Val C. Sheffield

44.6k total citations · 6 hit papers
312 papers, 27.6k citations indexed

About

Val C. Sheffield is a scholar working on Molecular Biology, Genetics and Ophthalmology. According to data from OpenAlex, Val C. Sheffield has authored 312 papers receiving a total of 27.6k indexed citations (citations by other indexed papers that have themselves been cited), including 220 papers in Molecular Biology, 140 papers in Genetics and 67 papers in Ophthalmology. Recurrent topics in Val C. Sheffield's work include Genetic and Kidney Cyst Diseases (91 papers), Genetic Syndromes and Imprinting (75 papers) and Retinal Development and Disorders (56 papers). Val C. Sheffield is often cited by papers focused on Genetic and Kidney Cyst Diseases (91 papers), Genetic Syndromes and Imprinting (75 papers) and Retinal Development and Disorders (56 papers). Val C. Sheffield collaborates with scholars based in United States, Israel and Canada. Val C. Sheffield's co-authors include Edwin M. Stone, Darryl Nishimura, Charles Searby, Wallace L.M. Alward, Rivka Carmi, Ruth E. Swiderski, Diane C. Slusarski, John H. Fingert, John S. Beck and David R. Cox and has published in prestigious journals such as Science, New England Journal of Medicine and Cell.

In The Last Decade

Val C. Sheffield

308 papers receiving 27.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Identification of a Gene That Causes Primary Open Angle Glaucoma

1997 1.1k citations Edwin M. Stone, John H. Fingert et al. profile →
A Core Complex of BBS Proteins Cooperates with the GTPase Rab8 to Promote Ciliary Membrane Biogenesis

2007 1.1k citations Diane C. Slusarski, Val C. Sheffield et al. profile →
Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes.

1989 1.1k citations Val C. Sheffield et al. Proceedings of the National Academy of Sciences profile →
Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS)

1997 866 citations Val C. Sheffield et al. profile →
Comprehensive Human Genetic Maps: Individual and Sex-Specific Variation in Recombination

1998 852 citations Val C. Sheffield et al. The American Journal of Human Genetics profile →
The Sensitivity of Single-Strand Conformation Polymorphism Analysis for the Detection of Single Base Substitutions

1993 567 citations Val C. Sheffield, John S. Beck et al. profile →

Peers

Countries citing papers authored by Val C. Sheffield

Since Specialization

Citations

This map shows the geographic impact of Val C. Sheffield's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Val C. Sheffield with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Val C. Sheffield more than expected).

Fields of papers citing papers by Val C. Sheffield

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Val C. Sheffield. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Val C. Sheffield. The network helps show where Val C. Sheffield may publish in the future.

