Takashi Tsuruo

32.7k total citations · 7 hit papers
446 papers, 27.7k citations indexed

About

Takashi Tsuruo is a scholar working on Molecular Biology, Oncology and Cancer Research. According to data from OpenAlex, Takashi Tsuruo has authored 446 papers receiving a total of 27.7k indexed citations (citations by other indexed papers that have themselves been cited), including 288 papers in Molecular Biology, 241 papers in Oncology and 42 papers in Cancer Research. Recurrent topics in Takashi Tsuruo's work include Drug Transport and Resistance Mechanisms (127 papers), Cancer therapeutics and mechanisms (60 papers) and Cell death mechanisms and regulation (42 papers). Takashi Tsuruo is often cited by papers focused on Drug Transport and Resistance Mechanisms (127 papers), Cancer therapeutics and mechanisms (60 papers) and Cell death mechanisms and regulation (42 papers). Takashi Tsuruo collaborates with scholars based in Japan, United States and Canada. Takashi Tsuruo's co-authors include Naoya Fujita, Shigeru Tsukagoshi, Mikihiko Naito, Harumi Iida, Yoshio Sakurai, Saori Sato, Tetsuo Mashima, Akihiro Tomida, Hiroyuki Seimiya and Takao Yamori and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Nucleic Acids Research and Journal of Biological Chemistry.

In The Last Decade

Takashi Tsuruo

443 papers receiving 26.9k citations

Hit Papers

Overcoming of vincristine resistance in P388 leukemia in ... 1981 2026 1996 2011 1981 2000 1999 1982 1999 400 800 1.2k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.
    1981 1.3k citations Takashi Tsuruo et al. profile →
  2. Modulation of Akt kinase activity by binding to Hsp90
    2000 810 citations Naoya Fujita, Takashi Tsuruo et al. profile →
  3. A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors
    1999 602 citations Takashi Yamashita, Takashi Tsuruo et al. profile →
  4. Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.
    1982 598 citations Takashi Tsuruo et al. profile →
  5. Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors
    1999 574 citations Takashi Tsuruo et al. profile →
  6. Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion
    1985 493 citations Takashi Tsuruo et al. profile →
  7. Circumvention of vincristine and Adriamycin resistance in vitro and in vivo by calcium influx blockers.
    1983 337 citations Takashi Tsuruo et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Takashi Tsuruo Japan 89 16.6k 12.4k 2.8k 2.1k 2.1k 446 27.7k
Joseph R. Bertino United States 75 10.2k 0.6× 8.6k 0.7× 2.5k 0.9× 859 0.4× 718 0.3× 471 23.2k
Scott H. Kaufmann United States 95 25.8k 1.6× 11.9k 1.0× 3.7k 1.3× 4.2k 2.0× 2.8k 1.4× 406 36.2k
Mark C. Willingham United States 90 17.6k 1.1× 9.4k 0.8× 2.2k 0.8× 5.5k 2.5× 4.7k 2.3× 425 33.5k
Michihiko Kuwano Japan 75 11.4k 0.7× 6.9k 0.6× 2.5k 0.9× 2.1k 1.0× 829 0.4× 357 18.4k
Igor B. Roninson United States 67 11.1k 0.7× 10.6k 0.9× 1.4k 0.5× 1.1k 0.5× 1.1k 0.5× 158 18.1k
Boris Zhivotovsky Sweden 85 19.5k 1.2× 3.8k 0.3× 3.5k 1.3× 3.0k 1.4× 2.6k 1.3× 344 30.5k
C. Patrick Reynolds United States 74 12.7k 0.8× 5.0k 0.4× 4.8k 1.7× 2.6k 1.2× 1.1k 0.5× 338 21.8k
H. Phillip Koeffler United States 101 22.4k 1.4× 9.9k 0.8× 6.6k 2.4× 5.6k 2.6× 2.1k 1.0× 666 42.0k
James A. McCubrey United States 79 16.1k 1.0× 6.8k 0.6× 3.9k 1.4× 3.2k 1.5× 1.6k 0.8× 421 24.9k
Klaus‐Michael Debatin Germany 85 20.6k 1.2× 6.5k 0.5× 5.1k 1.8× 9.1k 4.2× 1.3k 0.6× 521 33.1k

Countries citing papers authored by Takashi Tsuruo

Since Specialization
Citations

This map shows the geographic impact of Takashi Tsuruo's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Takashi Tsuruo with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Takashi Tsuruo more than expected).

Fields of papers citing papers by Takashi Tsuruo

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Takashi Tsuruo. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Takashi Tsuruo. The network helps show where Takashi Tsuruo may publish in the future.

Co-authorship network of co-authors of Takashi Tsuruo

This figure shows the co-authorship network connecting the top 25 collaborators of Takashi Tsuruo. A scholar is included among the top collaborators of Takashi Tsuruo based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Takashi Tsuruo. Takashi Tsuruo is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Ohishi, Tomokazu, Toru Hirota, Takashi Tsuruo, & Hiroyuki Seimiya. (2010). TRF1 Mediates Mitotic Abnormalities Induced by Aurora-A Overexpression. Cancer Research. 70(5). 2041–2052. 26 indexed citations
2.
Tanaka, Hiroshi, Yutaka Hoshikawa, Tomoko Oh‐hara, et al.. (2009). PRMT5, a Novel TRAIL Receptor-Binding Protein, Inhibits TRAIL-Induced Apoptosis via Nuclear Factor-κB Activation. Molecular Cancer Research. 7(4). 557–569. 62 indexed citations
3.
Saito, Sakae, Junko Sakurai, Asami Sakamoto, et al.. (2009). Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation. Cancer Research. 69(10). 4225–4234. 137 indexed citations
4.
Isomura, Minoru, Natsuo Oya, Seiji Tachiiri, et al.. (2008). IL12RB2 and ABCA1 Genes Are Associated with Susceptibility to Radiation Dermatitis. Clinical Cancer Research. 14(20). 6683–6689. 32 indexed citations
5.
Morishita, Daisuke, Ryohei Katayama, Kazuhisa Sekimizu, Takashi Tsuruo, & Naoya Fujita. (2008). Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels. Cancer Research. 68(13). 5076–5085. 237 indexed citations
6.
Sekine, Keiko, Ryo Kikuchi, Masayuki Kitagawa, et al.. (2008). Small Molecules Destabilize cIAP1 by Activating Auto-ubiquitylation. Journal of Biological Chemistry. 283(14). 8961–8968. 147 indexed citations
7.
Tokuda, Emi, Naoya Fujita, Tomoko Oh‐hara, et al.. (2007). Casein Kinase 2–Interacting Protein-1, a Novel Akt Pleckstrin Homology Domain-Interacting Protein, Down-regulates PI3K/Akt Signaling and Suppresses Tumor Growth In vivo. Cancer Research. 67(20). 9666–9676. 53 indexed citations
8.
Kunita, Akiko, Takeshi Kashima, Yasuyuki Morishita, et al.. (2007). The Platelet Aggregation-Inducing Factor Aggrus/Podoplanin Promotes Pulmonary Metastasis. American Journal Of Pathology. 170(4). 1337–1347. 166 indexed citations
9.
Muramatsu, Yukiko, Tomokazu Ohishi, Michiko Sakamoto, Takashi Tsuruo, & Hiroyuki Seimiya. (2007). Cross‐species difference in telomeric function of tankyrase 1. Cancer Science. 98(6). 850–857. 27 indexed citations
10.
Kobayashi, Jun’ichi, Hideyuki Shigemori, Hirokazu Hosoyama, et al.. (2000). Multidrug Resistance Reversal Activity of Taxoids from Taxus cuspidate in KB‐C2 and 2780AD Cells. Japanese Journal of Cancer Research. 91(6). 638–642. 13 indexed citations
11.
Nakagawa, Takumi, Sakae Tanaka, Hiroyuki Suzuki, et al.. (2000). Overexpression of thecsk gene suppresses tumor metastasisin vivo. International Journal of Cancer. 88(3). 384–391. 43 indexed citations
12.
Nakagawa, Takumi, Naoya Fujita, Tomoko Oh‐hara, et al.. (1999). Interleukin-1? induces cyclooxygenase-2 expression in bone-derived endothelial cells. Journal of Cellular Physiology. 179(2). 226–232. 8 indexed citations
13.
Takesako, Kazutoh, et al.. (1998). Aureobasidins as New Inhibitors of P-Glycoprotein in Multidrug Resistant Tumor Cells.. The Journal of Antibiotics. 51(3). 353–358. 6 indexed citations
14.
Vasudevan, Sona, Takashi Tsuruo, & David R. Rose. (1998). Mode of Binding of Anti-P-glycoprotein Antibody MRK-16 to Its Antigen. Journal of Biological Chemistry. 273(39). 25413–25419. 12 indexed citations
15.
Oka, Mikio, Minoru Fukuda, Kôki Ikeda, et al.. (1997). A novel quinoline derivative, MS-209, overcomes drug resistance of human lung cancer cells expressing the multidrug resistance-associated protein (MRP) gene. Cancer Chemotherapy and Pharmacology. 40(5). 425–432. 29 indexed citations
16.
Naito, Mikihiko, et al.. (1997). Apoxin I, a Novel Apoptosis-inducing Factor with L-Amino Acid Oxidase Activity Purified from Western Diamondback Rattlesnake Venom. Journal of Biological Chemistry. 272(14). 9539–9542. 159 indexed citations
17.
Sakai, Teruyuki, Hiroyuki Kawai, Masaru Kamishohara, et al.. (1995). Synthesis and Antitumor Activities of Glycine-exchanged Analogs of Spicamycin.. The Journal of Antibiotics. 48(6). 504–508. 8 indexed citations
18.
Kataoka, Shiro, Mikihiko Naito, Akihiro Tomida, & Takashi Tsuruo. (1994). Resistance to Antitumor Agent-Induced Apoptosis in a Mutant of Human Myeloid Leukemia U937 Cells. Experimental Cell Research. 215(1). 199–205. 37 indexed citations
19.
Hamada, Hirofumi, et al.. (1992). Mouse‐Human Chimeric Antibody MH171 against the Multidrug Transporter P‐Glycoprotein. Japanese Journal of Cancer Research. 83(5). 515–521. 10 indexed citations
20.
O’Meara, Anne, Atsushi Imamura, Pauline Johnson, et al.. (1992). Reactivity of P-Glycoprotein Monoclonal Antibodies in Childhood Cancers. Oncology. 49(3). 203–208. 19 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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