal of Medicinal Chemistry. 53(7). 2766–2778. 55 indexed citations
17.
Foss, Frank W., Thomas P. Mathews, Yugesh Kharel, et al.. (2009). Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs. Bioorganic & Medicinal Chemistry. 17(16). 6123–6136. 27 indexed citations
18.
Kharel, Yugesh, Seiji Takahashi, Satoshi Yamashita, & Tanetoshi Koyama. (2006). Manipulation of prenyl chain length determination mechanism of cis‐prenyltransferases. FEBS Journal. 273(3). 647–657. 51 indexed citations
19.
Kharel, Yugesh & Tanetoshi Koyama. (2002). Molecular analysis of cis-prenyl chain elongating enzymes. Natural Product Reports. 20(1). 111–118. 70 indexed citations
20.
Kharel, Yugesh, Yuan‐Wei Zhang, M. Fujihashi, Kunio Miki, & Tanetoshi Koyama. (2001). Identification of Significant Residues for Homoallylic Substrate Binding of Micrococcus luteus B-P 26 Undecaprenyl Diphosphate Synthase. Journal of Biological Chemistry. 276(30). 28459–28464. 32 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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