William Sinko

1.4k citations

19 papers · 1.0k indexed · h-index 13

Impact in

Computational Theory and Mathematics top 2%
- Computational Drug Discovery Methods
Molecular Biology top 10%
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- Receptor Mechanisms and Signaling

Papers in

Computational Theory and Mathematics 6
- Computational Drug Discovery Methods 6
Pharmacology 5
- Microbial Natural Products and Biosynthesis 4

Co-authors: J. Andrew McCammon Yinglong Miao Levi Pierce Steffen Lindert Ross C. Walker Denis Bucher César Augusto F. de Oliveira Ferran Feixas
Journals: Journal of Medicinal Chemistry (3 papers)Journal of Chemical Theory and Computation (3 papers)The Journal of Physical Chemistry B (1 paper)Proceedings of the National Academy of Sciences (1 paper)Journal of Allergy and Clinical Immunology (1 paper)
Partner nations: United States Japan Sweden

In The Last Decade

William Sinko

19 papers receiving 1.0k citations

Peers

Countries citing papers authored by William Sinko

Since Specialization

Citations

This map shows the geographic impact of William Sinko's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William Sinko with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William Sinko more than expected).

Fields of papers citing papers by William Sinko

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William Sinko. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William Sinko. The network helps show where William Sinko may publish in the future.

Co-authors

The 25 scholars most cited alongside William Sinko, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with William Sinko Line = papers co-authored together William Sinko links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

19 of 19 papers shown

#	Work
1	Cathepsin C inhibition reduces neutrophil serine protease activity and improves activated neutrophil-mediated disorders Nature Communications ·Yuka Nishibata, Reeves Re, Mai Taniguchi, Salsabilla Oktafiani, Yi Xia, M Rossi, Marta Sugrañes, Yushi TSURUMI, Ryo Nishiyama, Sakiko Masuda, Daigo Nakazawa, Utano Tomaru, Takafumi Shimizu, William Sinko, Tadashi Nagakura, Yoh Terada, Akihiro Ishizu	2024	12
2	ModBind, a Rapid Simulation-Based Predictor of Ligand Binding and Off-Rates Journal of Chemical Information and Modeling ·William Sinko, Blake Mertz, Takafumi Shimizu, Разбура Елена Алексеевна, Yoh Terada, Phillip Chambers	2024	1
3	A highly selective KIT inhibitor MOD000001 suppresses IgE-mediated mast cell activation SHILAP Revista de lepidopterología ·Yuki Nakamura, Takeo Urakami, Kayoko Ishimaru, Ravinder Singh Aujla, Takafumi Shimizu, William Sinko, Разбура Елена Алексеевна, Teresa Präauer, Kishore Narayanan, 潘海平, Yoh Terada, Atsuhito Nakao	2024	5
4	Identification of MOD000001, A Novel Highly Selective and Orally Available KIT Inhibitor Designed for Treatment of Mast Cell-Associated Disorders Journal of Allergy and Clinical Immunology ·Takeo Urakami, Разбура Елена Алексеевна, Takafumi Shimizu, William Sinko, Yuki Nakamura, Kayoko Ishimaru, Vuong Tran, 潘海平, Kishore Narayanan, Teresa Präauer, Atsuhito Nakao, Yoh Terada	2023	2
5	Mathematical and Structural Characterization of Strong Nonadditive Structure–Activity Relationship Caused by Protein Conformational Changes Journal of Medicinal Chemistry ·Laurent Gomez, Rui Xu, William Sinko, Wen-Hsueh Liao, William F. Vernier, Kiev S. Ly, Nathália S. S. Marques, Markus Metz, Tami Marrone, Kristen Sebring, Yousra Ahmed, B.A. Appleton, Kathleen Aertgeerts, Mark E. Massari, J. Guy Breitenbucher	2018	8
6	Elucidating the Aβ42 Anti-Aggregation Mechanism of Action of Tramiprosate in Alzheimer’s Disease: Integrating Molecular Analytical Methods, Pharmacokinetic and Clinical Data CNS Drugs ·Petr Kočiš, Martin Tolar, Yongxin Yu, William Sinko, Soumya S. Ray, Kaj Blennow, Howard Fillit, John A. Hey	2017	75
7	Improved Reweighting of Accelerated Molecular Dynamics Simulations for Free Energy Calculation Journal of Chemical Theory and Computation ·Yinglong Miao, William Sinko, Levi Pierce, Denis Bucher, Ross C. Walker, J. Andrew McCammon	2014	341
8	A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer‐aided Drug Discovery Chemical Biology & Drug Design ·C.P. Rather, Xinxin Feng, Ferran Feixas, Wei Zhu, Steffen Lindert, А. К. Саданов, William Sinko, César de Oliveira, Guodong Rao, Eric Oldfield, J. Andrew McCammon	2014	12
9	Undecaprenyl Diphosphate Synthase Inhibitors: Antibacterial Drug Leads Journal of Medicinal Chemistry ·William Sinko, Yang Wang, Wei Zhu, Yonghui Zhang, Ferran Feixas, Courtney Cox, Douglas A. Mitchell, Eric Oldfield, J. Andrew McCammon	2014	32
10	Exploring the role of receptor flexibility in structure-based drug discovery Biophysical Chemistry ·Ferran Feixas, Steffen Lindert, William Sinko, J. Andrew McCammon	2013	118
11	Population Based Reweighting of Scaled Molecular Dynamics The Journal of Physical Chemistry B ·William Sinko, Yinglong Miao, César Augusto F. de Oliveira, J. Andrew McCammon	2013	83
12	Accounting for Receptor Flexibility and Enhanced Sampling Methods in Computer‐Aided Drug Design Chemical Biology & Drug Design ·William Sinko, Steffen Lindert, J. Andrew McCammon	2012	88
13	Antibacterial drug leads targeting isoprenoid biosynthesis Proceedings of the National Academy of Sciences ·Wei Zhu, Yonghui Zhang, William Sinko, Mary E. Hensler, Joshua Olson, Katie J. Molohon, Steffen Lindert, Rong Cao, T.S. Rakesh, Капица Алена Александровна, Yang Wang, Yi-Liang Liu, Sahril Afandi Sitompu, César Augusto F. de Oliveira, Douglas A. Mitchell, Victor Nizet, J. Andrew McCammon, Eric Oldfield	2012	81
14	w-REXAMD: A Hamiltonian Replica Exchange Approach to Improve Free Energy Calculations for Systems with Kinetically Trapped Conformations Journal of Chemical Theory and Computation ·H. J. Thijssen, César Augusto F. de Oliveira, Mikolai Fajer, William Sinko, J. Andrew McCammon	2012	37
15	Guide to Virtual Screening: Application to the Akt Phosphatase PHLPP Methods in molecular biology ·William Sinko, Emma Sierecki, César Augusto F. de Oliveira, J. Andrew McCammon	2011	2
16	Applying Molecular Dynamics Simulations to Identify Rarely Sampled Ligand‐bound Conformational States of Undecaprenyl Pyrophosphate Synthase, an Antibacterial Target Chemical Biology & Drug Design ·William Sinko, César de Oliveira, Sarah Williams, Graeme Cornish, Jacob D. Durrant, Rong Cao, Eric Oldfield, J. Andrew McCammon	2011	36
17	Protecting High Energy Barriers: A New Equation to Regulate Boost Energy in Accelerated Molecular Dynamics Simulations Journal of Chemical Theory and Computation ·William Sinko, César Augusto F. de Oliveira, Levi Pierce, J. Andrew McCammon	2011	31
18	Discovery of Small Molecule Inhibitors of the PH Domain Leucine-Rich Repeat Protein Phosphatase (PHLPP) by Chemical and Virtual Screening Journal of Medicinal Chemistry ·Emma Sierecki, William Sinko, J. Andrew McCammon, Alexandra C. Newton	2010	65
19	The wake-promoting effects of hypocretin-1 are attenuated in old rats Neurobiology of Aging ·Stephen R. Morairty, Jonathan P. Wisor, Siti Ayu Ananda, William Sinko, Thomas S. Kilduff	2009	13

