Shu Chien

62.9k total citations · 16 hit papers
642 papers, 47.2k citations indexed

About

Shu Chien is a scholar working on Molecular Biology, Pulmonary and Respiratory Medicine and Physiology. According to data from OpenAlex, Shu Chien has authored 642 papers receiving a total of 47.2k indexed citations (citations by other indexed papers that have themselves been cited), including 225 papers in Molecular Biology, 187 papers in Pulmonary and Respiratory Medicine and 168 papers in Physiology. Recurrent topics in Shu Chien's work include Blood properties and coagulation (163 papers), Erythrocyte Function and Pathophysiology (130 papers) and Cell Adhesion Molecules Research (86 papers). Shu Chien is often cited by papers focused on Blood properties and coagulation (163 papers), Erythrocyte Function and Pathophysiology (130 papers) and Cell Adhesion Molecules Research (86 papers). Shu Chien collaborates with scholars based in United States, Taiwan and China. Shu Chien's co-authors include Jeng‐Jiann Chiu, Shunichi Usami, Richard Skalak, Yi‐Shuan Li, S. Usami, Yingxiao Wang, Jason Haga, Jing Zhou, Kung-Ming Jan and Suli Yuan and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Shu Chien

630 papers receiving 45.7k citations

Hit Papers

Effects of Disturbed Flow... 1966 2026 1986 2006 2011 2009 2016 2004 2006 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives
    2011 1.7k citations Jeng‐Jiann Chiu, Shu Chien profile →
  2. Stem cell fate dictated solely by altered nanotube dimension
    2009 966 citations Shu Chien et al. Proceedings of the National Academy of Sciences profile →
  3. Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting
    2016 701 citations Yi‐Shuan Li, Shu Chien et al. Proceedings of the National Academy of Sciences profile →
  4. Molecular basis of the effects of shear stress on vascular endothelial cells
    2004 685 citations Shu Chien et al. profile →
  5. Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell
    2006 676 citations Shu Chien profile →
  6. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response
    1991 668 citations Shu Chien et al. profile →
  7. Piezo1, a mechanically activated ion channel, is required for vascular development in mice
    2014 643 citations Sung Sik Hur, Shu Chien et al. Proceedings of the National Academy of Sciences profile →
  8. Strain Energy Function of Red Blood Cell Membranes
    1973 637 citations Shu Chien et al. profile →
  9. An extracellular matrix microarray for probing cellular differentiation
    2005 636 citations Shu Chien et al. profile →
  10. Visualizing the mechanical activation of Src
    2005 535 citations Yingxiao Wang, Shunichi Usami et al. profile →
  11. Red Cell Deformability and its Relevance to Blood Flow
    1987 458 citations Shu Chien profile →
  12. Piezo1 links mechanical forces to red blood cell volume
    2015 439 citations Shu Chien et al. profile →
  13. Shear Stress–Initiated Signaling and Its Regulation of Endothelial Function
    2014 427 citations Jing Zhou, Yi‐Shuan Li et al. profile →
  14. Effects of hematocrit and plasma proteins on human blood rheology at low shear rates.
    1966 382 citations Shu Chien et al. profile →
  15. Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis
    2016 347 citations Kuei-Chun Wang, Phu Hung Nguyen et al. Proceedings of the National Academy of Sciences profile →
  16. Vascular mechanotransduction
    2023 114 citations Yi‐Shuan Li, Shu Chien et al. profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
Shu Chien 16.0k 9.7k 9.7k 9.2k 8.9k 642 47.2k
Giulio Gabbiani 13.3k 0.8× 7.2k 0.7× 7.1k 0.7× 1.8k 0.2× 2.4k 0.3× 361 42.2k
Simon C. Watkins 28.3k 1.8× 6.0k 0.6× 4.9k 0.5× 3.0k 0.3× 7.8k 0.9× 788 59.2k
Martin A. Schwartz 22.6k 1.4× 19.2k 2.0× 2.8k 0.3× 5.5k 0.6× 3.8k 0.4× 409 46.8k
Christer Betsholtz 28.8k 1.8× 6.5k 0.7× 4.8k 0.5× 1.9k 0.2× 4.4k 0.5× 327 52.3k
Darwin J. Prockop 28.9k 1.8× 6.3k 0.7× 6.2k 0.6× 6.0k 0.6× 3.5k 0.4× 578 84.0k
Peter Carmeliet 53.1k 3.3× 7.7k 0.8× 9.1k 0.9× 5.7k 0.6× 6.4k 0.7× 729 100.0k
Kari Alitalo 56.8k 3.5× 8.6k 0.9× 5.9k 0.6× 2.5k 0.3× 10.9k 1.2× 716 94.3k
Elisabetta Dejana 22.7k 1.4× 8.4k 0.9× 3.0k 0.3× 1.8k 0.2× 3.7k 0.4× 389 44.0k
Richard Lee 16.8k 1.1× 3.6k 0.4× 3.0k 0.3× 3.0k 0.3× 3.5k 0.4× 412 37.9k
Harold F. Dvorak 24.4k 1.5× 3.7k 0.4× 5.1k 0.5× 4.6k 0.5× 2.8k 0.3× 279 47.8k

Countries citing papers authored by Shu Chien

Since Specialization
Citations

This map shows the geographic impact of Shu Chien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Shu Chien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Shu Chien more than expected).

Fields of papers citing papers by Shu Chien

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Shu Chien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Shu Chien. The network helps show where Shu Chien may publish in the future.

Co-authorship network of co-authors of Shu Chien

This figure shows the co-authorship network connecting the top 25 collaborators of Shu Chien. A scholar is included among the top collaborators of Shu Chien based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Shu Chien. Shu Chien is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Zhao, Guojun, Yajuan Li, Shijie Qin, et al.. (2025). METTL3 mediates atheroprone flow–induced glycolysis in endothelial cells. Proceedings of the National Academy of Sciences. 122(19). e2424796122–e2424796122. 4 indexed citations
2.
Chen, Lijing, Julie Yi-Shuan Li, Phu Hung Nguyen, et al.. (2024). Single-cell RNA sequencing unveils unique transcriptomic signatures of endothelial cells and role of ENO1 in response to disturbed flow. Proceedings of the National Academy of Sciences. 121(5). e2318904121–e2318904121. 20 indexed citations
3.
Qin, Peng, Ziliang Huang, Kun Sun, et al.. (2022). Engineering inducible biomolecular assemblies for genome imaging and manipulation in living cells. Nature Communications. 13(1). 7933–7933. 14 indexed citations
4.
Wei, Shu‐Yi, Jinhua Chen, Weili Wang, et al.. (2022). Vinculin phosphorylation impairs vascular endothelial junctions promoting atherosclerosis. European Heart Journal. 44(4). 304–318. 32 indexed citations
5.
Han, Yue, Ming He, Traci Marin, et al.. (2021). Roles of KLF4 and AMPK in the inhibition of glycolysis by pulsatile shear stress in endothelial cells. Proceedings of the National Academy of Sciences. 118(21). 42 indexed citations
6.
Wu, Yiqian, Yahan Liu, Ziliang Huang, et al.. (2021). Control of the activity of CAR-T cells within tumours via focused ultrasound. Nature Biomedical Engineering. 5(11). 1336–1347. 161 indexed citations
7.
Zhao, Chuanrong, Qinghua Cui, Dong Wang, et al.. (2021). Vitexin inhibits APEX1 to counteract the flow-induced endothelial inflammation. Proceedings of the National Academy of Sciences. 118(48). 37 indexed citations
8.
9.
Liu, Longwei, Praopim Limsakul, Xianhui Meng, et al.. (2021). Integration of FRET and sequencing to engineer kinase biosensors from mammalian cell libraries. Nature Communications. 12(1). 5031–5031. 27 indexed citations
10.
Lin, Hsin‐Hung, Hannah M. Hollandsworth, Yahan Liu, et al.. (2021). Monocytes engineered with iSNAP inhibit human B‐lymphoma progression. Bioengineering & Translational Medicine. 7(2). e10285–e10285. 4 indexed citations
11.
Kuo, Chin‐Sung, Jia-Shiong Chen, Liang‐Yu Lin, et al.. (2020). Inhibition of Serine Protease Activity Protects Against High Fat Diet-Induced Inflammation and Insulin Resistance. Scientific Reports. 10(1). 1725–1725. 22 indexed citations
12.
Huang, Ziliang, Yiqian Wu, Yijia Pan, et al.. (2020). Engineering light-controllable CAR T cells for cancer immunotherapy. Science Advances. 6(8). eaay9209–eaay9209. 129 indexed citations
13.
Chen, Yu-Fan, Chih‐Hung Chou, Hsien‐Da Huang, et al.. (2020). Control of matrix stiffness promotes endodermal lineage specification by regulating SMAD2/3 via lncRNA LINC00458. Science Advances. 6(6). eaay0264–eaay0264. 50 indexed citations
14.
Yan, Zhangming, Norman Huang, Weixin Wu, et al.. (2019). Genome-wide colocalization of RNA–DNA interactions and fusion RNA pairs. Proceedings of the National Academy of Sciences. 116(8). 3328–3337. 45 indexed citations
15.
Hur, Sung Sik, Chia‐Ming Chang, Hsiao‐Hui Lee, et al.. (2018). Lis1 dysfunction leads to traction force reduction and cytoskeletal disorganization during cell migration. Biochemical and Biophysical Research Communications. 497(3). 869–875. 23 indexed citations
16.
Qin, Peng, Shaoying Lu, Yuxin Shi, et al.. (2018). Coordinated histone modifications and chromatin reorganization in a single cell revealed by FRET biosensors. Proceedings of the National Academy of Sciences. 115(50). E11681–E11690. 45 indexed citations
17.
Li, Shuai, Shen‐Chih Wang, Ming He, et al.. (2016). TIFA as a crucial mediator for NLRP3 inflammasome. Proceedings of the National Academy of Sciences. 113(52). 15078–15083. 37 indexed citations
18.
Wu, Wei, Han Xiao, Andrés Laguna-Fernández, et al.. (2011). Flow-Dependent Regulation of Krüppel-Like Factor 2 Is Mediated by MicroRNA-92a. Circulation. 124(5). 633–641. 240 indexed citations
19.
Chen, Zhen, et al.. (2010). Shear stress, SIRT1, and vascular homeostasis. Proceedings of the National Academy of Sciences. 107(22). 10268–10273. 234 indexed citations
20.
Wang, Yingxiao, et al.. (2006). Integrins regulate VE-cadherin and catenins: Dependence of this regulation on Src, but not on Ras. Proceedings of the National Academy of Sciences. 103(6). 1774–1779. 77 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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