William E. O’Brien

7.4k citations

114 papers · 4.5k indexed · h-index 40

Impact in

Clinical Biochemistry top 0.2%
- Metabolism and Genetic Disorders
Biochemistry top 0.5%
- Amino Acid Enzymes and Metabolism

Papers in ⓘ

Molecular Biology 41
- Biochemical and Molecular Research 15
- Polyamine Metabolism and Applications 7
Clinical Biochemistry 38
- Metabolism and Genetic Disorders 38

Co-authors: Arthur L. Beaudet (27 shared papers)Anthony R. Gregg (8 shared papers)Sidney M. Morris (7 shared papers)Tsung‐Sheng Su (5 shared papers)Joseph H. Nadeau (5 shared papers)Lars G. Ljungdahl (3 shared papers)Fernando Scaglia (6 shared papers)Annie E. Hill (3 shared papers)
Journals: Biochemistry (4 papers)Nucleic Acids Research (4 papers)Molecular Genetics and Metabolism (4 papers)Proceedings of the National Academy of Sciences (4 papers)Genomics (4 papers)
Partner nations: United States Canada Austria

In The Last Decade

William E. O’Brien

113 papers receiving 4.4k citations

Peers

Countries citing papers authored by William E. O’Brien

Since Specialization

Citations

This map shows the geographic impact of William E. O’Brien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William E. O’Brien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William E. O’Brien more than expected).

Fields of papers citing papers by William E. O’Brien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William E. O’Brien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William E. O’Brien. The network helps show where William E. O’Brien may publish in the future.

