Stephen Neidle

39.4k citations

478 papers · 32.8k indexed · 8 hit papers · h-index 93

Impact in

Molecular Biology top 0.02%
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- Cancer therapeutics and mechanisms
Organic Chemistry top 0.2%
- Synthesis and Biological Evaluation

Papers in

Molecular Biology 388
- DNA and Nucleic Acid Chemistry 310
- Advanced biosensing and bioanalysis techniques 195
- RNA Interference and Gene Delivery 130
- RNA and protein synthesis mechanisms 73
- Cancer therapeutics and mechanisms 52
Toxicology 17

Co-authors: Gary N. Parkinson Shankar Balasubramanian Anthony P. Reszka Laurence H. Hurley Alan K. Todd Shozeb Haider Pascale Hazel Sarah Burge
Journals: Nucleic Acids Research (40 papers)Journal of Medicinal Chemistry (30 papers)Bioorganic & Medicinal Chemistry Letters (25 papers)Journal of the American Chemical Society (24 papers)Nature (18 papers)
Partner nations: United Kingdom United States Italy

In The Last Decade

Stephen Neidle

473 papers receiving 32.2k citations

Hit Papers

8 papers align trajectories log scale

Quadruplex nucleic acids as targets for anticancer therapeutics 2017 · 379 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2017 Nature Reviews Chemistry
2016 Journal of Medicinal Chemistry
2011 Nature Reviews Drug Discovery
2009 Current Opinion in Chemical Biology
2006 Nucleic Acids Research
2002 Nature
2002 Nature Reviews Drug Discovery
1997 Journal of Medicinal Chemistry

Peers

Countries citing papers authored by Stephen Neidle

Since Specialization

Citations

This map shows the geographic impact of Stephen Neidle's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Stephen Neidle with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Stephen Neidle more than expected).

Fields of papers citing papers by Stephen Neidle

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Stephen Neidle. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Stephen Neidle. The network helps show where Stephen Neidle may publish in the future.

