Steven M. Opal

87.1k total citations · 13 hit papers
275 papers, 44.6k citations indexed

About

Steven M. Opal is a scholar working on Epidemiology, Immunology and Infectious Diseases. According to data from OpenAlex, Steven M. Opal has authored 275 papers receiving a total of 44.6k indexed citations (citations by other indexed papers that have themselves been cited), including 163 papers in Epidemiology, 111 papers in Immunology and 49 papers in Infectious Diseases. Recurrent topics in Steven M. Opal's work include Sepsis Diagnosis and Treatment (118 papers), Immune Response and Inflammation (101 papers) and Nosocomial Infections in ICU (16 papers). Steven M. Opal is often cited by papers focused on Sepsis Diagnosis and Treatment (118 papers), Immune Response and Inflammation (101 papers) and Nosocomial Infections in ICU (16 papers). Steven M. Opal collaborates with scholars based in United States, Belgium and Canada. Steven M. Opal's co-authors include Jean‐Louis Vincent, John C. Marshall, Derek C. Angus, Tom van der Poll, Mitchell M. Levy, Richard S. Hotchkiss, Gordon R. Bernard, Djillali Annane, Michael Bauer and Rinaldo Bellomo and has published in prestigious journals such as New England Journal of Medicine, The Lancet and JAMA.

In The Last Decade

Steven M. Opal

274 papers receiving 43.5k citations

Hit Papers

The Third International C... 1996 2026 2006 2016 2016 2003 2003 2000 2016 5.0k 10.0k 15.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
    2016 17.0k citations Djillali Annane, Gordon R. Bernard et al. JAMA profile →
  2. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    2003 4.5k citations Mitchell M. Levy, Mitchell P. Fink et al. Critical Care Medicine profile →
  3. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    2003 2.1k citations Mitchell M. Levy, Mitchell P. Fink et al. profile →
  4. Anti-Inflammatory Cytokines
    2000 1.3k citations Steven M. Opal et al. CHEST Journal profile →
  5. Sepsis and septic shock
    2016 1.1k citations Lyle L. Moldawer, Steven M. Opal et al. profile →
  6. High-Dose Antithrombin III in Severe Sepsis
    2001 937 citations Brian Warren, Sigurd Knaub et al. JAMA profile →
  7. Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein
    1996 930 citations Charles J. Fisher, Steven M. Opal et al. profile →
  8. Sepsis: a roadmap for future research
    2015 714 citations Jonathan Cohen, Jean‐Louis Vincent et al. profile →
  9. Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome
    2015 599 citations Bita Shakoory, Joseph A. Carcillo et al. Critical Care Medicine profile →
  10. Pathogenesis, treatment, and prevention of pneumococcal pneumonia
    2009 539 citations Steven M. Opal et al. profile →
  11. Sepsis definitions: time for change
    2013 517 citations Jean‐Louis Vincent, Steven M. Opal et al. profile →
  12. Relationship between Plasma Levels of Lipopolysaccharide (LPS) and LPS‐Binding Protein in Patients with Severe Sepsis and Septic Shock
    1999 505 citations Steven M. Opal, Jean‐Louis Vincent et al. profile →
  13. A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens
    2013 432 citations Xavier Wittebole, Steven M. Opal et al. profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
Steven M. Opal 24.8k 10.0k 8.3k 6.4k 6.2k 275 44.6k
Richard S. Hotchkiss 22.5k 0.9× 14.7k 1.5× 7.6k 0.9× 5.0k 0.8× 9.1k 1.5× 203 43.7k
Greg S. Martin 19.4k 0.8× 5.6k 0.6× 7.7k 0.9× 6.0k 0.9× 11.9k 1.9× 377 45.1k
Mervyn Singer 22.9k 0.9× 5.0k 0.5× 10.1k 1.2× 10.2k 1.6× 6.3k 1.0× 462 45.6k
Djillali Annane 20.6k 0.8× 4.5k 0.5× 9.8k 1.2× 6.7k 1.0× 4.6k 0.7× 405 42.4k
Michael Bauer 16.0k 0.6× 5.3k 0.5× 5.4k 0.7× 6.9k 1.1× 7.1k 1.1× 618 36.6k
Mitchell M. Levy 27.7k 1.1× 5.1k 0.5× 11.6k 1.4× 8.6k 1.3× 3.7k 0.6× 205 46.8k
Tom van der Poll 30.8k 1.2× 20.6k 2.1× 8.6k 1.0× 8.3k 1.3× 13.8k 2.2× 876 71.6k
Craig M. Coopersmith 14.2k 0.6× 5.7k 0.6× 5.7k 0.7× 4.3k 0.7× 4.6k 0.7× 234 27.7k
Clifford S. Deutschman 15.4k 0.6× 3.9k 0.4× 5.8k 0.7× 4.8k 0.7× 3.8k 0.6× 148 27.0k
Gordon D. Rubenfeld 20.0k 0.8× 4.9k 0.5× 11.5k 1.4× 6.4k 1.0× 4.0k 0.6× 253 46.3k

Countries citing papers authored by Steven M. Opal

Since Specialization
Citations

This map shows the geographic impact of Steven M. Opal's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Steven M. Opal with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Steven M. Opal more than expected).

Fields of papers citing papers by Steven M. Opal

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Steven M. Opal. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Steven M. Opal. The network helps show where Steven M. Opal may publish in the future.