Co-authors

The 25 scholars most cited alongside William E. O’Brien, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with William E. O’Brien Line = papers co-authored together William E. O’Brien links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 114 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Genetic Dissection of Complex Traits with Chromosome Substitution Strains of Mice Science ·Jonathan B. Singer, Annie E. Hill, Lindsay C. Burrage, Keith R. Olszens, Junghan Song, Monica J. Justice, William E. O’Brien, David V. Conti, John S. Witte, Eric S. Lander, Joseph H. Nadeau	2004	260
2	Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis Proceedings of the National Academy of Sciences ·Haifeng Shao, Lindsay C. Burrage, David S. Sinasac, Annie E. Hill, Sheila Ernest, William E. O’Brien, Hayden‐William Courtland, Karl J. Jepsen, Andrew Kirby, Edward J. Kulbokas, Mark J. Daly, Karl W. Broman, Eric S. Lander, Joseph H. Nadeau	2008	198
3	Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation Proceedings of the National Academy of Sciences ·David M. Kurtz, Piero Rinaldo, William J. Rhead, Liqun Tian, David S. Millington, Jerry Vockley, Doug A. Hamm, Amy E. Brix, J. Russell Lindsey, Carl A. Pinkert, William E. O’Brien, Philip A. Wood	1998	195
4	The Mushroom at the End of the World: On the Possibility of Life in Capitalist Ruins The AAG Review of Books ·William E. O’Brien	2018	187
5	Mutation Analysis for Heterozygote Detection and the Prenatal Diagnosis of Cystic Fibrosis New England Journal of Medicine ·Wanda K. Lemna, Gerald L. Feldman, Batsheva Kerem, Susan Fernbach, Elaine P. Zevkovich, William E. O’Brien, John R. Riordan, Francis S. Collins, Lap‐Chee Tsui, Arthur L. Beaudet	1990	173
6	Mouse Model for Human Arginase Deficiency Molecular and Cellular Biology ·Ramaswamy K. Iyer, Paul K. Yoo, Rita M. Kern, Nora Rozengurt, Rosemarie W. Tsoa, William E. O’Brien, Hong Yu, Wayne W. Grody, Stephen D. Cederbaum	2002	146
7	Arginase I Expression and Activity in Human Mononuclear Cells After Injury Annals of Surgery ·Juan B. Ochoa, Andrew C. Bernard, William E. O’Brien, Margaret M. Griffen, Mary E. Maley, Anna K. Rockich, Betty J. Tsuei, Bernard R. Boulanger, Paul A. Kearney, Sidney M. Morris	2001	131
8	Generation of a Mouse Model for Arginase II Deficiency by Targeted Disruption of the Arginase II Gene Molecular and Cellular Biology ·Ou Shi, Sidney M. Morris, Huda Y. Zoghbi, Carl W. Porter, William E. O’Brien	2001	120
9	Regulation of mRNA levels for five urea cycle enzymes in rat liver by diet, cyclic AMP, and glucocorticoids Archives of Biochemistry and Biophysics ·Sidney M. Morris, Carole L. Moncman, Katherine D. Rand, George J. Dizikes, Stephen D. Cederbaum, William E. O’Brien	1987	117
10	MAMMALIAN UREA CYCLE ENZYMES Annual Review of Genetics ·Marian J. Jackson, Arthur L. Beaudet, William E. O’Brien	1986	107
11	Arginase I Suppresses IL-12/IL-23p40–Driven Intestinal Inflammation during Acute Schistosomiasis The Journal of Immunology ·De’Broski R. Herbert, Tatyana Orekov, Amanda Roloson, Monica Ilies, Charles Perkins, William E. O’Brien, Stephen D. Cederbaum, David W. Christianson, Nives Zimmermann, Marc E. Rothenberg, Fred D. Finkelman	2010	106
12	Perinatal Development of Endothelial Nitric Oxide Synthase-Deficient Mice1 Biology of Reproduction ·Lukas Hefler, Christine Reyes, William E. O’Brien, Anthony R. Gregg	2001	85
13	Properties of Carboxytransphosphorylase; Pyruvate, Phosphate Dikinase; Pyrophosphate‐Phosphofructokinase and Pyrophosphate‐acetate Kinase and their Roles in the Metabolism of Inorganic Pyrophosphate Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects ·Harland G. Wood, William E. O’Brien, George Michaels	1977	83
14	Effect of alternative pathway therapy on branched chain amino acid metabolism in urea cycle disorder patients Molecular Genetics and Metabolism ·Fernando Scaglia, Susan Carter, William E. O’Brien, Brendan Lee	2004	79
15	Citrin deficiency, a perplexing global disorder Molecular Genetics and Metabolism ·David Dimmock, Bruno Maranda, Carlo Dionisi‐Vici, Jing Wang, Soledad Kleppe, Giuseppe Fiermonte, Renkui Bai, Bryan E. Hainline, Ada Hamosh, William E. O’Brien, Fernando Scaglia, Lee-Jun Wong	2008	77
16	Analysis of guanidinoacetate and creatine by isotope dilution electrospray tandem mass spectrometry Clinica Chimica Acta ·Olaf A. Bodamer, Shannon M Bloesch, Anthony R. Gregg, Silvia Stockler-Ipsiroglu, William E. O’Brien	2001	72
17	Clinical Consequences of Urea Cycle Enzyme Deficiencies and Potential Links to Arginine and Nitric Oxide Metabolism Journal of Nutrition ·Fernando Scaglia, Nicola Brunetti‐Pierri, Soledad Kleppe, Juan C. Marini, Susan Carter, Peter J. Garlick, Farook Jahoor, William E. O’Brien, Brendan Lee	2004	69
18	Nitric oxide release and contractile properties of skeletal muscles from mice deficient in type III NOS American Journal of Physiology-Regulatory, Integrative and Comparative Physiology ·Wulf Hirschfield, Melanie R. Moody, William E. O’Brien, Anthony R. Gregg, Robert M. Bryan, Michael B. Reid	2000	65
19	Disruption of the Purine Nucleotide Cycle Journal of Clinical Investigation ·Richard L. Sabina, Judith L. Swain, Bernard M. Patten, Tetsuo Ashizawa, William E. O’Brien, Edward W. Holmes	1980	65
20	Increased translatable messenger ribonucleic acid for argininosuccinate synthetase in canavanine-resistant human cells Biochemistry ·Tsung‐Sheng Su, Arthur L. Beaudet, William E. O’Brien	1981	64

About William E. O’Brien

William E. O’Brien is a scholar working on Molecular Biology, Clinical Biochemistry, Biochemistry, Physiology and Genetics, having authored 114 papers that have together received 4.5k indexed citations. Recurring topics across this work include Metabolism and Genetic Disorders (38 papers), Amino Acid Enzymes and Metabolism (23 papers), Biochemical and Molecular Research (15 papers), Nitric Oxide and Endothelin Effects (13 papers), Muscle metabolism and nutrition (9 papers), Cancer Research and Treatments (8 papers), Virus-based gene therapy research (8 papers) and Polyamine Metabolism and Applications (7 papers). The work is most often cited by research in Clinical Biochemistry (1.0k citations), Biochemistry (697 citations), Physiology (984 citations), Genetics (790 citations) and Molecular Biology (1.8k citations). William E. O’Brien has collaborated with scholars based in United States, Canada and Austria. Frequent co-authors include Arthur L. Beaudet, Anthony R. Gregg, Sidney M. Morris, Tsung‐Sheng Su, Joseph H. Nadeau, Lars G. Ljungdahl, Fernando Scaglia, Annie E. Hill, Lindsay C. Burrage and Harland G. Wood. Their work appears in journals such as Biochemistry, Nucleic Acids Research, Molecular Genetics and Metabolism, Proceedings of the National Academy of Sciences and Genomics.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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