X. Sunney Xie

38.4k total citations · 13 hit papers
184 papers, 27.9k citations indexed

About

X. Sunney Xie is a scholar working on Biophysics, Molecular Biology and Biomedical Engineering. According to data from OpenAlex, X. Sunney Xie has authored 184 papers receiving a total of 27.9k indexed citations (citations by other indexed papers that have themselves been cited), including 104 papers in Biophysics, 63 papers in Molecular Biology and 40 papers in Biomedical Engineering. Recurrent topics in X. Sunney Xie's work include Spectroscopy Techniques in Biomedical and Chemical Research (87 papers), Advanced Fluorescence Microscopy Techniques (53 papers) and Spectroscopy and Chemometric Analyses (31 papers). X. Sunney Xie is often cited by papers focused on Spectroscopy Techniques in Biomedical and Chemical Research (87 papers), Advanced Fluorescence Microscopy Techniques (53 papers) and Spectroscopy and Chemometric Analyses (31 papers). X. Sunney Xie collaborates with scholars based in United States, China and United Kingdom. X. Sunney Xie's co-authors include Ji‐Xin Cheng, Gary R. Holtom, Conor L. Evans, Wei Min, Christian W. Freudiger, Gene‐Wei Li, S. C. Kou, Brian G. Saar, Eric O. Potma and Sijia Lü and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

X. Sunney Xie

180 papers receiving 27.1k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Label-Free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy

2008 1.6k citations Sijia Lü, Gary R. Holtom et al. Science profile →
Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells

2010 1.5k citations Yuichi Taniguchi, Paul Choi et al. Science profile →
Three-Dimensional Vibrational Imaging by Coherent Anti-Stokes Raman Scattering

1999 1.2k citations Andreas Zumbusch, Gary R. Holtom et al. profile →
Coherent Anti-Stokes Raman Scattering Microscopy: Chemical Imaging for Biology and Medicine

2008 890 citations X. Sunney Xie et al. profile →
Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy

2005 759 citations Eric O. Potma, Charles P. Lin et al. Proceedings of the National Academy of Sciences profile →
Coherent Anti-Stokes Raman Scattering Microscopy: Instrumentation, Theory, and Applications

2003 705 citations X. Sunney Xie et al. profile →
Probing Gene Expression in Live Cells, One Protein Molecule at a Time

2006 685 citations Ji Yu, Jie Xiao et al. Science profile →
Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering

2010 640 citations Gary R. Holtom, X. Sunney Xie et al. Science profile →
Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited

2005 612 citations X. Sunney Xie et al. profile →
Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine

2015 596 citations X. Sunney Xie et al. Science profile →
Coherent Nonlinear Optical Imaging: Beyond Fluorescence Microscopy

2011 459 citations Sijia Lü, X. Sunney Xie et al. profile →
Single-molecule imaging of transcription factor binding to DNA in live mammalian cells

2013 389 citations Alec R. Chapman, X. Sunney Xie et al. profile →
Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells

2016 287 citations X. Sunney Xie, Fan Bai et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
X. Sunney Xie United States	82	14.7k	10.8k	6.2k	5.9k	4.5k	184	27.9k
Enrico Gratton United States	109	9.7k 0.7×	20.7k 1.9×	9.4k 1.5×	509 0.1×	5.2k 1.2×	723	40.5k
Michael S. Feld United States	92	11.6k 0.8×	5.5k 0.5×	15.0k 2.4×	4.6k 0.8×	12.0k 2.7×	436	36.8k
Ramachandra R. Dasari United States	72	8.6k 0.6×	5.3k 0.5×	12.4k 2.0×	2.9k 0.5×	7.3k 1.6×	228	25.7k
Richard R. Ernst Switzerland	93	6.0k 0.4×	18.2k 1.7×	890 0.1×	551 0.1×	6.1k 1.4×	307	47.5k
Richard A. Mathies United States	102	3.2k 0.2×	10.9k 1.0×	12.2k 2.0×	687 0.1×	7.3k 1.6×	413	32.9k
Ad Bax United States	131	5.3k 0.4×	61.5k 5.7×	1.2k 0.2×	432 0.1×	4.0k 0.9×	464	89.2k
Petra Schwille Germany	85	6.2k 0.4×	20.9k 1.9×	5.2k 0.8×	270 0.0×	3.2k 0.7×	391	28.7k
Stefan W. Hell Germany	117	29.7k 2.0×	17.5k 1.6×	18.0k 2.9×	181 0.0×	9.0k 2.0×	480	51.8k
Thomas M. Jovin Germany	73	2.1k 0.1×	11.8k 1.1×	1.8k 0.3×	383 0.1×	957 0.2×	298	19.4k
Andrew Dalke United States	9	640 0.0×	26.7k 2.5×	5.9k 1.0×	597 0.1×	5.1k 1.1×	13	56.0k

Countries citing papers authored by X. Sunney Xie

Since Specialization

Citations

This map shows the geographic impact of X. Sunney Xie's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by X. Sunney Xie with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites X. Sunney Xie more than expected).

Fields of papers citing papers by X. Sunney Xie

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by X. Sunney Xie. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by X. Sunney Xie. The network helps show where X. Sunney Xie may publish in the future.

