Thomas C. Terwilliger

83.9k citations

215 papers · 53.2k indexed · 20 hit papers · h-index 65

Impact in

Structural Biology top 0.05%
Molecular Biology top 0.01%
- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
- Biochemical and Molecular Research
- RNA modifications and cancer
- Photosynthetic Processes and Mechanisms

Papers in

Structural Biology 15
- Advanced Electron Microscopy Techniques and Applications 15
Materials Chemistry 112
- Enzyme Structure and Function 108
- Machine Learning in Materials Science 14

Co-authors: Paul D. Adams Pavel V. Afonine Nigel W. Moriarty Randy J. Read Ralf W. Grosse‐Kunstleve Li‐Wei Hung Peter H. Zwart Joel Berendzen
Journals: Acta Crystallographica Section D Structural Biology (15 papers)Biochemistry (12 papers)Proceedings of the National Academy of Sciences (11 papers)Journal of Structural and Functional Genomics (10 papers)Journal of Biological Chemistry (7 papers)
Partner nations: United States United Kingdom France

In The Last Decade

Thomas C. Terwilliger

213 papers receiving 52.8k citations

Hit Papers

15 papers align trajectories log scale

AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination 2023 · 168 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2023 Nature Methods
2018 Acta Crystallographica Section D Structural Biology
2018 Acta Crystallographica Section D Structural Biology
2017 Acta Crystallographica Section D Structural Biology
2012 Acta Crystallographica Section D Biological Crystallography
2011 Methods
2010 Acta Crystallographica Section D Biological Crystallography
2009 Acta Crystallographica Section D Biological Crystallography
2007 Acta Crystallographica Section D Biological Crystallography
2005 Nature Biotechnology
2004 Nature Biotechnology
2002 Acta Crystallographica Section D Biological Crystallography
2002 Acta Crystallographica Section D Biological Crystallography
2000 Acta Crystallographica Section D Biological Crystallography
1999 Nature Biotechnology
1999 Acta Crystallographica Section D Biological Crystallography
1984 Proceedings of the National Academy of Sciences
1982 Biophysical Journal
1982 Journal of Biological Chemistry
1982 Nature

Peers

Countries citing papers authored by Thomas C. Terwilliger

Since Specialization

Citations

This map shows the geographic impact of Thomas C. Terwilliger's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas C. Terwilliger with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas C. Terwilliger more than expected).

