Steven M. Opal

87.1k total citations · 13 hit papers
275 papers, 44.6k citations indexed

About

Steven M. Opal is a scholar working on Epidemiology, Immunology and Infectious Diseases. According to data from OpenAlex, Steven M. Opal has authored 275 papers receiving a total of 44.6k indexed citations (citations by other indexed papers that have themselves been cited), including 163 papers in Epidemiology, 111 papers in Immunology and 49 papers in Infectious Diseases. Recurrent topics in Steven M. Opal's work include Sepsis Diagnosis and Treatment (118 papers), Immune Response and Inflammation (101 papers) and Nosocomial Infections in ICU (16 papers). Steven M. Opal is often cited by papers focused on Sepsis Diagnosis and Treatment (118 papers), Immune Response and Inflammation (101 papers) and Nosocomial Infections in ICU (16 papers). Steven M. Opal collaborates with scholars based in United States, Belgium and Netherlands. Steven M. Opal's co-authors include Jean‐Louis Vincent, John C. Marshall, Derek C. Angus, Tom van der Poll, Mitchell M. Levy, Richard S. Hotchkiss, Gordon R. Bernard, Djillali Annane, Mervyn Singer and Jean‐Daniel Chiche and has published in prestigious journals such as New England Journal of Medicine, The Lancet and JAMA.

In The Last Decade

Steven M. Opal

274 papers receiving 43.5k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

2016 17.0k citations Djillali Annane, Gordon R. Bernard et al. JAMA profile →
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

2003 4.5k citations Mitchell M. Levy, Mitchell P. Fink et al. Critical Care Medicine profile →
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

2003 2.1k citations Mitchell M. Levy, Mitchell P. Fink et al. profile →
Anti-Inflammatory Cytokines

2000 1.3k citations Steven M. Opal et al. CHEST Journal profile →
Sepsis and septic shock

2016 1.1k citations Lyle L. Moldawer, Steven M. Opal et al. profile →
High-Dose Antithrombin III in Severe Sepsis

2001 937 citations Brian Warren, Sigurd Knaub et al. JAMA profile →
Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein

1996 930 citations Charles J. Fisher, Steven M. Opal et al. profile →
Sepsis: a roadmap for future research

2015 714 citations Jonathan Cohen, Jean‐Louis Vincent et al. profile →
Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome

2015 599 citations Bita Shakoory, Joseph A. Carcillo et al. Critical Care Medicine profile →
Pathogenesis, treatment, and prevention of pneumococcal pneumonia

2009 539 citations Steven M. Opal et al. profile →
Sepsis definitions: time for change

2013 517 citations Jean‐Louis Vincent, Steven M. Opal et al. profile →
Relationship between Plasma Levels of Lipopolysaccharide (LPS) and LPS‐Binding Protein in Patients with Severe Sepsis and Septic Shock

1999 505 citations Steven M. Opal, Jean‐Louis Vincent et al. profile →
A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens

2013 432 citations Xavier Wittebole, Steven M. Opal et al. profile →

Peers

Countries citing papers authored by Steven M. Opal

Since Specialization

Citations

This map shows the geographic impact of Steven M. Opal's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Steven M. Opal with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Steven M. Opal more than expected).

Fields of papers citing papers by Steven M. Opal

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Steven M. Opal. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Steven M. Opal. The network helps show where Steven M. Opal may publish in the future.