Co-authorship network of co-authors of Val C. Sheffield

This figure shows the co-authorship network connecting the top 25 collaborators of Val C. Sheffield. A scholar is included among the top collaborators of Val C. Sheffield based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Val C. Sheffield. Val C. Sheffield is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Progressive retinal degeneration of rods and cones in a Bardet-Biedl syndrome type 10 mouse model 2022 ·Disease Models & Mechanisms ·(unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), Kai Wang, Poppy Datta, Charles Searby, Seongjin Seo, Ying Hsu, Sajag Bhattarai, Val C. Sheffield, Arlene V. Drack	8
2	Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin 2021 ·JCI Insight ·Ramesh B. Kasetti, Prabhavathi Maddineni, Charles Kiehlbauch, (unknown), Charles Searby, Beth Levine, Val C. Sheffield, Gulab Zode	38
3	A mouse model of Bardet-Biedl Syndrome has impaired fear memory, which is rescued by lithium treatment 2021 ·PLoS Genetics ·Thomas Pak, Calvin S. Carter, Qihong Zhang, Sunny C. Huang, Charles Searby, Ying Hsu, Rebecca J. Taugher, (unknown), (unknown), (unknown), (unknown), Hanna E. Stevens, John A. Wemmie, Andrew A. Pieper, Kai Wang, Val C. Sheffield	8
4	ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load 2020 ·Nature Communications ·Ramesh B. Kasetti, Pinkal D. Patel, Prabhavathi Maddineni, (unknown), Charles Kiehlbauch, J. Cameron Millar, Charles Searby, Vijay Krishna Raghunathan, Val C. Sheffield, Gulab Zode	62
5	Retinal degeneration in BBS10 mice is ameliorated by subretinal gene replacement 2020 ·Investigative Ophthalmology & Visual Science ·Arlene V. Drack, Sajag Bhattarai, (unknown), (unknown), Poppy Datta, Ying Hsu, (unknown), Charles Searby, Luk H. Vandenberghe, Elise Héon, Seongjin Seo, Val C. Sheffield	1
6	Genetic and pharmacological inhibition of ER stress-induced ATF4/CHOP pro-death pathway prevents myocilin misfolding and rescues mouse models of glaucoma 2016 ·Investigative Ophthalmology & Visual Science ·Ramesh B. Kasetti, (unknown), Charles Searby, Val C. Sheffield, Gulab Zode	1
7	Elevation of IOP triggers responses from cytokines IL-6 and IL-1β; involvement of both optic nerve head astrocytes and retinal ganglion cells 2013 ·Investigative Ophthalmology & Visual Science ·Wennan Lu, Jonathan M. Beckel, Jason Lim, Gulab Zode, Val C. Sheffield, Alan M. Laties, Claire H. Mitchell	3
8	A Genome-Wide Association Study for Primary Open Angle Glaucoma and Macular Degeneration Reveals Novel Loci 2013 ·PLoS ONE ·Todd E. Scheetz, John H. Fingert, Kai Wang, Markus H. Kuehn, Kevin L. Knudtson, Wallace L.M. Alward, H. Culver Boldt, Stephen R. Russell, James C. Folk, Thomas L. Casavant, Terry A. Braun, Abbot F. Clark, Edwin M. Stone, Val C. Sheffield	28
9	Copy number variations on chromosome 12q14 in patients with normal tension glaucoma 2011 ·Human Molecular Genetics ·John H. Fingert, Alan L. Robin, Jennifer Stone, Ben R. Roos, Lea K. Davis, Todd E. Scheetz, (unknown), Thomas H. Wassink, Young H. Kwon, Wallace L.M. Alward, Robert F. Mullins, Val C. Sheffield, Edwin M. Stone	159
10	BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly 2010 ·Proceedings of the National Academy of Sciences ·Seongjin Seo, Lisa M. Baye, (unknown), John S. Beck, Qihong Zhang, Diane C. Slusarski, Val C. Sheffield	239
11	Regulation of gene expression in the mammalian eye and its relevance to eye disease 2006 ·Proceedings of the National Academy of Sciences ·Todd E. Scheetz, Kwang‐Youn A. Kim, Ruth E. Swiderski, Alisdair R. Philp, Terry A. Braun, Kevin L. Knudtson, Anne M. Dorrance, Gerald F. DiBona, Jian Huang, Thomas L. Casavant, Val C. Sheffield, Edwin M. Stone	193
12	Bardet–Biedl syndrome type 4 (BBS4)-null mice implicate Bbs4 in flagella formation but not global cilia assembly 2004 ·Proceedings of the National Academy of Sciences ·Kirk Mykytyn, Robert F. Mullins, Michael Andrews, Annie Chiang, Ruth E. Swiderski, Baoli Yang, Terry A. Braun, Thomas L. Casavant, Edwin M. Stone, Val C. Sheffield	268
13	Delayed secondary glucocorticoid responsiveness of MYOC in human trabecular meshwork cells. 2001 ·PubMed ·Allan R. Shepard, Nasreen Jacobson, John H. Fingert, Edwin M. Stone, Val C. Sheffield, A.F. Clark	59
14	Glucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissues. 2001 ·PubMed ·A.F. Clark, H. Thomas Steely, Jaime E. Dickerson, (unknown), (unknown), Mitchell D. McCartney, Nasreen Jacobson, Allan R. Shepard, John I. Clark, Hiroshi Matsushima, Elaine R. Peskind, James B. Leverenz, Charles W. Wilkinson, Ruth E. Swiderski, John H. Fingert, Val C. Sheffield, Edwin M. Stone	131
15	Evaluation of the myocilin (MYOC) glaucoma gene in monkey and human steroid-induced ocular hypertension. 2001 ·PubMed ·John H. Fingert, A.F. Clark, Jamie E. Craig, Wallace L.M. Alward, Grant R. Snibson, Marsha A. McLaughlin, (unknown), David A. Mackey, Val C. Sheffield, Edwin M. Stone	98
16	Localization of MYOC transcripts in human eye and optic nerve by in situ hybridization. 2000 ·PubMed ·Ruth E. Swiderski, (unknown), John H. Fingert, A.F. Clark, Wallace L.M. Alward, Edwin M. Stone, Val C. Sheffield	80
17	Allelic variation in the VMD2 gene in best disease and age-related macular degeneration. 2000 ·PubMed ·Andrew Lotery, F.L. Munier, Gerald A. Fishman, Richard G. Weleber, Samuel G. Jacobson, Louisa M. Affatigato, Brian E. Nichols, Daniel F. Schorderet, Val C. Sheffield, Edwin M. Stone	126
18	Predictive DNA testing for glaucoma with the GLC1A gene: experience with a large Australian family 1998 ·eCite Digital Repository (University of Tasmania) ·Joanne L. Dickinson, (unknown), (unknown), (unknown), C. D. W. Wilkinson, (unknown), JL Rait, (unknown), (unknown), (unknown), (unknown), (unknown), Val C. Sheffield	1
19	Photoreceptor function in patients with heterozygous peripherin/RDS gene mutations 1995 ·Investigative Ophthalmology & Visual Science ·Artur V. Cideciyan, Samuel G. Jacobson, C.M. Kemp, (unknown), (unknown), Val C. Sheffield, Edwin M. Stone	3
20	Medical genetics: An illustrated outline 1990 ·The American Journal of Human Genetics ·Val C. Sheffield	1

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact