Wi S. Lai

7.8k total citations · 4 hit papers
61 papers, 6.6k citations indexed

About

Wi S. Lai is a scholar working on Molecular Biology, Oncology and Immunology. According to data from OpenAlex, Wi S. Lai has authored 61 papers receiving a total of 6.6k indexed citations (citations by other indexed papers that have themselves been cited), including 56 papers in Molecular Biology, 7 papers in Oncology and 7 papers in Immunology. Recurrent topics in Wi S. Lai's work include RNA Research and Splicing (41 papers), RNA and protein synthesis mechanisms (26 papers) and RNA modifications and cancer (23 papers). Wi S. Lai is often cited by papers focused on RNA Research and Splicing (41 papers), RNA and protein synthesis mechanisms (26 papers) and RNA modifications and cancer (23 papers). Wi S. Lai collaborates with scholars based in United States, United Kingdom and Bulgaria. Wi S. Lai's co-authors include Perry J. Blackshear, Ester Carballo, Elizabeth A. Kennington, Deborah J. Stumpo, Michael J. Thompson, Gregory A. Taylor, Ruth S. Phillips, Judith M. Thorn, Esam E. El‐Fakahany and Danielle M. Carrick and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Nucleic Acids Research.

In The Last Decade

Wi S. Lai

61 papers receiving 6.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Feedback Inhibition of Macrophage Tumor Necrosis Factor-α Production by Tristetraprolin

1998 1.0k citations Ester Carballo, Wi S. Lai et al. profile →
A Pathogenetic Role for TNFα in the Syndrome of Cachexia, Arthritis, and Autoimmunity Resulting from Tristetraprolin (TTP) Deficiency

1996 666 citations Gregory A. Taylor, Ester Carballo et al. profile →
Evidence that Tristetraprolin Binds to AU-Rich Elements and Promotes the Deadenylation and Destabilization of Tumor Necrosis Factor Alpha mRNA

1999 649 citations Wi S. Lai, Ester Carballo et al. Molecular and Cellular Biology profile →
Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA

2017 474 citations Wi S. Lai, Perry J. Blackshear et al. profile →

Peers

Wi S. Lai

IMMUN

ONCOL

CCM

Erhard Hofer Austria

Hans van Dam Netherlands

Peter E. Shaw United Kingdom

Zhipeng Meng United States

Xiaohong Mao China

Xiao-Hong Sun United States

Elizabeth J. Taparowsky United States

Nikolay Malinin United States

Christoph Reinhard United States

Laura Sanz Spain

Erhard Hofer Austria

Wi S. Lai

2.8k ×0.5

1.7k ×1.2

IMMUN

770 ×0.6

928 ×0.9

ONCOL

204 ×0.8

CCM

Citations per year, relative to Wi S. Lai Wi S. Lai (= 1×) peers Erhard Hofer

Countries citing papers authored by Wi S. Lai

Since Specialization

Citations

This map shows the geographic impact of Wi S. Lai's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Wi S. Lai with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Wi S. Lai more than expected).

Fields of papers citing papers by Wi S. Lai

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Wi S. Lai. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Wi S. Lai. The network helps show where Wi S. Lai may publish in the future.

Co-authorship network of co-authors of Wi S. Lai

This figure shows the co-authorship network connecting the top 25 collaborators of Wi S. Lai. A scholar is included among the top collaborators of Wi S. Lai based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Wi S. Lai. Wi S. Lai is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Lecoutre, Simon, Fatiha Merabtene, Christine Rouault, et al.. (2022). Beta-hydroxybutyrate dampens adipose progenitors’ profibrotic activation through canonical Tgfβ signaling and non-canonical ZFP36-dependent mechanisms. Molecular Metabolism. 61. 101512–101512. 6 indexed citations

Lai, Wi S., et al.. (2019). Inhibiting transcription in cultured metazoan cells with actinomycin D to monitor mRNA turnover. Methods. 155. 77–87. 39 indexed citations

Angiolilli, Chiara, Pawel A. Kabala, Aleksander M. Grabiec, et al.. (2018). Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation. Arthritis Research & Therapy. 20(1). 148–148. 23 indexed citations

Qiu, Lianqun, Wi S. Lai, Deborah J. Stumpo, & Perry J. Blackshear. (2016). Mouse Embryonic Fibroblast Cell Culture and Stimulation. BIO-PROTOCOL. 6(13). 47 indexed citations

Qiu, Lianqun, Wi S. Lai, Deborah J. Stumpo, & Perry J. Blackshear. (2016). Measurement of mRNA Decay in Mouse Embryonic Fibroblasts. BIO-PROTOCOL. 6(13). 8 indexed citations

