Laurence H. Hurley

28.5k total citations · 4 hit papers
259 papers, 24.1k citations indexed

About

Laurence H. Hurley is a scholar working on Molecular Biology, Organic Chemistry and Pharmacology. According to data from OpenAlex, Laurence H. Hurley has authored 259 papers receiving a total of 24.1k indexed citations (citations by other indexed papers that have themselves been cited), including 226 papers in Molecular Biology, 59 papers in Organic Chemistry and 33 papers in Pharmacology. Recurrent topics in Laurence H. Hurley's work include DNA and Nucleic Acid Chemistry (151 papers), Advanced biosensing and bioanalysis techniques (89 papers) and RNA Interference and Gene Delivery (76 papers). Laurence H. Hurley is often cited by papers focused on DNA and Nucleic Acid Chemistry (151 papers), Advanced biosensing and bioanalysis techniques (89 papers) and RNA Interference and Gene Delivery (76 papers). Laurence H. Hurley collaborates with scholars based in United States, United Kingdom and Czechia. Laurence H. Hurley's co-authors include Daekyu Sun, Haiyong Han, David J. Bearss, Stephen Neidle, Adam Siddiqui-Jain, Cory L. Grand, Shankar Balasubramanian, Danzhou Yang, Vijay Gokhale and Tracy A. Brooks and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Laurence H. Hurley

258 papers receiving 23.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c- MYC transcription

2002 1.9k citations Adam Siddiqui-Jain, Cory L. Grand et al. Proceedings of the National Academy of Sciences profile →
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

2011 1.4k citations Shankar Balasubramanian, Laurence H. Hurley et al. Nature Reviews Drug Discovery profile →
DNA and its associated processes as targets for cancer therapy

2002 1.2k citations Laurence H. Hurley profile →
Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound

1997 664 citations Miguel Salazar, Stephen Neidle et al. Journal of Medicinal Chemistry profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Laurence H. Hurley United States	81	21.5k	3.6k	2.0k	974	866	259	24.1k
Stephen Neidle United Kingdom	93	28.8k 1.3×	4.9k 1.3×	2.7k 1.3×	427 0.4×	420 0.5×	478	32.8k
Peter B. Dervan United States	82	21.5k 1.0×	4.5k 1.2×	2.3k 1.2×	229 0.2×	593 0.7×	358	24.7k
Michael J. Waring United Kingdom	56	9.9k 0.5×	4.1k 1.1×	2.9k 1.5×	771 0.8×	433 0.5×	263	13.9k
M.E.M. Noble United Kingdom	63	9.9k 0.5×	1.5k 0.4×	2.9k 1.4×	388 0.4×	537 0.6×	144	13.7k
S. Mark Roe United Kingdom	46	9.9k 0.5×	1.4k 0.4×	1.6k 0.8×	441 0.5×	650 0.8×	126	12.6k
Rob M. J. Liskamp Netherlands	58	10.2k 0.5×	6.6k 1.8×	1.4k 0.7×	598 0.6×	236 0.3×	338	15.1k
Bruce C. Baguley New Zealand	64	9.1k 0.4×	3.8k 1.0×	4.3k 2.1×	803 0.8×	1.9k 2.2×	384	15.0k
Paul A. Wender United States	83	10.5k 0.5×	13.3k 3.7×	1.4k 0.7×	1.8k 1.9×	618 0.7×	361	24.5k
Jonathan B. Chaires United States	64	13.4k 0.6×	4.0k 1.1×	5.1k 2.6×	440 0.5×	192 0.2×	199	16.9k
William G. Bornmann United States	66	7.7k 0.4×	2.9k 0.8×	3.6k 1.8×	647 0.7×	1.5k 1.7×	167	14.7k

Countries citing papers authored by Laurence H. Hurley

Since Specialization

Citations

This map shows the geographic impact of Laurence H. Hurley's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Laurence H. Hurley with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Laurence H. Hurley more than expected).

Fields of papers citing papers by Laurence H. Hurley

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Laurence H. Hurley. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Laurence H. Hurley. The network helps show where Laurence H. Hurley may publish in the future.

Co-authorship network of co-authors of Laurence H. Hurley

This figure shows the co-authorship network connecting the top 25 collaborators of Laurence H. Hurley. A scholar is included among the top collaborators of Laurence H. Hurley based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Laurence H. Hurley. Laurence H. Hurley is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Jin, Meiyu, Laurence H. Hurley, & Hong Xu. (2023). A synthetic lethal approach to drug targeting of G-quadruplexes based on CX-5461. Bioorganic & Medicinal Chemistry Letters. 91. 129384–129384. 10 indexed citations

Evans, Cameron W., Rupesh V. Chikhale, Christopher J. Morris, et al.. (2020). DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells. Journal of the American Chemical Society. 142(49). 20600–20604. 85 indexed citations

Wai, Daniel, David W. Lee, Vijay Gokhale, et al.. (2019). In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells. BMC Cancer. 19(1). 1251–1251. 22 indexed citations

Kendrick, Samantha, Andrea Murányi, Vijay Gokhale, Laurence H. Hurley, & Lisa M. Rimsza. (2017). Simultaneous Drug Targeting of the Promoter MYC G-Quadruplex and BCL2 i-Motif in Diffuse Large B-Cell Lymphoma Delays Tumor Growth. Journal of Medicinal Chemistry. 60(15). 6587–6597. 35 indexed citations

Kaiser, Christine, et al.. (2017). Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression. Journal of the American Chemical Society. 139(25). 8522–8536. 148 indexed citations

Kendrick, Samantha, Hyun-Jin Kang, Mohammad P. Alam, et al.. (2014). The Dynamic Character of the BCL2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure. Journal of the American Chemical Society. 136(11). 4161–4171. 237 indexed citations

Balasubramanian, Shankar, Laurence H. Hurley, & Stephen Neidle. (2011). Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?. Nature Reviews Drug Discovery. 10(4). 261–275. 1422 indexed citations breakdown →

Brown, Robert V., et al.. (2011). Demonstration that Drug-targeted Down-regulation of MYC in Non-Hodgkins Lymphoma Is Directly Mediated through the Promoter G-quadruplex. Journal of Biological Chemistry. 286(47). 41018–41027. 139 indexed citations

Henderson, Meredith C., Hong Wang, Haiyong Han, et al.. (2009). UA62784, a novel inhibitor of centromere protein E kinesin-like protein. Molecular Cancer Therapeutics. 8(1). 36–44. 42 indexed citations

10.

Guo, Kun, Vijay Gokhale, Laurence H. Hurley, & D. Sun. (2008). Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene. Nucleic Acids Research. 36(14). 4598–4608. 166 indexed citations

11.

Qin, Yong, Evonne M. Rezler, Vijay Gokhale, D. Sun, & Laurence H. Hurley. (2007). Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4. Nucleic Acids Research. 35(22). 7698–7713. 182 indexed citations

12.

Dexheimer, Thomas S., et al.. (2007). Transcriptional consequences of targeting the i-motif structure of the c-Myc promoter with TMPyP4. Cancer Research. 67. 3169–3169. 4 indexed citations

13.

Hurley, Laurence H., Daniel D. VonHoff, Adam Siddiqui-Jain, & Danzhou Yang. (2006). Drug Targeting of the c-MYC Promoter to Repress Gene Expression via a G-Quadruplex Silencer Element. Seminars in Oncology. 33(4). 498–512. 103 indexed citations

14.

Siddiqui-Jain, Adam, Cory L. Grand, David J. Bearss, & Laurence H. Hurley. (2002). Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c- MYC transcription. Proceedings of the National Academy of Sciences. 99(18). 11593–11598. 1905 indexed citations breakdown →

15.

Raymond, Éric, et al.. (2000). DNA G-Quadruplexes, Telomere-Specific Proteins and Telomere-Associated Enzymes as Potential Targets for New Anticancer Drugs. Investigational New Drugs. 18(2). 123–137. 28 indexed citations

16.

Han, Haiyong, Laurence H. Hurley, & Miguel Salazar. (1999). A DNA polymerase stop assay for G-quadruplex-interactive compounds. Nucleic Acids Research. 27(2). 537–542. 208 indexed citations

17.

Henderson, Douglas P. & Laurence H. Hurley. (1995). Molecular struggle for transcriptional control. Nature Medicine. 1(6). 525–527. 50 indexed citations

18.

Kizu, Ryoichi, et al.. (1993). Correlation of DNA sequence specificity of anthramycin and tomaymycin with reaction kinetics and bending of DNA. Biochemistry. 32(33). 8712–8722. 22 indexed citations

19.

Hurley, Laurence H., et al.. (1983). A rational basis for development of antitumor agents in the pyrrolo[1,4]benzodiazepine group. Drugs of the Future. 8(11). 957–971. 13 indexed citations

20.

Malhotra, R. K., et al.. (1979). Pyrrolo(1,4)benzodiazepine antibiotics. Chemical conversion of anthramycin into didehydroanhydroanthramycin and its utilization in biosynthetic and mode of action studies. Journal of Natural Products. 42(6). 679–680. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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