Santhakumar Manicassamy

7.8k total citations · 1 hit paper
55 papers, 6.3k citations indexed

About

Santhakumar Manicassamy is a scholar working on Immunology, Molecular Biology and Genetics. According to data from OpenAlex, Santhakumar Manicassamy has authored 55 papers receiving a total of 6.3k indexed citations (citations by other indexed papers that have themselves been cited), including 40 papers in Immunology, 23 papers in Molecular Biology and 9 papers in Genetics. Recurrent topics in Santhakumar Manicassamy's work include Immune Cell Function and Interaction (23 papers), Immunotherapy and Immune Responses (18 papers) and T-cell and B-cell Immunology (11 papers). Santhakumar Manicassamy is often cited by papers focused on Immune Cell Function and Interaction (23 papers), Immunotherapy and Immune Responses (18 papers) and T-cell and B-cell Immunology (11 papers). Santhakumar Manicassamy collaborates with scholars based in United States, Georgia and Australia. Santhakumar Manicassamy's co-authors include Bali Pulendran, Muthusamy Thangaraju, Puttur D. Prasad, David H. Munn, Vadivel Ganapathy, Huidong Shi, Ravi N. Padia, Nagendra Singh, Evan Brady and Stefan Offermanns and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Nature Medicine.

In The Last Decade

Santhakumar Manicassamy

54 papers receiving 6.2k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

2014 1.8k citations Nagendra Singh, Ashish Gurav et al. Immunity profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Santhakumar Manicassamy United States	32	3.1k	2.9k	858	715	676	55	6.3k
Yun Kyung Lee South Korea	27	3.4k 1.1×	2.4k 0.8×	951 1.1×	571 0.8×	799 1.2×	59	7.1k
Paul deRoos United States	17	3.1k 1.0×	3.2k 1.1×	696 0.8×	532 0.7×	916 1.4×	31	6.6k
Nagendra Singh United States	36	4.2k 1.4×	2.8k 1.0×	1.2k 1.4×	678 0.9×	1.3k 1.9×	86	8.3k
Frédéric Sierro Australia	23	2.3k 0.8×	1.6k 0.6×	639 0.7×	448 0.6×	845 1.3×	32	4.8k
Roberta Caruso Italy	38	2.5k 0.8×	2.9k 1.0×	856 1.0×	906 1.3×	546 0.8×	104	6.9k
Takashi Yokochi Japan	41	1.9k 0.6×	2.5k 0.9×	626 0.7×	827 1.2×	513 0.8×	295	6.3k
Yan Zheng China	28	2.0k 0.7×	4.7k 1.6×	1.2k 1.5×	698 1.0×	634 0.9×	152	7.9k
François Trottein France	53	2.7k 0.9×	4.4k 1.5×	729 0.8×	1.2k 1.7×	1.2k 1.8×	159	8.9k
Joris van der Veeken United States	19	3.0k 1.0×	1.8k 0.6×	602 0.7×	401 0.6×	824 1.2×	22	5.1k
Jason A. Hall United States	19	2.3k 0.8×	5.5k 1.9×	574 0.7×	675 0.9×	573 0.8×	26	8.2k

Countries citing papers authored by Santhakumar Manicassamy

Since Specialization

Citations

This map shows the geographic impact of Santhakumar Manicassamy's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Santhakumar Manicassamy with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Santhakumar Manicassamy more than expected).

Fields of papers citing papers by Santhakumar Manicassamy

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Santhakumar Manicassamy. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Santhakumar Manicassamy. The network helps show where Santhakumar Manicassamy may publish in the future.

Co-authorship network of co-authors of Santhakumar Manicassamy

This figure shows the co-authorship network connecting the top 25 collaborators of Santhakumar Manicassamy. A scholar is included among the top collaborators of Santhakumar Manicassamy based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Santhakumar Manicassamy. Santhakumar Manicassamy is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Han, Julianna, Athmane Teghanemt, Henry L. Keen, et al.. (2025). Transcriptional repressor Capicua is a gatekeeper of cell-intrinsic interferon responses. Cell Host & Microbe. 33(4). 512–528.e7.

Ramachandran, Sabarish, Pachiappan Arjunan, Nikhil Patel, et al.. (2021). RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy. Molecular Cancer Research. 19(9). 1486–1497. 15 indexed citations

Manicassamy, Santhakumar, Puttur D. Prasad, & Daniel Swafford. (2021). Mouse Models of Colitis-Associated Colon Cancer. Methods in molecular biology. 2224. 133–146. 2 indexed citations

Swafford, Daniel, Arulkumaran Shanmugam, Punithavathi Ranganathan, et al.. (2020). The Wnt–β-Catenin–IL-10 Signaling Axis in Intestinal APCs Protects Mice from Colitis-Associated Colon Cancer in Response to Gut Microbiota. The Journal of Immunology. 205(8). 2265–2275. 11 indexed citations

Suryawanshi, Amol, Mohamed S. Hussein, Puttur D. Prasad, & Santhakumar Manicassamy. (2020). Wnt Signaling Cascade in Dendritic Cells and Regulation of Anti-tumor Immunity. Frontiers in Immunology. 11. 122–122. 45 indexed citations

Swafford, Daniel, Arulkumaran Shanmugam, Punithavathi Ranganathan, et al.. (2018). Canonical Wnt Signaling in CD11c+ APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon. The Journal of Immunology. 200(9). 3259–3268. 30 indexed citations

Ranganathan, Punithavathi, Daniel Swafford, Amol Suryawanshi, et al.. (2018). GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis. The Journal of Immunology. 200(5). 1781–1789. 130 indexed citations

Pathania, Rajneesh, Sabarish Ramachandran, G. Mariappan, et al.. (2016). Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth. Cancer Research. 76(11). 3224–3235. 129 indexed citations

Yuan, Hong, Indumathi Manoharan, Amol Suryawanshi, et al.. (2015). β-Catenin Promotes Regulatory T-cell Responses in Tumors by Inducing Vitamin A Metabolism in Dendritic Cells. Cancer Research. 75(4). 656–665. 100 indexed citations

10.

Singh, Nagendra, Ashish Gurav, Sathish Sivaprakasam, et al.. (2014). Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis. Immunity. 40(1). 128–139. 1790 indexed citations breakdown →

11.

Manicassamy, Santhakumar, Boris Reizis, Rajesh Ravindran, et al.. (2010). Activation of β-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine. Science. 329(5993). 849–853. 412 indexed citations

12.

Pulendran, Bali, Hua Tang, & Santhakumar Manicassamy. (2010). Programming dendritic cells to induce TH2 and tolerogenic responses. Nature Immunology. 11(8). 647–655. 275 indexed citations

13.

Manicassamy, Santhakumar, Rajesh Ravindran, Jiusheng Deng, et al.. (2009). Toll-like receptor 2–dependent induction of vitamin A–metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity. Nature Medicine. 15(4). 401–409. 251 indexed citations

14.

Huang, Zhaofeng, Ruiqing Wang, Huimin Xie, et al.. (2008). Stabilized β-Catenin Potentiates Fas-Mediated T Cell Apoptosis. The Journal of Immunology. 180(10). 6586–6592. 10 indexed citations

15.

Manicassamy, Santhakumar, et al.. (2008). A Critical Role for Protein Kinase C-θ-Mediated T Cell Survival in Cardiac Allograft Rejection. The Journal of Immunology. 181(1). 513–520. 31 indexed citations

16.

Cao, Weiping, Santhakumar Manicassamy, Hua Tang, et al.. (2008). Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway. Nature Immunology. 9(10). 1157–1164. 327 indexed citations

17.

Manicassamy, Santhakumar & Zuoming Sun. (2007). The Critical Role of Protein Kinase C-θ in Fas/Fas Ligand-Mediated Apoptosis. The Journal of Immunology. 178(1). 312–319. 33 indexed citations

18.

Manicassamy, Santhakumar, Sonal Gupta, Zhaofeng Huang, & Zuoming Sun. (2006). Protein Kinase C-θ-Mediated Signals Enhance CD4+ T Cell Survival by Up-Regulating Bcl-xL. The Journal of Immunology. 176(11). 6709–6716. 59 indexed citations

19.

Gudi, Radhika, John Barkinge, Fei Chu, et al.. (2006). Siva-1 negatively regulates NF-κB activity: effect on T-cell receptor-mediated activation-induced cell death (AICD). Oncogene. 25(24). 3458–3462. 30 indexed citations

20.

Manicassamy, Santhakumar, et al.. (2000). Effect of monocrotophos on plasma phosphatase activity of a fresh water fish, Anabas testudineus (bloch). 19(2). 257–259. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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