X. Edward Guo

12.5k citations

170 papers · 9.8k · 2 hit papers · h-index 57

Impact in

Orthopedics and Sports Medicine top 0.1%
- Bone health and osteoporosis research
- Bone and Joint Diseases
Nephrology top 1%

Papers in

Orthopedics and Sports Medicine 80
- Bone health and osteoporosis research 75
- Bone and Joint Diseases 26
Molecular Biology 61
- Bone Metabolism and Diseases 39

Co-authors: X. Sherry Liu (39 shared papers)Steven A. Goldstein (4 shared papers)C. Edward Hoffler (2 shared papers)Philippe K. Zysset (2 shared papers)Bin Zhou (30 shared papers)Donald J. McMahon (23 shared papers)Tony M. Keaveny (9 shared papers)Gérard Karsenty (11 shared papers)
Journals: Journal of Bone and Mineral Research (26 papers)Bone (12 papers)Journal of Biomechanics (11 papers)The Journal of Clinical Endocrinology & Metabolism (10 papers)Osteoporosis International (5 papers)
Partner nations: United States China United Kingdom

In The Last Decade

X. Edward Guo

162 papers receiving 9.6k citations

X. Edward Guo's Hit Papers

align trajectories log scale

Biomechanics in the tumor microenvironment: from biological functions to potential clinical applications 2025 · 17 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2025 Experimental Hematology and Oncology
1999 Journal of Biomechanics

Peers

Countries citing papers authored by X. Edward Guo

Since Specialization

Citations

This map shows the geographic impact of X. Edward Guo's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by X. Edward Guo with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites X. Edward Guo more than expected).

Fields of papers citing papers by X. Edward Guo

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by X. Edward Guo. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by X. Edward Guo. The network helps show where X. Edward Guo may publish in the future.