Co-authorship network of co-authors of Steven M. Opal

This figure shows the co-authorship network connecting the top 25 collaborators of Steven M. Opal. A scholar is included among the top collaborators of Steven M. Opal based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Steven M. Opal. Steven M. Opal is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Inter-α-inhibitor Ameliorates Endothelial Inflammation in Sepsis 2019 ·Lung ·Vandy P. Stober, Yow‐Pin Lim, Steven M. Opal, Lisheng Zhuo, Koji Kimata, Stavros Garantziotis	28
2	Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome breakdown → 2015 ·Critical Care Medicine ·Bita Shakoory, Joseph A. Carcillo, W. Winn Chatham, Richard Amdur, Huaqing Zhao, Charles A. Dinarello, Randy Q. Cron, Steven M. Opal	599
3	Future Perspectives on Regulating Pro-and Anti-Inflammatory Responses in Sepsis 2011 ·PubMed ·(unknown), Steven M. Opal	25
4	Efficacy and safety of a phospholipid emulsion (GR270773) in Gram-negative severe sepsis: Results of a phase II multicenter, randomized, placebo-controlled, dose-finding clinical trial 2009 ·Critical Care Medicine ·R. Phillip Dellinger, John Tomayko, Derek C. Angus, Steven M. Opal, (unknown), (unknown), Annie Ducher, Thierry Calandra, Jonathan B. Cohen	53
5	Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis* 2009 ·Critical Care Medicine ·Mark Tidswell, William Tillis, Steven P. LaRosa, Melvyn Lynn, Alec E. Wittek, Richard Kao, (unknown), Jagadish Gogate, Steven M. Opal	183
6	Sepsis: Time to reconsider the concept 2008 ·Critical Care Medicine ·Jean Carlet, Jonathan Cohen, Thierry Calandra, Steven M. Opal, Henry Masur	67
7	High-dose antithrombin III in the treatment of severe sepsis in patients with a high risk of death: Efficacy and safety* 2006 ·Critical Care Medicine ·Christian J. Wiedermann, Johannes Hoffmann, (unknown), Helmut Ostermann, Joachim Kienast, Josef Briegel, Richard Strauß, Heinz-Otto Keinecke, Brian Warren, Steven M. Opal	124
8	COAGULATION STATUS AND RESPONSE TO TIFACOGIN IN COMMUNITY-ACQUIRED PNEUMONIA 2005 ·CHEST Journal ·Richard G. Wunderink, Lona Poole, Fang Xie, Pierre‐François Laterre, Steven M. Opal	2
9	Recombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: Results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trial* 2004 ·Critical Care Medicine ·Steven M. Opal, Pierre‐François Laterre, Edward Abraham, Bruno François, Xavier Wittebole, S. C. Lowry, Jean-François Dhainaut, Brian Warren, Thierry Dugernier, Ángel Crespo López, Miguel Sánchez, Ignace Demeyer, Luis Jáuregui, José A. Lorente, William T. McGee, Konrad Reinhart, (unknown), Sonia Souza, John P. Pribble	103
10	CD14 receptor occupancy in severe sepsis: Results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14)* 2004 ·Critical Care Medicine ·Konrad Reinhart, Thomas Glück, Jack J. M. Ligtenberg, Klaus Tschaikowsky, (unknown), Jan Bakker, Steven M. Opal, Lyle L. Moldawer, Tim Axtelle, Terence Turner, Sonia Souza, John P. Pribble	57
11	Corticosteroids for patients with septic shock. Authors' reply 2003 ·JAMA ·Julian Brown, (unknown), Juan A. March, Julian Millo, Steven M. Opal, Jan G. Zijlstra, Iwan C.C. van der Horst, Jaap E. Tulleken, Tjip S. van der Werf, Jack J. M. Ligtenberg, David Williamson, Martin Albert, (unknown), Babak Mokhlesi, Djillali Annane, Véronique Sebille, Éric Bellissant	3
12	2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference breakdown → 2003 ·Critical Care Medicine ·Mitchell M. Levy, Mitchell P. Fink, John C. Marshall, Edward Abraham, Derek C. Angus, (unknown), Jonathan Cohen, Steven M. Opal, Jean‐Louis Vincent, Graham Ramsay	4516
13	Interactions between Coagulation and Inflammation 2003 ·Scandinavian Journal of Infectious Diseases ·Steven M. Opal	61
14	Antithrombin, heparin, and heparan sulfate 2002 ·Critical Care Medicine ·Steven M. Opal, Craig M. Kessler, Juergen Roemisch, Sigurd Knaub	111
15	Phase 1 study with recombinant chimeric monoclonal antibody against human CD14 (IC14) in patients with severe sepsis 2001 ·Critical Care Medicine ·Konrad Reinhart, (unknown), Jack J. M. Ligtenberg, Klaus Tschaikowsky, (unknown), Joost M. Bakker, Steven M. Opal, Terence Turner, (unknown), Tim Axtelle, John P. Pribble	3
16	New strategies for clinical trials in patients with sepsis and septic shock 2001 ·Critical Care Medicine ·Jonathan B. Cohen, Gordon Guyatt, Gordon R. Bernard, Thierry Calandra, (unknown), Diana Elbourne, John C. Marshall, Andrew Nunn, Steven M. Opal	125
17	Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: Time for a reevaluation 2000 ·Critical Care Medicine ·Edward Abraham, Michael A. Matthay, Charles A. Dinarello, Jean‐Louis Vincent, Jonathan Cohen, Steven M. Opal, M. P. Glauser, Polly E. Parsons, Charles J. Fisher, John E. Repine	263
18	The role of interleukin-10 in critical illness 2000 ·Current Opinion in Infectious Diseases ·Steven M. Opal, (unknown)	20
19	CLINICAL EXPERIENCE WITH RIFAMPIN-ISONIAZID-STREPTOMYCIN-ETHAMBUTOL (RISE)-RESISTANT TUBERCULOSIS 1996 ·Infectious Diseases in Clinical Practice ·David L. Horn, Dial Hewlett, (unknown), Ashok Kumar Patel, Karen Brudney, Jack T. Crawford, David Alland, Barry N. Kreiswirth, Steven M. Opal, Stephen J. Peterson	2
20	Manson’s Tropical Diseases. Twentieth Edition 1996 ·(unknown), Steven M. Opal	3

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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