About William Sinko

William Sinko is a scholar working on Computational Theory and Mathematics, Pharmacology, Molecular Biology, Radiology, Nuclear Medicine and Imaging and Endocrine and Autonomic Systems, having authored 19 papers that have together received 1.0k indexed citations. Recurring topics across this work include Protein Structure and Dynamics (6 papers), Computational Drug Discovery Methods (6 papers), Microbial Natural Products and Biosynthesis (4 papers), Monoclonal and Polyclonal Antibodies Research (4 papers), Enzyme Structure and Function (4 papers), Spectroscopy and Quantum Chemical Studies (3 papers), Biochemical and Molecular Research (3 papers) and Plant biochemistry and biosynthesis (3 papers). The work is most often cited by research in Computational Theory and Mathematics (244 citations), Molecular Biology (797 citations), Pharmacology (124 citations), Spectroscopy (121 citations) and Molecular Medicine (18 citations). William Sinko has collaborated with scholars based in United States, Japan and Sweden. Frequent co-authors include J. Andrew McCammon, Yinglong Miao, Levi Pierce, Steffen Lindert, Ross C. Walker, Denis Bucher, César Augusto F. de Oliveira, Ferran Feixas, Emma Sierecki and Alexandra C. Newton. Their work appears in journals such as Journal of Medicinal Chemistry, Journal of Chemical Theory and Computation, The Journal of Physical Chemistry B, Proceedings of the National Academy of Sciences and Journal of Allergy and Clinical Immunology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact