Hiroyuki Arai

40.4k total citations · 2 hit papers
489 papers, 29.2k citations indexed

About

Hiroyuki Arai is a scholar working on Molecular Biology, Physiology and Cell Biology. According to data from OpenAlex, Hiroyuki Arai has authored 489 papers receiving a total of 29.2k indexed citations (citations by other indexed papers that have themselves been cited), including 204 papers in Molecular Biology, 145 papers in Physiology and 71 papers in Cell Biology. Recurrent topics in Hiroyuki Arai's work include Alzheimer's disease research and treatments (94 papers), Dementia and Cognitive Impairment Research (53 papers) and Sphingolipid Metabolism and Signaling (52 papers). Hiroyuki Arai is often cited by papers focused on Alzheimer's disease research and treatments (94 papers), Dementia and Cognitive Impairment Research (53 papers) and Sphingolipid Metabolism and Signaling (52 papers). Hiroyuki Arai collaborates with scholars based in Japan, United States and South Korea. Hiroyuki Arai's co-authors include Junken Aoki, Keizo Inoue, Masafumi Tsujimoto, Kotaro Hama, Makoto Arita, Nozomu Kono, Keizo Inoue, Mitsuharu Hattori, Yasuhiro Kishi and Hideki Adachi and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and The Lancet.

In The Last Decade

Hiroyuki Arai

480 papers receiving 28.6k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

2002 794 citations Makiko Umezu‐Goto, Naoshi Dohmae et al. profile →
Activation of STING requires palmitoylation at the Golgi

2016 518 citations Kojiro Mukai, Takefumi Uemura et al. Nature Communications profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Hiroyuki Arai Japan	95	15.2k	6.6k	4.3k	3.2k	2.8k	489	29.2k
Salvatore Cuzzocrea Italy	97	14.0k 0.9×	8.6k 1.3×	1.2k 0.3×	5.8k 1.8×	2.4k 0.8×	923	43.4k
Stuart A. Lipton United States	125	26.9k 1.8×	12.3k 1.9×	3.2k 0.7×	3.2k 1.0×	3.2k 1.1×	386	52.8k
Pál Pacher United States	112	11.9k 0.8×	8.2k 1.2×	1.4k 0.3×	4.7k 1.5×	1.8k 0.6×	391	44.6k
Roland Stocker Australia	87	13.8k 0.9×	4.4k 0.7×	2.1k 0.5×	4.3k 1.3×	2.2k 0.8×	314	32.0k
Jason D. Morrow United States	113	12.7k 0.8×	8.1k 1.2×	1.6k 0.4×	3.1k 1.0×	6.5k 2.3×	404	42.4k
Louis J. Ignarro United States	89	7.4k 0.5×	13.7k 2.1×	1.9k 0.4×	3.0k 0.9×	4.5k 1.6×	281	29.5k
Kelvin J.A. Davies United States	104	20.6k 1.4×	8.0k 1.2×	6.3k 1.5×	2.0k 0.6×	1.5k 0.5×	266	38.2k
Victor Darley‐Usmar United States	101	15.2k 1.0×	10.0k 1.5×	2.4k 0.6×	3.5k 1.1×	4.5k 1.6×	373	33.2k
Michael P. Murphy United Kingdom	121	33.6k 2.2×	12.0k 1.8×	2.4k 0.6×	4.6k 1.4×	4.2k 1.5×	535	56.2k
José Viña Spain	84	8.3k 0.5×	7.9k 1.2×	2.0k 0.5×	801 0.2×	1.8k 0.6×	374	25.2k

Countries citing papers authored by Hiroyuki Arai

Since Specialization

Citations

This map shows the geographic impact of Hiroyuki Arai's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hiroyuki Arai with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hiroyuki Arai more than expected).

Fields of papers citing papers by Hiroyuki Arai

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hiroyuki Arai. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hiroyuki Arai. The network helps show where Hiroyuki Arai may publish in the future.

Co-authorship network of co-authors of Hiroyuki Arai

This figure shows the co-authorship network connecting the top 25 collaborators of Hiroyuki Arai. A scholar is included among the top collaborators of Hiroyuki Arai based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hiroyuki Arai. Hiroyuki Arai is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Tachibana, Hiroshi, Kohjiro Nagao, Takafumi Ichikawa, et al.. (2023). The plasma membrane of focal adhesions has a high content of cholesterol and phosphatidylcholine with saturated acyl chains. Journal of Cell Science. 136(16). 5 indexed citations

Mukai, Kojiro, Emari Ogawa, Yoshihiko Kuchitsu, et al.. (2021). Homeostatic regulation of STING by retrograde membrane traffic to the ER. Nature Communications. 12(1). 61–61. 105 indexed citations

Nishimura, Taki, Norito Tamura, Nozomu Kono, et al.. (2017). Autophagosome formation is initiated at phosphatidylinositol synthase‐enriched ER subdomains. The EMBO Journal. 36(12). 1719–1735. 158 indexed citations