Co-authorship network of co-authors of X. Sunney Xie

This figure shows the co-authorship network connecting the top 25 collaborators of X. Sunney Xie. A scholar is included among the top collaborators of X. Sunney Xie based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with X. Sunney Xie. X. Sunney Xie is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Yao, Jialin, et al.. (2025). Characterization of humidity sensing based on optical microbubble resonators. Optics Express. 33(17). 36632–36632. 1 indexed citations

Hu, Chaoying, Jinxia Chen, X. Sunney Xie, et al.. (2024). Safety and Intranasal Retention of a Broad-Spectrum Anti-SARS-CoV-2 Monoclonal Antibody SA55 Nasal Spray in Healthy Volunteers: A Phase I Clinical Trial. Pharmaceutics. 17(1). 43–43. 2 indexed citations

Bashkirova, Elizaveta, Kevin D. Monahan, Christine Campbell, et al.. (2023). Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice. eLife. 12. 12 indexed citations

Oh, Seungeun, ChangHee Lee, Wenlong Yang, et al.. (2022). Protein and lipid mass concentration measurement in tissues by stimulated Raman scattering microscopy. Proceedings of the National Academy of Sciences. 119(17). e2117938119–e2117938119. 71 indexed citations

Wu, Wanqing, Longzhi Tan, Cheng Tang, et al.. (2021). Coordination of two enhancers drives expression of olfactory trace amine-associated receptors. Nature Communications. 12(1). 3798–3798. 15 indexed citations

Lu, Fake, David Calligaris, Olutayo I. Olubiyi, et al.. (2016). Label-Free Neurosurgical Pathology with Stimulated Raman Imaging. Cancer Research. 76(12). 3451–3462. 120 indexed citations

Wang, Siyuan, Jeffrey R. Moffitt, Graham T. Dempsey, X. Sunney Xie, & Xiaowei Zhuang. (2014). Characterization and development of photoactivatable fluorescent proteins for single-molecule–based superresolution imaging. Proceedings of the National Academy of Sciences. 111(23). 8452–8457. 266 indexed citations

Fu, Dan, Jing Zhou, Paul W. Manley, et al.. (2014). Imaging the intracellular distribution of tyrosine kinase inhibitors in living cells with quantitative hyperspectral stimulated Raman scattering. Nature Chemistry. 6(7). 614–622. 231 indexed citations

Shiroguchi, Katsuyuki, Tony Z. Jia, Peter A. Sims, & X. Sunney Xie. (2012). Digital RNA sequencing minimizes sequence-dependent bias and amplification noise with optimized single-molecule barcodes. Proceedings of the National Academy of Sciences. 109(4). 1347–1352. 193 indexed citations

10.

Lü, Sijia, Chenghang Zong, Wei Fan, et al.. (2012). Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole-Genome Sequencing. Science. 338(6114). 1627–1630. 230 indexed citations

11.

Lefrançois, Simon, Dan Fu, Gary R. Holtom, et al.. (2012). Fiber four-wave mixing source for coherent anti-Stokes Raman scattering microscopy. Optics Letters. 37(10). 1652–1652. 70 indexed citations

12.

Wang, Wenqin, Gene‐Wei Li, Chongyi Chen, X. Sunney Xie, & Xiaowei Zhuang. (2011). Chromosome Organization by a Nucleoid-Associated Protein in Live Bacteria. Science. 333(6048). 1445–1449. 312 indexed citations

13.

Imitola, Jaime, Stine Rasmussen, X. Sunney Xie, et al.. (2011). Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and axonal dysfunction in multiple sclerosis-like lesions in mice. Journal of Biomedical Optics. 16(2). 21109–21109. 60 indexed citations

14.

Taniguchi, Yuichi, Paul Choi, Gene‐Wei Li, et al.. (2010). Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells. Science. 329(5991). 533–538. 1505 indexed citations breakdown →

15.

Lyn, Rodney K., David C. Kennedy, Selena M. Sagan, et al.. (2009). Direct imaging of the disruption of hepatitis C virus replication complexes by inhibitors of lipid metabolism. Virology. 394(1). 130–142. 50 indexed citations

16.

Choi, Paul, Long Cai, Kirsten L. Frieda, & X. Sunney Xie. (2008). A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell. Science. 322(5900). 442–446. 329 indexed citations

17.

Yu, Ji, Jie Xiao, Xiaojia Ren, Kaiqin Lao, & X. Sunney Xie. (2006). Probing Gene Expression in Live Cells, One Protein Molecule at a Time. Science. 311(5767). 1600–1603. 685 indexed citations breakdown →

18.

Nan, Xiaolin, Eric O. Potma, & X. Sunney Xie. (2006). Nonperturbative Chemical Imaging of Organelle Transport in Living Cells with Coherent Anti-Stokes Raman Scattering Microscopy. Biophysical Journal. 91(2). 728–735. 178 indexed citations

19.

Potma, Eric O. & X. Sunney Xie. (2004). Direct Visualization of Lipid Phase Segregation in Single Lipid Bilayers with Coherent Anti‐Stokes Raman Scattering Microscopy. ChemPhysChem. 6(1). 77–79. 78 indexed citations

20.

Zumbusch, Andreas, et al.. (1999). Three-Dimensional Vibrational Imaging by Coherent Anti-Stokes Raman Scattering. 175. 92–95. 22 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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