Shu Chien

62.9k total citations · 16 hit papers
642 papers, 47.2k citations indexed

About

Shu Chien is a scholar working on Molecular Biology, Pulmonary and Respiratory Medicine and Physiology. According to data from OpenAlex, Shu Chien has authored 642 papers receiving a total of 47.2k indexed citations (citations by other indexed papers that have themselves been cited), including 225 papers in Molecular Biology, 187 papers in Pulmonary and Respiratory Medicine and 168 papers in Physiology. Recurrent topics in Shu Chien's work include Blood properties and coagulation (163 papers), Erythrocyte Function and Pathophysiology (130 papers) and Cell Adhesion Molecules Research (86 papers). Shu Chien is often cited by papers focused on Blood properties and coagulation (163 papers), Erythrocyte Function and Pathophysiology (130 papers) and Cell Adhesion Molecules Research (86 papers). Shu Chien collaborates with scholars based in United States, Taiwan and China. Shu Chien's co-authors include Jeng‐Jiann Chiu, Shunichi Usami, Richard Skalak, Yi‐Shuan Li, S. Usami, Yingxiao Wang, Jason Haga, Jing Zhou, Kung-Ming Jan and Suli Yuan and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Shu Chien

630 papers receiving 45.7k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

2011 1.7k citations Jeng‐Jiann Chiu, Shu Chien profile →
Stem cell fate dictated solely by altered nanotube dimension

2009 966 citations Shu Chien et al. Proceedings of the National Academy of Sciences profile →
Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting

2016 701 citations Yi‐Shuan Li, Shu Chien et al. Proceedings of the National Academy of Sciences profile →
Molecular basis of the effects of shear stress on vascular endothelial cells

2004 685 citations Shu Chien et al. profile →
Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell

2006 676 citations Shu Chien profile →
Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response

1991 668 citations Shu Chien et al. profile →
Piezo1, a mechanically activated ion channel, is required for vascular development in mice

2014 643 citations Shu Chien et al. Proceedings of the National Academy of Sciences profile →
Strain Energy Function of Red Blood Cell Membranes

1973 637 citations Shu Chien et al. profile →
An extracellular matrix microarray for probing cellular differentiation

2005 636 citations Shu Chien et al. profile →
Visualizing the mechanical activation of Src

2005 535 citations Yingxiao Wang, Shunichi Usami et al. profile →
Red Cell Deformability and its Relevance to Blood Flow

1987 458 citations Shu Chien profile →
Piezo1 links mechanical forces to red blood cell volume

2015 439 citations Shu Chien et al. profile →
Shear Stress–Initiated Signaling and Its Regulation of Endothelial Function

2014 427 citations Jing Zhou, Yi‐Shuan Li et al. profile →
Effects of hematocrit and plasma proteins on human blood rheology at low shear rates.

1966 382 citations Shu Chien et al. profile →
Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis

2016 347 citations Kuei-Chun Wang, Phu Hung Nguyen et al. Proceedings of the National Academy of Sciences profile →
Vascular mechanotransduction

2023 114 citations Yi‐Shuan Li, Shu Chien et al. profile →

Peers

Countries citing papers authored by Shu Chien

Since Specialization

Citations

This map shows the geographic impact of Shu Chien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Shu Chien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Shu Chien more than expected).

Fields of papers citing papers by Shu Chien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Shu Chien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Shu Chien. The network helps show where Shu Chien may publish in the future.

Co-authorship network of co-authors of Shu Chien

This figure shows the co-authorship network connecting the top 25 collaborators of Shu Chien. A scholar is included among the top collaborators of Shu Chien based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Shu Chien. Shu Chien is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Identification of KU-55933 as an anti-atherosclerosis compound by using a hemodynamic-based high-throughput drug screening platform 2024 ·Proceedings of the National Academy of Sciences ·Shu‐Yi Wei, (unknown), (unknown), Weili Wang, (unknown), Shu Chien, Jeng‐Jiann Chiu	2
2	Melatonin Ameliorates Atherosclerotic Plaque Vulnerability by Regulating PPARδ‐Associated Smooth Muscle Cell Phenotypic Switching 2024 ·Journal of Pineal Research ·Sy‐Jou Chen, (unknown), Shih‐Hung Tsai, (unknown), (unknown), Po‐Shiuan Hsieh, (unknown), Shu Chien, Min‐Chien Tsai	3
3	Single-cell RNA sequencing unveils unique transcriptomic signatures of endothelial cells and role of ENO1 in response to disturbed flow 2024 ·Proceedings of the National Academy of Sciences ·Lijing Chen, Julie Yi-Shuan Li, Phu Hung Nguyen, (unknown), Zhen Chen, Shankar Subramaniam, (unknown), Shu Chien	20
4	Engineering inducible biomolecular assemblies for genome imaging and manipulation in living cells 2022 ·Nature Communications ·Peng Qin, Ziliang Huang, Kun Sun, Yahan Liu, Chi Woo Yoon, R Harrison, Danielle L. Schmitt, (unknown), Yiqian Wu, Ipek Tasan, Huimin Zhao, Jin Zhang, Sheng Zhong, Shu Chien, Yingxiao Wang	14
5	Biomechanical interactions of Schistosoma mansoni eggs with vascular endothelial cells facilitate egg extravasation 2022 ·PLoS Pathogens ·Yi‐Ting Yeh, Danielle Skinner, Ernesto Criado-Hidalgo, (unknown), (unknown), (unknown), (unknown), Shun Zhang, (unknown), Shu Chien, Juan C. Lasheras, Juan C. del Álamo, Conor R. Caffrey	7
6	Long noncoding RNA LEENE promotes angiogenesis and ischemic recovery in diabetes models 2022 ·Journal of Clinical Investigation ·Xiaofang Tang, Yingjun Luo, (unknown), Riccardo Calandrelli, (unknown), (unknown), Yifei Miao, (unknown), Walter Tsark, (unknown), (unknown), Guangyu Zhang, (unknown), Markus Kalkum, Zhao V. Wang, Shu Chien, Rama Natarajan, John P. Cooke, Sheng Zhong, Zhen Chen	21
7	Monocytes engineered with iSNAP inhibit human B‐lymphoma progression 2021 ·Bioengineering & Translational Medicine ·(unknown), (unknown), Hsin‐Hung Lin, Hannah M. Hollandsworth, (unknown), Yahan Liu, Yiqian Wu, Julie Y.-S. Li, Hongquan Xu, Shu Chien, Michael Bouvet, Yingxiao Wang	4
8	Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions 2021 ·Proceedings of the National Academy of Sciences ·Mano R. Maurya, Shakti Gupta, Julie Yi-Shuan Li, Nassim E. Ajami, Zhen Chen, (unknown), Shu Chien, Shankar Subramaniam	69
9	Integration of FRET and sequencing to engineer kinase biosensors from mammalian cell libraries 2021 ·Nature Communications ·Longwei Liu, Praopim Limsakul, Xianhui Meng, Yan Huang, R Harrison, Tse‐Shun Huang, (unknown), Yiyan Yu, (unknown), Sheng Zhong, Shaoying Lu, Jin Zhang, Shu Chien, Jie Sun, Yingxiao Wang	27
10	Control of the activity of CAR-T cells within tumours via focused ultrasound 2021 ·Nature Biomedical Engineering ·Yiqian Wu, Yahan Liu, Ziliang Huang, Xin Wang, Zhen Jin, Jiayi Li, Praopim Limsakul, (unknown), M. M. Allen, Yijia Pan, Robert H. Bussell, Aaron Jacobson, Thomas T. Liu, Shu Chien, Yingxiao Wang	161
11	Roles of KLF4 and AMPK in the inhibition of glycolysis by pulsatile shear stress in endothelial cells 2021 ·Proceedings of the National Academy of Sciences ·Yue Han, Ming He, Traci Marin, Hui Shen, Wei‐Ting Wang, Tzong-Yi Lee, Hsiao-Chin Hong, Zong‐Lai Jiang, Theodore Garland, (unknown), Brendan Gongol, Shu Chien	42
12	Vitexin inhibits APEX1 to counteract the flow-induced endothelial inflammation 2021 ·Proceedings of the National Academy of Sciences ·Chuanrong Zhao, (unknown), Qinghua Cui, Dong Wang, Yiran Zhou, Yi‐Shuan Li, Yunpeng Zhang, (unknown), Weijuan Yao, Xiaohong Wang, Wei Pang, Jianan Zhao, (unknown), Juanjuan Zhu, Shu Chien, Jing Zhou	37
13	Inhibition of Serine Protease Activity Protects Against High Fat Diet-Induced Inflammation and Insulin Resistance 2020 ·Scientific Reports ·Chin‐Sung Kuo, Jia-Shiong Chen, Liang‐Yu Lin, Geert W. Schmid‐Schönbein, Shu Chien, Po‐Hsun Huang, Jaw‐Wen Chen, Shing‐Jong Lin	22
14	Engineering light-controllable CAR T cells for cancer immunotherapy 2020 ·Science Advances ·Ziliang Huang, Yiqian Wu, (unknown), Yijia Pan, Phillip Kyriakakis, Shaoying Lu, Ya‐Ju Chang, Xin Wang, Shu Chien, Yingxiao Wang	129
15	Genome-wide colocalization of RNA–DNA interactions and fusion RNA pairs 2019 ·Proceedings of the National Academy of Sciences ·Zhangming Yan, Norman Huang, Weixin Wu, Weizhong Chen, Yiqun Jiang, Jingyao Chen, (unknown), Xingzhao Wen, Jie Xu, Qiushi Jin, Kang Zhang, Zhen Chen, Shu Chien, Sheng Zhong	45
16	Mechanogenetics for the remote and noninvasive control of cancer immunotherapy 2018 ·Proceedings of the National Academy of Sciences ·Yijia Pan, Sangpil Yoon, Jie Sun, Ziliang Huang, Changyang Lee, M. M. Allen, Yiqian Wu, Ya‐Ju Chang, Michel Sadelain, K. Kirk Shung, Shu Chien, Yingxiao Wang	207
17	TIFA as a crucial mediator for NLRP3 inflammasome 2016 ·Proceedings of the National Academy of Sciences ·(unknown), (unknown), Shuai Li, Shen‐Chih Wang, Ming He, Marcy Martin, Jiao Zhang, Tzu‐Pin Shentu, Han Xiao, Jian Kang, Kuei-Chun Wang, Zhen Chen, Shu Chien, Ming‐Daw Tsai, (unknown)	37
18	Flow-Dependent Regulation of Krüppel-Like Factor 2 Is Mediated by MicroRNA-92a 2011 ·Circulation ·Wei Wu, Han Xiao, Andrés Laguna-Fernández, Guadalupe Villarreal, Kuei-Chun Wang, Greg G. Geary, Yuzhi Zhang, Wei-Chi Wang, Hsien‐Da Huang, Jing Zhou, Yi-Shuan Li, Shu Chien, Guillermo García‐Cardeña, (unknown)	240
19	Shear stress, SIRT1, and vascular homeostasis 2010 ·Proceedings of the National Academy of Sciences ·Zhen Chen, I‐Chen Peng, Xiaopei Cui, Yi‐Shuan Li, Shu Chien, (unknown)	234
20	Integrins regulate VE-cadherin and catenins: Dependence of this regulation on Src, but not on Ras 2006 ·Proceedings of the National Academy of Sciences ·Yingxiao Wang, (unknown), Hui Miao, Julie Y.-S. Li, Shunichi Usami, Shu Chien	77

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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