Stumpo, Deborah J., et al.. (2015). Emergence and evolution of Zfp36l3. Molecular Phylogenetics and Evolution. 94(Pt B). 518–530. 9 indexed citations

Fabian, Marc R., Filipp Frank, Nadeem Siddiqui, et al.. (2013). Structural basis for the recruitment of the human CCR4–NOT deadenylase complex by tristetraprolin. Nature Structural & Molecular Biology. 20(6). 735–739. 209 indexed citations

Horner, Thierry, Wi S. Lai, Deborah J. Stumpo, & Perry J. Blackshear. (2009). Stimulation of Polo-Like Kinase 3 mRNA Decay by Tristetraprolin. Molecular and Cellular Biology. 29(8). 1999–2010. 30 indexed citations

Ehlting, Christian, Wi S. Lai, Fred Schaper, et al.. (2007). Regulation of Suppressor of Cytokine Signaling 3 (SOCS3) mRNA Stability by TNF-α Involves Activation of the MKK6/p38MAPK/MK2 Cascade. The Journal of Immunology. 178(5). 2813–2826. 97 indexed citations

10.

Lai, Wi S., Danielle M. Carrick, & Perry J. Blackshear. (2005). Influence of Nonameric AU-rich Tristetraprolin-binding Sites on mRNA Deadenylation and Turnover. Journal of Biological Chemistry. 280(40). 34365–34377. 46 indexed citations

11.

Blackshear, Perry J., et al.. (2005). Zfp36l3, a Rodent X Chromosome Gene Encoding a Placenta-Specific Member of the Tristetraprolin Family of CCCH Tandem Zinc Finger Proteins. Biology of Reproduction. 73(2). 297–307. 77 indexed citations

12.

Twizere, Jean‐Claude, Véronique Kruys, Laurent Lefèbvre, et al.. (2003). Interaction of Retroviral Tax Oncoproteins With Tristetraprolin and Regulation of Tumor Necrosis Factor- Expression. JNCI Journal of the National Cancer Institute. 95(24). 1846–1859. 48 indexed citations

13.

Blackshear, Perry J., Wi S. Lai, Judith M. Thorn, et al.. (2001). The NIEHS Xenopus maternal EST project: interim analysis of the first 13,879 ESTs from unfertilized eggs. Gene. 267(1). 71–87. 17 indexed citations

14.

Lai, Wi S., Ester Carballo, Judith M. Thorn, Elizabeth A. Kennington, & Perry J. Blackshear. (2000). Interactions of CCCH Zinc Finger Proteins with mRNA. Journal of Biological Chemistry. 275(23). 17827–17837. 323 indexed citations

15.

Lai, Wi S., et al.. (1999). Evidence that Tristetraprolin Binds to AU-Rich Elements and Promotes the Deadenylation and Destabilization of Tumor Necrosis Factor Alpha mRNA. Molecular and Cellular Biology. 19(6). 4311–4323. 649 indexed citations breakdown →

16.

Swierczynski, Sharon L., et al.. (1998). Transgenic Complementation of MARCKS Deficiency with a Nonmyristoylatable, Pseudo-Phosphorylated Form of MARCKS: Evidence for Simultaneous Positive and Dominant-Negative Effects on Central Nervous System Development. Developmental Biology. 200(2). 146–157. 12 indexed citations

17.

Lai, Wi S., Michael J. Thompson, Gregory A. Taylor, Yi Liu, & Perry J. Blackshear. (1995). Promoter Analysis of Zfp-36 the Mitogen-inducible Gene Encoding the Zinc Finger Protein Tristetraprolin. Journal of Biological Chemistry. 270(42). 25266–25272. 63 indexed citations

18.

Taylor, Gregory A., Michael J. Thompson, Wi S. Lai, & Perry J. Blackshear. (1995). Phosphorylation of Tristetraprolin, a Potential Zinc Finger Transcription Factor, by Mitogen Stimulation in Intact Cells and by Mitogen-activated Protein Kinase in Vitro. Journal of Biological Chemistry. 270(22). 13341–13347. 114 indexed citations

19.

Taylor, Gregory A., Wi S. Lai, Rebecca J. Oakey, et al.. (1991). The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes. Nucleic Acids Research. 19(12). 3454–3454. 85 indexed citations

20.

Lai, Wi S. & Esam E. El‐Fakahany. (1990). Antagonism by the diacylglycerol kinase inhibitor R59 022 of muscarinic receptor-mediated cyclic GMP formation and binding of [3HN-methylscopolamine. Biochemical Pharmacology. 39(1). 221–222. 4 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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