Thomas R. Gadek

6.4k total citations · 1 hit paper
35 papers, 5.0k citations indexed

About

Thomas R. Gadek is a scholar working on Molecular Biology, Immunology and Allergy and Organic Chemistry. According to data from OpenAlex, Thomas R. Gadek has authored 35 papers receiving a total of 5.0k indexed citations (citations by other indexed papers that have themselves been cited), including 16 papers in Molecular Biology, 13 papers in Immunology and Allergy and 11 papers in Organic Chemistry. Recurrent topics in Thomas R. Gadek's work include Cell Adhesion Molecules Research (12 papers), Chemical Synthesis and Analysis (7 papers) and Monoclonal and Polyclonal Antibodies Research (7 papers). Thomas R. Gadek is often cited by papers focused on Cell Adhesion Molecules Research (12 papers), Chemical Synthesis and Analysis (7 papers) and Monoclonal and Polyclonal Antibodies Research (7 papers). Thomas R. Gadek collaborates with scholars based in United States, France and Poland. Thomas R. Gadek's co-authors include Hardy Chan, Jeffrey P. Northrop, R. M. Roman, Philip L. Felgner, Mark Danielsen, Mai Marie Holm, G M Ringold, John B. Nicholas, Robert S. McDowell and Charles P. Semba and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of the American Chemical Society and Angewandte Chemie International Edition.

In The Last Decade

Thomas R. Gadek

35 papers receiving 4.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 4.0k citations Thomas R. Gadek et al. profile →

Peers

Thomas R. Gadek

GENET

IMMUN

Michael Overduin United Kingdom

Martin Spiess Switzerland

Éric Vivès France

M. Teresa Pisabarro Germany

Ikuhiko Nakase Japan

Kevin G. Rice United States

F. Heitz France

Timothy D. Heath United States

R. M. Roman United States

R.L. Brady United Kingdom

Michael Overduin United Kingdom

Thomas R. Gadek

5.8k ×1.5

717 ×0.5

GENET

620 ×1.2

IMMUN

245 ×0.6

360 ×1.0

Citations per year, relative to Thomas R. Gadek Thomas R. Gadek (= 1×) peers Michael Overduin

Countries citing papers authored by Thomas R. Gadek

Since Specialization

Citations

This map shows the geographic impact of Thomas R. Gadek's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas R. Gadek with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas R. Gadek more than expected).

Fields of papers citing papers by Thomas R. Gadek

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas R. Gadek. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas R. Gadek. The network helps show where Thomas R. Gadek may publish in the future.

Co-authorship network of co-authors of Thomas R. Gadek

This figure shows the co-authorship network connecting the top 25 collaborators of Thomas R. Gadek. A scholar is included among the top collaborators of Thomas R. Gadek based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Thomas R. Gadek. Thomas R. Gadek is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Semba, Charles P. & Thomas R. Gadek. (2016). Development of lifitegrast: a novel T-cell inhibitor for the treatment of dry eye disease. Clinical ophthalmology. 10. 1083–1083. 60 indexed citations

Sun, Yan, Rui Zhang, Thomas R. Gadek, Charles O’Neill, & Eric Pearlman. (2012). Corneal Inflammation Is Inhibited by the LFA-1 Antagonist, Lifitegrast (SAR 1118). Journal of Ocular Pharmacology and Therapeutics. 29(4). 395–402. 26 indexed citations

Nguyen, Quan Dong, Peter Gehlbach, James T. Handa, et al.. (2012). Safety, tolerability, and bioavailability of topical SAR 1118, a novel antagonist of lymphocyte function-associated antigen-1: a phase 1b study. Eye. 26(7). 944–949. 10 indexed citations

Zhong, Min, Thomas R. Gadek, Minna Bui, et al.. (2012). Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye. ACS Medicinal Chemistry Letters. 3(3). 203–206. 72 indexed citations