Co-authorship network of co-authors of Steven M. Opal

This figure shows the co-authorship network connecting the top 25 collaborators of Steven M. Opal. A scholar is included among the top collaborators of Steven M. Opal based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Steven M. Opal. Steven M. Opal is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Stober, Vandy P., Yow‐Pin Lim, Steven M. Opal, et al.. (2019). Inter-α-inhibitor Ameliorates Endothelial Inflammation in Sepsis. Lung. 197(3). 361–369. 28 indexed citations
2.
Lewis, Roger, Derek C. Angus, Pierre‐François Laterre, et al.. (2018). Rationale and Design of an Adaptive Phase 2b/3 Clinical Trial of Selepressin for Adults in Septic Shock. Selepressin Evaluation Programme for Sepsis-induced Shock—Adaptive Clinical Trial. Annals of the American Thoracic Society. 15(2). 250–257. 21 indexed citations
3.
Shakoory, Bita, Joseph A. Carcillo, W. Winn Chatham, et al.. (2015). Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome. Critical Care Medicine. 44(2). 275–281. 599 indexed citations breakdown →
4.
Opal, Steven M., et al.. (2011). Future Perspectives on Regulating Pro-and Anti-Inflammatory Responses in Sepsis. PubMed. 17. 137–156. 25 indexed citations
5.
Dellinger, R. Phillip, John Tomayko, Derek C. Angus, et al.. (2009). Efficacy and safety of a phospholipid emulsion (GR270773) in Gram-negative severe sepsis: Results of a phase II multicenter, randomized, placebo-controlled, dose-finding clinical trial. Critical Care Medicine. 37(11). 2929–2938. 53 indexed citations
6.
Tidswell, Mark, William Tillis, Steven P. LaRosa, et al.. (2009). Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis*. Critical Care Medicine. 38(1). 72–83. 183 indexed citations
7.
Carlet, Jean, Jonathan Cohen, Thierry Calandra, Steven M. Opal, & Henry Masur. (2008). Sepsis: Time to reconsider the concept. Critical Care Medicine. 36(3). 964–966. 67 indexed citations
8.
Wiedermann, Christian J., Johannes Hoffmann, Helmut Ostermann, et al.. (2006). High-dose antithrombin III in the treatment of severe sepsis in patients with a high risk of death: Efficacy and safety*. Critical Care Medicine. 34(2). 285–292. 124 indexed citations
9.
Wunderink, Richard G., Lona Poole, Fang Xie, Pierre‐François Laterre, & Steven M. Opal. (2005). COAGULATION STATUS AND RESPONSE TO TIFACOGIN IN COMMUNITY-ACQUIRED PNEUMONIA. CHEST Journal. 128(4). 151S–151S. 2 indexed citations
10.
Opal, Steven M., Pierre‐François Laterre, Edward Abraham, et al.. (2004). Recombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: Results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trial*. Critical Care Medicine. 32(2). 332–341. 103 indexed citations
11.
Reinhart, Konrad, Thomas Glück, Jack J. M. Ligtenberg, et al.. (2004). CD14 receptor occupancy in severe sepsis: Results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14)*. Critical Care Medicine. 32(5). 1100–1108. 57 indexed citations
12.
Levy, Mitchell M., Mitchell P. Fink, John C. Marshall, et al.. (2003). 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Critical Care Medicine. 31(4). 1250–1256. 4516 indexed citations breakdown →
13.
Brown, Julian, Juan A. March, Julian Millo, et al.. (2003). Corticosteroids for patients with septic shock. Authors' reply. JAMA. 289(1). 41–44. 3 indexed citations
14.
Opal, Steven M., Craig M. Kessler, Juergen Roemisch, & Sigurd Knaub. (2002). Antithrombin, heparin, and heparan sulfate. Critical Care Medicine. 30(Supplement). S325–S331. 111 indexed citations
15.
Cohen, Jonathan B., Gordon Guyatt, Gordon R. Bernard, et al.. (2001). New strategies for clinical trials in patients with sepsis and septic shock. Critical Care Medicine. 29(4). 880–886. 125 indexed citations
16.
Reinhart, Konrad, Jack J. M. Ligtenberg, Klaus Tschaikowsky, et al.. (2001). Phase 1 study with recombinant chimeric monoclonal antibody against human CD14 (IC14) in patients with severe sepsis. Critical Care Medicine. 29(12). 3 indexed citations
17.
Abraham, Edward, Michael A. Matthay, Charles A. Dinarello, et al.. (2000). Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: Time for a reevaluation. Critical Care Medicine. 28(1). 232–235. 263 indexed citations
18.
Opal, Steven M., et al.. (2000). The role of interleukin-10 in critical illness. Current Opinion in Infectious Diseases. 13(3). 221–226. 20 indexed citations
19.
Horn, David L., Dial Hewlett, Ashok Kumar Patel, et al.. (1996). CLINICAL EXPERIENCE WITH RIFAMPIN-ISONIAZID-STREPTOMYCIN-ETHAMBUTOL (RISE)-RESISTANT TUBERCULOSIS. Infectious Diseases in Clinical Practice. 5(1). 68–72. 2 indexed citations
20.
Opal, Steven M., et al.. (1996). Manson’s Tropical Diseases. Twentieth Edition. 9(5). 394–395. 3 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Breakdown of academic impact, for papers by Richard S. Hotchkiss Breakdown of academic impact, for papers by Greg S. Martin Breakdown of academic impact, for papers by Mervyn Singer Breakdown of academic impact, for papers by Djillali Annane Breakdown of academic impact, for papers by Michael Bauer Breakdown of academic impact, for papers by Mitchell M. Levy Breakdown of academic impact, for papers by Tom van der Poll Breakdown of academic impact, for papers by Craig M. Coopersmith Breakdown of academic impact, for papers by Clifford S. Deutschman Breakdown of academic impact, for papers by Gordon D. Rubenfeld
Rankless by CCL
2026