Co-authors

The 25 scholars most cited alongside X. Edward Guo, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with X. Edward Guo Line = papers co-authored together X. Edward Guo links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 170 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur Journal of Biomechanics ·Philippe K. Zysset, X. Edward Guo, C. Edward Hoffler, K. E. Moore, Steven A. Goldstein Hit paper breakdown →	1999	758
2	A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure Cell ·Vijay K. Yadav, Franck Oury, Nina Suda, Liu Hon, Xiao‐Bing Gao, Cyrille B. Confavreux, Kristen C. Klemenhagen, Kenji F. Tanaka, Jay A. Gingrich, X. Edward Guo, Laurence H. Tecott, J. John Mann, René Hen, Tamás L. Horváth, Gérard Karsenty	2009	492
3	Engineering anatomically shaped human bone grafts Proceedings of the National Academy of Sciences ·Warren L. Grayson, Mirjam Fröhlich, Keith Yeager, Sarindr Bhumiratana, M. Ete Chan, Christopher Cannizzaro, Leo Q. Wan, X. Sherry Liu, X. Edward Guo, Gordana Vunjak‐Novakovic	2009	310
4	Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis Nature Medicine ·Vijay K. Yadav, Balaji Santhanam, Padmanaban S. Suresh, X. Sherry Liu, Xin Lü, Zhishan Li, X. Edward Guo, J. John Mann, Anil K. Balapure, Michael D. Gershon, R. Medhamurthy, Marc Vidal, Gérard Karsenty, Patricia Ducy	2010	257
5	Trabecular bone exhibits fully linear elastic behavior and yields at low strains Journal of Biomechanics ·Tony M. Keaveny, X. Edward Guo, Edward F. Wachtel, Thomas A. McMahon, Wilson C. Hayes	1994	243
6	Establishing Biomechanical Mechanisms in Mouse Models: Practical Guidelines for Systematically Evaluating Phenotypic Changes in the Diaphyses of Long Bones Journal of Bone and Mineral Research ·Karl J. Jepsen, Matthew J. Silva, Deepak Vashishth, X. Edward Guo, Marjolein C. H. van der Meulen	2015	237
7	The dependence of transversely isotropic elasticity of human femoral cortical bone on porosity Journal of Biomechanics ·Xuesong Dong, X. Edward Guo	2004	226
8	High-resolution peripheral quantitative computed tomography can assess microstructural and mechanical properties of human distal tibial bone Journal of Bone and Mineral Research ·X. Sherry Liu, X Henry Zhang, Kiranjit K Sekhon, Mark F. Adams, Donald J. McMahon, John P. Bilezikian, Elizabeth Shane, X. Edward Guo	2009	195
9	miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2 The Journal of Cell Biology ·Jianwen Wei, Yu Shi, Lihua Zheng, Bin Zhou, Hiroyuki Inose, Ji Wang, X. Edward Guo, Rudolf Grosschedl, Gérard Karsenty	2012	190
10	Adiponectin Regulates Bone Mass via Opposite Central and Peripheral Mechanisms through FoxO1 Cell Metabolism ·Daisuke Kajimura, Ha Won Lee, Kyle J. Riley, Emilio Arteaga‐Solis, Mathieu Ferron, Bin Zhou, Christopher J. Clarke, Yusuf A. Hannun, Ronald A. DePinho, X. Edward Guo, J. John Mann, Gérard Karsenty	2013	183
11	Complete Volumetric Decomposition of Individual Trabecular Plates and Rods and Its Morphological Correlations With Anisotropic Elastic Moduli in Human Trabecular Bone Journal of Bone and Mineral Research ·X. Sherry Liu, Paul Sajda, Punam K. Saha, Félix W. Wehrli, Grant Bevill, Tony M. Keaveny, X. Edward Guo	2007	183
12	An Application of Nanoindentation Technique to Measure Bone Tissue Lamellae Properties Journal of Biomechanical Engineering ·C. Edward Hoffler, X. Edward Guo, Philippe K. Zysset, Steven A. Goldstein	2005	171
13	lincRNA-Cox2 regulates NLRP3 inflammasome and autophagy mediated neuroinflammation Cell Death and Differentiation ·Zhenyi Xue, Zimu Zhang, Hongkun Liu, Wen Li, X. Edward Guo, Zhihui Zhang, Ying Liu, Long Jia, Yan Li, Yinghui Ren, Hongwei Yang, Lijuan Zhang, Qi Zhang, Yurong Da, Junwei Hao, Zhi Yao, Rongxin Zhang	2018	162
14	Bone density, geometry, microstructure, and stiffness: Relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal women Journal of Bone and Mineral Research ·X. Sherry Liu, Adi Cohen, Elizabeth Shane, Perry T. Yin, Emily M. Stein, Halley Rogers, Shannon L Kokolus, Donald J. McMahon, Joan M. Lappe, Robert R. Recker, Thomas Lang, X. Edward Guo	2010	151
15	Trabecular Bone Score (TBS)—A Novel Method to Evaluate Bone Microarchitectural Texture in Patients With Primary Hyperparathyroidism The Journal of Clinical Endocrinology & Metabolism ·Barbara C. Silva, Stéphanie Boutroy, Chiyuan Zhang, Donald J. McMahon, Bin Zhou, Ji Wang, Julia Udesky, Serge Cremers, Marta Sarquis, X. Edward Guo, Didier Hans, John P. Bilezikian	2013	148
16	miR-142-5p regulates tumor cell PD-L1 expression and enhances anti-tumor immunity Biochemical and Biophysical Research Communications ·Long Jia, Qing Xi, Huafeng Wang, Zimu Zhang, Hongkun Liu, Yingnan Cheng, X. Edward Guo, Jieyou Zhang, Qi Zhang, Lijuan Zhang, Zhenyi Xue, Yan Li, Yurong Da, (unknown), Rongxin Zhang	2017	142
17	Mechanical consequence of trabecular bone loss and its treatment: a three-dimensional model simulation Bone ·X. Edward Guo, C.H Kim	2002	141
18	Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures Journal of Bone and Mineral Research ·Emily M. Stein, X. Sherry Liu, Thomas L. Nickolas, Adi Cohen, Valerie M. Thomas, Donald J. McMahon, Chiyuan Zhang, Perry T. Yin, Felicia Cosman, Jeri W. Nieves, X. Edward Guo, Elizabeth Shane	2010	139
19	Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: comparison with transiliac bone biopsy Osteoporosis International ·Adi Cohen, David W. Dempster, Ralph Müller, X. Edward Guo, Thomas L. Nickolas, X. Sherry Liu, Xuanming Zhang, A. Wirth, Harry van Lenthe, Thomas Köhler, Donald J. McMahon, Hua Zhou, Mishaela R. Rubin, John P. Bilezikian, Joan M. Lappe, Robert R. Recker, Elizabeth Shane	2009	133
20	Mechanically induced Ca2+ oscillations in osteocytes release extracellular vesicles and enhance bone formation Bone Research ·Andrea E. Morrell, Genevieve Brown, Samuel T. Robinson, Rachel L. Sattler, Andrew D. Baik, Gehua Zhen, Xu Cao, Lynda F. Bonewald, Weiyang Jin, Lance C. Kam, X. Edward Guo	2018	131

About X. Edward Guo

X. Edward Guo is a scholar working on Orthopedics and Sports Medicine, Molecular Biology, Surgery, Oncology and Biomedical Engineering, having authored 170 papers that have together received 9.8k indexed citations. Recurring topics across this work include Bone health and osteoporosis research (75 papers), Bone Metabolism and Diseases (39 papers), Bone and Joint Diseases (26 papers), Cellular Mechanics and Interactions (20 papers), Bone health and treatments (20 papers), Orthopaedic implants and arthroplasty (14 papers), Medical Imaging Techniques and Applications (10 papers) and Bone Tissue Engineering Materials (9 papers). The work is most often cited by research in Orthopedics and Sports Medicine (3.7k citations), Nephrology (415 citations), Surgery (2.4k citations), Biomedical Engineering (2.2k citations) and Oncology (1.3k citations). X. Edward Guo has collaborated with scholars based in United States, China and United Kingdom. Frequent co-authors include X. Sherry Liu, Steven A. Goldstein, C. Edward Hoffler, Philippe K. Zysset, Bin Zhou, Donald J. McMahon, Tony M. Keaveny, Gérard Karsenty, Elizabeth Shane and Xuesong Dong. Their work appears in journals such as Journal of Bone and Mineral Research, Bone, Journal of Biomechanics, The Journal of Clinical Endocrinology & Metabolism and Osteoporosis International.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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X. Edward Guo

X. Edward Guo's Hit Papers

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All Works

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