Semba, Charles P., Dennis Swearingen, Valerie Smith, et al.. (2010). Safety and Pharmacokinetics of a Novel Lymphocyte Function-associated Antigen-1 Antagonist Ophthalmic Solution (SAR 1118) in Healthy Adults. Journal of Ocular Pharmacology and Therapeutics. 27(1). 99–104. 27 indexed citations

Khojasteh, S. Cyrus, Douglas D. Leipold, Kelly E. Desino, et al.. (2008). Preclinical absorption, distribution, metabolism and excretion (ADME) characterization of ICAM1988, an LFA-1/ICAM antagonist, and its prodrug. Xenobiotica. 38(3). 340–352. 6 indexed citations

Keating, Susan M., Kevin Clark, F Arellano, et al.. (2005). Competition between intercellular adhesion molecule‐1 and a small‐molecule antagonist for a common binding site on the αl subunit of lymphocyte function‐associated antigen‐1. Protein Science. 15(2). 290–303. 33 indexed citations

Burdick, Daniel J., James C. Marsters, Mark Stanley, et al.. (2004). N -Benzoyl amino acids as ICAM/LFA-1 inhibitors. Part 2: Structure–activity relationship of the benzoyl moiety. Bioorganic & Medicinal Chemistry Letters. 14(9). 2055–2059. 10 indexed citations

Burdick, Daniel J., Kenneth J. Weese, Mark Stanley, et al.. (2003). N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure–activity relationship. Bioorganic & Medicinal Chemistry Letters. 13(6). 1015–1018. 15 indexed citations

10.

Gadek, Thomas R. & Robert S. McDowell. (2003). Discovery of small molecule leads in a biotechnology datastream. Drug Discovery Today. 8(12). 545–550. 6 indexed citations

11.

Dotson, Jenna, et al.. (2003). Structure–activity relationships by mass spectrometry: identification of novel MMP-3 inhibitors. Bioorganic & Medicinal Chemistry. 12(1). 37–44. 25 indexed citations

12.

Gadek, Thomas R., et al.. (2003). Discovery of novel PTP1b inhibitors. Bioorganic & Medicinal Chemistry Letters. 14(2). 389–391. 12 indexed citations

13.

Gadek, Thomas R. & John B. Nicholas. (2002). Small molecule antagonists of proteins. Biochemical Pharmacology. 65(1). 1–8. 103 indexed citations

14.

Gadek, Thomas R., et al.. (2002). Inhibitors of protein-protein interactions. Expert Opinion on Therapeutic Patents. 12(3). 393–400. 19 indexed citations

15.

Peyman, Anusch, K. Scheunemann, David W. Will, et al.. (2001). αvβ3 Antagonists Based on a Central Thiophene Scaffold. Bioorganic & Medicinal Chemistry Letters. 11(15). 2011–2015. 10 indexed citations

16.

Peyman, Anusch, Volkmar Wehner, Jochen Knolle, et al.. (2000). RGD Mimetics containing a central hydantoin scaffold: αVβ3 vs αIIbβ3 selectivity requirements. Bioorganic & Medicinal Chemistry Letters. 10(2). 179–182. 30 indexed citations

17.

Peyman, Anusch, et al.. (2000). Vitronectin Receptor Antagonists: Purine-Based Peptidomimetics. Angewandte Chemie International Edition. 39(16). 2874–2877. 7 indexed citations

18.

Chamow, Steven M., Timothy P. Kogan, Michael C. Venuti, et al.. (1994). Modification of CD4 Immunoadhesin with Monomethoxypoly(Ethylene Glycol) Aldehyde via Reductive Alkylation. Bioconjugate Chemistry. 5(2). 133–140. 31 indexed citations

19.

Barker, Peter L., Sherron Bullens, Stuart Bunting, et al.. (1992). Cyclic RGD peptide analogs as antiplatelet antithrombotics. Journal of Medicinal Chemistry. 35(11). 2040–2048. 134 indexed citations

20.

McDowell, Robert S. & Thomas R. Gadek. (1992). Structural studies of potent constrained RGD peptides. Journal of the American Chemical Society. 114(24). 9245–9253. 59 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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