Otoki, Yurika, Shunji Kato, Fumiko Kimura, et al.. (2016). Accurate quantitation of choline and ethanolamine plasmalogen molecular species in human plasma by liquid chromatography–tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 134. 77–85. 32 indexed citations

Ogasawara, Yuta, Eisuke Itakura, Nozomu Kono, et al.. (2014). Stearoyl-CoA Desaturase 1 Activity Is Required for Autophagosome Formation. Journal of Biological Chemistry. 289(34). 23938–23950. 56 indexed citations

Kishino, Shigenobu, Michiki Takeuchi, Akiko Hirata, et al.. (2013). Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition. Proceedings of the National Academy of Sciences. 110(44). 17808–17813. 294 indexed citations

Eguchi, Kosei, Ichiro Manabe, Yumiko Tanaka, et al.. (2012). Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation. Cell Metabolism. 15(4). 518–533. 427 indexed citations

Hozawa, Atsushi, Shinichi Kuriyama, Naoki Nakaya, et al.. (2010). Relationship between Peripheral Arterial Disease and Incident Disability among Elderly Japanese: the Tsurugaya Project. Journal of Atherosclerosis and Thrombosis. 17(12). 1290–1296. 13 indexed citations

Nakazawa, Youya, Hiroyuki Arai, & Naoya Fujita. (2010). The Novel Metastasis Promoter Merm1/Wbscr22 Enhances Tumor Cell Survival in the Vasculature by Suppressing Zac1/p53-Dependent Apoptosis. Cancer Research. 71(3). 1146–1155. 42 indexed citations

10.

Arai, Hiroyuki, Nobuyuki Okamura, Masaaki Waragai, et al.. (2010). Pathobiology of Alzheimer’s disease and biomarker development.. Folia Pharmacologica Japonica. 135(1). 3–7. 1 indexed citations

11.

Tanaka, Hiroshi, Yutaka Hoshikawa, Tomoko Oh‐hara, et al.. (2009). PRMT5, a Novel TRAIL Receptor-Binding Protein, Inhibits TRAIL-Induced Apoptosis via Nuclear Factor-κB Activation. Molecular Cancer Research. 7(4). 557–569. 62 indexed citations

12.

Takahashi, Keiko, Sawako Yoshina, Masashi Maekawa, et al.. (2008). Nematode Homologue of PQBP1, a Mental Retardation Causative Gene, Is Involved in Lipid Metabolism. PLoS ONE. 4(1). e4104–e4104. 20 indexed citations

13.

Watanabe, Nobuo, Jaroslaw W. Zmijewski, Wakako Takabe, et al.. (2006). Activation of Mitogen-Activated Protein Kinases by Lysophosphatidylcholine-Induced Mitochondrial Reactive Oxygen Species Generation in Endothelial Cells. American Journal Of Pathology. 168(5). 1737–1748. 89 indexed citations

14.

Iwasaki, Koh, Takuma Satoh‐Nakagawa, Masahiro Maruyama, et al.. (2005). A Randomized, Observer-Blind, Controlled Trial of the Traditional Chinese Medicine Yi-Gan San for Improvement of Behavioral and Psychological Symptoms and Activities of Daily Living in Dementia Patients. The Journal of Clinical Psychiatry. 66(2). 248–252. 252 indexed citations

15.

Horiguchi, Masakuni, et al.. (2003). pH‐dependent translocation of α‐tocopherol transfer protein (α‐TTP) between hepatic cytosol and late endosomes. Genes to Cells. 8(10). 789–800. 57 indexed citations

16.

Mizoguchi, Toshihide, Masami Nagahama, Mitsuo Tagaya, et al.. (2002). A Novel Phospholipase A1 with Sequence Homology to a Mammalian Sec23p-interacting Protein, p125. Journal of Biological Chemistry. 277(13). 11329–11335. 78 indexed citations

17.

Pei, Yong, Michael D. Southall, John M. Johnston, et al.. (2002). Identification of Platelet-Activating Factor Acetylhydrolase II in Human Skin. Journal of Investigative Dermatology. 119(4). 913–919. 41 indexed citations

18.

Matsushita, Sachio, Hiroyuki Arai, Takefumi Yuzuriha, et al.. (2001). No association between DLST gene and Alzheimer’s disease or Wernicke-Korsakoff syndrome. Neurobiology of Aging. 22(4). 569–574. 10 indexed citations

19.

Nomura, Tomoko, Junken Aoki, Hiroyuki Arai, et al.. (1998). Purification, cDNA Cloning, and Expression of UDP-Gal: Glucosylceramide β-1,4-Galactosyltransferase from Rat Brain. Journal of Biological Chemistry. 273(22). 13570–13577. 107 indexed citations

20.

Sakuragawa, N, et al.. (1985). A case of recurrent thrombosis associated with the low response og plasminogen activator and the high response of factor VIII: C from the vessel wall by DDAVP injection. 33(2). 113–121.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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