Tomáš Smutný

910 total citations
33 papers, 710 citations indexed

About

Tomáš Smutný is a scholar working on Pharmacology, Oncology and Molecular Biology. According to data from OpenAlex, Tomáš Smutný has authored 33 papers receiving a total of 710 indexed citations (citations by other indexed papers that have themselves been cited), including 22 papers in Pharmacology, 12 papers in Oncology and 9 papers in Molecular Biology. Recurrent topics in Tomáš Smutný's work include Pharmacogenetics and Drug Metabolism (21 papers), Drug Transport and Resistance Mechanisms (12 papers) and Hormonal Regulation and Hypertension (7 papers). Tomáš Smutný is often cited by papers focused on Pharmacogenetics and Drug Metabolism (21 papers), Drug Transport and Resistance Mechanisms (12 papers) and Hormonal Regulation and Hypertension (7 papers). Tomáš Smutný collaborates with scholars based in Czechia, Finland and Germany. Tomáš Smutný's co-authors include Petr Pávek, Sridhar Mani, Alejandro Carazo, František Trejtnar, Ján Dušek, Zdeněk Dvořák, Kateřina Vávrová, Alexandr Hrabálek, Věra Klimešová and Jaroslav Roh and has published in prestigious journals such as Biomaterials, International Journal of Molecular Sciences and Journal of Medicinal Chemistry.

In The Last Decade

Tomáš Smutný

32 papers receiving 697 citations

Peers

Tomáš Smutný
Cong Huai China
Nita Patel United States
Arunima Biswas India
Michael W. Voice United Kingdom
Daniel R. Mudra United States
Ken‐ichi Nunoya Japan
Caitlin Lynch United States
Atsuko Miyajima Japan
Song‐Hee Han South Korea
Cong Huai China
Tomáš Smutný
Citations per year, relative to Tomáš Smutný Tomáš Smutný (= 1×) peers Cong Huai

Countries citing papers authored by Tomáš Smutný

Since Specialization
Citations

This map shows the geographic impact of Tomáš Smutný's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tomáš Smutný with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tomáš Smutný more than expected).

Fields of papers citing papers by Tomáš Smutný

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tomáš Smutný. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tomáš Smutný. The network helps show where Tomáš Smutný may publish in the future.

Co-authorship network of co-authors of Tomáš Smutný

This figure shows the co-authorship network connecting the top 25 collaborators of Tomáš Smutný. A scholar is included among the top collaborators of Tomáš Smutný based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Tomáš Smutný. Tomáš Smutný is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Smutný, Tomáš, et al.. (2025). Quantifying expression and metabolic activity of genes regulated by pregnane X receptor in primary human hepatocyte spheroids. PLoS Computational Biology. 21(4). e1012886–e1012886.
2.
Smutný, Tomáš, et al.. (2025). LIM and SH3 protein 2 (Lasp2) is a novel pregnane X receptor target gene in mouse liver. Molecular Pharmacology. 107(3). 100019–100019. 1 indexed citations
3.
Smutný, Tomáš, et al.. (2024). Rifampicin and its derivatives: stability, disposition, and affinity towards pregnane X receptor employing 2D and 3D primary human hepatocytes. Biochemical Pharmacology. 229. 116500–116500. 3 indexed citations
4.
Dušek, Ján, Karel Chalupský, Ivona Pávková, et al.. (2023). Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure. Journal of Medicinal Chemistry. 66(4). 2422–2456. 13 indexed citations
5.
Pávek, Petr, Ján Dušek, Tomáš Smutný, et al.. (2022). Gene Expression Profiling of 1α,25(OH)2D3 Treatment in 2D/3D Human Hepatocyte Models Reveals CYP3A4 Induction but Minor Changes in Other Xenobiotic‐Metabolizing Genes. Molecular Nutrition & Food Research. 66(9). e2200070–e2200070. 2 indexed citations
6.
Smutný, Tomáš, et al.. (2021). Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids. Archives of Toxicology. 96(1). 195–210. 5 indexed citations
7.
Holas, Ondřej, M Hroch, Tomáš Smutný, et al.. (2020). 3β-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3α-epimer by hepatic metabolism. The Journal of Steroid Biochemistry and Molecular Biology. 202. 105702–105702. 7 indexed citations
8.
Smutný, Tomáš, et al.. (2019). Sesquiterpenes Are Agonists of the Pregnane X Receptor but Do Not Induce the Expression of Phase I Drug-Metabolizing Enzymes in the Human Liver. International Journal of Molecular Sciences. 20(18). 4562–4562. 3 indexed citations
9.
10.
Smutný, Tomáš, Ján Dušek, Jana Nekvindová, et al.. (2019). The 3ʹ-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids. Acta Pharmaceutica Sinica B. 10(1). 136–152. 23 indexed citations
11.
12.
Smutný, Tomáš, Riina Harjumäki, Liisa Kanninen, et al.. (2018). A feasibility study of the toxic responses of human induced pluripotent stem cell-derived hepatocytes to phytochemicals. Toxicology in Vitro. 52. 94–105. 6 indexed citations
13.
Carazo, Alejandro, Ján Dušek, Ondřej Holas, et al.. (2018). Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling. Frontiers in Pharmacology. 9. 993–993. 17 indexed citations
14.
Cermanová, Jolana, M Hroch, Eva Doleželová, et al.. (2017). Iron depletion induces hepatic secretion of biliary lipids and glutathione in rats. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1862(12). 1469–1480. 21 indexed citations
15.
Dušek, Ján, Alejandro Carazo, František Trejtnar, et al.. (2017). Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation. Food and Chemical Toxicology. 109(Pt 1). 130–142. 16 indexed citations
16.
Kanninen, Liisa, Riina Harjumäki, Pauliina Porola, et al.. (2016). Laminin-511 and laminin-521-based matrices for efficient hepatic specification of human pluripotent stem cells. Biomaterials. 103. 86–100. 55 indexed citations
17.
Karabanovich, Galina, Jaroslav Roh, Tomáš Smutný, et al.. (2014). 1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria. European Journal of Medicinal Chemistry. 82. 324–340. 46 indexed citations
18.
Smutný, Tomáš & Petr Pávek. (2014). Resveratrol as an Inhibitor of Pregnane X Receptor (PXR): Another Lesson in PXR Antagonism. Journal of Pharmacological Sciences. 126(2). 177–178. 11 indexed citations
19.
Pávek, Petr & Tomáš Smutný. (2013). Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier. Drug Metabolism Reviews. 46(1). 19–32. 29 indexed citations
20.
Krausová, Lucie, Tomáš Smutný, Radim Vrzal, et al.. (2013). Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes. Pharmacological Reports. 65(5). 1322–1335. 25 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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