Fields of papers citing papers by Thomas C. Terwilliger

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas C. Terwilliger. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas C. Terwilliger. The network helps show where Thomas C. Terwilliger may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Thomas C. Terwilliger, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Thomas C. Terwilliger Line = papers co-authored together Thomas C. Terwilliger links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Likelihood-based docking of models into cryo-EM maps Acta Crystallographica Section D Structural Biology ·Claudia Millán, Airlie J. McCoy, Thomas C. Terwilliger, Randy J. Read	2023	15
2	Overall protein structure quality assessment using hydrogen-bonding parameters Acta Crystallographica Section D Structural Biology ·Pavel V. Afonine, Oleg V. Sobolev, Nigel W. Moriarty, Thomas C. Terwilliger, Paul D. Adams	2023	4
3	Accelerating crystal structure determination with iterative AlphaFold prediction Acta Crystallographica Section D Structural Biology ·Thomas C. Terwilliger, Pavel V. Afonine, Dorothée Liebschner, Tristan I. Croll, Airlie J. McCoy, Robert D. Oeffner, Christopher J. Williams, Billy K. Poon, Jane S. Richardson, Randy J. Read, Paul D. Adams	2023	34
4	Protein identification from electron cryomicroscopy maps by automated model building and side-chain matching Acta Crystallographica Section D Structural Biology ·Thomas C. Terwilliger, Oleg V. Sobolev, Pavel V. Afonine, Paul D. Adams, C Pickstone, Xiaorun Li, Z. Hong Zhou	2021	7
5	Density modification of cryo-EM maps Acta Crystallographica Section D Structural Biology ·Thomas C. Terwilliger, Oleg V. Sobolev, Pavel V. Afonine, Paul D. Adams, Randy J. Read	2020	28
6	Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu Nature Methods ·Chi-Min Ho, Xiaorun Li, Mason Lai, Thomas C. Terwilliger, Josh R. Beck, James A. Wohlschlegel, Daniel E. Goldberg, Anthony W. P. Fitzpatrick, Z. Hong Zhou	2019	79
7	New tools for the analysis and validation of cryo-EM maps and atomic models Acta Crystallographica Section D Structural Biology ·Pavel V. Afonine, Bruno P. Klaholz, Nigel W. Moriarty, Billy K. Poon, Oleg V. Sobolev, Thomas C. Terwilliger, Paul D. Adams, Alexandre Urzhumtsev Hit paper breakdown →	2018	516
8	Real-space refinement in PHENIX for cryo-EM and crystallography Acta Crystallographica Section D Structural Biology ·Pavel V. Afonine, Billy K. Poon, Randy J. Read, Oleg V. Sobolev, Thomas C. Terwilliger, Alexandre Urzhumtsev, Paul D. Adams Hit paper breakdown →	2018	2004
9	Automated map sharpening by maximization of detail and connectivity Acta Crystallographica Section D Structural Biology ·Thomas C. Terwilliger, Oleg V. Sobolev, Pavel V. Afonine, Paul D. Adams	2018	178
10	A fully automatic method yielding initial models from high-resolution cryo-electron microscopy maps Nature Methods ·Thomas C. Terwilliger, Paul D. Adams, Pavel V. Afonine, Oleg V. Sobolev	2018	100
11	Polder maps: improving OMIT maps by excluding bulk solvent Acta Crystallographica Section D Structural Biology ·Dorothée Liebschner, Pavel V. Afonine, Nigel W. Moriarty, Billy K. Poon, Oleg V. Sobolev, Thomas C. Terwilliger, Paul D. Adams Hit paper breakdown →	2017	495
12	Crystal structure of the CRISPR RNA–guided surveillance complex from Escherichia coli Science ·Ryan N. Jackson, Sarah Golden, Sreenivasul Reddy Meegada, Joshua Carter, Edze R. Westra, Stan J. J. Brouns, John van der Oost, Thomas C. Terwilliger, Randy J. Read, Blake Wiedenheft	2014	201
13	Protein crystallography from the perspective of technology developments Crystallography Reviews ·Xiao‐Dong Su, Heng Zhang, Thomas C. Terwilliger, Anders Liljas, Junyu Xiao, Yuhui Dong	2014	29
14	Towards automated crystallographic structure refinement with phenix.refine Acta Crystallographica Section D Biological Crystallography ·Pavel V. Afonine, Ralf W. Grosse‐Kunstleve, Nathaniel Echols, Jeffrey J. Headd, Nigel W. Moriarty, Marat Mustyakimov, Thomas C. Terwilliger, Alexandre Urzhumtsev, Peter H. Zwart, Paul D. Adams Hit paper breakdown →	2012	4181
15	phenix.mr_rosetta: molecular replacement and model rebuilding with Phenix and Rosetta Journal of Structural and Functional Genomics ·Thomas C. Terwilliger, Frank DiMaio, Randy J. Read, David Baker, G. Bunkóczi, Paul D. Adams, Ralf W. Grosse‐Kunstleve, Pavel V. Afonine, Nathaniel Echols	2012	112
16	A high-throughput immobilized bead screen for stable proteins and multi-protein complexes Protein Engineering Design and Selection ·Henning Spett, Pawel Listwan, J.D. Pédelacq, Stéphanie Cabantous, Hau B. Nguyen, Thomas C. Terwilliger, Geoffrey S. Waldo	2011	11
17	Functional Linkages Can Reveal Protein Complexes for Structure Determination Structure ·MOHAMMAD YOGIE SYAHBANDAR, Peter M. Bowers, Debnath Pal, Michael Strong, Thomas C. Terwilliger, Markus Kaufmann, David Eisenberg	2007	3
18	SOLVE and RESOLVE: Automated Structure Solution and Density Modification Methods in enzymology on CD-ROM/Methods in enzymology ·Thomas C. Terwilliger	2003	422
19	Rapid automatic NCS identification using heavy-atom substructures Acta Crystallographica Section D Biological Crystallography ·Thomas C. Terwilliger	2002	25
20	Bayesian Weighting for Macromolecular Crystallographic Refinement Acta Crystallographica Section D Biological Crystallography ·Thomas C. Terwilliger, Joel Berendzen	1996	8

About Thomas C. Terwilliger

Thomas C. Terwilliger is a scholar working on Structural Biology, Materials Chemistry, Molecular Biology, Biophysics and Genetics, having authored 215 papers that have together received 53.2k indexed citations. Recurring topics across this work include Enzyme Structure and Function (108 papers), Protein Structure and Dynamics (83 papers), RNA and protein synthesis mechanisms (46 papers), Biochemical and Molecular Research (21 papers), Bacterial Genetics and Biotechnology (20 papers), Bacteriophages and microbial interactions (15 papers), Advanced Electron Microscopy Techniques and Applications (15 papers) and Machine Learning in Materials Science (14 papers). The work is most often cited by research in Structural Biology (1.2k citations), Molecular Biology (39.5k citations), Molecular Medicine (1.4k citations), Endocrinology (1.4k citations) and Cell Biology (4.4k citations). Thomas C. Terwilliger has collaborated with scholars based in United States, United Kingdom and France. Frequent co-authors include Paul D. Adams, Pavel V. Afonine, Nigel W. Moriarty, Randy J. Read, Ralf W. Grosse‐Kunstleve, Li‐Wei Hung, Peter H. Zwart, Joel Berendzen, Airlie J. McCoy and Nathaniel Echols. Their work appears in journals such as Acta Crystallographica Section D Structural Biology, Biochemistry, Proceedings of the National Academy of Sciences, Journal of Structural and Functional Genomics and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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