Co-authors

The 25 scholars most cited alongside Stephen Neidle, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Stephen Neidle Line = papers co-authored together Stephen Neidle links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Structure–activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling Scientific Reports ·Ahmed A. Ahmed, Shuang Chen, E. Braun, Richard Angell, Sally Oxenford, Gc. Black, T Ramaroson, Sarah Elizabeth Kabler, Brian E. Compas, Shozeb Haider, D. Naylor and P.M. Shannon, Stephen Neidle	2024	22
2	Interaction of N-methylmesoporphyrin IX with a hybrid left-/right-handed G-quadruplex motif from the promoter of the SLC2A1 gene Nucleic Acids Research ·Jean Krasno, Eric P. Xing, (unknown), Kevin Li, Robert C. Monsen, Jonathan B. Chaires, Stephen Neidle, Liliya A. Yatsunyk	2024	0
3	Synergistic binding of actinomycin D and echinomycin to DNA mismatch sites and their combined anti-tumour effects Nucleic Acids Research ·谭蕾, Fe Esperanza Ingalla, Long‐Yuan Li, Sheng‐Hao Lin, Stephen Neidle, Ming‐Hon Hou	2023	9
4	QN-302 demonstrates opposing effects between i-motif and G-quadruplex DNA structures in the promoter of the S100P gene Organic & Biomolecular Chemistry ·张忆勇, Rosa Ibarra Ureña, Stephen Neidle, Zoë A. E. Waller	2023	7
5	Combining 1,3‐Ditriazolylbenzene and Quinoline to Discover a New G‐Quadruplex‐Interactive Small Molecule Active against Cancer Stem‐Like Cells ChemMedChem ·Eduarda Mendes, Enrico Cadoni, Chuo-Li Rau, Marta B. Afonso, F Winston Gwathmey, João Lavrado, Daniel J. V. A. dos Santos, Jorge M. B. Vítor, Stephen Neidle, Cecília M. P. Rodrigues, Alexandra Paulo	2019	9
6	Loop flexibility in human telomeric quadruplex small-molecule complexes Nucleic Acids Research ·Gavin W. Collie, N. Campbell, Stephen Neidle	2015	41
7	Small-molecule quadruplex-targeted drug discovery Bioorganic & Medicinal Chemistry Letters ·Stephan A. Ohnmacht, Stephen Neidle	2014	155
8	A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus International Journal of Antimicrobial Agents ·Winnie Ka Po Shiu, John P. Malkinson, M. Mukhlesur Rahman, Mellynia Tari Andini, Paul Stapleton, Mekala Gunaratnam, Stephen Neidle, Shazad Mushtaq, Marina Warner, David M. Livermore, Dimitrios Evangelopoulos, Chandrakala Basavannacharya, Sanjib Bhakta, Bryan D. Schindler, Susan M. Seo, David Coleman, Glenn W. Kaatz, Simon Gibbons	2013	60
9	Methods for studying quadruplexes: Sequence, structure, recognition and biological behaviour Methods ·Stephen Neidle	2012	5
10	Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nature Reviews Drug Discovery ·Shankar Balasubramanian, Laurence H. Hurley, Stephen Neidle Hit paper breakdown →	2011	1422
11	Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands Molecular BioSystems ·Adam D. Moorhouse, Shozeb Haider, Mekala Gunaratnam, Deeksha Munnur, Stephen Neidle, John E. Moses	2008	33
12	Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands Bioorganic & Medicinal Chemistry Letters ·Francisco Cuenca, Luiz R. Falleiros, Mekala Gunaratnam, Shozeb Haider, Deeksha Munnur, Rupesh Nanjunda, W. David Wilson, Stephen Neidle	2008	118
13	Structure of an Unprecedented G-Quadruplex Scaffold in the Human c-kit Promoter Journal of the American Chemical Society ·Anh Tuân Phan, Vitaly Kuryavyi, Sarah Burge, Stephen Neidle, Dinshaw J. Patel	2007	405
14	Targeting imatinib-resistant gastrointestinal stromal tumors by down-regulation of KIT gene expression with quadruplex-stabilizing small molecules UCL Discovery (University College London) ·Mekala Gunaratnam, Francisco Cuenca, Daniel Marx, Rajiha Abdul Satar Al-Naimi, J. Fletcher, Stephen Neidle	2007	1
15	Synthesis and evaluation of analogues of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase Organic & Biomolecular Chemistry ·Yannick Barbu, Christoph Schultes, Pascale Hazel, John Mann, Stephen Neidle	2004	91
16	Sequence-dependent effects in drug-DNA interaction: the crystal structure of Hoechst 33258 bound to the d(CGCAAATTTGCG)₂duplex Nucleic Acids Research ·Dr.Sigit Sasongko, D. Brown, Jane V. Skelly, Stephen Neidle	1994	91
17	A new class of non-covalent sequence-selective DNA groove-binders with potential antitumour activity UCL Discovery (University College London) ·林健丹, Jinli Zhao, Traute Fabich-Görg, Ivan Kriaacuteni, Martin Dekeyser, Stephen Neidle	1989	1
18	Experimental DNA-Binding and Computer Modelling Studies on an Analogue of the Anti-Tumour Drug Amsacrine Journal of Biomolecular Structure and Dynamics ·Z. H. L. Abraham, Mavis Agbandje, Stephen Neidle, R. M. Acheson	1988	11
19	The crystal and molecular structure of streptomycin oxime selenate tetrahydrate Proceedings of the Royal Society of London A Mathematical and Physical Sciences ·Stephen Neidle, D. Rogers, M.B. Hursthouse	1978	7
20	A hypothesis concerning possible new derivatives of daunorubicin and adriamycin with enhanced DNA-binding properties. Munich Personal RePEc Archive (Ludwig Maximilian University of Munich) ·Stephen Neidle	1977	7

About Stephen Neidle

Stephen Neidle is a scholar working on Molecular Biology, Toxicology, Organic Chemistry, Oncology and Pharmaceutical Science, having authored 478 papers that have together received 32.8k indexed citations. Recurring topics across this work include DNA and Nucleic Acid Chemistry (310 papers), Advanced biosensing and bioanalysis techniques (195 papers), RNA Interference and Gene Delivery (130 papers), RNA and protein synthesis mechanisms (73 papers), Cancer therapeutics and mechanisms (52 papers), Metal complexes synthesis and properties (34 papers), Enzyme Structure and Function (25 papers) and Synthesis and Biological Evaluation (19 papers). The work is most often cited by research in Molecular Biology (28.8k citations), Organic Chemistry (4.9k citations), Toxicology (556 citations), Oncology (2.7k citations) and Physical and Theoretical Chemistry (615 citations). Stephen Neidle has collaborated with scholars based in United Kingdom, United States and Italy. Frequent co-authors include Gary N. Parkinson, Shankar Balasubramanian, Anthony P. Reszka, Laurence H. Hurley, Alan K. Todd, Shozeb Haider, Pascale Hazel, Sarah Burge, Mekala Gunaratnam and Lloyd R. Kèlland. Their work appears in journals such as Nucleic Acids Research, Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Journal of the American Chemical Society and Nature.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact